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Journal of Geriatric Cardiology 2016年第9期13卷 733-739页

作者： Evan Kurniawan feng-hua ding Qi ZHANG Zhen-Kun YANG Jian HU Wei-feng SHEN Rui-Yan ZHANG Department of Cardiology Rui Jin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China

Objective To evaluate the predictive value of SYNTAX Score II （SS-II） for percutaneous coronary intervention （PCI） in octogenarian （≥ 80 years old） undergoing PCI. Methods ＆ Results Data from three consecutive years of octogenarian undergoing PCI from Ruijin Hospital （Shanghai, China） was retrospectively collected （n = 308）. Follow up clinical data at one year including all cause mortality, cardiac mortality and main adverse cardiovascular and cerebrovascular events （MACCE） were collected. Patients were stratified according to tertiles of SS-II for PCI： SS-II 〈 26 （n = 104）, SS-II： 27-31 （n = 102）, SS-II 〉 31 （n = 102）. After adjustment for confounding factors, SS-II for PCI was an independent risk factors for all cause mortality （odds ratio： 2.77, 95% CI： 1.13-8.06; P = 0.04）. Kaplan-Meier curves showed higher event rates for all cause mortality and cardiac mortality in higher tertile of SS-II for PCI （Log-Rank test P = 0.002 and P = 0.001, respectively）. SSdl for PCI predicted one year mortality in octogenarian population undergoing PCI. Conclusions In octogenarian, SS-II which incorporated clinical variables with angiographic anatomy variable was suitable in risk stratifying and predicting clinical outcomes at one year.

关键词： Clinical research Elderly Risk stratification

Screening for significant atherosclerotic renal artery stenosis with a regression model in patients undergoing transradial coronary angiography/intervention

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第8期13卷 631-637页

作者： Li-jin PU Ying SHEN Rui-yan ZHANG Qi ZHANG Lin LU feng-hua ding Jian HU Zheng-kun YANG Wei-feng SHEN Department of Cardiology Ruijin Hospital Shanghai Jiao Tong Uniwzrsity School of MedicineShanghai 200025China Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of MedicineShanghai 200025China

Objective:Early detection of atherosclerotic renal artery stenosis (ARAS) is clinically important with respect to blood pressure control, prevention of renal insufficiency, and even improving survival. We investigated whether the presence of significant ARAS (luminal diameter narrowing ≥70%) could be predicted using a logistic regression model before coronary angiography/intervention. Methods:Initially, we developed a logistic regression model for detecting significant ARAS based upon clinical and angiographic features and biochemical measurements in a cohort of 1 813 patients undergoing transfemoral coronary and renal angiography. This model was then prospectively applied to an additional 495 patients who received transradial renal angiography to ascertain its predictive accuracy for the presence of significant ARAS. Results:Multivariate regression analysis revealed that older age (≥65 years), resistant hypertension, type 2 diabetes, creatinine clearance (Ccr) ≤60 ml/min, and multivessel coronary disease were independent predictors for significant ARAS. A logistic regression model for detecting ARAS by incorporating conventional risk factors and multivessel coronary disease was generated as:P/(1 P)=exp( 2.618+1.112[age≥65 years]+1.891[resistant hypertension]+0.453[type 2 diabetes]+0.587[Ccr≤60 ml/min]+2.254[multivessel coronary disease]). When this regression model was prospectively applied to the additional 495 patients undergoing transradial coronary and renal angiography, significant ARAS could be detected with a sensitivity of 81.2%, specificity of 88.9%, and positive and negative predictive accuracies of 53.8% and 96.7%, respectively. Conclusions:The logistic regression model generated in this study may be useful for screening for significant ARAS in patients undergoing transradial coronary angiography/intervention.

关键词： Renal artery stenosis Transradial coronary angiography Resistant hypertension

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任意多边形的非结构网格快速生成算法研究

国防科技大学学报 2010年第6期32卷 111-115页

作者：刘枫冯定华丁国昊潘沙李桦国防科技大学航天与材料工程学院湖南长沙410073

对于包含大尺度运动边界的CFD数值模拟,网格重构是其中的关键,快速稳定的网格生成技术是其中的重要组成部分。建立了基于有向边的适用于任意多边形的快速三角初始化算法;证明了最长边剖分网格细化算法在一定条件下发散,并结合Delaunay... 详细信息

对于包含大尺度运动边界的CFD数值模拟,网格重构是其中的关键,快速稳定的网格生成技术是其中的重要组成部分。建立了基于有向边的适用于任意多边形的快速三角初始化算法;证明了最长边剖分网格细化算法在一定条件下发散,并结合Delaunay边交换技术使细化算法封闭;建立了基于顶点弹簧理论的网格优化方法,以提高网格生成的质量。结果表明,算法具有较好的鲁棒性和高效性。

关键词：任意多边形非结构网格有向边网格细化

Analysis of risk factors for early stent thrombosis in the Chinese population:A multicenter restrospective study

