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International Journal of Automation and computing 2020年第3期17卷 453-463页

作者： fernando agustin pazos Anibal Zanini Amit Bhaya Department of Electronics and Telecommunication Engineering State University of Rio de JaneiroRua São Fransciso Xavier 524Rio de Janeiro 20550-900Brazil Universidad de Buenos Aires-ITHES-UBA-CONICET Departamento de Ingenieria QuimicaPabellón de IndustriasCiudad UniversitariaBuenos Aires C1428EGAArgentina Department of Electrical Engineering Federal University of Rio de JaneiroPEE/COPPE/UFRJRio de Janeiro 21945-970Brazil

Methods to stabilize discrete-time linear control systems subject to variable sampling rates,i.e.,using state feedback controllers,are well known in the *** recent works address the use of the Tikhonov regularization method,originally designed to attenuate the noise effects on ill-posed problems,with the aim of improving performance and stabilizing approximately controllable dynamical *** by these works,we propose the use of a feedback controller designed using the Tikhonov method to regularize discrete-time linear systems subject to varying sampling *** goal is to minimize an error function,thus improving the performance of the closed loop system and reducing the possibility of *** examples show the effectiveness of the proposed method.

关键词： Discrete-time switched systems Tikhonov regularization varying sampling rates discrete-time control systems networked control systems

Range of adiposity and cardiorenal syndrome

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World Journal of Diabetes 2020年第8期11卷 322-350页

作者： fernando pazos Department of Medicine Medicine FacultyCantabria UniversityValdecilla HospitalSantander 39080CantabriaSpain

Obesity and obesity-related co-morbidities,diabetes mellitus,and hypertension are among the fastest-growing risk factors of heart failure and kidney disease ***,which is not a unitary concept,or a static process,ranges from alterations in distribution to the amount of *** adiposity,which includes intraabdominal visceral fat mass and ectopic fat deposition such as hepatic,cardiac,or renal,was robustly associated with a greater risk for cardiorenal morbidity than subcutaneous *** addition,morbid obesity has also demonstrated a negative effect on cardiac and renal *** mechanisms by which adipose tissue is linked with the cardiorenal syndrome(CRS)are hemodynamic and mechanical changes,as well neurohumoral pathways such as insulin resistance,endothelial dysfunction,nitric oxide bioavailability,renin-angiotensin-aldosterone,oxidative stress,sympathetic nervous systems,natriuretic peptides,adipokines and *** and other associated co-morbidities induce adverse cardiac remodeling and interstitial *** failure with preserved ejection fraction has been associated with obesity-related functional and structural *** might also impair kidney function through hyperfiltration,increased glomerular capillary wall tension,and podocyte dysfunction,which leads to tubulointerstitial fibrosis and loss of nephrons and,finally,chronic kidney *** development of new treatments with renal and cardiac effects in the context of type 2 diabetes,which improves mortality outcome,has highlighted the importance of CRS and its *** body fat triggers cellular,neurohumoral and metabolic pathways,which create a phenotype of the CRS with specific cellular and biochemical *** has become a single cardiorenal umbrella or type of cardiorenal metabolic *** review article provides a clinical overview of the available data on the relationship between a range of adiposity

关键词： Obesity Morbid obesity Cardiorenal syndrome Heart failure Chronic kidney disease

Punctual mutations in 23S rRNA gene of clarithromycinresistant Helicobacter pylori in Colombian populations

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World Journal of Gastroenterology 2018年第14期24卷 1531-1539页

作者： Andrés Jenuer Matta Diana Carolina Zambrano Alvaro Jairo pazos Registro Poblacional de Cáncer de Cali Department of Pathology School of Medicine Universidad del Valle Faculty of Education and Sports Sciences Institución Universitaria Escuela Nacional del Deporte Department of Biology Universidad de Nari?o

