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Elevated calprotectin levels are associated with mortality in patients with acute decompensation of liver cirrhosis

World Journal of Hepatology 2022年第11期14卷 1964-1976页

作者： Camila Matiollo Elayne cristina de Morais Rateke Emerita Quintina de Andrade Moura Michelle Andrigueti fernanda cristina de augustinho Tamara Liana Zocche Telma Erotides Silva Lenyta Oliveira Gomes Mareni Rocha Farias Janaina Luz Narciso-Schiavon Leonardo Lucca Schiavon Clinical Analysis Laboratory Unit University HospitalFederal University of Santa CatarinaFlorianopolis 88040-900Brazil Division of Gastroenterology University HospitalFederal University of Santa CatarinaFlorianópolis 88040-900Brazil department of Pharmaceutical Sciences Health Sciences Center Federal University of Santa CatarinaFlorianópolis 88040-370Brazil Division of Gastroenterology Department of Internal MedicineFederal University of Santa CatarinaFlorianopolis 88040-900SCBrazil

BACKGROUND Acute decompensation(AD)of cirrhosis is related to systemic inflammation and elevated circulating *** this context,biomarkers of inflammation,such as calprotectin,may be of prognostic *** To evaluate serum calprotectin levels in patients hospitalized for complications of *** This is a prospective cohort study that included 200 subjects hospitalized for complications of cirrhosis,20 outpatients with stable cirrhosis,and 20 healthy *** calprotectin was measured by enzyme-linked immunosorbant *** Calprotectin levels were higher among groups with cirrhosis when compared to healthy *** median calprotectin was related to Child-Pugh C,ascites,and hepatic *** calprotectin was related to acute-on-chronic liver failure(ACLF)and infection in the bivariate,but not in multivariate *** was not associated with survival among patients with ACLF;however,in patients with AD without ACLF,higher calprotectin was associated with a lower 30-d survival,even after adjustment for chronic liver failure-consortium(CLIF-C)AD score.A high-risk group(CLIF-C AD score≥60 and calprotectin≥580 ng/mL)was identified,which had a 30-d survival(27.3%)similar to that of patients with grade 3 ACLF(23.3%).CONCLUSION Serum calprotectin is associated with prognosis in patients with AD without ACLF and may be useful in clinical practice to early identify patients with a very low short-term survival.

关键词： Inflammation Liver cirrhosis Acute-on-chronic liver failure

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