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Where to go?Predicting next location in IoT environment

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Frontiers of Computer Science 2021年第1期15卷 113-125页

作者： Hao liN Guannan liU fengzhi li Yuan ZUO School of Economics and Management Beihang UniversityBeijing 100191China

Next location prediction has aroused great inter-ests in the era of internet of things(IoT).With the ubiquitous deployment of sensor devices,e.g..GPS and Wi-Fi,loT en-vironment offers new opportunities for proactively analyzing human mobility patterns and predicting user's future visit in low cost,no matter outdoor and indoor.In this paper,we con-sider the problem of next location prediction in loT environ-ment via a session-based manner.We suggest that user's future intention in each session can be better inferred for more ac-curate prediction if patterns hidden inside both trajectory and signal strength sequences ollected from IoT devices can be jointly modeled,which however existing state-of the-art meth-ods have rarely addressed.To this end,we propose a trajectory and sIgnal sequence(TSIS)model,where the trajectory transi-tion regularities and signal temporal dynamics are jointly embedded in a neural network based model.Specifically,we employ gated recurrent unit(GRU)for capturing the temporal dy-namics in the mutivariate signal strength sequence.Moreover,we adapt gated graph neural networks(gated GNNs)on loca-tion transition graphs to explicitly model the transition patterns of trajectories.Finally,both the low-dimensional representa-tions learned from trajectory and signal sequence are jointly optimized to construct a session embedding,which is further employed to predict the next location.Extensive experiments on two real-world Wi-Fi based mobility datasets demonstrate that TSIS is effective and robust for next location prediction pompared with other competitive baselines.

关键词： internet of things next location prediction neural networks trajectory signal

The structure of WbnH in a near active state

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Protein & Cell 2015年第8期6卷 615-618页

作者： fengzhi li Siwei li Xiaofen liu Xue Yang Peng Wang Yuequan Shen State Key Laboratory of Medicinal Chemical Biology Nankai University Tianjin 300071 China College of life Sciences Nankai University Tianjin 300071 China Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences Tianjin 300308 China Synergetic Innovation Center of Chemical Science and Engineer- ing Tianjin 300071 China

Dear Editor, Gram-negative bacteria possess a complicated membrane system that plays an essential role in interactions between bacteria and the envJronment （Reeves and Wang, 2002）. The inner leaflet of the membrane is composed of various glycerophospholipids, and the outer leaflet consists primarily of lipopolysaccharide （LPS） molecules.

关键词： Corynebacterium Glutamicum Solvent Region Core Oligosaccharide Undecaprenyl Nucleotide Sugar Donor

CHO细胞外源抗体基因拷贝数实时定量PCR检测方法的建立及验证

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中国生物制品学杂志 2024年第1期37卷 72-78页

作者：张慧高文丽李凤智胡加亮李剑中国药科大学生命科学与技术学院江苏南京211100 天士力生物医药股份有限公司上海201203

目的采用SYBR GreenⅠ染料建立实时定量PCR法检测CHO细胞外源抗体轻链(light chain,LC)、重链(heavy chain,HC)基因拷贝数,并进行方法的验证及初步应用。方法以CHO细胞中稳定表达的B2m(β2-microglobulin)基因作为内参基因,分别设计... 详细信息

目的采用SYBR GreenⅠ染料建立实时定量PCR法检测CHO细胞外源抗体轻链(light chain,LC)、重链(heavy chain,HC)基因拷贝数,并进行方法的验证及初步应用。方法以CHO细胞中稳定表达的B2m(β2-microglobulin)基因作为内参基因,分别设计适宜的LC和HC基因引物及内参基因引物,确定实时定量PCR方法的反应体系和反应程序。对建立的方法进行特异性、线性、精密性及耐用性验证,并采用建立的方法检测重组细胞株工作细胞库(WCB)及不同传代次数细胞中LC和HC基因拷贝数。结果外源基因与内参基因引物可特异性结合目标片段;B2m、LC、HC基因引物扩增效率分别为106.7%、106.3%和99.1%,线性方程相关系数均大于0.99,具有良好的线性关系;精密性验证的相对标准偏差(relative standard deviation,RSD)均小于1%;短时间内少次冻融对检测结果影响较小。利用建立的方法检测不同代次重组细胞株LC和HC基因拷贝数,未见明显变化。结论成功建立了CHO细胞外源基因拷贝数实时定量PCR检测方法,该方法特异性、线性、精密性及耐用性良好,为其他CHO细胞株表达的外源基因拷贝数检测提供了参考。

