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Testosterone replacement maintains smooth muscle content in the corpus cavernosum of orchiectomized rats

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Asian Journal of Urology 2017年第4期4卷 223-229页

作者： Graziele Halmenschlager Ernani Luis rhoden Gabriela Almeida Motta Lucas Sagrillo Fagundes Jorge Luiz Medeiros Jr Rosalva Meurer Claudia ramos rhoden Centro Universitario Ritter dos Reis(UniRitter)and Universidade Federal de Cieˆncias da Sau´de de Porto Alegre(UFCSPA)e PPG Cieˆncias da Sau´de Porto AlegreRSBrazil Department of Urology at Universidade Federal de Cieˆncias da Sau´de de Porto Alegre(UFCSPA) Urologist at Irmandade Santa Casa de Miserico´rdia de Porto Alegre(ISCMPA)and Hospital Moinhos de Vento de Porto Alegre(HMV)Porto AlegreRSBrazil Universidade Federal de Cieˆncias da Sau´de de Porto Alegre(UFCSPA)e PPG Cieˆncias da Sau´de-Porto Alegre RSBrazil INRS Institut Armand Frappier(Universit.du Que´bec)and BioMed Research Center Laval QuebecCanada Laboratory of Morphometry Metabolismand Cardiovascular DiseaseBiomedical CenterInstitute of BiologyState University of Rio de JaneiroRio de JaneiroBrazil Laboratory of Multidisciplinary of Sciences Biomedical CenterMedical School of Valenc¸aValenc¸a/Rio de JaneiroBrazil

Objective:To evaluate the effects of testosterone(T)on the maintenance of corpus cavernosum(CC)structure and ***:Animals were divided into three groups:sham operation group(n Z 8)underwent sham operation;Orchiectomized(Orchiec)t oily vehicle group(n Z 8)underwent bilateral orchiectomy and received a single dose of oily vehicle by intramuscular injection(i.m.)30 days after orchiectomy;and Orchiec t T group(n Z 8)underwent bilateral orchiectomy and received a single dose of T undecanoate 100 mg/kg i.m.30 days after the *** were euthanized 60 days after the beginning of the experiment with an anesthetic overdose of ketamine and *** samples and penile tissue were collected on euthanasia.

关键词： Testosterone replacement Histomorphometry Androgen deprivation Hypogonadism Corpus cavernosum

Delay Times and Clinical Outcomes in Acute Myocardial Infarction: Comparison of Periods before and during the COVID-19 Pandemic—Myocardial Infarction and the Pandemic

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World Journal of Cardiovascular Diseases 2024年第6期14卷 392-400页

作者： Clarice Teixeira Silva Araújo Arnon Salviato Mameri Thúlio Carrera Guarçoni Venturini Marcus Tadeu Aguilar Constantino Matos Igor Morais Araujo Lopes Luiz Gustavo Ribeiro de Carvalho Murad Cleberson Duartes Ovani Guilherme Vassalo Morais fernanda Venturini de Castro Danielle Lopes Rocha Lucas Crespo de Barros Rodolfo Costa Sylvestre Luiz Fernando Machado Barbosa Roberto ramos Barbosa Internal Medicine Universidade Federal do Esprito Santo (UFES) Vitria Brazil Hospital Santa Casa de Misericrdia de Vitria Vitria Brazil Hospital Santa Rita de Cssia Vitria Brazil Hospital Estadual Dr. Jayme Santos Neves Serra Brazil Grupo Kora Sade Vitria Brazil Hospital Estadual Infantil e Maternidade Alzir Bernardino Alves (HIMABA) Vila Velha Brazil

