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Identifying genetic susceptibility to Aspergillus fumigatus infection using collaborative cross mice and RNA-Seq approach

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Animal Models and Experimental Medicine 2024年第1期7卷 36-47页

作者： Roa'a H.S.Yosief Iqbal M.lone Aharon Nachshon Heinz Himmelbauer Irit Gat-Viks Fuad A.Iraqi Department of Clinical Microbiology and Immunology Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael School of Molecular Cell Biology and Biotechnology George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Institute of Computational Biology Department of BiotechnologyUniversity of Natural Resources and Life SciencesMuthgasse 181190 ViennaAustria

Background:Aspergillus fumigatus(Af)is one of the most ubiquitous fungi and its infection potency is suggested to be strongly controlled by the host genetic *** aim of this study was to search for candidate genes associated with host susceptibility to Aspergillus fumigatus(Af)using an RNAseq approach in CC lines and hepatic gene ***:We studied 31 male mice from 25 CC lines at 8 weeks old;the mice were infected with *** tissues were extracted from these mice 5 days post-infection,and next-generation RNA-sequencing(RNAseq)was *** GENE-E analysis platform was used to generate a clustered heat map ***:Significant variation in body weight changes between CC lines was *** gene expression revealed 12 top prioritized candidate genes differ-entially expressed in resistant versus susceptible mice based on body weight ***,three candidate genes are located within genomic intervals of the previ-ously mapped quantitative trait loci(QTL),including Gm16270 and Stox1 on chromo-some 10 and Gm11033 on chromosome ***:Our findings emphasize the CC mouse model's power in fine mapping the genetic components underlying susceptibility towards *** a next step,eQTL analysis will be performed for our RNA-Seq *** candidate genes from our study will be further assessed with a human cohort with aspergillosis.

关键词： aspergillus fumigatus infection collaborative cross(CC)mice gene expression profile gene-network host susceptibility quantitative trait loci(QTL)mapping RNA-Seq

Contribution of GIS to Soil Landscape Mapping by Multi-Criteria Analysis Using Weighting: The Case of the Square Degrees of M’Bahiakro (Centre) and Daloa (Centre-West) in Ivory Coast

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Open Journal of Geology 2024年第1期14卷 101-116页

作者： Guy fernand Yao Derving Baka Nestor Kouman Yao Kouakou Bala Mamadou Ouattara Kouadio Amani Jean Lopez Essehi Brou Kouame Albert Yao-Kouame Sustainable Soil Management and Water Control Program Central Laboratory Soils Water and Plants (LCSEP) National Agricultural Research Center (CNRA) Bouaké Ivory Coast Department of Soil Sciences Training and Research Unit for Earth Sciences and Mining Resources (UFR STRM) University Félix Houphou&#235t-Boigny of Cocody-Abidjan Abidjan Ivory Coast Department of Geography Training and Research Unit (UFR) Communication Environment and Society University Alassane Ouattara Bouaké Ivory Coast Soil Water and Geomaterials Sciences Laboratory (LS2EG) Earth Sciences and Mining Resources Training and Research Unit (UFR STRM) Félix Houphou&#235t-Boigny University Abidjan Ivory Coast

As part of the drive to improve coffee and cocoa production in Ivory Coast, studies are carried out to identify soils that are favourable for these crops. It is therefore necessary to orientate soil investigations based on reliable criteria that best discriminate soil cover. With this in mind, this study is being carried out to help improve survey methods by mapping soil landscapes. It uses GIS and weighted multicriteria analysis. To do this, satellite images were processed and the geological map of the square degrees of M’Bahiakro and Daloa was reclassified. The results show that relief is the main factor in soil landscape differentiation, with respective weights of 0.58 and 0.67 for the forest and pre-forest zones. In contrast, the weight of geological formation in soil landscape differentiation remains low (0.05 for the forest zone and 0.07 for the pre-forest zone). The criteria used on the base of aggregation sum methods have made it possible to formulate soil landscape mapping prediction functions according to agro-ecological environments in the humid intertropical zone. This is essential for the orientation of soil survey work. Nevertheless, other comparative methods, such as the coding mapping method, could provide elements for discussion to validate the models.

