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Reappraisal of Hepatocellular Adenoma from Federal Health System, Rio de Janeiro, Brazil

Open Journal of Organ Transplant Surgery 2019年第1期9卷 1-10页

作者： Reinaldo fernandes Klaus Steinbruck Danielle B. Delai Jú lia R. N. Souza Igor Duque Daniel Barbosa Marcelo Enne Renato Cano Marcelo D’Oliveira Luiza Maciel Giuliano Bento Hepatobiliary Surgery Bonsucesso Federal Hospital Health Ministry Rio de Janeiro Brazil Surgery Department Antonio Pedro University Hospital Fluminense Federal University Niter&oacute i Brazil Hepatobiliary Surgery Bonsucesso Federal Hospital Health Ministry Rio de Janeiro Brazil antonio Pedro University Hospital Fluminense Federal University Niter&oacute i Brazil Hepatobiliary Surgery Servidores do Estado Federal Hospital Health Ministry Rio de Janeiro Brazil Hepatobiliary Surgery Ipanema Federal Hospital Health Ministry Rio de Janeiro Brazil Nacional Cancer Institute Rio de Janeiro Brazil

Background: Hepatocellular adenoma is a rare liver tumor that may require surgical treatment in cases of hemorrhage or suspicion of malignant lesions. Aim: To analyze data from patients who underwent hepatectomy for hepatocellular adenoma (HCA) in Rio de Janeiro, Brazil. Methods: From January 2005 to March 2019, sixty-nine patients with HCA underwent hepatectomy at centers in Rio de Janeiro. They were included in the analysis patients undergoing hepatectomy with pathological diagnosis of hepatocellular adenoma and excluded patients with hepatectomy with anatomopathological diagnosis other than hepatocellular adenoma, mainly nodular focal hyperplasia. Data related to patients, tumor and surgery were analyzed retrospectively. Results: Sixty patients (87%) were female and nine were male. Among women, 83% had a history of contraceptive use;among men, only one had an androgen intake history. Overall mean age was 36.4 years (15 - 49), with men older than women (33.9 ± 8.14 years vs. 40.4 ± 6.27 years;P = 0.02). Forty one patients reported abdominal pain, associated or not to other symptoms;32% had an episode of hemorrhage;28 were asymptomatic with an incidental radiological finding. In total, 45 patients presented only one lesion and overall mean size was 8.1 cm (2 - 31);tumors were larger among men (mean size 12.9 ± 9.86 cm vs. 7.7 ± 4.58 cm;P = 0.009). Twenty one surgeries were laparoscopic. Hepatocellular carcinoma (HCC) was identified in three specimens and the incidence was higher among men (22.2% vs. 1.6%;P = 0.042) and in tumors larger than 20 cm (66.6% vs. 0.02%). There was no perioperative mortality. Two of the three patients with HCC died with extrahepatic recurrence;the remaining patient is well after 36 months. Overall mean follow-up time was 14.2 months (2 - 76). Conclusion: Male patients with HCA were older and had larger tumors when compared to females. Incidence of HCC was higher among men and in lesions larger than 20 cm. Male patients with HCA should be

关键词： Hepatocellular Adenoma Hepatocellular Carcinoma Hepatectomy

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使用不同的软件程序对心脏和肝脏铁超负荷T2*的评估

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国际医学放射学杂志 2012年第1期 97-98页

作者： J.L.fernandes E.F.Sampaio M.Verissimo F.B.Pereira J.A.da Silva G.S.de Figueiredo 张济 Department of Internal Medicine CardiologyRua Antonio Lapa 103213025-292 CampinasSPBraz

目的评估不同软件程序计算铁超负荷T2*值之间的一致性和相互之间的差别。方法分别用3个软件程序,主要采用截断方法对60例地中海贫血病人的T2*图像进行分

关键词：肝脏铁超负荷心脏软件程序

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Punica granatum Leaf Lipophilic Fraction Favours Mortality by Attenuating Inflammation in Mice with Polymicrobial Sepsis

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 355-367页

作者： Nagila Caroline Fialho Sousa Isabella fernandes da Silva Figueiredo Mizael Calacio de Araujo Elaine Pereira de Andrade Thais Costa Alves Bruna Letícia Rosa da Silva Domingos Magno Santos Pereira Saulo JoseFigueiredo Mendes Joao Francisco Silva Rodrigues Jaqueline Pessoa Pontes Simone Aparecida Teixeira AndreAlvares Marques Vale Marcus Vinicius Dias-Souza Lidio Goncalves Lima-Neto Vera Lucia dos Santos Ana Paula Azevedo-Santos Marcelo Nicolas Muscara Valerio Monteiro-Neto Andrea de Souza Monteiro Luis Claudio Nascimento da Silva Elizabeth Soares fernandes Programa de Pos-graduacao Universidade CEUMARua JosueMontellon°1RenascencaSao LuisMA 65075-120Brazil Departamento de Farmacologia Universidade de Sao PauloAv.Prof.Lineu Prestesn°1524Sala 326ButantanSao PauloSP 05508-900Brazil Programa de Pos-graduacao em Ciências em Saude Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuisMA 65080-805Brazil Departamento de Microbiologia Universidade Federal de Minas GeraisAv.Antonio Carlosn°6627PampulhaBelo HorizonteMG 31270-901Brazil Departamento de Patologia Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuísMA 65080-805Brazil

Punica granatum *** known antimicrobial and anti-inflammatory *** of different parts of this plant have been commonly used in the folk medicine to prevent and treat infections;and studies have supported the use of *** extracts for this ***,little is known of the effects of ***-derived fractions in severe infectious diseases such as ***,we investigated the actions of the hexane fraction(HF),rich in lipophilic compounds,obtained from the leaves of this plant,in a murine model of polymicrobial *** pre-treatment with HF increased mortality in septic *** same animals presented with lower levels of interleukin-6,nitric oxide and hydrogen peroxide in their peritoneal lavage samples than vehicle *** also increased polymorphonuclear cell accumulation in to the peritoneum of mice with ***-derived nitric oxide upon lipopolysaccharide stimuli was markedly reduced by incubation with ***,triterpenes,phytosterols,vitamin E and ascorbyl palmitate were detected in the *** results indicate that *** leaf lipophilic fractions may worsen sepsis *** effect may be associated with its bioactive compounds which act synergistically or not,increasing sepsis mortality in vivo.

关键词： P.granatum infection inflammation

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