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Molecular Dynamics Study of Interaction between Acrylamide Copolymers and Alumina Crystal

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Chinese Journal of Chemical Physics 2012年第5期25卷 571-576,I0003,I0004页

作者： feng-he wang feng-yun wang Xue-dong Gong Department of Environmental Science and Engineering Nanjing Normal UniversityNanjing 210042China Department of Chemistry Nanjing University of Science and TechnologyNanjing 210094China

Four acrylamide polymer flocculants, anionic polyacrylamide P（AA-co-AM）, cationic poly- acrylamide P（DMB-co-AM）, nonionic polyacrylamide P（AM）, and hydrophobical polyacry- lamide P（OA-co-AM） have been prepared by copolymerizing with acrylic acid, cationic monomer dimethylethyl （acryloxyethyl） ammonium bromide （DMB） and hydrophobical monomer octadecyl acrylate with acrylamide. The interactions between the flocculants with the （012） surface of alumina crystal （A1203） have been simulated by molecular dynamics method. All the polymers can bind tightly with A1203 crystal, the interaction between the O of polymers and A1 of the （012） surface of A1203 is significantly strong. The order of binding energy is as follows： P（DMB-co-AM）〉P（OA-co-AM）〉P（AA-co-AM）〉P（AM）, implying a better flocculation performance of P（DMB-co-AM） than the others. Analy- sis indicates that binding energy is mainly determined by Coulomb interaction. Bonds are found between the O atoms of the polymers and the A1 atoms of A1203. The poly- mers＇ structures deform when they combine with A1203 crystal, but the deformation en- ergies are low and far less than non-bonding energies. Flocculation experiments in sus- pension medium of l%Kaolin show a transmittancy of 90.8% for 6 mg/L P（DMB-co-AM） and 73.0% for P（AM）. The sequence of flocculation performance of four polymers is P（DMB-co-AM）〉P（OA-co-AM）〉P（AA-co-AM）〉P（AM）, which is in excellent agreement with the simulation results of binding energy.

关键词： Molecular dynamics simulation Acrylamide copolymer Binding energy Floc-culation

Molecular mechanisms and the role of the protein kinase pathway in rat spatial memory impairment following isoflurane anesthesia

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Neural Regeneration Research 2010年第7期5卷 508-513页

作者： Qing Zhang Guanyu Lu Zhipeng Xu Chunsheng feng Anshi Wu yun wang Hui wang yun Yue Department of Anesthesia Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China

BACKGROUND： Animal experiments have demonstrated that isoflurane exposure alone induces learning and memory deficits for weeks or months. However, the molecular mechanisms of learning and memory remain poorly understood. Hippocampal expression of calcium/phospholipid- dependent protein kinase （PKC） and cAMP-dependent protein kinase （PKA） in rats have been shown to be associated with memory processing. OBJECTIVE： To investigate changes in rat spatial memory and hippocampal CA1 neuronal kinase system following isoflurane anesthesia, and to explore the correlation between molecular changes in cerebral neurons and behavioral manifestations following anesthesia. DESIGN, TIME AND SE＇rFING： A randomized, controlled, animal study. All experiments were performed at the Department of Anesthesia, Beijing Chaoyang Hospital, Capital Medical University from November 2007 to December 2008. MATERIALS： A total of 72 male, 3 month-old （young group）, Sprague Dawley rats, and 36 male, 20 month-old （aged group）, Sprague-Dawley rats were used in the study. Isoflurane was purchased from Baxter, USA. METHODS： Young and aged rats were randomly assigned to control, training （no anesthesia, Morris water maze training）, and isoflurane （1.2% isoflurane, Morris water maze training） groups. The isoflurane group was further subdivided into four groups, which were exposed to anesthesia for 2 or 4 hours, and were subjected to Morris water maze training at 2 days or 2 weeks postanesthesia. Finally, each aged group comprised 6 rats, and the young group comprised 12 rats. MAIN OUTCOME MEASURES： Spatial learning and memory were observed during Morris water maze training. Hippocampal CA1 PKA and PKC expression and activity were detected by immunohistochemistry and enzyme-linked immunosorbent assay （ELISA）. RESULTS： A 4-hour isoflurane exposure induced spatial memory deficits in all rats for 2 days to 2 weeks. In particular, aged rats exhibited more severe spatial memory deficits. Immunohistochemistry and

关键词： isoflurane Morris water maze hippocampus cAMP-dependent protein kinase calcium/phospholipid-dependent protein kinase

Heuristic Genetic Algorithm for Discretization of Continuous Attributes in Rough Set Theory

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Journal of China University of Mining and Technology 2006年第2期16卷 147-150,155页

作者： CAO yun-feng wang Yao-cai wang Jun-wei School of Information and Electric Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Discretization based on rough set theory aims to seek the possible minimum number of the cut set without weakening the indiscemibility of the original decision system. Optimization of discretization is an NP-complete problem and the genetic algorithm is an appropriate method to solve it. In order to achieve optimal discretization, first the choice of the initial set of cut set is discussed, because a good initial cut set can enhance the efficiency and quality of the follow-up algorithm. Second, an effective heuristic genetic algorithm for discretization of continuous attributes of the decision table is proposed, which takes the significance of cut dots as heuristic information and introduces a novel operator to maintain the indiscernibility of the original decision system and enhance the local research ability of the algorithm. So the algorithm converges quickly and has global optimizing ability. Finally, the effectiveness of the algorithm is validated through experiment.

