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经食管超声心动图在Amplatzer Cardiac Plug（ACP）左心耳封堵术中的应用

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中华超声影像学杂志 2017年第2期26卷 110-115页

作者：陈立斌张盛敏毛锋张涛储慧民俞霏朱雪丽许幼峰尹凤英宁波市第一医院超声科 315010 宁波市第一医院心内科 315010

目的评估经食管超声心动图（TEE）在Amplatzer Cardiac Plug（ACP）左心耳封堵术中的应用价值。方法对32例高卒中风险非瓣膜性心房颤动患者（CHADS2≥1分）在TEE引导下用ACP封堵器行左心耳封堵术。术前二维TEE测量左心耳锚定区（着陆区... 详细信息

目的评估经食管超声心动图（TEE）在Amplatzer Cardiac Plug（ACP）左心耳封堵术中的应用价值。方法对32例高卒中风险非瓣膜性心房颤动患者（CHADS2≥1分）在TEE引导下用ACP封堵器行左心耳封堵术。术前二维TEE测量左心耳锚定区（着陆区）和左心耳口部的最大径、最小径以及左心耳深度，分析影响封堵结果的相关因素。结果封堵成功27例，其中2例封堵器周边有残余分流，分别为2．8mm、3．6mm。5例封堵失败患者中，3例由于左心耳着陆区直径过大（〉30mm），1例由于深度过浅（深度15mm），1例由于左心耳位置过低。二维TEE测量左心耳口最大径、最小径、深度分别为（25．9±4．9）mm、（20．0±3．8）mm、（31．0±5．6）mm；二维TEE测量左心耳着陆区最大径、最小径分别为（26．2±6．2）mm、（19．4±4．3）mm。10例着陆区直径≥30mm的患者中7例封堵成功，3例封堵失败。最终置入封堵器大小平均（26．4±3．8）mm，封堵器平均压缩率（7．6±5．5）％。封堵器大小与TEE测量左心耳着陆区及口部最大径相关（r分别为0．770、0．717）。1例发生心包填塞并发症。结论二维TEE测量数据均在ACP左心耳封堵器型号选择方面具有指导意义，其中二维TEE测量左心耳着陆区直径与ACP封堵器尺寸相关性较好，左心耳大小可能是影响封堵成败的主要因素。

关键词：超声心动描记术经食管左心耳封堵 Amplatzer Cardiac Plug

二维斑点追踪成像评估2型糖尿病患者右心室功能

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中华超声影像学杂志 2015年第8期24卷 657-660页

作者：俞霏许幼峰毛锋姜月茗茗陈立斌胡芳芳张盛敏尹凤英宁波市第一医院超声科 315010 宁波市第一医院内分泌科 315010

目的应用二维斑点追踪成像（2D-STI）评估2型糖尿病患者的右心室收缩功能。方法连续选取50例2型糖尿病患者及50例年龄匹配的正常对照者行超声心动图检查，测量：①右心腔大小、右室壁厚度；②右心室面积变化率（RVFAC）、三尖瓣环侧壁... 详细信息

目的应用二维斑点追踪成像（2D-STI）评估2型糖尿病患者的右心室收缩功能。方法连续选取50例2型糖尿病患者及50例年龄匹配的正常对照者行超声心动图检查，测量：①右心腔大小、右室壁厚度；②右心室面积变化率（RVFAC）、三尖瓣环侧壁收缩期组织速度（S’）、三尖瓣环平面收缩期位移（TAPSE）、四腔心切面右心室壁6个节段纵向应变；③三尖瓣口舒张期血流E、A峰比值（E／A）、E峰与组织多普勒三尖瓣环舒张速度E’峰比值（E／E＇）、右心室Tei指数等。统计分析组间测值差异。结果与对照组相比，糖尿病组右心腔大小差异无统计学意义（P〉0．05），而右室壁厚度增加（P=0．000）；右室侧壁中间段、室间隔中间段与基底段的二维应变绝对值降低（P=0．001、0．000及0．005），而另3个节段应变值以及RVFAC、TAPSE、S’差异无统计学意义（P〉0．05）；E／E’增高、E／A降低、右心室Tei指数增高（P=0．000、0．000及0．006）。结论2D-STI较常规参数更敏感，能在早期反映2型糖尿病患者的右心室收缩功能改变；而右心室6个节段中，侧壁中间段、室间隔中间段及室间隔基底段的应变测值更可靠。

