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Adrenal Insufficiency by Adrenoleukodystrophy

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Health 2020年第1期12卷 1-13页

作者： Elda Cristinne Mattos Botelho Eduardo Romero Sampaio Botelho Luciana Correa de souza Rodrigues Tatiana Prado Wanderley fernanda Navarini Queiroz Pollyana Cirino Gomes Borges Sabrina Arrais Rolim Aragao Ximenes Cruz Janete Pacheco da Silva Larissa Bianca Cunha de Sa Alberto Krayyem Arbex IPEMED Medical School AFYA EducationalBrasíliaBrazil Medical Clinic in Endocrinology and Diabetology Schleswig-FlensburgGermany

The X-linked adrenoleukodystrophy (ALD) is a severe neurodegenerative disorder due to mutations in the ABCD1 gene. Objective: To report a case of a 19-year-old man with adrenal insufficiency due to adrenoleukodystrophy. Method: Case report and literature review. Result: A previously healthy 19-year-old male patient was admitted to the emergency room with nausea and vomiting for 5 days, who progressed to abdominal pain, severe asthenia, and fever (38.5°C). He referred progressive darkening of the skin, oral mucosa, tongue and nail bed of the hands and feet, observed in the last 6 years. Emergency laboratory evaluation showed severe hyponatremia and hyperkalemia, which, together with decreased plasma cortisol, directed the investigation to causes of adrenal insufficiency. High ACTH (Adrenocorticotropic hormone) and very long chain fatty acid levels closed the diagnosis. Discussion: ALD is characterized by progressive demyelination in the central and peripheral nervous system and adrenal insufficiency consequence to the accumulation of very long chain fatty acids (VLCFA) in the adrenal. The overall incidence of ALD is 1:17,000. Adrenal insufficiency may be the first symptom of ALD in boys and adults. The diagnosis is based on the measurement of VLCFA plasma levels. Allogeneic bone marrow transplantation is the only treatment that provides a permanent cure when the procedure is performed at an early stage of brain demyelination, i.e. when patients are asymptomatic, although brain magnetic resonance imaging (MRI) is abnormal. Treatment of Addison’s disease is obligatory, but does not change the course of neurological symptoms.

关键词： Adrenoleukodystrophy Adrenomyeloneuropathy Adrenal Insufficiency Addison’s Disease

Synthesis, Characterization, and Study of PLGA Copolymer <i>in Vitro</i>degradation

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Journal of Biomaterials and Nanobiotechnology 2015年第1期6卷 8-19页

作者： Anamaria Teodora Coêlho Rios Silva Barbara Camilla Oliveira Cardoso Maria Elisa Scarpelli Ribeiro e Silva Roberto Fernando souza freitas Ricardo Geraldo Sousa Polymer Science and Technology Laboratory Chemical Engineering Department School of Engineering Federal University of Minas Gerais Belo Horizonte Brazil

The poly(lactic-co-glycolic acid), known as PLGA, is one of the main bioreabsorbable polymers used in the field of medicine today. This copolymer is widely applied in sutures, devices geared toward the controlled release of medication, and the guided regeneration of bone tissue as it presents a short degradation time. This work aimed to synthesize the 82/18 PLGA (expressed by the mass ratio of D,L-lactide and glycolide, respectively), to characterize and study the in Vitro degradation in the form of rods in phosphate buffer solution (PBS). The copolymer was synthesized by opening the cyclic dimer rings of the monomers D,L-lactide and glycolide, in the presence of the tin octanoate initiator and of the lauryl alcohol co-initiator. The characterization of the copolymer and the follow-up of its in vitro degradation were studied using: Differential Scanning Calorimetry (DSC), Thermogravimetry (TG), Infrared Molecular Absorption Spectroscopy with Fourier Transform (FTIR), Rheometry, and Scanning Electron Microscopy (SEM). Through these characterization techniques, it was possible to obtain the glass transition temperature, thermal stability, chemical composition, morphology, and molar mass of both the synthesized and the degraded copolymer. The molar mass of the synthesized copolymer was, approximately, 106 g·mol-1. The degradation rate of PLGA significantly increased from the 19th to the 28th day in PBS. After 28 days in PBS, the glass transition temperature and the molar mass reduced from 45°C to 17°C and from 1.5 × 106 g·mol-1?to 7.5 × 104?g·mol-1, respectively. The pH of the medium has a significant influence on the copolymer degradation profile. When it diminishes, it accelerates the degradation process, resulting in smaller PLGA polymer chains. This pH dependent degradation can be useful for drug release systems.

