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Comprehensive Left Ventricular Mechanics Analysis by Speckle Tracking Echocardiography in COVID-19

World Journal of Cardiovascular Diseases 2021年第2期11卷 113-125页

作者： Francisco J. González-Ruiz Emmanuel A. Lazcano-Díaz Zuilma Y. Vásquez-Ortiz fernanda bernal-ceballos Rodrigo Gopar-Nieto Consuelo Orihuela-Sandoval José P. Hernández-Reyes Edgar García-Cruz Eduardo Bucio-Reta Ángel Ramos-Enríquez Luis A. Cota-Apodaca Luis Efren-Santos Blanca Estela Broca-García Daniel Manzur-Sandoval Efrén Melano-Carranza Fernandez de la Reguera Guillermo Gustavo Rojas-Velasco Francisco Baranda-Tovar Department of Cardiovascular Critical Care National Institute of Cardiology “Dr. Ignacio Chávez” México City México Department of Echocardiography National Institute of Medical Science and Nutrition “Dr. Salvador Zubirán” México City México PhD Program National University of Mexico (UNAM) México City México Cardiovascular Diseases Department National Institute of Cardiology “Dr. Ignacio Chávez” México City México

Background: Cardiac involvement and the consequences of inflammation induced by SARS-CoV2 infection could have catastrophic long-term consequences. Left ventricular mechanics could identify a specific pattern of myocardial fiber damage in patients infected with COVID-19. To our knowledge there are no publications referring to the global description of ventricular mechanics in patients with COVID-19. Objective: To describe left ventricular mechanics in hospitalized patients with COVID-19. Methods: In this cross-sectional study, we included 40 hospitalized patients with confirmed diagnostic of COVID-19, from April 11, 2020, to September 6, 2020. Demographic and laboratory data, clinical and echocardiographic characteristics were collected, as well as events during hospitalization. Left ventricular deformation was analyzed and reported. Results: Subclinical dysfunction was observed in 82.5% (left ventricular longitudinal strain [LVGLS] -17.05% and global circumferential strain [GCS] -18.6%) of the patients, likewise, the mean twist and apical rotation were preserved, and even increased as part of the compensating mechanism to maintain the ejection fraction. Conclusion: In patients hospitalized with COVID-19, despite having a normal left ventricular ejection fraction, subclinical myocardial damage was found, manifested by a decrease in Global Longitudinal Strain (GLS) and Global Circumferential Strain (GCS). This behavior is similar to that of cardiomyopathies in the early stage of the disease, and given the pathophysiological mechanisms involved in the disease, its long-term consequences should be monitored and evaluated.

关键词： COVID-19 Speckle Tracking Echocardiography Myocarditis Cardiomyopa-thy Cardiac Mechanics Strain Myocardial Damage Deformation Imaging Myocardial Strain

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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana Milena Silva Olaya fernanda Martins Almeida Ana Maria Blanco Martinez Suelen Adriani Marques PhD Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological Anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Filtering cylindrical–conical hydrocyclone

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Particuology 2019年第6期17卷 54-62页

作者： fernanda FSalvador Marcos ASBarrozo Luiz GMVieira Federal University of Espírito Santo Center of Agricultural Sciences and EngineeringDepartment of Rural EngineeringZIP Code:29500-000AlegreESBrazil Federal University of Uberlândia Chemical Engineering SchoolBlock 1 KCampus Santa MônicaZIP Code:38400-902UberlândiaMGBrazil

Hydrocyclones have versatile applications in various industrial *** functionn on the principle of centrifugal separation to remove a dispersed phase(particles or drops)from a continuous phase(fluid).In unconventional filtering hydrocyclones,the separation efficiency and energy costs have been improved by combining filtration with centrifugal *** work investigated experimentally the effect of incorporating a cylinder and a porous cone in a conventional *** also evaluated the effects of the main geometric dimensions of the separator on the hydrocyclone performance.A differential-evolution algorithm was applied to optimize the hydrocyclone performance,which was represented as the maximum total efficiency and minimum Euler *** experimental results validated the optimization results and showed that hydrocyclones with optimized geometries exhibited higher total efficiencies(89.59%)and lower Euler numbers(582)than hydrocyclones with other experimental configurations.

关键词： Solid–liquid separation Hydrocyclone Filtration Differential evolution

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Release the iron: does the infection of magnetotactic bacteria by phages play a role in making iron available in aquatic environments?

