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Deep sedation during gastrointestinal endoscopy: Propofol-fentanyl and midazolam-fentanyl regimens

World Journal of Gastroenterology 2013年第22期19卷 3439-3446页

作者： Marcos Eduardo Lera dos santos Fauze Maluf-Filho Dalton Marques Chaves Sergio Eiji Matuguma Edson Ide Gustavo de Oliveira Luz Thiago Ferreira de Souza fernanda C Simoes Pessorrusso Eduardo Guimares Hourneaux de Moura Paulo Sakai Department of Gastroenterology Hospital das Clínicas University of Sao Paulo Medical School Sao Paulo CEP 05403-900 Brazil Cancer Institute of Sao Paulo State Sao Paulo CEP 01246-000 Brazil

AIM: To compare deep sedation with propofol-fentanyl and midazolam-fentanyl regimens during upper gastrointestinal endoscopy. METHODS: After obtaining approval of the research ethics committee and informed consent, 200 patients were evaluated and referred for upper gastrointestinal endoscopy. Patients were randomized to receive propofol-fentanyl or midazolam-fentanyl (n = 100/group).We assessed the level of sedation using the observer's assessment of alertness/sedation (OAA/S) score and bispectral index (BIS). We evaluated patient and physician satisfaction, as well as the recovery time and complication rates. The statistical analysis was performed using SPSS statistical software and included the MannWhitney test, χ 2 test, measurement of analysis of variance, and the κ statistic. RESULTS: The times to induction of sedation, recovery, and discharge were shorter in the propofolfentanyl group than the midazolam-fentanyl group. According to the OAA/S score, deep sedation events occurred in 25% of the propofol-fentanyl group and 11% of the midazolam-fentanyl group (P = 0.014). Additionally, deep sedation events occurred in 19% of the propofol-fentanyl group and 7% of the midazolamfentanyl group according to the BIS scale (P = 0.039). There was good concordance between the OAA/S score and BIS for both groups (κ = 0.71 and κ = 0.63, respectively). Oxygen supplementation was required in 42% of the propofol-fentanyl group and 26% of the midazolam-fentanyl group (P = 0.025). The mean time to recovery was 28.82 and 44.13 min in the propofolfentanyl and midazolam-fentanyl groups, respectively (P < 0.001). There were no severe complications in either group. Although patients were equally satisfied with both drug combinations, physicians were more satisfied with the propofol-fentanyl combination. CONCLUSION: Deep sedation occurred with propofolfentanyl and midazolam-fentanyl, but was more frequent in the former. Recovery was faster in the propofol-fentanyl group.

关键词： Endoscopy Deep sedation Anesthetic administration Anesthetic dose Adverse effects

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Pró-Saúde and PET-Saúde in the Context of Reorientation Policy of Health Professions Training

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Health 2015年第13期7卷 1800-1805页

作者： Ana Maria Gomes dos santos Maria José Medeiros da Fonseca fernanda Fayane C. Belarmino Adriana Vitória dos santos Fábia Barbosa de Andrade City Health Department Municipal Government Santa Cruz Brazil Faculty of Health Sciences of Trairi (FACISA) Federal University of Rio Grande do Norte (UFRN) Santa Cruz Brazil

The health education has been a topic discussed throughout Brazil, as the country is experiencing a period of expansion of higher education and it needs to give quality. So they were implanted two federal programs to allow that health students to approach their professional reality to make them capable of full mode. The paper aims to discuss the experience of the participating members of these programs for professional reorientation. The study is exploratory and descriptive conducted with participants of the programs in the city of Santa Cruz, Rio Grande do Norte, Brazil, in the year 2014. This study aims to present an experience report from the experience of the mentors in Reorientation National Program for Health Professional Training (Pró-Saúde), associated with the Labor Education Program for Health (PET-Saúde) at the Federal University of Rio Grande do Norte (UFRN)/Sciences College of Trairi (FACISA), with emphasis on the reorientation of professional practice, provided by integrating teaching-service and community as well as exchange of knowledge between tutors, mentors and students participating in the project, from the development of interdisciplinary activities, giving the opportunity to reflect on these actions and services offered based on the epidemiological analysis provided by research, intervening in this reality.