关键词：超声心动描记术糖尿病心室功能,右应变

超声二维应变检测冠状动脉粥样硬化性心脏病患者区域室壁收缩功能

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现代实用医学 2010年第12期22卷 1333-1336页

作者：许幼峰陈立斌曹涌尹凤英陈伟英宁波市第一医院浙江宁波315010

目的探讨利用二维应变检测冠状动脉粥样硬化性心脏病(冠心病)患者区域室壁收缩功能价值。方法对42例冠心病患者按照冠状动脉(冠脉)供血区室壁计算如下参数:左室区域峰值应变(Ter-PSS),区域室壁收缩指数(Ter-WMSI),区域组织收缩峰值速度(... 详细信息

目的探讨利用二维应变检测冠状动脉粥样硬化性心脏病(冠心病)患者区域室壁收缩功能价值。方法对42例冠心病患者按照冠状动脉(冠脉)供血区室壁计算如下参数:左室区域峰值应变(Ter-PSS),区域室壁收缩指数(Ter-WMSI),区域组织收缩峰值速度(Ter-TVI),计算无狭窄冠脉、轻-中度狭窄冠脉(狭窄率0.05)。(2)诊断冠脉重度狭窄ROC曲线下面积(AUC):Ter-PSS、Ter-WMSI、Ter-TVI分别为0.794、0.752、0.533,Ter-PSS、Ter-WMSI取最佳界值点-12.5%、1.2时敏感性、特异性分别为73.8%、88.0%;67.2%、76.0%。结论冠心病组Ter-PSS、Ter-TVI均低于正常对照组,Ter-WMSI明显高于对照组,Ter-PSS、Ter-WMSI能较准确鉴别冠脉重度狭窄与轻-中度狭窄,且Ter-PSS敏感性、特异性均高于Ter-WMSI。

关键词：冠状动脉疾病冠状动脉狭窄超声检查二维应变区域应变

Vinyl-functionalized multicolor benzothiadiazoles: design,synthesis, crystal structures and mechanically-responsive performance

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Science China Chemistry 2019年第4期62卷 440-450页

作者： Jianhua Chen fengying Ye Yan Lin Zhao Chen Shenghua Liu Jun yin Key Laboratory of Pesticide and Chemical Biology Ministry of Education College of Chemistry Central China Normal University Department of Pharmacy Jiangxi University of Traditional Chinese Medicine Jiangxi Key Laboratory of Organic Chemistry Jiangxi Science and Technology Normal University

Benzothiadiazole(BTD) has been extensively used as a building block in optical materials. In this work, a class of π-conjugated BTD-based luminogens BTD-685, BTD-580, BTD-675 and BTD-565 were designed by varying donor units and facilely synthesized by Heck coupling reaction. It was found that their emission in solid state covered the regio from orange, red to near infrared fluorescence. Investigation on photo-physical property manifested that they had strong solvatochromic behavior except symmetric 2-vinylpyridine substituted BTD-565. Crystal X-ray diffraction analysis revealed that they involved in multi weak intermolecular interactions. And loose molecular packing implied that they can be easily rearranged under external force ***, all compounds showed reversible mechanically-responsive behavior in solid state. Interestingly, the vinylpyridinecontaining BTD-565 exhibited hypochromatic mechanochromic behavior, whereas others showed bathochromic mechanochromism behavior. It was worth mentioning that BTD-675 had self-recovery behavior after grinding. The powder X-ray diffraction study showed that these chromic processes may be mainly attributed to the reversible morphological changes between crystalline and amorphous phase upon grinding or fuming. These observations suggested that the vinyl-functionalized benzothiadiazoles can be considered as a type of excellent candidates in mechanically-responsive chromic materials.