AIM To characterize punctual mutations in 23S rRNA gene of clarithromycin-resistant Helicobacter pylori(H. pylori) and determine their association with therapeutic *** PCR products of 23S rRNA gene V domain of 74 H. pylori isolates; 34 resistant to clarithromycin(29 from a low-risk gastric cancer(GC) population: TumacoColombia, and 5 from a high-risk population: TuquerresColombia) and 40 from a susceptible population(28 from Tumaco and 12 from Túquerres) were sequenced using capillary electrophoresis. The concordance between mutations of V domain 23S rRNA gene of H. pylori and therapeutic failure was determined using the Kappa coefficient and Mc Nemar's test was performed to determine the relationship between H. pylori mutationsand clarithromycin ***23S rRNA gene from H. pylori was amplified in 56/74 isolates, of which 25 were resistant to clarithromycin(20 from Tumaco and 5 from Túquerres, respectively). In 17 resistant isolates(13 from Tumaco and 4 from Túquerres) the following mutations were found: A1593 T1, A1653 G2, C1770 T, C1954 T1, and G1827 C in isolates from Tumaco, and A2144 G from Túquerres. The mutations T2183 C, A2144 G and C2196 T in H. pylori isolates resistant to clarithromycin from Colombia are reported for the first time. No association between the H. pylori mutations and in vitro clarithromycin resistance was found. However, therapeutic failure of eradication treatment was associated with mutations of 23S rRNA gene in clarithromycin-resistant H. pylori(κ = 0.71).CONCLUSION The therapeutic failure of eradication treatment in the two populations from Colombia was associated with mutations of the 23S rRNA gene in clarithromycinresistant H. pylori.

关键词： Clarithromycin In vitro resistance Point mutation Helicobacter pylori Gastric cancer 23S rRNA

The USLE soil erodibility nomograph revisited

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International Soil and Water Conservation Research 2023年第1期11卷 1-13页

作者： Eva Corral-pazos-de-Provens ígor Rapp-Arraras Juan M.Domingo-Santos School of Engineering University of HuelvaE-21007 HuelvaSpain

The nomograph by Wischmeier et al.(1971)for calculating the K-factor in the USLE was extremely useful when there was low access to ***,the generalised calculation of this factor requires the development of analytic *** paper presents a detailed analysis of the nomograph and its underlying equation,which is applicable only when the silt plus very find sand fraction does not exceed 70%.We also examined the quality of fit on the nomograph of the adaptations to the equation that have been proposed,as a means of dealing with those areas where the original equation is not *** models are shown to have areas where the fit is deficient or even ***,the family of curves on the nomograph for the various values taken by the organic matter are not coincident with the mathematical function from which they presumably *** study also identifies those areas of the textural triangle in which the soils originally used in developing the USLE are located,with a view to according a lower predictive value to the contrasting areas in which calculations of the K-factor will necessarily be ***,a new equation for calculating the K-factor is presented,which accurately reproduces the different sections of the nomograph,and allows the poorly functioning graph to be dispensed *** paper ends with a link to a tool in R for simplifying the procedure for calculating the K-factor,taking into account varying situations of data availability.

关键词： K-factor RUSLE Soil texture Organic matter Very find sand Soil loss prediction

Effect of treatment failure on the Cag A EPIYA motif in Helicobacter pylori strains from Colombian subjects

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World Journal of Gastroenterology 2017年第11期23卷 1980-1989页

作者： Javier Andres Bustamante-Rengifo Andres Jenuer Matta Alvaro Jairo pazos Luis Eduardo Bravo Department of Microbiology School of Basic ScienceUniversidad del Valle Registro Poblacional de Cáncer de Cali Department of PathologySchool of MedicineUniversidad del Valle Department of Biology Universidad de Narino

AIM To evaluate effect of treatment failure on cag A and vac A genotypes in Helicobacter pylori(H. pylori) isolates from *** One hundred and seventy-six participants infected with H. pylori from Colombia were treated during 14 d with the triple-standard therapy. Six weeks later, eradication was evaluated by 13C-Urea breath test. Patients with treatment failure were subjected to endoscopy control; biopsies obtained were used for histopathology and culture. DNA from H. pylori isolates was amplified using primers specific for cag A and vac A genes. The phylogenetic relationships among isolates obtained before and after treatment were established by conglomerate analysis based on random amplified polymorphic DNA(RAPD) *** Treatment effectiveness was at 74.6%. Of the par-ticipants with treatment failure, 25 accepted subjected to a second endoscopy. Prevalence of posttreatment infection was 64%(16/25) and 40%(10/25) by histology and culture, respectively. Upon comparing the cag A and vac A genotypes found before and after therapy, multiple cag A genotypes(cag A-positive and cag A-negative) were found before treatment; in contrast, cag A-negative genotypes decreased after treatment. vac A s1m1 genotype was highly prevalent in patients before and after therapy. The 3'cag A region was successfully amplified in 95.5%(21/22) of the isolates obtained before and in 81.8%(18/22) of the isolates obtained after treatment. In the isolates obtained from patients with treatment failure, it was found that 72.7%(16/22) presented alterations in the number of EPIYA motifs, compared to isolates found before *** Unsuccessful treatment limits colonization by lowvirulence strains resulting in partial and selective eradication in mixed infections, and acts on the cag A-positive strains inducing genetic rearrangements in cag A variable region that produces a loss or gain of EPIYA repetitions.