关键词： Health Education Education Community Learning Students Family Health

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Medium-chain acyl-CoA dehydrogenase deficiency: prevalence of ACADM pathogenic variants c.985A>G and c.199T>C in a healthy population in Rio Grande do Sul, Brazil

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Reproductive and Developmental Medicine 2022年第2期6卷 92-97页

作者： Mariana Lopes dos santos Devora Natalia Randon fernanda Hendges de Bitencourt fernanda Sperb-Ludwig fernanda Sales Luiz Vianna Carmen Regia Vargas Angela Sitta Ida Vanessa Doederlein Schwartz Postgraduate Program in Medicine:Medical Sciences(PPGCM) Universidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreRSBrazil Laboratory of Basic Research and Advanced Investigations in Neurosciences(BRAIN) Experimental Research ServiceHospital de Clinicas de Porto AlegrePorto AlegreRSBrazil Postgraduate Program in Genetics and Molecular Biology Universidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreRSBrazil INaGEMP Instituto Nacional de Genetica Medica PopulacionalHospital de Clinicas de Porto AlegrePorto AlegreRSBrazil Laboratory of Genomic Medicine Experimental Research ServiceHospital de Clinicas de Porto AlegrePorto AlegreRSBrazil Servico de Genetica Medica(SGM) Hospital de Clinicas de Porto AlegrePortoAlegreRSBrazil Genetics Department Universidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreRSBrazil

Objectives::To investigate the prevalence of ACADM pathogenic variants, c.985A>G and c.199T>C, for medium chain acyl CoA dehydrogenase deficiency (MCADD) in a healthy population in the southern region of Brazil. Methods::This was an observational cross-sectional study with a convenience sampling strategy. The participants were recruited from the blood bank of the Hospital de Clínicas of Porto Alegre, Brazil. A total of 1000 healthy individuals from the state of Rio Grande do Sul were included. Genotyping for the c.199T>C and c.985A>G variants was performed using real-time polymerase chain reaction (PCR) and the PCR-restriction fragment length polymorphism (RFLP) technique, respectively. Individuals considered heterozygous for c.985A>G were subjected to additional acylcarnitine profile analysis using tandem mass spectrometry. Carrier frequency was obtained by calculating the ratio of heterozygous individuals to the total number of individuals analyzed and reported with a 95% confidence interval. Allele and genotype frequencies were calculated based on the Hardy-Weinberg ***::The c.985A>G variant was detected as heterozygotes in three individuals (frequency of the heterozygous genotype = 1:333, allele frequency= 0.0015, minimum frequency of MCADD= 1:444,444) whose acylcarnitine profiles were within normal limits. The c.199T>C variant was not ***::Considering the small sample size and associated allelic heterogeneity with MCADD, these findings are believed to denote the rarity or underdiagnosis of MCADD in southern Brazil. This study provides evidence for the need for further investigation to ascertain the contribution of these diseases to child morbidity and mortality in the country.

关键词： ACADM Medium-chain acyl-CoA dehydrogenase deficiency Sudden unexpected death in infancy

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Translation, Adaptation and Validation of a Chinese Medicine Questionnaire to Brazilian Portuguese

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Open Journal of Applied Sciences 2021年第10期11卷 1149-1156页

作者： Ciro Blujus dos santos Rohde Lukas Blumrich Pedro Oliveira Dias Martins fernanda Babler Wu Tu Hsing Hermano Tavares Service of Phytotherapy Medicinal Plants and Acupuncture of the Impulse Control Disorders and Behavioral Addictions Outpatient Unit Institute and Department of Psychiatry University of S&#227o Paulo S&#227o Paulo Brazil Impulse Control Disorders and Behavioral Addictions Outpatient Unit Institute and Department of Psychiatry University of S&#227o Paulo S&#227o Paulo Brazil School of Medicine University of S&#227o Paulo S&#227o Paulo Brazil Institute of Radiology Hospital of Clinics University of S&#227o Paulo S&#227o Paulo Brazil Center of Acupuncture of the Institute of Orthopedics and Traumatology of the Hospital of Clinics School of Medicine University of S&#227o Paulo S&#227o Paulo Brazil

The Constitution in Chinese Medicine Questionnaire [CCMQ] organizes 9 body constitutions according to Traditional Chinese Medicine [TCM]. The translation was realized by a Medical Doctor [MD] specialized in TCM and the back translation by an english-speaking MD. Comprehensibility assessment was performed (N = 40, main scores ranged from 4.20 to 4.95). On the test-retest reliability Cronbach’s alpha was 0.920 in the first application and 0.943 in the second, the intraclass correlation scores ranged between good and excellent (0.6 - >0.80). The results show that the adaptation of the CCMQ is valid and ready to be used.