关键词：实时定量PCR CHO细胞抗体轻链重链基因拷贝数

1例长期鼻饲营养并发食管结石致食管梗阻患者的护理

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军事医学 2024年第4期48卷 319-320页

作者：郭靖武兰兰李凤芝林乐拉空军军医大学空军特色医学中心呼吸与危重症医学科北京100142

鼻饲喂养是指将鼻饲管从鼻腔插入胃中,为卧床患者补充或提供营养物质、药物和水的关键方法之一。在临床实践中,管路脱出、反流及误吸、管路堵塞、胃潴留、黏膜损伤为鼻饲喂养常见的并发症[1],食管结石较为罕见。空军特色医学中心呼吸与... 详细信息

鼻饲喂养是指将鼻饲管从鼻腔插入胃中,为卧床患者补充或提供营养物质、药物和水的关键方法之一。在临床实践中,管路脱出、反流及误吸、管路堵塞、胃潴留、黏膜损伤为鼻饲喂养常见的并发症[1],食管结石较为罕见。空军特色医学中心呼吸与危重症医学科收治的1例长期鼻饲喂养患者,2021年住院过程中出现食管结石致食管梗阻,现报告如下。

关键词：食管结石食管梗阻护理

新就业形态从业人员劳动权益保障的法治路径研究

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阜阳师范大学学报（社会科学版） 2024年第1期 112-116页

作者：项贤国唐晨李风志宿迁学院江苏宿迁223800 河北省景县人民法院河北景县053500

新就业形态是以共享经济为代表的新兴行业催生的平台就业、远程办公、用工共享等新就业类型,为新就业形态下的各行各业提供劳动服务的从业人员属于新就业形态从业人员。通过深入新就业形态用工单位和有关人民法院开展调研,基于劳动关系... 详细信息

新就业形态是以共享经济为代表的新兴行业催生的平台就业、远程办公、用工共享等新就业类型,为新就业形态下的各行各业提供劳动服务的从业人员属于新就业形态从业人员。通过深入新就业形态用工单位和有关人民法院开展调研,基于劳动关系认定、分层保护、分类保护与政府监管探究新业态从业人员权益保障的现实困境,明确新就业形态从业人员劳动权益保障的立法对策,包括构建多层次劳动关系保护体系、健全劳务关系保护的法律规范和完善具体的权益制度设计。进而,基于发布指导性案例、准确认定劳动关系、休息休假权、平等就业权、职业安全权、经济补偿权等方面,厘清人民法院在审理新就业形态从业人员劳动权益保障案件时的司法裁判规则。

关键词：新就业形态劳动权益现实困境立法对策裁判规则

胸苷激酶1、细胞角质蛋白19片段抗原21-1在非小细胞肺癌中的表达及与患者临床特征和预后的关系

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癌症进展 2024年第8期22卷 917-920,925页

作者：李杨李凤芝黄晗胡朝阳常瑞张小红郑州大学附属郑州中心医院呼吸与危重症医学科郑州450000

目的探讨胸苷激酶1(TK1)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)在非小细胞肺癌(NSCLC)中的表达及与患者临床特征和预后的关系。方法选取100例NSCLC患者,采用免疫组化法检测肿瘤组织及癌旁组织中TK1、CYFRA21-1表达情况,比较NSCLC患... 详细信息

