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Asymmetric side-chain engineering of organic semiconductor for ultrasensitive gas sensing

Chinese Chemical Letters 2024年第3期35卷 428-433页

作者： Xiaoying Ma Xiaojuan Dai Lanyi Xiang Jiajun Chang Danfeng Zhi Haozhen Zhao Zhenjie Ni Ye Zou Xike Gao fengjiao zhang School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China Laboratory of Organic Solids Institute of ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China Binzhou Institute of Technology Binzhou 256606China

Molecular structure of organic semiconductor plays a critical role in determining the performance and functionality of organic electronic devices,by optimizing the electrical,optical and physicochemical properties.Substituted alkyl chains are fundamental units in tailering the solubility and assemblability,among which the asymmetric properties have been reported as key element for controlling the packing motifs and intrinsic charge transport.Here,we expanded the scope of molecular asymmetry dependent sensing features based on a new series of naphthalene diimides(NDI)-based derivatives substituted with a same branching alkyl chain but various linear-shaped alkyl chains(Cn-).A clear molecular stacking change,from head-to-head bilayer to head-to-tail monolayer packing model,is observed based on the features of anisotropic molecular interactions with the change in the chain length.Most importantly,a unique LUMO level shift of 0.17 eV is validated for NDI-PhC4,providing a record sensitivity up to 150%to 0.01 ppb ammonia,due to the desired molecular reactivity and device amplification properties.These results indicate that asymmetric side-chain engineering opens a route for breath healthcare.

关键词： Organic thin film transistor Asymmetric side chain Gas sensing Molecular stacking Energy level manipulating

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Emerging role of graphene oxide as sorbent for pesticides adsorption:Experimental observations analyzed by molecular modeling

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Journal of Materials Science & Technology 2021年第4期63卷 192-202页

作者： Hanxun Wang Baichun Hu Zisen Gao fengjiao zhang Jian Wang Key Laboratory of Structure-Based Drug Design&Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang110016China

The accumulation of pesticide residues in the environment due to their persistence and stability is causing increasing health concern.Indeed,researchers have rekindled their interest in eliminating pesticides from the environment by a range of biological and chemical approaches.In particular,graphene oxide(GO)has drawn great attention because it impressively enhances adsorption of pesticides in aqueous solutions,which provides promising environmental applications on water purification to remove pesticide residuals.However,although multiple studies have highlighted the adsorption of environmental contaminants by GO,the underlining molecular mechanisms remain limited.Consequently,we further delved into the knowledge regarding their adsorption molecular mechanism that is of both practical and theoretical importance.It was revealed that theπ-πstacking and van der Waals interactions accounted for the major adsorption interactions between GO and its removing pesticides through integrating both density functional theory(DFT)calculation,fully atomistic molecular dynamics(MD)simulation,and binding free energy calculation.These findings not only bridged the theoretical gap of the adsorption mechanisms of GO,but also provided a venue for visualizing the adsorption process,which were essential for guiding its future adsorption applications.

关键词： calculation. adsorption pesticides

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Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells

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Acta Pharmaceutica Sinica B 2022年第6期12卷 2905-2922页

作者： Peilu Song Fan Zhao Dahong Li Jiqiang Qu Miao Yao Yuan Su Hanxun Wang Miaomiao Zhou Yujie Wang Yinli Gao Feng Li Dongmei Zhao fengjiao zhang Yu Rao Mingyu Xia Haitao Li Jian Wang Maosheng Cheng Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China MOE Key Laboratory of Protein Sciences School of Pharmaceutical SciencesMOE Key Laboratory of Bioorganic Phosphorus Chemistry Chemical BiologyTsinghua UniversityBeijing 100084China MOE Key Laboratory of Protein Sciences Beijing Advanced Innovation Center for Structural BiologyTsinghua-Peking Joint Center for Life SciencesSchool of Life Sciences and School of MedicineTsinghua UniversityBeijing 100084China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShengyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Department of Cell Biology Key Laboratory of Cell BiologyMinistry of Public Healthand Key Laboratory of Medical Cell BiologyMinistry of EducationChina Medical UniversityShenyang 110001China