关键词： Traditional Chinese Medicine Body Constitution Cross-Cultural Questionnaire Portuguese

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Taxifolin stability: In silico prediction and in vitro degradation with HPLC-UV/UPLCe ESI-MS monitoring

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Journal of Pharmaceutical Analysis 2021年第2期11卷 232-240页

作者： fernanda Cristina Stenger Moura Carmem Lúciados santos Machado Favero Reisdorfer Paula Angelica Garcia Couto Maurizio Ricci Valdir Cechinel-Filho Tiago J.Bonomini Louis P.Sandjo Tania Mari Belle Bresolin Pharmaceutical Sciences Graduate Program School of Health SciencesCourse of PharmacyUniversidade do Vale do ItajaíItajaíSC88302-202Brazil Laboratory of Research and Development of Drugs Pharmaceutical Sciences Graduate ProgramSchool of Health SciencesCourse of PharmacyUniversidade Federal do PampaUruguaianaRS97500-970Brazil Department of Pharmaceutical Science Universita degli Studi di PerugiaPerugiaPG06123Italy Chemistry Department Universidade Federal de Santa CatarinaTrindadeFlorian opolisSC88040-900Brazil

Taxifolin has a plethora of therapeutic activities and is currently isolated from the stem bark of the tree Larix gmelinni(Dahurian larch). It is a flavonoid of high commercial interest for its use in supplements or in antioxidant-rich functional foods. However, its poor stability and low bioavailability hinder the use of flavonoid in nutritional or pharmaceutical formulations. In this work, taxifolin isolated from the seeds of Mimusops balata, was evaluated by in silico stability prediction studies and in vitro forced degradation studies(acid and alkaline hydrolysis, oxidation, visible/UV radiation, dry/humid heating) monitored by high performance liquid chromatography with ultraviolet detection(HPLC-UV) and ultrahigh performance liquid chromatography-electrospray ionization-mass spectrometry(UPLC-ESI-MS). The in silico stability prediction studies indicated the most susceptible regions in the molecule to nucleophilic and electrophilic attacks, as well as the sites susceptible to oxidation. The in vitro forced degradation tests were in agreement with the in silico stability prediction, indicating that taxifolin is extremely unstable(class 1) under alkaline hydrolysis. In addition, taxifolin thermal degradation was increased by *** the other hand, with respect to photosensitivity, taxifolin can be classified as class 4(stable).Moreover, the alkaline degradation products were characterized by UPLC-ESI-MS/MS as dimers of taxifolin. These results enabled an understanding of the intrinsic lability of taxifolin, contributing to the development of stability-indicating methods, and of appropriate drug release systems, with the aims of preserving its stability and improving its bioavailability.

关键词： Dihydroquercetin In silico stability prediction Forced degradation

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GPR Tomographic Imaging of Concrete Tubes and Steel/Plastic Tanks Buried in IAG/USP Geophysical Test Site, Brazil

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International Journal of Geosciences 2017年第5期8卷 647-658页

作者： Jorge Luís Porsani Emerson Rodrigo Almeida bruno Poluha Vinícius Rafael Neris dos santos Universidade de Sã o Paulo Instituto de Astronomia Geofísica e Ci&ecirc ncias Atmosféricas Departamento de Geofísica. Rua do Mat&atilde o 1226 Butant&atilde S&atilde o Paulo Brazil

In this paper, the Ground Penetrating Radar (GPR) method was used to characterize concrete tubes and steel/plastic tanks buried in IAG/USP test site. The microwave tomography was used to improve the GPR images, aiming to retrieve the geometry of the targets. The numerical modeling studies also were done in order to predict the GPR results of the buried targets and to give more reliability to the results interpretation. The targets were installed in the first shallow geophysical test site of the Brazil located at Institute of Astronomy, Geophysics, and Atmospheric Science (IAG) of the University of S?o Paulo (USP). GPR profiles of 200 MHz (shielded bistatic antennas) were acquired along three lines containing concrete tubes and steel/plastic tanks buried in subsoil. The concrete tubes show a hyperbolic reflector for the top, and the vertical tube also presented a reflection on its bottom. The horizontal steel tanks were characterized by a strong GPR reflection on their top. The empty plastic tank shows a strong reflector for the top with normal polarity. On the other hand, the plastic tank filled with water shows a weaker reflector for its top characterized by the inverted polarity of GPR signal when compared with empty plastic tank. The plastic tank filled with water also went characterized by the strong reflection to its bottom, being a good indicative to interpret GPR data on target in subsoil with some types of fluid inside of tank. The results of polarity difference for the top of tank can be used as guide pattern to identify buried tank empty or filled with water. The application of microwave tomography to the GPR data permitted to determine the position and get a good identification of the edges of the targets studied. The numeric modeling presented a good accordance with real data reducing the ambiguities in interpretation of results. These results can be used as a reference, and they can be extrapolated for areas where there is no subsurface information.