关键词： benzothiadiazole mechanochromism multicolor aggregation

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结节病合并隐球菌病的研究进展

国际呼吸杂志 2019年第1期39卷 60-63页

作者：钱国清杨乃彬石洁君尹凤英李国祥浙江大学宁波医院宁波市第一医院内科315010 浙江大学宁波医院宁波市第一医院全科医学科315010

结节病是一种病因不明,但可累及多种脏器的非干酪性坏死性肉芽肿性疾病,隐球菌病是由新型隐球菌感染导致的深部真菌病;然而,结节病患者自身存在免疫缺陷、或未知的免疫缺陷和长期使用糖皮质激素或免疫抑制剂等药物,可导致2种疾病共存。... 详细信息

结节病是一种病因不明,但可累及多种脏器的非干酪性坏死性肉芽肿性疾病,隐球菌病是由新型隐球菌感染导致的深部真菌病;然而,结节病患者自身存在免疫缺陷、或未知的免疫缺陷和长期使用糖皮质激素或免疫抑制剂等药物,可导致2种疾病共存。由于结节病合并隐球菌病少见、临床认识不足、发病机制不明,易引起误诊和漏诊。本文拟对结节病合并隐球菌病的流行病学、发病机制、临床表现、诊断和鉴别诊断、治疗和预后等进行综述。

关键词：结节病隐球菌病进展

Stimuli-responsive organic chromic materials with near-infrared emission

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Chinese Chemical Letters 2018年第10期29卷 1429-1435页

作者： Weijie Chen yingle Pan Jianhua Chen fengying Ye Sheng Hua Liu Jun yin Key Laboratory of Pesticide and Chemical Biology Ministry of EducationCollege of ChemistryCentral China Normal University

Organic chromic materials that respond to external stimuli, especially in the solid state, have sparked extensive interest owing to their potential use as smart materials. In particular, the availability of chromic materials, which emit fluorescence or phosphorescence in the deep penetrating, near-infrared（NIR）region, has led to great improvements in imaging. Various methods that were commonly applied to construct chromic materials, have been reformed to develop the novel type of compounds, and some have received rewards with excellent fingdings. Relevant research achievements of practical applications have showed their potential with the changes that locate in the NIR region, while further in-depth explorations about the inherent chromic chromism are underway. In this review, several representative studies, which have led the development of responsive organic chromic materials with near-infrared emission, will be discussed.

关键词： Stimuli-response Near-infrared emission Fluorescent dyes Chromic materials Mechanochromism

Seismic studies of coal bed methane content in the west coal mining area of Qinshui Basin

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International Journal of Mining Science and Technology 2013年第6期23卷 795-803页

作者： Zou Guangui Peng Suping yin Caiyun Xu Yanyong Chen fengying Liu Jinkai State Key Laboratory of Coal Resource and Safe Mining China University of Mining&Technology

The coal bed methane content(CBMC)in the west mining area of Jincheng coalfield,southeastern Qjnshui Basin,is studied based on seismic data and well-logs together with laboratory *** results show that the Shuey approximation has better adaptability according to the Zoeppritz equation result;the designed fold number for an ordinary seismic data is sufficient for post-stack data but insufficient for pre-stack data regarding the signal to noise ratio(SNR).Therefore a larger grid analysis was created in order to improve the *** velocity field created by logging is better than that created by stack velocity in both accuracy and effectiveness.A reasonable distribution of the amplitude versus offset(AVO)attributes can be facilitated by taking the AVO response from logging as a standard for calibrating the amplitude *** AVO attributes have a close relationship with *** worst attribute is polarization magnitude,for which the correlation coefficient is 0.308;and the best attribute is the polarization product from intercept,of which the correlation coefficient *** predicted by AVO attributes is better overall than that predicted by direct interpolation of CBMC;the validation error of the former is 14.47%,which is lower than that of the latter 23.30%.CBMC of this area ranges from2.5 m^3/t to 22 m^3/*** CBMC in the syncline is over 10m^3/t,but it is below 10m^3/t in the anticline;on the whole,CBMC in the syncline is higher than that in anticline.