关键词： Synthesis Characterization In Vitro degradation PLGA

Influence of Cleaning Time in Household Reservoirs on Trihalomethane Formation in Treated Water

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Journal of Water Resource and Protection 2019年第11期11卷 1389-1397页

作者： Ricardo Andreola Péricles Martim Reche Gervasio Tono Graciene de souza Bido Daniele fernanda Felipe Anny Rosi Mannigel André Ribeiro da Costa Gisele Caroline Novakowski Letycia Lopes Ricardo Flavia Helena de Moura Liborio Stephane Raquel Almeida Velande da Fonseca Isabela Silva de Oliveira Giuliano Patrick Rasera Thaise Moser Teixeira University Center of Maringá (UNICESUMAR) Master in Science Technology and Food Safety Maringá Brazil State University of Ponta Grossa Campus Uvaranas Ponta Grossa Brazil State University of Maringá Maringá Brazil Federal University of Paraná Palotina Brazil

Chlorination is an efficient and low-cost technique in disinfecting water for public water supply. However, during the process, the formation of undesirable by-products called halogen compounds, such as trihalome-thanes (THMs), occurs. Some of these compounds are proven to be carcinogenic to laboratory animals. The goal of this study was to investigate the occurrence of THMs in household reservoirs and the influence of cleaning time of these reservoirs on the formation of THMs. A total of 103 households were investigated in the city of Maringá, State of Paraná, Brazil. The residences were classified according to the cleaning time of the reservoir into: up to one year, one to two years and more than two years. Samples were taken from the reservoirs and total trihalomethanes (THMt) were analyzed by gas chromatography (GC-MS), total organic carbon (TOC) by means of a Hach kit for low concentrations and free residual chlorine (CLres) by means of a kit for in loco determination. According to the results, the highest concentrations of THMt were observed in the reservoirs with cleaning time of more than 2 years. However, no amount has exceeded the maximum limit allowed by law. In general, the longer the time for cleaning the reservoir, the greater the degradation of water quality in THMt.

关键词： Trihalomethanes Distribution Network Chlorination Cancer

developing a protocol based on the Brazilian Dietary Guidelines for individual dietary advice in the primary healthcare:theoretical and methodological bases

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Family Medicine and Community Health 2022年第1期10卷 15-24页

作者： Maria Laura da Costa Louzada Cláudia Raulino Tramontt Juliana Giaj Levra de Jesus fernanda Rauber Jacqueline Resende Berriel Hochberg Thanise Sabrina souza Santos Patricia Constante Jaime department of Nutrition University of Sao PauloSao PauloBrazil Center for Epidemiological Research in Nutrition and Health(NUPENS) University of Sao PauloSao PauloBrazil

To describe the methodology of development of a protocol for application of the Brazilian Dietary Guidelines by primary healthcare professionals in individual dietary advice.A five-step approach was followed:(1)format definition;(2)definition of the instrument for assessment of individuals’food consumption;(3)Dietary Guidelines’content extraction;(4)protocol content development;(5)content and face *** example from Brazil was displayed with the development of a protocol to guide healthcare professional decision-making when providing nutrition advice based on the Brazilian Dietary *** instrument of the Brazilian Nutrition Surveillance System(SISVAN)was chosen to the food consumption assessment,which contains questions about the consumption of seven healthy or unhealthy food groups and one question about eating *** Guidelines’content extraction process led to the identification of recommendations related to the food consumption markers assessed by the SISVAN ***,a protocol was developed in a flowchart format,in which the professional’s conduct is guided by the answer given to each question of the SISVAN *** each‘non-compliant’answer(unhealthy eating practice),the professional is instructed how to provide recommendations and identify ***,experts and healthcare professionals highlighted pertinence,clarity and usability of the *** study provides the blueprint for the phase-wise development of protocols of application of the Dietary Guidelines and may contribute to promote healthier eating and ending malnutrition in all its forms.