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Journal of Oceanology and Limnology 2021年第6期39卷 2063-2069页

作者： Igor TAVEIRA Dennis ABAZYLINSKI fernanda ABREU Instituto de Microbiologia Paulo de Góes Departamento de Microbiologia GeralUniversidade Federal do Rio de JaneiroRio de Janeiro 21941-902Brazil School of Life Sciences University of Nevada at Las VegasLas Vegas 94720USA

Magnetotactic bacteria(MTB)are ubiquitous prokaryotes that orient along magnetic field lines due to magnetosomes’biomineralization within the *** structures are ferrimagnetic organelles that impart a magnetic moment to the *** succeed in producing magnetosomes,MTB accumulate iron in(i)cytoplasm;(ⅱ)magnetosomes;and(ⅲ)nearby the *** has already been estimated that a single MTB has an iron content of 10 to 100-fold higher than Escherichia *** are the most abundant entity in oceans and are known for controlling nutrient flow such as carbon and nitrogen by viral shunt and *** current work addresses the putative role of phages that infect MTB on the iron biogeochemical *** phage infection in MTB hosts cause a biogenic iron fertilization-like event in localized microenvironments?Are phages critical players in driving magnetosome biomineralization genes(BGs)horizontal transfer?Further investigation of those events,including frequency of occurrence,is necessary to fully comprehend MTB’s effect on iron cycling in aqueous environments.

关键词： horizontal gene transfer iron biogeochemical cycle magnetotactic bacteria magnetosome biomineralization genes phages

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Long-term Regional Dynamic Sea Level Changes from CMIP6 Projections

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Advances in Atmospheric Sciences 2021年第2期38卷 157-167页

作者： Bruno FERRERO Marcos TONELLI fernanda MARCELLO Ilana WAINER University of São Paulo São Paulo 05508120Brazil

Anthropogenic climate forcing will cause the global mean sea level to rise over the 21st ***,regional sea level is expected to vary across ocean basins,superimposed by the influence of natural internal climate ***,we address the detection of dynamic sea level(DSL)changes by combining the perspectives of a single and a multimodel ensemble approach(the 50-member CanESM5 and a 27-model ensemble,respectively,all retrieved from the CMIP6 archive),under three CMIP6 projected scenarios:SSP1-2.6,SSP3-7.0 and *** ensemble analysis takes into account four key metrics:signal(S),noise(N),S/N ratio,and time of emergence(ToE).The results from both sets of ensembles agree in the fact that regions with higher S/N(associated with smaller uncertainties)also reflect earlier *** DSL signal is projected to emerge in the Southern Ocean,Southeast Pacific,Northwest Atlantic,and the *** common for both sets of ensemble simulations show that while S progressively increases with increased projected emissions,N,in turn,does not vary substantially among the SSPs,suggesting that uncertainty arising from internal climate variability has little dependence on changes in the magnitude of external *** changes are greater and quite similar for the scenarios SSP3-7.0 and SSP5-8.5 and considerably smaller for the SSP1-2.6,highlighting the importance of public policies towards lower emission scenarios and of keeping emissions below a certain threshold.

关键词： dynamic sea level CMIP6 sea level rise signal-to-noise time of emergence

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Prospects for bone marrow cell therapy in amyotrophic lateral sclerosis：how far are we from a clinical treatment？

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Neural Regeneration Research 2016年第8期11卷 1216-1219页

作者： fernanda Gubert Marcelo F.Satiago Instituto de Biofisica Carlos Chagas Filho Universidade Federal do Rio de Janeiro Rio de Ianeiro RJ Brasil

Amyotrophic lateral sclerosis（ALS） is a fatal neurodegenerative disease that causes progressive muscular atrophy and death within 3–5 years after its *** the significant advances in knowledge of ALS pathology,no effective treatment is ***,it is imperative to search for new alternatives to treat *** therapy,especially using bone-marrow cells,has showed to be very useful to protect the neural tissue in different brain disease or traumatic *** ALS,most published results show beneficial effects of the use bone marrow cells,especially mesenchymal stromal ***,until now,the best outcome extends animal＇s lifespan by only a few *** is essential to continue the search for a really effective therapy,testing different cells,routes and time-windows of *** the mechanisms that initiate and spread the degenerative process is also important to find out an effective ***,we discussed here some progresses that have been made using bone-marrow cell therapy as a therapeutic tool for ALS.

