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Pleiotrophin promotes perineural invasion in pancreatic cancer

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World Journal of Gastroenterology 2013年第39期19卷 6555-6558页

作者： Jun Yao xiu-feng Hu Xiao-Shan feng She-Gan Gao Department of Oncology the First Affiliated Hospital of Henan University of Science and Technology

Perineural invasion(PNI)in pancreatic cancer is an important cause of local recurrence,but little is known about its ***(PTN)is an important neurotrophic *** is of interest that our recent experimental data showed its involvement in PNI of pancreatic *** strongly presents in the cytoplasm of pancreatic cancer cells,and high expression of PTN and its receptor may contribute to the high PNI of pancreatic ***,PNI is prone to happen in PTN-positive *** thus hypothesize that,as a neurite growth-promoting factor,PTN may promote PNI in pancreatic *** is released at the time of tumor cell necrosis,and binds with its highaffinity receptor,N-syndecan on pancreatic nerves,to promote neural growth in pancreatic ***,neural destruction leads to a distorted neural *** and Schwann cells produce more N-syndecan in an effort to repair the pancreatic ***,the abundance of N-syndecan attracts further PTN-positive cancer cells to the site of injury,creating a vicious ***,increased PTN and N-syndecan levels,due to the continuous nerve injury,may promote cancer invasion and propagation along the neural ***,it is meaningful to discuss the relationship between PTN/N-syndecan signaling and PNI in pancreatic cancer,which may lead to a better understanding of the mechanism of PNI in pancreatic cancer.

关键词： Pleiotrophin N-syndecan Neurite outgrowth Perineural invasion Pancreatic cancer

Brain magnetic resonance imaging findings and radiologic review of maple syrup urine disease:Report of three cases

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World Journal of Clinical Cases 2021年第8期9卷 1844-1852页

作者： Yang Li Xia Liu Chong-feng Duan xiu-feng Song Xun-Hui Zhuang Department of Radiology Qingdao Women and Children’s HospitalQingdao 266011Shandong ProvinceChina Department of Ultrasound The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Radiology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Maple syrup urine disease(MSUD)is a rare autosomal-recessive disorder that affects branched-chain amino acid(BCAA)metabolism and is named after the distinctive sweet odor of affected infants’*** disease is characterized by the accumulation of BCAAs and corresponding branched-chain ketoacids of leucine,isoleucine,and valine in the plasma,urine,and cerebrospinal ***,the mechanisms of MSUD-induced brain damage remain poorly *** accumulation of BCAAs in the brain inhibits the activity of pyruvate dehydrogenase andα-ketoglutarate,disrupting the citric acid cycle and consequently impacting the synthesis of amino acids,causing cerebral edema and abnormal *** SUMMARY We report three neonates admitted to our hospital with the classic subtype of *** three patients,with a transient normal period,presented with poor feeding,vomiting,poor weight gain,and increasing lethargy after *** testing revealed metabolic *** serum tandem mass spectrometry amino acid profile showed elevated plasma levels of BCAAs(leucine,isoleucine,and valine).Brain magnetic resonance imaging(MRI)presented abnormal signals mainly involving the globus pallidus,thalamus,internal capsule,brainstem,and cerebellar white matter,which represent the typical myelinated areas in normal full-term *** In our patients,MRI showed typical features,in concordance with the available *** detection and timely treatment are very helpful for the prognosis of MSUD ***,we discuss the neuroimaging features of MSUD to enhance the knowledge of pediatricians about this disease.