The p21 activated kinase 4(PAK4) is serine/threonine protein kinase that is critical for cancer progression.Guided by X-ray crystallography and structure-based optimization,we report a novel subseries of C-3-substituted 6-ethynyl-1 H-indole derivatives that display high potential and specificity towards group Ⅱ PAKs.Among these inhibitors,compound 55 exhibited excellent inhibitory activity and kinase selectivity,displayed superior anti-migratory and anti-invasive properties against the lung cancer cell line A549 and the melanoma cell line B16.Compound 55 exhibited potent in vivo antitumor metastatic efficacy,with over 80% and 90% inhibition of lung metastasis in A549 or B16-BL6 lung metastasis models,respectively.Further mechanistic studies demonstrated that compound 55 mitigated TGF-β1-induced epithelial-mesenchymal transition(EMT).

关键词： Anti-cancer PAK4 inhibitor Kinase selectivity Cocrystallization Lung metastasis EMT

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Electronic structure engineering in organic thermoelectric materials

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Journal of Energy Chemistry 2021年第11期30卷 204-219,I0005页

作者： Xiaojuan Dai Qing Meng fengjiao zhang Ye Zou Chong-an Di Daoben Zhu Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China

Electronic structures, which play a key role in determining electrical and optical properties of π-conjugated organic materials, have attracted tremendous interest. Efficient thermoelectric (TE) conversion of organic materials has rigorous requirements on electronic structures. Recently, the rational design and precise modulation of electronic structures have exhibited great potential in exploring state-of-the-art organic TE materials. This review focuses on the regulation of electronic structures of organic materials toward efficient TE conversion. First, we present the basic knowledge regarding electronic structures and the requirements for efficient TE conversion of organic materials, followed by a brief introduction of commonly used methods for electronic structure characterization. Next, we highlight the key strategies of electronic structure engineering for high-performance organic TE materials. Finally, an overview of the electronic structure engineering of organic TE materials, along with current challenges and future research directions, are provided.

关键词： Organic thermoelectric materials Electronic structure Organic semiconductors

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Advances in organic thermoelectric materials and devices for smart applications

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SmartMat 2021年第4期2卷 426-445页

作者： Yue Zhao Liyao Liu fengjiao zhang Chong‐an Di Daoben Zhu School of Chemical Science University of Chinese Academy of SciencesBeijingChina Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijingChina

Organic thermoelectric(OTE)materials have been considered to be promising candidates for large area and low‐cost wearable devices owing to their tailorable molecular structure,intrinsic flexibility,and prominent solution processability.More importantly,OTE materials offer direct energy conversion from the human body,solid‐state cooling at low electric consumption,and diversified functions.Herein,we summarize recent developments of OTE materials and devices for smart applications.We first review the fundamentals of OTE materials from the viewpoint of thermoelectric performance,mechanical properties and bionic functions.Second,we describe OTE devices in flexible generators,photothermoelectric detectors,self‐powered sensors,and ultra‐thin cooling elements.Finally,we present the challenges and perspectives on OTE materials as well as devices in wearable electronics and fascinating applications in the Internet of Things.

关键词： flexible generators organic thermoelectric materials self‐powered sensors smart electronics thin‐film cooling

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米糠蛋白的提取、特性、功能复合物及应用研究进展

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食品工业科技 2024年第12期45卷 367-378页

作者：唐彩云张风姣刘金光曲亚男刘玉茜山东农业大学食品科学与工程学院山东泰安271018

米糠作为稻谷加工的主要副产物,富含油脂、蛋白质及生物活性物质等诸多营养成分。米糠中蛋白质含量约占米糠的15%~17%,分为清蛋白、球蛋白、醇溶性蛋白和谷蛋白,其氨基酸组成接近FAO/WHO推荐的模式,致敏性低,生物效价高,是一种优质的植... 详细信息