关键词： rough set discretization genetic algorithm

Hollow carbon spheres and their noble metal-free hybrids in catalysis

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Frontiers of Chemical Science and Engineering 2021年第6期15卷 1380-1407页

作者： Xiang-Hui Yu Jin-Long Yi Ru-Liang Zhang feng-yun wang Lei Liu School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao266590China College of Physics and State Key Laboratory of Bio Fibers and Eco Textiles Qingdao UniversityQingdao 266071China

Hollow carbon spheres have garnered great interest owing to their high surface area,large surface-tovolume ratio and reduced transmission ***,we overview hollow carbon sphere-based materials and their noble metal-free hybrids in ***,we summarize the key fabrication techniques for various kinds of hollow carbon spheres,with a particular emphasis on controlling pore structure and surface morphology,and then heterogeneous doping as well as their metal-free/containing hybrids are presented;next,possible applications for non-noble metal/hollow carbon sphere hybrids in the area of energy-related catalysis,including oxygen reduction reaction,hydrogen evolution reaction,oxygen evolution reaction,water splitting,rechargeable Zn-air batteries and pollutant degradation are discussed;finally,we introduce the various challenges and opportunities offered by hollow carbon spheres from the perspective of synthesis and catalysis.

关键词： hollow carbon spheres functionalization noble metal-free catalysis

Evaluating the causal relationship between human blood metabolites and gastroesophageal reflux disease

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World Journal of Gastrointestinal Oncology 2023年第12期15卷 2169-2184页

作者： Jia-Yan Hu Mi Lv Kun-Li Zhang Xi-yun Qiao Yu-Xi wang feng-yun wang Institute of Digestive Diseases Xiyuan HospitalChina Academy of Chinese Medical SciencesXiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China

BACKGROUND Gastroesophageal reflux disease(GERD)affects approximately 13% of the global ***,the pathogenesis of GERD has not been fully *** development of metabolomics as a branch of systems biology in recent years has opened up new avenues for the investigation of disease *** a powerful statistical tool,Mendelian randomization(MR)is widely used to explore the causal relationship between exposure and *** To analyze of the relationship between 486 blood metabolites and *** Two-sample MR analysis was used to assess the causal relationship between blood metabolites and GERD.A genome-wide association study(GWAS)of 486 metabolites was the exposure,and two different GWAS datasets of GERD were used as endpoints for the base analysis and replication and *** correction is used to determine causal correlation features(P<1.03×10^(-4)).The results were subjected to sensitivity analysis to assess heterogeneity and *** the MR Steiger filtration method to detect whether there is a reverse causal relationship between metabolites and *** addition,metabolic pathway analysis was conducted using the online database based MetaboAnalyst 5.0 *** In MR analysis,four blood metabolites are negatively correlated with GERD:Levulinate(4-oxovalerate),stearate(18:0),adrenate(22:4n6)and ***,we also found a positive correlation between four blood metabolites and GERD:Kynurenine,1-linoleoylglycerophosphoethanolamine,butyrylcarnitine and *** bonferroni correction showed that butyrylcarnitine(odd ratio 1.10,95% confidence interval:1.05-1.16,P=7.71×10^(-5))was the most reliable causal *** addition,one significant pathways,the"glycerophospholipid metabolism"pathway,can be involved in the pathogenesis of *** Our study found through the integration of genomics and metabolomics that butyrylcarnitine may be a potential biomarker for GERD,whic

关键词： Blood metabolites Gastroesophageal reflux disease Mendelian randomization Causality Pathogenesis Biomarkers Metabolic pathway

CCT Curves of Low-Carbon Mn-Si Steels and Development of Water-Cooled Bainitic Steels

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Journal of Iron and Steel Research International 2010年第3期17卷 46-50页

作者： XU feng-yun wang Yong-wei BAI Bing-zhe FANG Hong-sheng Key Laboratory for Advanced Materials of Ministry of Education Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

CCT curves of Mn-Si steels with different manganese contents or carbon contents were determined. The results show that the transformation range of bainite can be separated from that of ferrite when the manganese content approaches a certain content, and the incubation period of ferrite increases more significantly than that of bainite transformation with the increase of carbon content in Mn-Si steels. Furthermore, water-cooled bainitic steels without adding expensive alloying element were developed. Granular bainite was obtained when a bar with diameter of 300 mm was cooled by water, and a mixed microstructure of granular bainite and martensite was obtained in watercooled plate with thickness of 40 mm. The developed water-cooled bainitic Steels containing no expensive alloying element showed a good combination of strength and toughness. The tensile strength, yield strength, and toughness （AKU at --20℃ ） of bar with diameter of 300 mm after water cooling were higher than 850 MPa, 620 MPa, and 65 J, respectively, and those of plate with thickness of 40mm after water cooling were higher than 1000 MPa, 800 MPa, and 50J, respectively.