Introduction: At the beginning of the COVID-19 pandemic, a drop in the number of patients treated for cardiac emergencies raised concern about cardiovascular mortality in that period. An increase in care delay for patients with ST-segment elevation myocardial infarction (STEMI) may have affected clinical outcomes. Objectives: To analyze delay times and clinical outcomes of patients with STEMI undergoing primary percutaneous coronary intervention (PPCI), before and during the COVID-19 pandemic. Methods: Retrospective observational study that included patients with STEMI undergoing PPCI from December 2018 to July 2021. The COVID-19 pandemic cases were divided into two groups: pandemic I—from March to August 2020;and pandemic II—from September 2020 to July 2021. Patients were compared according to the period of hospitalization. Primary outcomes were delay times in assistance and clinical outcomes (acute kidney injury [AKI], post-procedural vascular complications and in-hospital mortality). Results: 108 patients were included, 39 (36.1%) in the pre-pandemic period, 13 (12.1%) in pandemic I and 56 (51.8%) in pandemic II. Time from onset of symptoms to arrival at the service and door-to-balloon time did not differ significantly among groups. Vascular complications were more frequent during the pandemic (I and II) than in the pre-pandemic period (2.5% pre-pandemic vs 15.4% pandemic vs 12.5% pandemic II;p = 0.03). AKI incidence was similar in all three periods. There was a non-significant increase in in-hospital mortality during the COVID-19 pandemic. Conclusion: In patients with STEMI, there was an increase in vascular complications and a trend toward increased mortality during the COVID-19 pandemic. Delay times to admission and reperfusion did not differ significantly between before and during the pandemic.

关键词： Myocardial Infarction Primary Percutaneous Coronary Intervention Coronary Reperfusion Pandemic COVID-19

Major and minor risk factors for postoperative abdominoplasty complications:A case series

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Chinese Journal of Plastic and Reconstructive Surgery 2022年第2期4卷 56-62页

作者： Oona Tomie Daronch Renata fernanda ramos Marcante Aristides Augusto Palhares Neto Department of Plastic Surgery State University of Sao PauloBotucatuSao Paulo 18618-687Brazil

Background: Although abdominoplasty is a safe and popular surgery, it is associated with a higher complication rate than other body contouring procedures. Therefore, identifying predictive factors of major and minor complications in patients who have undergone abdominoplasty is necessary to achieve better treatment outcomes after major weight ***: This retrospective study analyzed the medical records of patients who underwent abdominoplasty between January 2016 and December 2019. The inclusion criteria were patients aged >18 years who underwent abdominoplasty as the only surgical procedure and had adequate follow-up. Other patients were excluded from the study. Statistical evaluation was performed using SPSS 20.0;statistical significance was set at a P-value of<***: The study included a total of 152 patients, of whom 146(96.1%) were women and 6(3.9%) were *** mean patient age was 41.1 ± 9.8 years. Comorbidities were reported in 67 patients(44.07%). A direct proportional relationship was observed between the weight of the resected tissue and occurrence of general complications(P=0.01), and the presence of comorbidities increased the occurrence of minor(P=0.04) and major complications(P=0.01).Conclusion: Abdominoplasty is an aesthetic surgical plastic procedure, and its application has increased over the years. Despite its popularity, patient safety requires further attention due to the high risk of complications. It is essential to study all risk factors.

关键词： Abdominoplasty Major complications Minor complications

Nasal sill reconstruction with the Abbe flap after skin cancer resection:A case report

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Chinese Journal of Plastic and Reconstructive Surgery 2023年第2期5卷 64-67页

作者： Renata fernanda ramos Marcante Oona Tomiê Daronch Murilo Sgarbi Secanho Maria Madalena Silva Department of Plastic Surgery State University of Sao PauloBotucatuSao Paulo 18618-687Brazil

Local flaps are widely known as the best option for partial nasal reconstructions depending on donor tissue laxity,vascularization,and defect shape and *** nasolabial flap is used more often in the nasal *** larger defects,greater tissue mobilization with larger scars or free flaps is ***,the Abbe flap has been used for lip reconstruction in patients with cleft lip *** allows less retraction than other local flaps or skin grafts in patients with large defect sizes and great defect *** study reported on the application of the Abbe flap for nasal sill reconstruction on a 71-year-old female patient with nasal sill basal cell carcinoma who had undergone resection surgery with a posterior lip switch operation with satisfactory *** application of the Abbe flap could be considered in patients with multiple previous surgeries and at risk for necrosis.