米糠作为稻谷加工的主要副产物,富含油脂、蛋白质及生物活性物质等诸多营养成分。米糠中蛋白质含量约占米糠的15%~17%,分为清蛋白、球蛋白、醇溶性蛋白和谷蛋白,其氨基酸组成接近FAO/WHO推荐的模式,致敏性低,生物效价高,是一种优质的植物蛋白资源。米糠蛋白的获取能够提高稻谷的附加值,在食品、医药领域有着广阔的应用前景。因此,本文综述了米糠蛋白的提取方法、功能特性及功能复合物,介绍了米糠蛋白及其复合物在生物活性肽、婴幼儿食品、食品添加剂、营养递送体系等领域的应用现状,最后提出了未来米糠蛋白的研究挑战,为米糠蛋白的工业化生产及高值利用提供一定的思路和参考。

关键词：米糠蛋白提取方法功能特性功能复合物

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具有触觉感知功能的有机晶体管研究进展

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中国科学：化学 2024年第4期54卷 575-593页

作者：张学锋姜紫灵项兰义颜超义肖余张凤娇中国科学院大学化学科学学院北京100049

触觉感知电子学将以电荷传输为主的有机光电器件与以离子信号为主的生物体桥接起来,被认为是新一代人工智能系统构建的重要研究领域.有机晶体管通过电场诱导或电化学离子掺杂调控半导体的导电能力,显示出独特的光电特性.基于其本征柔性... 详细信息

触觉感知电子学将以电荷传输为主的有机光电器件与以离子信号为主的生物体桥接起来,被认为是新一代人工智能系统构建的重要研究领域.有机晶体管通过电场诱导或电化学离子掺杂调控半导体的导电能力,显示出独特的光电特性.基于其本征柔性、可溶液加工性和生物相容性等特点,有机晶体管被认为是发展柔性智能感知器件的良好载体.过去10年,随着功能材料设计合成和器件结构开发,基于有机晶体管的生物物理信号传感和突触感知研究受到广泛关注并取得快速发展.本文从具有物理信号转化、信号传递与处理功能的有机晶体管器件结构设计、工作原理和制备技术等方面,概述了触觉感知功能的有机晶体管研究进展,重点介绍了温度/压力感知功能有机晶体管的发展与应用现状,最后总结了新一代触觉感知有机晶体管的研究策略并展望了面临的挑战与机遇.

关键词：触觉感知有机场效应晶体管共轭半导体功能仿生

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Exploring the Mechanism of CircRNA-vgll3 in Osteogenically Differentiated Human Bone Marrow Mesenchymal Stem Cells

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Journal of Clinical and Nursing Research 2023年第4期7卷 151-158页

作者： Yajie Huo Yu Mao Fang Luo fengjiao zhang Lifang Xie Xiaoke zhang Kai Liu Ling Sun Hongmei Liu Lige Song Huanhuan Wang Zhiqiang Kang Department of Endocrinology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou 450007Henan ProvinceChina

Objective:To explore the mechanism of circRNA-vgll3 in osteogenic differentiation of human bone marrow mesenchymal stem cells.Methods:BMSCs cells were transfected with circRNA-vgll3,and divided into circRNA-vgll3 high-level group,circRNA-vgll3 low-level group,and negative control group(circRNA-vgll3 not transfected)according to the amount of transfection.The proliferation and apoptosis of BMSCs osteoblasts in each group were analyzed,and the alkaline phosphatase(ALP)activity,type I collagen gray value,bone morphogenetic protein 2(BMP-2),Runx2 protein,and mRNA expression levels were detected.Results:The circRNA-vgll3 low-level group had a significant inhibitory effect on the proliferation of BMSCs osteoblasts,and the apoptosis rate of the circRNA-vgll3 low-level group was significantly higher than that of the circRNA-vgll3 high-level group(P<0.05);ALP activity,type I collagen gray value,BMP-2,Runx2 protein,and mRNA expression levels in the high-level circRNA-vgll3 group were significantly higher than those in the low-level circRNA-vgll3 group,and the difference was statistically significant(P<0.05).Conclusion:Overexpression of circRNA-vgll3 can promote the osteogenic differentiation ability of BMSCs,while low expression of circRNA-vgll3 can inhibit the osteogenic differentiation ability of BMSCs.The main mechanism of action is that circRNA-vgll3 can affect osteogenic differentiation by regulating the Runx2 protein.