关键词： GIS Multi-Criteria Analysis Soil Landscapes M’Bahiakro Daloa Ivory Coast

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基于FPGA的I/O控制器的设计和实现

计算机仿真 2013年第1期30卷 254-258页

作者：怀靓亮 fernand.lone sang 中航工业雷达与电子设备研究院江苏无锡214063 LAAS-CNRS 法国图卢兹31028

对于计算机信息系统受到攻击基本上可以分为基于CPU和I/O控制器这两种。对于CPU的攻击已经被深入研究,各种成熟的对策也被广泛的应用。但是对于I/O控制器攻击的研究非常缺乏有效的保护机制。为了研究关于I/O控制器的攻击,使用FPGA可编... 详细信息

对于计算机信息系统受到攻击基本上可以分为基于CPU和I/O控制器这两种。对于CPU的攻击已经被深入研究,各种成熟的对策也被广泛的应用。但是对于I/O控制器攻击的研究非常缺乏有效的保护机制。为了研究关于I/O控制器的攻击,使用FPGA可编程技术设计和实现了一款PCI Express总线的平台。平台能产生任意种类的关于PCI Express事务层的信息包,为研究各类I/O控制器的攻击提供了基础。

关键词：信息系统可编程技术攻击

Effects of Calcium and Magnesium on Phosphorus Availability in Ferralsols and Rice Production in Forest Zones of Côte d’Ivoire

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Journal of Agricultural Chemistry and Environment 2024年第1期13卷 33-53页

作者： Guy fernand Yao Brahima Kone Kouadio Amani Franck Michaël Lemonou Bahan Jean Lopez Essehi Brou Kouame François Lompo Albert Yao-Kouame National Center for Agronomic Research (CNRA) Central Laboratory Soils Water and Plants (LCSEP) Sustainable Soil and Water Management Program Bouaké C&ocircte d’Ivoire Soil Water and Geomaterials Sciences Laboratory (LS2EG) Earth Sciences and Mining Resources Training and Research Unit (UFR STRM) Félix Houphou&eumlt-Boigny University Abidjan C&ocircte d’Ivoire National Center for Agronomic Research (CNRA) Man Research Station Rice Program Man C&ocircte d’Ivoire Environment and Agricultural Research Institute (INERA) Ouagadougou Burkina Faso

Phosphorus bioavailability has long been a recurring problem in tropical acid soils. A pot experiment was carried out during three (3) successive rice production cycles at Adiopodoumé to evaluate the response of the NERICA 5 rice accession to various doses of calcium, magnesium and phosphorous. The experiment was conducted using a randomized split-plot design. The interactive effects of calcium carbonate (0, 25, 50 and 75 kg·Ca·ha-1) and magnesium sulfate (0, 25, 50 and 75 kg·Mg·ha-1) and Togo natural phosphate (0, 25, 50 and 75 kg·P·ha-1) were determined at each production cycle. The results showed that single-dose natural phosphate supplementation for three cropping cycles resulted in an average enrichment of around 2 mg·P·kg-1 after each trial following its continuous dissolution, with an increase in DSP (33.31% to 70.52%). The study revealed one strategy for managing and enhancing native P with cations and another for exogenous P: there would be a synergy of Ca/Mg on native P, whereas an antagonism would characterize the two parameters in phosphate fertilization.

关键词： Soil Acidity Native and Exogenous Phosphorus Free Iron Ca/Mg Balances Rice Growing Côte d’Ivoire

Response of the Maize Variety EV87-28 to a Fertilization Strategy Involving Indorama Granular Urea on Ferralsol in the Central Ivory Coast

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Agricultural Sciences 2024年第1期15卷 187-208页

作者： fernand Guy Yao Kouadio Amani Brou Kouame Jean Lopez Essehi Brahima Kone Kouadio Houphouet Cheikh Ahmed Diawara Bala Mamadou Ouattara Albert Yao-Kouame Central Laboratory Soils Water and Plants (LCSEP) National Agricultural Research Center (CNRA) Bouaké Ivory Coast Soil Water and Geomaterials Sciences Laboratory (LS2EG) Earth Sciences and Mining Resources Training and Research Unit (UFR STRM) University Félix Houphou&#235t-Boigny of Cocody-Abidjan Abidjan Ivory Coast Cotton Research Station National Agricultural Research Center (CNRA) Bouaké Ivory Coast Food Crops Research Station National Agricultural Research Center (CNRA) Bouaké Ivory Coast Department of Geography Unit of Training and Research (UFR) Communication Environment and Society University Alassane Ouattara Bouaké Ivory Coast