关键词： instrument bases instru

DNA Vaccines Approach:From Concepts to Applications

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World Journal of Vaccines 2014年第2期4卷 50-71页

作者： Vanessa Bastos Pereira Meritxell Zurita-Turk Tessalia Diniz Luerce Saraiva Camila Prosperi de Castro Bianca Mendes souza Pamela Mancha Agresti fernanda Alvarenga Lima Vanessa Nathalie Pfeiffer Marcela Santiago Pacheco Azevedo Clarissa Santos Rocha Daniela Santos Pontes Vasco Azevedo Anderson Miyoshi Laboratorio de Genetica Celular e Molecular Instituto de Ciencias BiologicasUniversidade Federal de Minas Gerais(UFMG)Belo HorizonteBrazil Universidade Estadual da Paraiba(UEPB) Joao PessoaBrazil

DNA vaccines are the third generation vaccines based on purified plasmid preparations containing transgenes that encode antigenic/therapeutic proteins or peptides capable of triggering an immune response against a wide range of diseases. This vaccine platform presents several attributes that confer distinct advantages over other vaccine technologies in terms of safety, ease of fabrication and stability. Many aspects, such as antigen expression and especially vector design, are under study because of their great influence on immunogenicity and efficacy of DNA vaccines. In this regard, with the attempt of improving the efficiency of DNA vaccines, co-expression of stimulatory sequences and diverse vector delivery systems are being optimized. With this in mind, this review aims to giving a conceptual approach of DNA vaccines, explaining their mechanisms of action and listing the already licensed veterinary DNA vaccines presented in the market.

关键词： DNA Vaccines Vector design delivery Systems Approved DNA Vaccines Bacterial delivery

Rheological and Thermal Behavior of High-density Polyethylene (HDPE) at Different Temperatures

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Materials Sciences and Applications 2014年第13期5卷 923-931页

作者： Cynthia D’Avila Carvalho Erbetta Getúlio F. Manoel Ana Paula Lelis Rodrigues Oliveira Maria Elisa Scarpelli Ribeiro e Silva Roberto Fernando souza freitas Ricardo Geraldo Sousa Polymer Science and Technology Laboratory Chemical Engineering Department Engineering School Federal University of Minas Gerais Belo Horizonte Brazil

In the present work, rheological properties of HDPE samples were measured at temperatures of 150°C, 190°C and 230°C. It was shown, by oscillatory tests, at low frequencies, that, for temperatures of 150°C and 190°C, there was a predominance of the viscous behavior over the elastic one. At 230°C, there was a predominance of the elastic contribution, and there was an increase of the molar mass compared with the ones obtained from the tests at 150°C and 190°C. The results obtained from the temperature ramp oscillatory test showed that, up to around 248°C, the viscous behavior prevailed, the opposite being observed at higher temperatures. At 230°C the sample showed significantly lower values of strain when compared with the ones observed at 150°C and 190°C. Oxidative induction time (OIT), melting point and degree of crystallinity were determined by differential scanning calorimetry (DSC). The DSC results and the rheological measurements showed a completely different behavior for the HDPE samples at 230°C compared with the 150°C and the 190°C ones, suggesting that HDPE, at the temperature of 230°C, underwent thermo-oxidative degradation with the initial predominance of crosslinking.

关键词： HDPE Rheology degradation DSC FTIR

OPINION ABOUT EVENTS PROMOTED BY FESPORTE AND THE GENERAL SPORT

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OPINION ABOUT EVENTS PROMOTED BY FESPORTE AND THE GENERAL SP...

Rhyacian and Neoproterozoic magmatic associations of the Gurupi Belt,Brazil: Implications for the tectonic evolution, and regional correlations

The 2004 Pre-Olympic Congress

作者： souza G.S. Machado L.C. Otuki J.K. Francalacci V. freitas H.P. Ghizoni J. University of the South of Santa Catarina-UNISUL FlorianopolisSanta CatarinaBrazil Catarinense Foundation of Sports/State Council of Sports

＜正＞Introduction The appearance of sporting talents has been a growing one in the state of Santa *** athletes that today are international prominences,in several modalities,began their competitive path in events accomplished in your municipal districts and later in state *** importance of these events seems to be clear for the sports leaders,however,the

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Geoscience Frontiers 2020年第6期11卷 2243-2269页