关键词： Maple syrup urine disease Magnetic resonance imaging Metabolic disorders Intramyelinic edema Neonates Case report

Particle interaction during magnetization reversal process of anisotropic Sm_2Fe_(17)N_x powders

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Rare Metals 2018年第10期37卷 875-880页

作者： Ci-Fu Lu xiu-feng Hong Xiao-Qian Bao Xue-Xu Gao Jie Zhu State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing

The particle interaction during magnetization reversal process is important for the applications and magnetic properties improvement of Sm2Fe17Nx powders. In this paper, an anisotropic Sm2Fe17Nx powder free of α- Fe was prepared by ball milling. The magnetically soft Sm2Fe17 powders with different particle sizes were added into the α-Fe-free SmaFe17Nx powder as easy nucleation sites, and the effects of these magnetically soft phases on the magnetization reversal process were investigated quantitatively. It is found that the squareness of Sm2Fe17Nx powder decreases obviously with the increasing number of Sm2Fe17 particle and the demagnetization curves can be divided into two stages. The magnetization reversal process suggests that the addition of magnetically soft powder should only reduce the coercivity of a specific part of Sm2Fe17Nx particles and the reversed domain walls cannot move easily across neighboring Sm2Fe17Nx particles. Based on the observed magnetization reversal process, the mechanical properties of magnetically soft phase should be considered in the preparation of anisotropic Sm2Fe17Nx powders.

关键词： Rare earth permanent magnets Sm2Fe17Nx Magnetic domain behavior

K-Shell Ionization of Molybdenum and Iron by Electron Bombardment

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Chinese Physics Letters 1996年第3期13卷 175-177页

作者： HE Fu-qing LONG Xian-guan PENG xiu-feng LUO Zheng-ming AN Zhu Institute of Nuclear Science and Technology Sichuan UniversityChengdu 610064

K-ionization cross sections of Mo and Fe by electron impact were measured by detecting characteristic x-ray emitted by thin solid Him targets of known mass thickness with a Si(Li)*** correction of a substrate was done by bipartition model of electron *** experrmenta.1 results are compared with theoretical calculation and empirical formula calculation.

关键词： calculation. correction partition

Production of low-silicon molten iron from high-silica hematite using biochar

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Journal of Iron and Steel Research International 2017年第1期24卷 27-33页

作者： Hui-qing Tang xiu-feng Fu Yan-qi Qin Shi-yu Zhao Qing-guo Xue State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

A new method of utilizing high-silica hematite to produce low-silicon molten iron was *** this method,FASTMELT,which comprised direct reduction and melt separation processes,was applied,with highly reactive biochar as the reductant in the direct reduction *** proposed method was experimentally investigated and the results show that the method is *** the direct reduction stage,ore-char briquette could achieve a metallization rate of 84%-88% and residual carbon of 0.27-0.89mass% at temperature of 1373 K,biochar mixing ratio of 0.8-0.9,and reduction time of 15 *** silica particles remained embedded in the iron phase after the *** the melting separation stage,molten iron with a carbon content of 0.02-0.03mass% and silicon content of 0.02-0.18mass%could be obtained from the metallic briquettes under the above-mentioned conditions;the iron recovery rate was83%-91% and impurities in the obtained metal were negligible.

关键词： High-silica hematite Low-silicon molten iron Biochar Direct reduction Melt separation

Type Ⅰ neurofibromatosis with spindle cell sarcoma: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3104-3110页

作者： Yu Zhang Jiao-Jiao Chao xiu-feng Liu Shu-Kui Qin BaYi Hospital Affiliated to Nanjing University of Chinese Medicine Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Oncology BaYi Hospital Affiliated to Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKGROUND Neurofibromatosis type Ⅰ(NF1) is the most frequent subtype of neurofibromatosis. Its related tumor-suppressor syndromes are characterized by a predisposition to multiple tumor types and other disorder presentations. In addition, the incidence of tumors is much higher in patients with neurofibromatosis type Ⅰ. However, there are very few reports at home and abroad on this topic. Here, we present a case of NF1 with spindle cell *** SUMMARY A 50-year-old male was found to have a right axillary mass for 20 *** examination found cafe-au-lait spots on many parts of the skin,rounded nodules in the skin, a bulge in the right armpit, touching a lump(10 cm× 6 cm, hard, unclear boundary, poor mobility, local tenderness). The anterior side of the thigh felt weakened on the opposite side;in the right groin a swollen lymph node(hard, clear border, good mobility, local tenderness). According to the results of positron emission tomography/computed tomography, puncture pathology and immunohistochemistry, genetic testing, a diagnosis of NF1 with spindle cell sarcoma was confirmed. According to the genetic testing result, the patient was given a targeted treatment with *** Surgery, chemotherapy and radiotherapy are the main treatment methods of NF1. However, with the continuous progress of molecular biology research,molecular targeted therapy may bring benefits for patients.