In Côte d’Ivoire, the decline in soil fertility strongly impacts the productivity of maize (Zea mays L.) on heavily leached ferralitic soil. In this study, the general objective was therefore to improve the productivity of maize EV87-28 on the Ferralsols in pre-forested areas during different cropping seasons. Eight (8) micro-plots were set up according to a total randomization device with three repetitions. Two factors were studied: nitrogen fertilizer modalities (main factor) and crop season (secondary factor). Growth, flowering and yield parameters were measured and analyzed. The results showed that there was no interaction between the nitrogen fertilizer factor and the cropping season factor. In addition, this study showed the short rainy season had the most positive impact on growth, flowering and yield parameters than the long rainy season. The results also showed that the different nitrogen fertilizer modalities had no statistically different effects on growth, flowering and yield parameters. However, quantitative differences were reported, highlighting one nitrogen fertilizer modality, which is the combination of urea granule + farm manure (75% urea indorama granules and 25% farm manure). The combination of urea granule + farm manure (75% urea indorama granules and 25% farm manure) had the best effect on corn grain yield. So, the combination of urea (75%) and manure (25%), that resulted in yield gain, could be recommended for corn fertilization during the small rainy season.

关键词： Indorama Granular Urea Ferralsol Cultural Seasons Maize Ivory Coast

Multicriteria Analysis by Codification for the Determination of Soil Landscape Units in Forest and Pre-Forest Zones of Cote D’Ivoire: The Case of the Square Degrees of M’Bahiakro and Daloa

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International Journal of Geosciences 2024年第1期15卷 12-24页

作者： Guy fernand Yao Derving Baka Koffi Emmauel Kassin Bala Mamadou Ouattara Nestor Kouman Yao Kouakou Kouadio Amani Jean Lopez Essehi Brou Kouame Albert Yao-Kouame National Agricultural Research Center (CNRA) Central Laboratory Soils Water and Plants (LCSEP) Sustainable Soil Management and Water Control Program Bouaké Ivory Coast Earth Sciences and Mining Resources Training and Research Unit (UFR STRM) Soil Water and Geomaterials Sciences Laboratory (LS2EG) Félix Houphou&#235t-Boigny University Cocody-Abidjan Abidjan C&#244te d’Ivoire Mondelez International Abidjan C&#244te d’Ivoire Training and Research Unit (UFR) Communication Environment and Society Department of Geography University Alassane Ouattara Bouaké C&#244te d’Ivoire Soil Water and Geomaterials Sciences Laboratory (LS2EG) Earth Sciences and Mining Resources Training and Research Unit (UFR STRM) Félix Houphou&#235t-Boigny University Abidjan Ivory Coast

The present study, carried out in the forest (Daloa) and pre-forest (M’Bahiakro) zones of Cote d’Ivoire, aims to determine soil landscape units using the coding method. Geological maps and satellite images (SRTM and Landsat) were used for this purpose. The methodological approach adopted consisted in producing maps of slope, geology, land use and topography using the codification method. These various maps, integrated into a GIS using the coding aggregation method, were used to generate soil landscape maps. Twenty-seven (27) soil landscapes have been identified for the pre-forest zone (M’Bahiakro), with a strong dominance of acid rock over a moderate relief under savannah, forest/degraded forest and crops/fallow. However, the forest zone (Daloa), with forty-one (41) soil landscapes identified over the entire zone, is characterized by a majority of mafic rocks on a medium altitude under forest/degraded forest, water and crops/fallow. The criteria used from the codification method (sum of aggregations) made it possible to predict the spatial distribution of soil map units according to agro-ecological environments in the humid intertropical zone. This is essential for the orientation and reinforcement of soil survey tools. However, a comparative evaluation of the different multicriteria analysis methods for coding and weighting soil landscape unit mapping would enable us to identify the most suitable and efficient method for drawing up base maps for soil surveys.

关键词： GIS Multicriteria Analysis by Coding Soil Landscapes Daloa M’Bahiakro Cote D’Ivoire

PSA screening for prostate cancer： why so muc ：ontroversy？

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Asian Journal of Andrology 2013年第5期15卷 603-607页

作者： fernand Labrie Laval University Quebec Que. GIV 4M7 Canada

Since prostate cancer reaches the advanced and non curable stage in the absence of any specific symptom or sign, it seems reasonable to diagnose this cancer at an early and curable stage. Screening by prostate-specific antigen （PSA） has been the common technology used. The last follow-up of the first two prospective and randomized screening studies for prostate cancer, namely the Quebec and ERSPC （European Randomized Study of Screening for Prostate Cancer） clinical trials started in 1988 and 1991, respectively, have shown reductions of prostate cancer death of 62% （P〈0.002） and 21% （P〈0.001）（38% in the tenth and eleventh years of follow-up, P〈0.003）, respectively, while the PLCO （Prostate Lung Colorectal and Ovarian Cancer） screening trial reported no benefit. It has been estimated, however, that 85% of men in the planned ＇non-screened＇ group of the US study have been screened. With such a serious flaw, the PLCO study does not have the statistical power to reach any valid conclusion. In the Quebec study, only 7.3% of men were screened in the control arm. The important benefit observed in the ERSPC study was achieved using a less than optimal 4-year PSA screening interval which misses a significant number of cancers while the Quebec study used the optimal 1-year interval. With proper information obtained from their physicians or otherwise using data collected only from the clinical trials having the required statistical power, men should be in a good position to decide about being or not being screened for prostate cancer.