作者： Evandro L.Klein Elem C.S.Lopes Joseneusa B.Rodrigues Sulsiene M.souza-Gaia Umberto G.Cordani Geological Survey of Brazil-SBN Quadra 02Bloco HEd.Central Brasília1°AndarAsa NorteBrasíliaDFCEP:70040-904Brazil GPGE-Grupo de Pesquisa Em Geologia Econômica PPGG-Programa de Pòs-Graduação Em Geologia e GeoquímicaUniversidade Federal Do ParáBelémPABrazil Geological Survey of Brazil Av.Dr.Freitas3645BelémPACEP:66095-110Brazil Universidade de São Paulo Instituto de GeociênciasRua Do Lago562Cidade UniversitariaSão Paulo-SPCEP:05508-080Brazil

The Gurupi Belt,in north-northeastern Brazil,is a mobile belt developed in the south-southwestern margin of the Sao Luis cratonic fragment and crops out as a tectonic and erosional window within the Phanerozoic ***,petrographic,geochemical,geochronological,and Nd isotopic information(new and published)constrain the timing and types of magmatic associations present in the belt and the tectonic settings in which they *** Rhyacian was the main period of magmatic activity,which can be grouped into two main stages.(1)~2185-2130 Ma:pre-collisional,juvenile,calc-alkaline magnesian and calcic ferroan granitoid suites,and minor calc-alkaline and tholeiitic mafic plutonism(now amphibolites),formed in intra-oceanic to transitional/continental arcs;and intra-or back-arc volcano-sedimentary basin.(2)~2125-2070 Ma:syn-(two-mica granites)to late-collisional(potassic to shoshonitic granites and quartz-syenite)plutonic suites produced after crustal thickening and melting,with localized migmatization,that intruded during the compressive D1 deformational phase and concomitantly with greenschist to amphibolite *** is a zonation of the Rhyacian episodes,with intra-oceanic stages occurring to the northeast,and the continental arc and collisional phases occurring to the southwest,indicating the presence of an active continental margin to the southwest,and subduction from NE to SW(present-day configuration).This magmatic framework is a continuation to the south of what is described for the Sao Luis cratonic fragment to the north,and the orogenic scenario is identical to what is observed for the same period in the West African Craton(Eburnean/Birrimian orogen),which additionally supports previous geological *** the Neoproterozoic,a few magmatic occurrences are *** extensional event allowed the intrusion of an anorogenic,nepheline syenite at ca.730 Ma,which was followed by the intrusion of a crustal,calc-alkaline microtonalite,of uncertain

关键词： Neoproterozoic Paleoproterozoic Accretionary orogeny Intracontinental orogeny West Gondwana Isotope geology

Endothelial Nitric Oxide Synthase Gene Polymorphism and Periodontal Disease

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Open Journal of Blood Diseases 2012年第2期2卷 34-37页

作者： fernanda Gobbi Amorim Maria Bernadete depoli Giovana Machado souza Simoes Bianca Prandi Campagnaro Clarissa Loureiro Tonini Iuri Drumond Louro Jose Airton Arruda Elisardo Corral Vasquez Silvana dos Santos Meyrelles Biotechnology Graduate Program Health Sciences CenterFederal University of Espirito SantoVitoriaBrazil department of Physiological Sciences Health Sciences CenterFederal University of Espirito SantoVitoriaBrazil Intercath-Meridional Hospital CariacicaBrazil.

The endothelial isoform of nitric oxide synthase (eNOS) is responsible for the physiological production of NO in endo-thelial cells and platelets. There is evidence that the G894T polymorphism of the eNOS gene is associated with this enzyme's basal activity and NO production, which could contribute to the pathogenesis of periodontal diseases (PD). Therefore, this study was designed to investigate the role of G894T polymorphism in the eNOS gene as a predisposing factor to periodontal disease. In this study we investigated the association of this polymorphism with PD in an admix-ture population (N = 119) separated into three groups: Healthy control, Moderate and Severe PD, without statistical differences among them for risk factors for PD, such as age, gender and smoking status. We observed that the GG ge-notype was associated with the progression of PD as indicated by an increase in frequency of approximately 18% in the Moderate and 26% in the Severe groups compared to the Healthy control group (p = 0.0302). This finding indicates that patients carrying the GG genotype have a greater chance of developing PD compared with those carrying the T allele, and it reinforces the notion that genetic factors contribute to the development and aggravation of PD.

关键词： eNOS Polymorphism Periodontal Disease