关键词： Helicobacter pylori RAPD-PCR Treatment failure EPIYA motifs 3’ cag A variable region

Impact of Adrenaline or Cortisol Injection on Meat Quality Development of Merino Hoggets

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Journal of Integrative Agriculture 2013年第11期12卷 1931-1936页

作者： Dario G Pighin Sebastian A Cunzolo Maria Zimerman Adriana A pazos Ernesto Domingo Anibal J Pordomingo Gabriela Grigioni Institute of Food Technology National Institute of Agricultural Technology(INTA)De Los Reseros y Las CabaasMorón 1708Argentina National Council of Scientific and Technological Research-CONICET Av.Rivadavia 1917Buenos Aires 1033Argentina Faculty of Agricultural and Food Sciences University of Moron Experimental Station-INTA Bariloche Modesta Victoria 4450San Carlos de Bariloche Río Negro 8400Argentina Institute of Food Technology National Institute of Agricultural Technology(INTA)De Los Reseros y Las Caba asMorón 1708Argentina Experimental Station-INTA Anguil Ruta Nacional No 5 Km.580(6326)La Pampa 6326Argentina

Increased levels of stress hormones in the muscle could lead to post mortem metabolic/structural modiifcations that could be relfected on meat quality. The present study investigated the metabolic effect of either adrenaline or cortisol injected into lambs in order to obtain an animal model of acute stress. Results showed that adrenaline or cortisol injection lead to glucose metabolism and muscle temperature increase. Muscle pH immediately post mortem was affected by adrenaline treatment. Water holding capacity （WHC） of fresh muscle, ifnal muscle pH and temperature registered at 24 h post mortem were not affected by injected hormones. Hardness and adhesiveness of LD muscle evaluated 3 d post mortem tended to increase as a result of adrenaline or cortisol injection. Results demonstrated that injected hormones were able to affect the post mortem muscle biochemistry and the pH/T curve independently of ifnal muscle pH.

关键词： stress hormones muscle metabolism meat quality

Genomic variability of Helicobacter pylori isolates of gastric regions from two Colombian populations

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World Journal of Gastroenterology 2017年第5期23卷 800-809页

作者： Andrés Jenuer Matta Alvaro Jairo pazos Javier Andrés Bustamante-Rengifo Luis Eduardo Bravo Registro Poblacional de Cáncer de Cali Department of PathologySchool of MedicineUniversidad del Valle Department of Biology Universidad de Narino

AIMTo compare the genomic variability and the multiple colonization of Helicobacter pylori (H. pylori) in patients with chronic gastritis from two Colombian populations with contrast in the risk of developing gastric cancer (GC): Túquerres-Nariño (High risk) and Tumaco-Nariño (Low risk).METHODSFour hundred and nine patients from both genders with dyspeptic symptoms were studied. Seventy-two patients were included in whom H. pylori was isolated from three anatomic regions of the gastric mucosa, (31/206) of the high risk population of GC (Túquerres) and (41/203) of the low risk population of GC (Tumaco). The isolates were genotyped by PCR-RAPD. Genetic diversity between the isolates was evaluated by conglomerates analysis and multiple correspondence *** proportion of virulent genotypes of H. pylori was 99% in Túquerres and 94% in Tumaco. The coefficient of similarity of Nei-Li showed greater genetic diversity among isolates of Túquerres (0.13) than those of Tumaco (0.07). After adjusting by age, gender and type of gastritis, the multiple colonization was 1.7 times more frequent in Túquerres than in Tumaco (P = 0.05).CONCLUSIONIn Túquerres, high risk of GC there was a greater probability of multiple colonization by H. pylori. From the analysis of the results of the PCR-RAPD, it was found higher genetic variability in the isolates of H. pylori in the population of high risk for the development of GC.