关键词： amyotrophic lateral sclerosis cell therapy bone-marrow mononuclear cells mesenchymal stromal cells neuroinflammation motor neurons

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Antarctic red algae in dye-sensitized photoelectrochemical cells for water splitting

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Advances in Polar Science 2024年第2期35卷 219-227页

作者： Florentina ARISPE María fernanda CERDÁ Laboratorio de Biomateriales IQBFacultad de CienciasUdelaRMontevideo 11400Uruguay

Phycoerythrin extracted from Antarctic red seaweeds shows promising characteristics to be applied as an anode sensitizer in water-splitting photoelectrochemical *** light irradiation and using an LED lamp,the red-colored protein shows an interesting ability to profit the incident light,as confirmed by the presence of oxygen bubbles next to the electrode surface without applying any external *** results showed that the addition of iodide is helpful to allow the regeneration of the dye;nevertheless,oxygen evolution is not *** analysis of the involved semi-reactions is also helpful to understand the observed *** exploration of Antarctic resources offers then an alternative for the development of green energies,with a particular focus on their use as sensitizers to profit from the sunlight in water-splitting as well as in photovoltaic devices.

关键词： sensitizers water-splitting red algae electrochemical

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Regional validity of the parameters of a distributed runoff-erosion model in the semi-arid region of Brazil

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Science China(Technological Sciences) 2009年第11期52卷 3348-3356页

作者： SRINIVASAN Vajapeyam Srirangachar PAIVA fernanda Maria de Lima Federal University of Campina Grande Post-graduate programme in Civil and Environmental Engineering Campus I 58429-900 Campina Grande PB Brazil

The present paper examines the validity of the application of a distributed rainfall-runoff-erosion model on a regional basis in a semi-arid region of Brazil. The model tested is known as WESP (Water Erosion Simulation Program) developed by Lopes (1987). The model simulates the hydrograph and the sediment graph for individual events and thus, the model when properly calibrated can serve as a predictive tool for runoff and soil erosion on an individual or a continuous basis. The possibility of the existence of regionally applicable values for the parameters of the model WESP would be very interesting from the point of view of predictability of runoff and soil erosion from ungauged basins in the region. For this purpose, data collected in several experimental units in the experimental basin of Sumé as well as in the experimental basin of So Joo de Cariri have been used. The model was calibrated and validated in each of the experimental units (consisting of erosion plots and micro-basins) and the average value from all of the units for each of the parameters was considered to be the regional value. With these average values, all the events in all the experimental units were simulated. The results show that the runoff and erosion values simulated with this single parameter set were very good in all the units, being well within the acceptable deviations.

关键词： regional parameters model WESP experimental basins semi-arid region soil erosion

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Nanosized magnetite in low cost materials for remediation of water polluted with toxic metals, azo- and antraquinonic dyes

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Frontiers of Environmental Science & Engineering 2015年第5期9卷 746-769页

作者： Maria fernanda HORST Veronica LASSALLE Maria Lujan FERREIRA Institute of Chemistry of the South (Inquisur Universidad Nacional del Sur~ONICET) Avda Alem 1253 Bahia Blanca Argentina Pilot Plant of Chemical Engineering (PLAPIQUI-UNS-CONICET) Universidad Nacional del Sur--CONICET Camino La Carrindanga km7 Bahia Blanca Argentina

Nanosized magnetite has emerged as an adsorbent of pollutants in water remediation. Nanoadsor- bents include magnetic iron oxide and its modifiers/ stabilizers, such as carbon, silica, clay, organic moieties （polymers, aminoaeids, and fatty acids） and other inorganic oxides. This review is focused on the recent developments on the synthesis and use of magnetic nanoparticles and nanocomposites in the treatment of contaminated water. The emphasis is on the influence of the iron oxide modifiers on some properties of interest such as size, BET area, and magnetization. The characteristics of these nanomaterials are related to their ability to eliminate heavy metal ions and dyes from wastewater. Comparative analysis of the actual literature was performed aiming to present the magnetic material, its preparation methodology and performance in the elimination of the selected pollutants. Vast information has been properly summarized according to the materials, their properties and preferential affinity for selected contaminants. The mechanisms governing nanomaterial＇s formation as well as the interactions with heavy metals and dyes have been carefully analyzed and associated to their efficiency.

关键词： nanomagnetite water remediation toxicmetals dyes supported magnetite

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