关键词： early diagnosis improved survival prostate cancer prostate-specific antigen screening

Calcium-Magnesium Ca/Mg Ratios and Their Agronomic Implications for the Optimization of Phosphate Fertilization in Rainfed Rice Farming on Acidic Ferralsol in the Forest Zone of Ivory Coast

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Open Journal of Soil Science 2024年第1期14卷 81-96页

作者： fernand G. Yao Brahima Kone Franck M. L. Bahan Kouadio Amani Jean L. Essehi Mamadou B. Ouattara Konan E. B. Dibi Brou Kouame François Lompo Albert Yao-Kouame Central Laboratory Soils Water and Plants (LCSEP) National Center for Agronomic Research (CNRA) Bouaké Ivory Coast Soil Water and Geomaterials Sciences Laboratory (LS2EG) Cocody-Abidjan Earth Sciences and Mining Resources Training and Research Unit (UFR STRM) Félix Houphou&#235t-Boigny University Abidjan Ivory Coast Department of Rice Program Man Research Station National Center for Agronomic Research (CNRA) Man Ivory Coast Department of Geography Unit of Training and Research (UFR) Communication Environment and Society University Alassane Ouattara Bouaké Ivory Coast Food Crops Research Station (SRCV) National Agricultural Research Center (CNRA) Bouaké Ivory Coast Institute of the Environment and Agricultural Research (INERA) Ouagadougou Burkina Faso

This study is a contribution to improving rice productivity on acidic plateau soils of the tropical rainforest zone. It is based on taking into account the cationic balances of the soil in order to optimize the phosphorus (P) nutrition of rice on these acidic soils, where this nutrient constitutes a limiting factor for agricultural production. Three (3) pot trials were conducted in Adiopodoumé in the forested south of Côte d’Ivoire. The interactive effects of calcium carbonate (0, 25, 50 and 75 kg Ca ha−1) and magnesium sulfate (0, 25, 50 and 75 kg Mg ha−1) were evaluated on the response of NERICA 5 rice at doses 0, 25, 50 and 75 kg P ha−1 of natural phosphate from Togo, applied only once at the start of the experiment. Additional fertilizers of nitrogen (N) (100 kg N ha−1) and potassium (K) (50 kg KCl ha−1) were added to each of the tests in a split-plot device. The test results revealed a paddy production potential of approximately 3 to 5 t⋅ha−1 for NERICA 5 on an acidic soil, under the effect of the interaction of P, Ca and Mg. The quadratic response of rice yield to the doses of these fertilizers would be more dependent on their balance, itself influenced by Ca nutrition. For the sustainability and maintenance of rice production in agro-ecology studied, it was recommended doses of 38 kg Ca ha−1, 34 kg Mg ha−1 in a Ca/Mg ratio (1/1) with intakes of 41 kg P ha−1, overall in a ratio 1/1/1 (P/Ca/Mg) more favorable to the availability of free iron considered a guiding element of mineral nutrition. Thus, these promising results should be confirmed in a real environment for better management of the fertilization of rice cultivated on acidic plateau soils in Côte d’Ivoire.

关键词： Soil Acidity Ca/Mg Ratios Phosphate Fertilization Rice Growing Ivory Coast

A review on offloading in fog-based Internet of Things:Architecture,machine learning approaches,and open issues

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高置信计算(英文) 2023年第2期3卷 83-92页

作者： Kalimullah lone Shabir Ahmad Sofi National Institute of Technology SrinagarJammu and Kashmir 190006India

There is an exponential increase in the number of smart devices,generating helpful information and posing a serious challenge while processing this huge *** processing is either done at fog level or cloud level depending on the size and nature of the *** data to fog or cloud adds latency,which is less in fog and more in the *** methods of processing data and tasks at fog level or cloud are mostly machine learning *** this paper,we will discuss all three levels in terms of architecture,starting from the internet of things to fog and fog to ***,we will describe machine learning-based offloading from the internet of things to fog and fog to ***,we will come up with current research directions,issues,and challenges in the IoT–fog–cloud environment.

关键词： Fog computing Internet of Things Machine learning Architectures Offloading Data