关键词： Helicobacter pylori Pathogenicity islet cag cagA vacA Multiple colonization PCR-RAPD

“The red cage”:implementation of pH-responsiveness within a macrobicyclic pyridinium-based molecular host

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Organic Chemistry Frontiers 2022年第1期9卷 81-87页

作者： Pablo Cortón Hongye Wang Iago Neira Arturo Blanco-Gómez Elena pazos Carlos Peinador Hao Li Marcos D.García Departamento de Química and Centro de Investigacións Científicas Avanzadas(CICA) Facultade de CienciasUniversidade da Coruña15071 A CoruñaSpain Department of Chemistry Zhejiang UniversityHangzhou 310027China

We present herein the implementation of pH-responsiveness into a new polycationic macrobicyclic structure,namely what we have termed the“red cage”.The hydrolytically-stable cryptand-like compound has been prepared in a relatively high yield in aqueous media by a kinetically-controlled hydrazone-exchange reaction,promoted by the unusual high stability of the new hydrazone CvN bonds *** organic media the macrobicycle was found not able to complex model aromatic *** buffered aqueous solutions,as a comparison,the“red cage”was found able to recognize them,but the binding was observed to be more efficient in acidic form of the cyclophane compared with its conjugate base.

关键词： bonds conjugate media

Probabilistic Load Flow Considering Correlation between Generation, Loads and Wind Power

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Smart Grid and Renewable Energy 2011年第1期2卷 12-20页

作者： Daniel Villanueva Andrés Feijóo José Luis pazos 不详

In this paper a procedure is established for solving the Probabilistic Load Flow in an electrical power network, considering correlation between power generated by power plants, loads demanded on each bus and power injected by wind farms. The method proposed is based on the generation of correlated series of power values, which can be used in a MonteCarlo simulation, to obtain the probability density function of the power through branches of an electrical network.

关键词： Correlation Monte Carlo Simulation Probabilistic Load Flow Wind Power Wind Farm

Participation of Auxin Transport in the Early Response of the Arabidopsis Root System to Inoculation with Azospirillum brasilense

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Phyton-International Journal of Experimental Botany 2022年第11期91卷 2383-2401页

作者： Elizabeth Carrillo-Flores Jonanci Arreola-Rivera DenníMariana pazos-Solís Moisés Bocanegra-Mondragón Grisel Fierro-Romero MaElena Mellado-Rojas Elda Beltrán-Peña Laboratorio de Transducción de Señales Edificio B3Instituto de Investigaciones Químico-Biológicas de la Universidad Michoacana de San Nicolás de HidalgoCiudad UniversitariaMorelia58030México Tecnológico de Monterrey School of Engineering and SciencesCampus QuerétaroSan PabloQuerétaro76130México School of the Environment Florida A&M UniversityTallahassee32307USA

The potential of Plant Growth Promoting Rhizobacteria(PGPR)has been demonstrated in the case of plant inoculation with bacteria of the genus Azospirillum which improves *** produces a wide variety of molecules,including the natural auxin indole-3-acetic acid(IAA),as well as other ***,several studies have suggested that auxin induces changes in plant development during their interaction with the *** effects of *** Sp245 on the development of Arabidopsis thaliana root were investigated to help explain the molecular basis of the *** results obtained showed a decrease in primary root length from the first day and remained so throughout the exposure,accompanied by a stimulation of initiation and maturation of lateral root primordia and an increase of lateral *** enhanced auxin response was evident in the vascular tissue and lateral root meristems of inoculated ***,after five days of bacterization,the response disappeared in the primary root *** role of polar auxin transport(PAT)in auxins relocation involved the PGP1,AXR4-1,and BEN2 proteins,which apparently mediated ***-induced root branching of Arabidopsis seedlings.

关键词： Auxin Azopirillum brasilense Arabidopsis auxin transport lateral roots