目的探讨胸苷激酶1(TK1)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)在非小细胞肺癌(NSCLC)中的表达及与患者临床特征和预后的关系。方法选取100例NSCLC患者,采用免疫组化法检测肿瘤组织及癌旁组织中TK1、CYFRA21-1表达情况,比较NSCLC患者肿瘤组织与癌旁组织中TK1、CYFRA21-1的表达情况,以及不同临床特征NSCLC患者肿瘤组织中TK1、CYFRA21-1的表达情况。根据预后情况将NSCLC患者分为预后不良组和预后良好组,采用Logistic回归分析NSCLC患者的预后影响因素。结果肿瘤组织中TK1、CYFRA21-1的阳性表达率均明显高于癌旁组织,差异均有统计学意义(P﹤0.01)。不同淋巴结转移情况NSCLC患者肿瘤组织中TK1、CYFRA21-1阳性表达率比较,差异均有统计学意义(P﹤0.05)。预后良好组(n=71)和预后不良组(n=29)患者淋巴结转移情况及TK1、CYFRA21-1表达情况比较,差异均有统计学意义(P﹤0.05)。多因素Logistic回归分析结果显示,有淋巴结转移及TK1、CYFRA21-1阳性表达均是NSCLC患者预后不良的独立危险因素(P﹤0.05)。结论TK1、CYFRA21-1在NSCLC中的阳性表达率较高,有淋巴结转移及TK1、CYFRA21-1阳性表达均是NSCLC患者预后不良的危险因素。

关键词：非小细胞肺癌胸苷激酶1 细胞角质蛋白19片段抗原21-1 预后

Dysbiosis of oral and gut microbiota and its association with metabolites in patients with different degrees of coronary artery stenosis

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中华医学杂志(英文版) 2024年第9期137卷 1121-1123页

作者： Wang Zekun li Long Wang Chenyang Wang Qian Wang fengzhi Xu Xin Zhou Xuedong State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan China Department of Cariology and Endodontics West China Hospital of Stomatology Sichuan University Chengdu Sichuan China Department of Cardiology Shanxi Provincial Key Laboratory of Cardiovascular Disease Diagnosis Treatment and Clinical Pharmacology The Second Hospital of Shanxi Medical University Taiyuan Shanxi China

To the Editor:Coronary atherosclerotic heart disease (CAD) arises from coronary atherosclerosis (CAS) plaque buildup,resulting in coronary stenosis (CS) and occlusion,ultimately causing myocardial ischemia,hypoxia,or necrosis.Studies showed that the high-grade CS may be an important predictor of ST segment elevation myocardial infarction in subsequent months.

关键词：

Numerical Analysis on Thermal Function of Clothing with PCM Microcapsules

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Transactions of Nanjing University of Aeronautics and Astronautics 2019年第2期36卷 320-329页

作者： liU Wenyi li fengzhi liU Weihua Nanjing Engineering Institute of Aircraft Systems Nanjing 210000P.R.China College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China

To study the influences of phase change material(PCM)microcapsules in clothing on human thermal responses,a mathematical model is developed.The improved Stolwijk’s model is used to simulate human thermo-regulatory process,and the coupled heat and moisture transfer including the moisture sorption/desorption of fibers and effects of phase transition temperature range on the phase change processes of the PCM is considered in clothing model.Meanwhile,the theoretical predictions are validated by experimental data.Then,the interactions between human body thermal responses and the heat and moisture transfer in clothing are discussed by comparing the prediction results with PCMs and without PCMs.Also the effects of fiber hygroscopicity on clothing and human thermal responses are compared.The conclusion shows that the clothing with PCMs microcapsules can delay the human temperature variations and decrease the sweat accumulation rate on the skin surface and heat loss during changing of ambient conditions,and fiber hygroscopicity reduces the effect of PCM microcapsules on delaying garment temperature variations very significantly.

关键词： PCM microcapsule porous textiles heat and moisture transfer numerical simulation human thermoregulatory model

Increment-Dimensional Scaled Boundary Finite Element Method for Solving Transient Heat Conduction Problem

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第6期35卷 1073-1079页

作者： li fengzhi li Tiantian Kong Wei Cai Junfeng College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China College of Aeronautic Science and Engineering Beihang UniversityBeijing 100191P.R.China The 610 Research Institute of Chinese Aeronautical Establishment Xiangyang 441000P.R.China

An increment-dimensional scaled boundary finite element method (ID-SBFEM) is developed to solve the transient temperature field.To improve the accuracy of SBFEM,the effect of high frequency factor on dynamic stiffness is considered,and the first-order continued fraction technique is used.After the derivation,the SBFE equations are obtained,and the dimensions of thermal conduction,the thermal capacity matrix and the vector of the right side term in the equations are doubled.An example is presented to illustrate the feasibility and good accuracy of the proposed method.

关键词： heat conduction scaled boundary finite element method(SBFEM) temperature field accuracy