关键词： Neurofibromatosis Type Ⅰ Spindle cell sarcoma Targeted therapy Crizotinib Case report

The synthesis of porphyrin-anthraquinone dyad via an azo-rearrangement

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Chinese Chemical Letters 2011年第5期22卷 539-542页

作者： Cheng Jie Li Ya Qing feng xiu Jun Liu Tian Yi Zhang School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

One novel porphyrin P-Q2 is planned to be synthesized by condensation between ATPP and ***,after separation by chromatography and characterization with IR,~1H NMR,HR-MS and X-ray,P-Q1 is obtained *** the structure of P-Q1 with that of P-Q2,it is realized that an intramolecular cyclization rearrangement takes place when the azo group is situated in the O-position to the amido *** rearrangement offers a new way to prepare indazole *** addition,the spectral properties of P-Q1 have been studied by UV-vis and steady state fluorescence *** fluorescence quenching is observed in the preliminary emission spectrum due to the proposed electron transfer from the excited porphyrin to the anthraquinone moieties.

关键词： Porphyrin Anthraquinone Azo-rearrangement Fluorescence quenching

SCI citation analysis and impact factor prediction of JZUS-B in 2008

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第1期10卷 77-78页

作者： Han-feng LIN xiu-fang WU Yue-hong (Helen) ZHANG Editors Journals of Zhejiang University SCIENCE (A&B) Zhejiang University Press Hangzhou 310027 China

In 2005, Journal of Zhejiang University-SCIENCE was split formally into two distinct sections making them in fact two separate journals: Journal of Zhejiang Uni- versity-SCIENCE A (JZUS-A) focused on Applied Physics and Engineering; Journal of Zhejiang Univer- sity-SCIENCE B (JZUS-B) focused on Biomedicine, Biochemistry and Biotechnology. Usually,

关键词： SCI 科学引文索引编辑出版

NUMERICAL SIMULATION OF IRREGULAR WAVE-SIMULATING IRREGULAR WAVE TRAIN

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Journal of Hydrodynamics 2010年第4期22卷 537-545页

作者： LIANG xiu-feng YANG Jian-min LI Jun XIAO Long-fei LI Xin State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University Shanghai 200030 China

In real sea states,damage incidents on offshore floating structures are not due to the whole time series of wave elevation characterized as statistical one but due to few extreme waves or wave groups in irregular wave ***,using CFD tools to precisely simulate predetermined irregular wave train will lay sound basis for understanding the local characteristic of the flow field and impact loads on offshore floating structures when damage incidents *** this article,the generation of single extreme wave is investigated in a numerical wave ***,experimental irregular wave train is decomposed into certain number of small-amplitude *** Fourier series expansion is performed to determine the amplitude and initial phase angle of each wave component.A hydrodynamic transfer function is used to calculate the amplitude of wave-maker motion associated with each wave *** superposition is carried out on all of the wave-maker motion components to get the final wave-maker *** the wave-maker motion as input,simulation of the single extreme irregular wave train is modeled *** the method is applied to simulating a much more complicated irregular wave *** again main features of the complicated irregular wave train are reproduced compared with experiment carried out in the new deepwater experimental basin at Shanghai Jiao Tong *** the simulation,dynamic mesh method is enabled to model the piston-type wave-maker,the Volume Of Fluid（VOF） method is employed to capture the free surface and a dissipation zone is introduced to deal with wave reflection.

关键词： numerical wave tank irregular wave train Volume of Fluid (VOF) dynamic mesh