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World Journal of Emergency Medicine 2021年第3期12卷 192-197页

作者： Yu-peng Wang Lei ding Rui-tao Zhang Xiao-zeng Wang Dan-qing Yu Shou-yan Hao Jin-wei Tian Zhen-yu Liu Xiang-qian Qi Hu Tan Hong-yi Wu feng-hua ding Li-jun Guo Ya-ling Han Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptor ResearchBeijing 100191China Department of Cardiology General Hospital of Northern Theatre CommandShenyang 110016China Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Cardiology the First Hospital of Jilin UniversityChangchun 130021China Department of Cardiology the Second Affi liated Hospital of Harbin Medical UniversityKey Laboratory of Myocardial IschemiaMinistry of EducationHarbin 150001China Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China TEDA International Cardiovascular Hospital Tianjin 300457China Institute of Cardiovascular Diseases of PLA the Second Affi liated HospitalArmy Medical UniversityChongqing 400037China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Cardiology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China

BACKGROUND:The predictive scoring systems for early stent thrombosis(EST)remains blank in *** study aims to evaluate the risk factors and conduct a prediction model of EST in the Chinese ***:EST was defined as thrombosis that occurs within the first 30 days after primary percutaneous coronary intervention(PCI).Patients from ten Chinese hospitals diagnosed as stent thrombosis(ST)from January 2010 to December 2016 were retrospectively included as the study group.A control group(1 case:2 controls)was created by including patients without ST,major adverse cardiovascular events,or cerebrovascular events during *** present study evaluated 426 patients with single-vessel lesions and ultimately included 40 patients with EST and 80 control patients,who were included to identify factors that predicted EST and to develop a prediction scoring *** other 171 patients without integrated 1:2 pair were used for external ***:EST was independently associated with a low hemoglobin concentration(adjusted odds ratio[OR]0.946,95%confi dence interval[95%CI]0.901-0.993,P=0.026),a high pre-PCI Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery(SYNTAX)score(OR 1.166,95%CI 1.049-1.297,P=0.004),and a DAPT(DAPT)duration of<30 days(OR 28.033,95%CI 5.302-272.834,P<0.001).The simple EST prediction score provided an area under the curve(AUC)of 0.854(95%CI 0.777-0.932,P<0.001)with 70.0%sensitivity and 90.0%specifi city,and 0.742(95%CI 0.649-0.835,P<0.001)with 54.5%sensitivity and 81.0%specifi city for external validation ***:EST may be independently associated with DAPT discontinuation within 30 days,a low hemoglobin concentration,and a high SYNTAX *** scoring system also has a good ability to predict the risk of EST and may be useful in the clinical setting.

关键词： Coronary heart disease Stent thrombosis Risk stratifi cation Predictive scoring system

Study on accumulation of 137Cs in aquatic organisms

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Nuclear Science and Techniques 1998年第3期 56-57页

作者： feng ding hua, Cheng Qi Jun ( Suzhou Medical College, Suzhou 215007, China) Cheung T ( City University of Hong Kong)

１Ｉｎｔｒｏｄｕｃｔｉｏｎ１３７Ｃｓｉｓｏｎｅｏｆｔｈｅｐｒｉｍａｒｙｆｉｓｉｏｎｐｒｏｄｕｃｔｓｄｉｓｃｈａｒｇｅｄｉｎｔｏｅｎｖｉｒｏｎｍｅｎｔａｔｎｕｃｌｅａｒａｃｃｉｄｅｎｔ．Ｂｅｃａｕｓｅｏｆｔｈｅｌｏｎｇ... 详细信息

１Ｉｎｔｒｏｄｕｃｔｉｏｎ１３７Ｃｓｉｓｏｎｅｏｆｔｈｅｐｒｉｍａｒｙｆｉｓｉｏｎｐｒｏｄｕｃｔｓｄｉｓｃｈａｒｇｅｄｉｎｔｏｅｎｖｉｒｏｎｍｅｎｔａｔｎｕｃｌｅａｒａｃｃｉｄｅｎｔ．Ｂｅｃａｕｓｅｏｆｔｈｅｌｏｎｇｈａｌｆｌｉｆｅｉｔｈａｓａｒｏ...