关键词： Coal bed methane content Amplitude versus offset AVO attribute Correlation coefficient

Modeling seismic wave propagation in a coal-bearing porous medium by a staggered-grid finite difference method

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Mining Science and Technology 2011年第5期21卷 727-731页

作者： Zou Guangui Peng Suping yin Caiyun Deng Xiaojuan Chen fengying Xu Yanyong State Key Laboratory of Coal Resources and Mine Safety China University of Mining ＆ Technology Beijing 100083 China

A staggered-grid finite difference method is used to model seismic wave records in a coal bearing, porous medium. The variables analyzed include the order of the difference calculations, the use of a perfect match layer to provide absorbing boundary conditions, the source location, the stability conditions, and dispersion in the medium. The results show that the location of the first derivative of the dynamic variable with respect to space is coincident with the location of the first derivative of the kinematic var- iable with respect to time. Outgoing waves are effectively absorbed and reflection at the boundary is very weak when more than 20 perfect match layer cells are used. Biot theory considers the liquid phase to be homogeneous so the ratio of liquid to solid exposure of the seismic source depends upon the medium porosity. Numerical dispersion and generation of false frequencies is reduced by increasing the accuracy of the difference calculations and by reducing the grid size and time step. Temporal second order accu- racy, a tenth order spatial accuracy, and a wavelength over more than ten grid points gave acceptable numerical results. Larger grid step sizes in the lateral direction and smaller grid sizes in the vertical direc- tion allow control of dispersion when the medium is a low speed body. This provides a useful way to sim- ulate seismic waves in a porous coal bearing medium.

关键词：多孔介质模型地震波传播有限差分法交错网格含煤吸收边界条件完美匹配层 Biot理论

黄槽竹及其变种自然极端低温后的生理响应特征

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北京林业大学学报 2022年第3期44卷 75-84页

作者：夏雯尹子旭官凤英国际竹藤中心国家林业和草原局/北京市共建竹藤科学与技术重点实验室北京100102 江苏宜兴竹林生态系统国家定位观测研究站国家林业和草原局江苏宜兴214200

【目的】为探究北京地区黄槽竹及其变种自然低温胁迫下的生理响应特征并对抗寒能力进行综合评价。【方法】以黄槽竹、金镶玉竹、黄秆京竹3个竹种为研究对象,分析其自然极端低温后的叶绿素含量、渗透调节物质、抗氧化系统指标、内源激素... 详细信息

【目的】为探究北京地区黄槽竹及其变种自然低温胁迫下的生理响应特征并对抗寒能力进行综合评价。【方法】以黄槽竹、金镶玉竹、黄秆京竹3个竹种为研究对象,分析其自然极端低温后的叶绿素含量、渗透调节物质、抗氧化系统指标、内源激素特征,并采用熵权TOPSIS法对抗寒性进行综合评价。【结果】黄槽竹叶绿素含量均高于其他两个竹种。黄秆京竹丙二醛(MDA)含量最高,但抗氧化物酶(SOD、POD、CAT)活性低于其他两个竹种。黄秆京竹幼壮竹叶片中可溶性糖、可溶性蛋白含量均显著高于其他两个竹种。金镶玉竹随着年龄的增大,其叶绿素含量、SOD、POD活性显著降低,渗透物质含量变化差异不显著(P>0.05)。黄秆京竹幼壮竹的3种渗透物质含量显著高于老竹,黄槽竹两个年龄阶段间抗氧化系统指标差异达显著水平(P<0.05)。3个竹种的ABA/GA_(3)比值大小排序为:金镶玉竹、黄槽竹、黄秆京竹。方差分析及相关性分析表明叶绿素a、叶绿素b、叶绿素总量、可溶性糖、可溶性蛋白、MDA、POD、CAT、SOD在竹种间差异显著(P<0.05),各指标间均存在不同程度的相关性。【结论】竹种是影响黄槽竹及其变种抗寒性的主要因子,竹种与竹龄的交互作用次之。基于熵权TOPSIS综合评价法,MDA含量在抗寒指标中所占的权重最大(35.44%),其次为POD、SOD活性。针对11个指标进行TOPSIS评价得出金镶玉竹抗寒能力最强。ABA/GA_(3)的比值越大竹种抗寒性越强,表明激素在植物体内的作用相互关联并不孤立。

关键词：黄槽竹极端低温生理生化指标熵权TOPSIS法