关键词： CircRNA-vgll3 Osteogenic differentiation Human bone marrow mesenchymal stem cells Mechanism of action

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High-efficiency Agrobacterium-mediated transformation of chrysanthemum via vacuum infiltration of internode

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Ornamental Plant Research 2022年第1期2卷 1-7页

作者： Sujuan Xu Ze Wu Jingya Zhao fengjiao zhang Xinqi zhang Fadi Chen Nianjun Teng Key Laboratory of Landscaping Agriculture Ministry of Agriculture and Rural Affairs/Key Laboratory of Biology of Ornamental Plants in East ChinaNational Forestry and Grassland AdministrationCollege of HorticultureNanjing Agricultural UniversityNanjing 210095China Nanjing Agricultural University-Nanjing Oriole Island Modern Agricultural Development Co. Ltd.Jiangsu Graduate WorkstationNanjing 210043China

Leaf disc transformation is one of the traditional methods that are now widely used in chrysanthemum with highly economical and ornamental value in world flower production,but it depends on plant genotypes and is time consuming and complicated.In addition,the transformation success rate of this method is low,generally ranging from 0.1%to 6.25%.Therefore,a highly efficient transformation system is needed.In this study,we are the first to establish a high-efficient chrysanthemum Agrobacterium-mediated transformation system via vacuum infiltration.Chrysanthemum stem internode explants were used as research material and CmLEC1 was used as a reporter gene.After approximately 3 months of culture and selection,the positive transgenic plants were obtained.Additionally,the positive probability was about 42%.The transformation efficiency was up to 37.7%,and if the escapes were removed,it was 16%.Furthermore,stable expression of CmLEC1 in transgenic'Yuhualuoying'was confirmed by qRT-PCR analysis.These results suggest that this genetic transformation system via vacuum infiltration of chrysanthemum stem internode is highly efficient and convenient,and much better than traditional leaf disc transformation,and it will play an important role in chrysanthemum transformation and functional genetics research.

关键词： transformation vacuum removed

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视觉感知功能化有机光电器件研究进展

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中国科学：化学 2024年第4期54卷 537-551页

作者：葛宇涛王薇贺紫晗刘力瑶张凤娇狄重安北京分子科学国家实验室中国科学院有机固体重点实验室中国科学院化学研究所北京100190 中国科学院大学化学科学学院北京100049 美国斯坦福大学化学工程系斯坦福94305

视觉感知是人与自然界最为重要的交互方式之一,提供了人体80%以上的外部环境信息.基于此,视觉仿生成为智能感知材料与器件研究中的前沿方向.过去30年,基于有机半导体的光电传感与感知器件历经多代发展,创新了光刺激(强度、色度等)的高... 详细信息

视觉感知是人与自然界最为重要的交互方式之一,提供了人体80%以上的外部环境信息.基于此,视觉仿生成为智能感知材料与器件研究中的前沿方向.过去30年,基于有机半导体的光电传感与感知器件历经多代发展,创新了光刺激(强度、色度等)的高灵敏度和选择性传感检测,并拓展了复杂的类生物视觉信号识别、学习与处理功能,已经成为新兴的跨学科领域.本文从单元光敏感的有机光电器件和多功能集成,介绍面向视觉感知功能化的有机光探测器、有机光电突触和有机适应型器件的构建策略和研究进展,并从柔性矩阵化和功能集成的视觉信号成像、学习与编码概述了新一代有机智能感知电子器件的仿生应用探索.

关键词：视觉感知视觉仿生有机光电器件有机半导体

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