关键词： Surgical flaps Myocutaneous flap Nose Nasal diseases Nasal defects Neoplasms Basal cell

Metabolic Syndrome and DNA Damage: The Interplay of Environmental and Lifestyle Factors in the Development of Metabolic Dysfunction

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Open Journal of Endocrine and Metabolic Diseases 2015年第7期5卷 65-76页

作者： Giuseppe Potrick Stefani Giovana Baldissera Ramiro Barcos Nunes Thiago Gomes Heck Cláudia ramos rhoden Laboratory of Physiology Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil Laboratory of Oxidative Stress and Atmospheric Pollution Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil Laboratory of Toxicological Genetics Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil Research Group in Physiology Regional University of Northwestern State’s Rio Grande do Sul (UNIJUI) Ijuí Brazil Postgraduate Program in Integral Attention to Health Regional University of Northwestern State’s Rio Grande do Sul (UNIJUI) Ijuí Brazil Department of Pharmacologic Sciences Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre Brazil

The Metabolic Syndrome (MetS) is a complex condition which is characterized by increased risk factor for cardiovascular diseases, such as dyslipidemia, hypertension and central obesity, in addition to increased risk for type 2 diabetes mellitus (T2DM). All of these factors alone have a notable relationship with DNA damage. However, when the risks are combined, the extent for major outcomes being related to DNA damage (cancer), the consequence can be accelerated by the metabolic dysfunction. This article will illustrate the scientific evidence of the role of DNA damage in MetS, as well as discuss the interplay of major risks factors (air pollution, physical inactivity and dietary interventions) in genomic stability.

关键词： Metabolic Syndrome DNA Damage Diet Physical Activity Air Pollution

Cardiac Oxidative Stress and Electrophysiological Changes in Rats Exposed to Concentrated Ambient Particles are Mediated by TRP-Dependent Pulmonary Reflexes

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Cardiac Oxidative Stress and Electrophysiological Changes in...

An aqueous extract of Liu Wei Di Huang Wan alters the labeling of blood constituents with Technetium-99m

第14届国际自由基学术大会

作者： Elisa Ghelfi Claudia ramos rhoden Gregory A. Wellenius Joy Lawrence Beatriz Gonzalez-Flecha Harvard School of Public Health Department of Environmental Health Boston Massachusetts

＜正＞Previous studies suggest that, through the stimulation of pulmonary nervous endings, ambient particles modulate the autonomic tone on the heart leading to cardiac oxidant stress and dysfunction. In this paper we investigated the effect of blockade of vanilloid receptor 1 （Transient Receptor Potential Vanilloid Receptor 1 [TRPV1]）

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Chinese Science Bulletin 2013年第18期58卷 2061-2065页

作者： MATOS Vernica Soares de CARMO fernanda Santos do DINIZ Claudia Leite NASCIMENTO Ana Lucia Rosa PEREIRA Márcia Oliveira FERNANDES Joelma Fonseca de Oliveira SANTOS-FILHO Sebastiao David MORENO Silvana ramos Farias BERNARDO-FILHO Mario Departamento de Biofísica e Biometria Instituto de Biologia Roberto Alcantara GomesUniversidade do Estado do Rio de Janeiro

The Liu Wei Di Huang Wan is a formula of a traditional Chinese medicine that is used to treat asthma patients and has been shown to have several important properties,such as antioxidant and free radical scavenging *** influence of an extract of Liu Wei Di Huang Wan on the labeling of blood constituents with technetium-99m was *** blood(Wistar rats) was incubated with the extract,stannous chloride and technetium-99m,as sodium *** were centrifuged and aliquots of plasma and blood cells were separated and precipitated with trichloroacetic acid,to obtain soluble and insoluble fractions of the blood *** percentage of radioactivity(%ATI) in all the fractions was *** analysis of the results shows that the extract at the highest concentration used(70 mg/mL) decreased significantly(P<0.05) the %ATI(from 96.48 ± 1.19 to 54.46 ± 7.38) on blood cells compartment,(from 81.11 ± 4.15 to 61.33 ± 4.74) on insoluble fractions of blood cells and(from 65.91 ± 2.44 to 13.15 ± 3.62) on insoluble fractions of *** conclusion,the results suggest that the substances present on this extract can alter this labeling process,probably due to(i) redox properties(antioxidant and chelator activities) and/or(ii) specific actions in the binding sites where the 99mTc would be bound on the blood *** a consequence,precaution is suggested on the interpretation of the nuclear medicine results from performed with blood constituents labeled with 99m Tc in patients that have undertaken LWDHW,although the current findings were obtained in experimental animal models.