关键词： Concentration factor Aquatic organisms Tissue distribution of 137 Cs

一组不同内收缩比二维进气道唇口开启过程实验研究

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实验流体力学 2008年第3期22卷 18-22页

作者：冯定华范晓樯丁国昊李桦国防科学技术大学航天与材料工程学院湖南长沙410073

设计了小型直联式实验台,模拟来流马赫数5.3,对一组具有不同内收缩比的二维进气道唇口开启过程及其特性开展了实验研究。进气道唇口的角度位置和隔离段高度均可调节,由此实现进气道不同内收缩比要求。通过分析进气道底板壁面压力分布,... 详细信息

设计了小型直联式实验台,模拟来流马赫数5.3,对一组具有不同内收缩比的二维进气道唇口开启过程及其特性开展了实验研究。进气道唇口的角度位置和隔离段高度均可调节,由此实现进气道不同内收缩比要求。通过分析进气道底板壁面压力分布,总结了进气道开启过程特性及其影响因素。

关键词：进气道起动实验外罩唇口开启过程内收缩比实验研究

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超燃冲压发动机唇口气动热计算研究与分析

航空动力学报 2009年第9期24卷 2096-2100页

作者：潘沙田正雨冯定华丁国昊李桦国防科技大学航天与材料工程学院长沙410073

采用数值模拟方法,对超燃冲压发动机进气道唇口的气动热进行了计算和分析.依据唇口与前体激波所处相对位置的不同,分三种情形进行了计算研究.结果表明,三种情形下,进气道前缘驻点热流均大于头部.通过算例验证,证明该方法和结论的正确性... 详细信息

采用数值模拟方法,对超燃冲压发动机进气道唇口的气动热进行了计算和分析.依据唇口与前体激波所处相对位置的不同,分三种情形进行了计算研究.结果表明,三种情形下,进气道前缘驻点热流均大于头部.通过算例验证,证明该方法和结论的正确性.研究表明,激波干扰以及前体激波压缩后超声速来流使唇口热流增大,热防护和结构设计时应当予以充分考虑.

关键词：超燃冲压发动机高超声速气动热数值模拟热防护

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含激波流场的光线追迹方法

国防科技大学学报 2010年第1期32卷 6-10页

作者：冯定华潘沙田正雨李桦国防科技大学航天与材料工程学院湖南长沙410073

高速流场中的激波会产生明显的气动光学效应,导致光线发生偏移、聚焦等。从理论上考察了在不同入射角条件下,光线经过激波后发生角偏移量与激波强度的关系;针对通过计算流体力学得到的激波流场,提出了追迹步长根据当地折射率梯度和网格... 详细信息

高速流场中的激波会产生明显的气动光学效应,导致光线发生偏移、聚焦等。从理论上考察了在不同入射角条件下,光线经过激波后发生角偏移量与激波强度的关系;针对通过计算流体力学得到的激波流场,提出了追迹步长根据当地折射率梯度和网格几何尺寸自适应调节的光线追迹的思想和方法,以提高追迹的精度;对所建立光线追迹方法的精度进行了考察。结果表明,所建立的光线追迹方法适用于激波流场的光线追迹,具有较高的精度。

关键词：激波光线追迹步长自适应折射率梯度

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脉冲风洞中进气道起动过程试验研究

推进技术 2007年第1期28卷 60-64页

作者：范晓樯贾地冯定华李桦国防科技大学航天与材料工程学院湖南长沙410073

在马赫8炮风洞中开展了不同初始真空压力条件下风洞喷管启动过程对侧压进气道启动的影响研究。通过调节进气道几何收缩比和风洞运行的初始真空压力,完成了收缩比分别为2,4.25,5.56,初始真空压力变化范围为60 Pa^3 kPa的多种工况测压、... 详细信息

在马赫8炮风洞中开展了不同初始真空压力条件下风洞喷管启动过程对侧压进气道启动的影响研究。通过调节进气道几何收缩比和风洞运行的初始真空压力,完成了收缩比分别为2,4.25,5.56,初始真空压力变化范围为60 Pa^3 kPa的多种工况测压、纹影实验。实验数据表明,当收缩比较小时,即使初始真空压力很高,甚至严重影响了风洞的有效运行时间,进气道也能够启动;当进气道收缩比较大时,炮风洞喷管启动过程会影响进气道启动,即进气道是否启动受风洞初始真空压力变化而十分敏感。

关键词：高超声速进气道炮风洞实验

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高超声速侧压式进气道溢流特性研究

航空动力学报 2007年第1期22卷 85-89页

作者：贾地范晓樯冯定华李桦国防科技大学航天与材料工程学院湖南长沙410073

首先介绍了高超声速侧压式进气道的构型,定义了侧压式进气道可能存在的两种溢流模态———构型溢流和压差溢流;然后对构型溢流进行了理论分析和计算,阐明了侧板后掠的侧压进气道设计参数对构型溢流影响;最后对不同侧板配置方式的侧压式... 详细信息

首先介绍了高超声速侧压式进气道的构型,定义了侧压式进气道可能存在的两种溢流模态———构型溢流和压差溢流;然后对构型溢流进行了理论分析和计算,阐明了侧板后掠的侧压进气道设计参数对构型溢流影响;最后对不同侧板配置方式的侧压式进气道进行了数值模拟,通过对比分析发现由唇口板位置所决定的溢流窗大小对进气道溢流特性的影响显著.

关键词：航空、航天推进系统高超声速进气道侧压溢流特性数值模拟