关键词： Ground Penetrating Radar (GPR) Microwave Tomography Numeric Modeling Concrete Tubes Steel Tanks Plastic Tanks IAG/USP Test Site Brazil

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Comparison of morphological and functional outcomes of mouse sciatic nerve repair with three biodegradable polymer conduits containing poly (lactic acid)

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Neural Regeneration Research 2018年第10期13卷 1811-1819页

作者： fernanda Marques Pestana Rui C.C.Domingues Júlia Teixeira Oliveira Daniela F.P.A.Durco Camila Oliveira Goulart Henrique Rocha Mendonca Anne Caroline Rodrigues dos santos Natália Tavares de Campos Beatriz Theodoro da Silva Cristina Cardoso Pereira Cristiano Piacsek Borges Ana Maria Blanco Martinez Pós Graduacao em Ciências Morfológicas Instituto de Ciências Biomédicas-UFRJRio de Janeiro RJ Brazil Anatomia Patológica-Faculdade de Medicina-HUCFF-UFRJ Rio de Janeiro RJ Brazil Laboratório de Neurodegeneracao e Reparo-Faculdade de Medicina-HUCFF-UFRJ Rio de Janeiro RJ Brazil Programa de Eng. Química COPPE-UFRJRio de Janeiro Brazil Polo Universitário de Macaé Laboratório Integrado de Produtos Bioativos e BiociênciasMacaê UFRJ Brazil

Poly（lactic acid）（PLA）-containing nerve guidance conduits（NGCs） are currently being investigated for nerve repair as an alternative to autograft, which leads to permanent functional impairment in the territory innervated by the removed nerve. Combination of polymers modifies the physical properties of the conduits, altering their nerve-guidance properties. Conduits made from PLA-only or combined with other polymers have been used successfully for nerve repair, but their efficiency has not been compared. We compared the morphological and functional outcomes of peripheral nerve repair by using NGCs made of poly（lactic acid） and combined or not with polycaprolactone（PLA/PCL） or polyvinylpyrrolidone（PLA/PVP）. To assess the functional recovery, we employed a mechanical hyperalgesia analysis, sciatic functional index（SFI）, and electroneuromyography. The mechanical hyperalgesia analysis showed that the PLA group improved more rapidly than the PLA/PVP and PLA/PCL groups; similarly, in the electroneuromyography assay, the PLA group exhibited higher amplitude than the PLA/PCL and PLA/PVP groups. However, the SFI improvement rates did not differ among the groups. Morphologically, the PLA group showed more vascularization, while the nerve fiber regeneration did not differ among the groups. In conclusion, the PLA-only conduits were superior to the other NGCs tested for nerve repair.

关键词： sciatic nerve tubulization biodegradable conduit poly(lactic acid) regeneration

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The Porcine Pulmonary Surfactant Protein A (pSP-A) Immunogenicity Evaluation in the Murine Model

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Pharmacology & Pharmacy 2010年第1期1卷 27-32页

作者： Sandra de Cássia Dias fernanda Lucio dos santos Dirce Sakauchi Dmitri Iourtov Isaias Raw Flavia Saldanha Kubrusly 不详

This paper investigated the porcine surfactant protein A (pSP-A) immunogenicity in murine model. Many elegant stu-dies about SP-A therapeutic applications are available however specific studies about its exogenous immunogenicity were not easily assumed. Therefore, we investigated the immunogenicity of this porcine protein in mice. The mice re-ceived pSP-A subcutaneously on days 0 and 7. The animals were observed during 90 days and the blood was collected on days 30, 60 and 90 for assessment the immunogenic potential of pSP-A. Some animals showed circulating antibodies above the screening cut point, which was calculated based on control mice sera signals. However, those antibodies were considered false positive read-outs by the performed competitive inhibition assay. Also no neutralizing antibodies were detected able to avoid the porcine protein ability to promote lipid aggregation. So far in this model, porcine surfactant protein-A could be considered not immunogenic.