关键词：六味地黄丸血液成分标签水提物 Wistar大鼠氧化还原性能锝实验动物模型

The Long Way from Complex Phenotypes to Genes: The Story of Rat Chromosome 4 and Its Behavioral Effects

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World Journal of Neuroscience 2014年第3期4卷 203-215页

作者： Gabriela Ferreira de Medeiros fernanda Junkes Corrêa María Elisa Corvino Geison de Souza Izídio André ramos Laboratório de Genética do Comportamento Departamento de Biologia Celular Embriologia e Genética Universidade Federal de Santa Catarina Florianópolis Brazil

Quantitative trait loci (QTLs) mapping has been performed during the past decades in an attempt to identify genes, gene products and mechanisms underlying numerous quantitative traits. It’s a strategy based on natural variations in genes and gene products, which facilitates translation from animal models to human clinical conditions. Our team has shown that the inbred rat strains Lewis (LEW) and Spontaneously Hypertensive Rats (SHR) differ with respect to several emotionality- related behaviors, one of which (inner locomotion in the open field) was strongly influenced by a QTL (Anxrr16) on rat chromosome 4. Since then, several other studies not only corroborated the initial description of Anxrr16, but also extrapolated its effects to a broader context (rats from both sexes and regardless of the estrous cycle phase) and suggested that this same region influences other emotionality-related behaviors as well as alcohol intake. Other QTLs affecting neurobiological traits were also found on rat chromosome 4 and several candidate genes have been pointed out as possibly influencing those phenotypes. Altogether, these studies suggest that rat chromosome 4 constitutes an interesting target for the study of the molecular bases of anxiety and other traits related to emotional reactivity.

关键词： Rat Chromosome 4 QTL Anxrr16 Emotionality-Related Behaviors Alcohol Consumption Stress-Response

Blueberry:Functional Traits and Obtention of Bioactive Compounds

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American Journal of Plant Sciences 2014年第18期5卷 2633-2645页

作者： fernanda Izabel Garcia da Rocha Concenco Paulo César Stringheta Afonso Mota ramos Igor Hiroshi Terayama Oliveira Food Science Department Federal University of VicosaVicosaBrazil

There is pressure from consumers about exchanging synthetic for natural dyes in foods. This review aimed to expose the potential of blueberry (Vaccinium myrtillus) as a source of natural dye, associated with its properties of functional food. Blueberry is a fruit plant natural from temperate climate, rich in phenolic compounds. The properties of phenolic compounds can be attributed to its ability to capture free radicals, deactivating or eliminating them from the body. Anthocyanins are flavonoid phenolic compounds responsible for color of fruits, flowers and vegetables. Blueberry is rich in anthocyanins, being its content more affected by genotype than by climatic or environmental factors. Brazil has the potential to assume an important position in the worldwide market of this fruit, both in natura and as byproducts, whose main destinations are populations from regions with higher income and educational level, as the North America and Europe. Due to the importance of blueberry as a source of natural pigments, as well as its high value while associated with functional food, it is important to improve extraction and stabilization processes of anthocyanins from blueberry fruits. Researches should focus on the technical viability and cost reduction in the extraction of this pigment. Pioneer studies with blueberry have been conducted in Brazil, but the intensification of researches will allow yield maximization, increased levels of anthocyanins in fruits, and compound stability after extraction. Another focus should be the use of these natural pigments in order to replace those currently used.

关键词： Vaccinium myrtillus Phenols Anthocyanins Antioxidant Activity Functional Properties Drying