关键词： bainitic steel water cooling granular bainite CCT curve Mn-Si steel

Size-controllable synthesis of monodispersed nitrogen-doped carbon nanospheres from polydopamine for high-rate supercapacitors

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Frontiers of Chemical Science and Engineering 2023年第11期17卷 1788-1800页

作者： Ning Zhang Fu-Cheng Gao Hong Liu feng-yun wang Ru-Liang Zhang Qing Yu Lei Liu School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China College of Physics and State Key Laboratory of Bio Fibers and Eco Textiles Qingdao UniversityQingdao 266071China

Monodispersed nitrogen-doped carbon nanospheres with tunable particle size(100-230 nm)were synthesized via self-polymerization of biochemical dopamine in the presence of hexamethylenetetramine as a buffer and F127 as a size controlling *** can mildly release NH3,which in turn initiates the polymerization reaction of *** carbon nanospheres obtained exhibited a significant energy storage capability of 265 F·g^(-1)at 0.5 A·g^(-1)and high-rate performance of 82%in 6 mol·L^(-1)KOH(20 A·g^(-1)),which could be attributed to the presence of abundant micromesoporous structure,doped nitrogen functional groups and the small particle ***,the fabricated symmetric supercapacitor device displayed a high stability of 94%after 5000 cycles,revealing the considerable potential of carbon nanospheres as electrode materials for energy storage.

关键词： carbon nanospheres size-controlled nitrogen-doped high-rate supercapacitors

In Vivo Confocal Microscopic Observation of Lamellar Corneal Transplantation in the Rabbit Using Xenogenic Acellular Corneal Scaffolds as a Substitute

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Chinese Medical Journal 2015年第7期128卷 933-940页

作者： yun feng Wei wang Department of Ophthalmology Peking University Third Hospital Peking University Eye Center Beijing 100191 China

Background： The limiting factor to corneal transplantation is the availability of donors. Research has suggested that xenogenic acellular corneal scaffolds （XACS） may be a possible alternative to transplantation. This study aimed to investigate the viability of performing lamellar corneal transplantation （LCT） in rabbits using canine XACS. Methods： Fresh dog corneas were decellularized by serial digestion, and LCT was performed on rabbit eyes using xenogeneic decellularized corneal matrix. Cellular and morphological changes were observed by slit-lamp, light, and scanning electron microscopy at 7, 30 and 90 days postoperatively, lmmunocytochemical staining for specific markers such as keratin 3, vimentin and MUC5AC, was used to identify cells in the graft. Results： Decellularized xenogenic corneal matrix remained transparent for about l-month after LCT. The recipient cells were able to survive and proliferate into the grafts. Three months after transplantation, grafts had merged with host tissue, and graft epithelialization and vascularization had occurred. Corneal nerve fibers were able to grow into the graft in rabbits transplanted with XACS. Conclusions： Xenogenic acellular corneal scaffolds can maintain the transparency of corneal grafts about 1-month and permit growth of cells and nerve fibers, and is, therefore, a potential substitute or carrier for a replacement cornea.

关键词： Corneal Substitute Decellularization Lamellar Corneal Transplantation Xenogenic Acellular Corneal Scaffolds

Tailoring chaotic motion of microcavity photons in ray and wave dynamics by tuning the curvature of space

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 107-112页

作者： Wei Lin Yechun Ding Yongsheng wang Peng Li Yanpeng Zhang feng yun feng Li Key Laboratory for Physical Electronics and Devices of the Ministry of Education Shaanxi Key Lab of Information Photonic TechniqueSchool of Electronic Science and EngineeringFaculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China Department of Electrical and Photonics Engineering Technical University of DenmarkKgs.Lyngby 2800Denmark Center for Regenerative and Reconstructive Medicine Med-X InstituteThe First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Solid-State Lighting Engineering Research Center Xi’an Jiaotong UniversityXi’an 710049China

Microcavity photon dynamics in curved space is an emerging interesting area at the crossing point of nanophotonics,chaotic science,and non-Euclidean *** report the sharp difference between the regular and chaotic motions of cavity photons subjected to the varying space *** the island modes of regular motion rise in the phase diagram in the curved space,the chaotic modes show special mechanisms to adapt to the space curvature,including the fast diffusion of ray dynamics,and the localization and hybridization of the Husimi wavepackets among different periodic *** observations are unique effects enabled by the combination of the chaotic trajectory,the wave nature of light,and the non-Euclidean orbital motion,and therefore make the system a versatile optical simulator for chaotic science under quantum mechanics in curved space-time.

关键词： microcavity chaotic motion curved space