关键词： Immunogenicity Porcine Surfactant Protein A Anti-Drug Antibody Murine Model

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Comparison of the systemic action of electroacupuncture and laserpuncture in experimental injuries on the back skin of Wistar rats(Rattus novergicus)

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Journal of Traditional Chinese Medicine 2021年第5期41卷 779-788页

作者： Ivens Takechi Nakagawa Hamilton Ricardo Alonso Fabrício Campos Kuroda JoséRoberto Passarini Junior Juan Guzman Quispe Cabanillas fernanda Aparecida Sampaio Mendonça Gláucia Maria Tech dos santos Andrea Aparecida de Aro Edson Rosa Pimentel Maria Esméria Corezola do Amaral Marcelo Augusto Marretto Esquisatto Graduate Program in Biomedical Sciences University Center of Herminio Ometto Foundation-FHOAvenida Dr.Maximiliano Baruto500-Jardim UniversitarioArarasSao Paulo 13607-339Brazil Department of Structural and Functional Biology Institute of BiologyState University of Campinas-UNICAMPAvenida Bertrand Russels/n.Caixa Postal 6109CampinasSao Paulo 13083-865Brazil

OBJECTIVE:To evaluate the systemic action of electroacupuncture and laserpuncture in the repair of excisional cutaneous injuries on the back of adult female Wistar ***:Ninety animals were divided into three experimental groups:C-control;E-treated with electroacupuncture[acupoints:Feishu(BL13),Geshu(BL17),Zusanli(ST36)];L-treated with laserpuncture(same acupoints)and euthanized on the 7 th,14 th and 21 st days for tissue removal and preparation for histomorphometric and biochemical(dosages,zymography and Western blotting)***:The number of fibroblasts in the E and L groups presented higher values than the C on the14 th and 21 st *** number of granulocytes was lower than C on the 21 st day in groups E and *** total number of newly formed vessels increased on the 21 st day and was higher in both treatments when compared to *** birefringent collagen fibers detected on the 21 st day was lower in groups E and L than group *** glycosaminoglycans and hydroxyproline amount was similar among groups throughout the experimental *** active isoform of matrixmetallo proteinase(MMP)-2 and the latent isoform of MMP-9 did not show any differences among all groups and experimental *** amount of collagenⅠpresented higher values in the L group on the 14 th day and in the E and L groups on the 21 st *** typeⅢcollagen,groups E and L presented values lower than C in all experimental *** amount of transforming growth factor-β1 in the E and L groups showed higher amounts than C on the 7 th day and lower on the 14 th and 21 st *** vascular endothelial growth factor,E and L groups presented similar and lower values than C on the 7 th and 14 th days,respectively,and similar on the 21 st ***:The therapies evaluated in this article stimulated fibroblast proliferation,neoangiogenesis and altered the reorganization of collagen fibers in the repair of excisional injuries in female adult rats.

关键词： wound healing electroacupuncture inflammation morphological and morphometric findings

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Influence of Organoclay Structure on Nanostructured Materials Based on Eva

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Materials Sciences and Applications 2015年第10期6卷 860-868页

作者： Gisele C.V.Iulianelli Pedro Jose Oliveira Sebastiao Maria Ines B.Tavares fernanda Abbate dos santos Instituto de Macromoleculas Professora Eloisa Mano da Universidade Federal do Rio de Janeiro(IMA/UFRJ) Centro de TecnologiaBloco JIlha do FundaoRio de JaneiroRJ CEP:21941-598Brazil Condensed Matter Physics Centre University of LisbonLisbonPortugal Departamento de Fisica Instituto Superior TecnicoTechnical University of LisbonLisbonPortugal

This article reports the preparation of a series of EVA nanocomposites employing solution casting methods using different types of organo-modified montmorillonite clay. The effect of the organoclay type on the structural organization and thermal behavior of EVA nanostructured materials were systematically investigated. Regarding thermal behavior, the thermogravimetric analysis showed that the nanocomposites presented a slight decrease in thermal degradation temperature compared to EVA, while differential scanning calorimetry, in general, did not show a significant change in the thermal transition temperatures such as glass transition, melting temperature and crystallization temperature of the nanocomposites, regardless of the type and proportion of organoclay in the systems. With respect to structural aspect, the X-ray diffractograms showed that all systems presented a heterogeneous distribution of the nanoparticles, containing part intercalated. Nuclear magnetic resonance relaxometry data provided complementary information for the X-ray results, showing that the EVA systems containing 5 wt% of both studied organoclays presented a mixture of intercalated and exfoliated structures, evidencing that there was a surface interaction between polymer chains and clay lamellae.

关键词： EVA Nanocomposites NMR Relaxometry

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