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3D chromatin architecture and epigenetic regulation in cancer stem cells

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Protein & Cell 2021年第6期12卷 440-454页

作者： Yuliang feng Xingguo Liu Siim Pauklin Botnar Research Centre Nuffield Department of OrthopaedicsRheumatology and Musculoskeletal Sciences Old RoadUniversity of OxfordOxford OX37LDUK Guangzhou Regenerative Medicine and Health Guangdong Laboratory CAS Key Laboratory of Regenerative BiologyJoint School of Life SciencesHefei Institute of Stem Cell and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou Medical UniversityGuangzhou 510530China Guangdong Provincial key Laboratory of Stem Cell and Regenerative Medicine Institute for Stem Cell and RegenerationGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China

Dedifferentiation of cell identity to a progenitor-like or stem cell-like state with increased cellular plasticity is frequently observed in cancer *** this process,a subpopulation of cells in tumours acquires a stem cell-like state partially resembling to naturally occurring pluripotent stem cells that are temporarily present during early *** characteristics allow these cancer stem cells(CSCs)to give rise to the whole tumour with its entire cellular heterogeneity and thereby support metastases formation while being resistant to current cancer *** development and progression are demarcated by transcriptional *** this article,we explore the epigenetic mechanisms shaping gene expression during tumorigenesis and cancer stem cell formation,with an emphasis on 3D chromatin *** the pluripotent stem cell state and epigenetic reprogramming to dedifferentiation in cellular transformation provides intriguing insight to chromatin *** suggest that the 3D chromatin architecture could be used as a target for re-sensitizing cancer stem cells to therapeutics.

关键词： chromatin architecture 3D chromatin topology epigenetics tumorigenesis cancer stem cells pluripotent stem cells

Highlights of mainstream solar cell efficiencies in 2021

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Frontiers in Energy 2022年第1期16卷 1-8页

作者： wenzhong SHEN Yixin ZHAO feng LIU Institute of Solar Energy and Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education)School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China School of Environmental Science and Engineering and Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China School of Chemistry and Chemical Engineering and Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China

Solar photovoltaic(PV)technology is expected to play a key role in global carbon *** global new installed solar PV capacity over the past 20 years has grown at a compound annual growth rate of approximately 40%,far outpacing other energy sources such as coal,oil,natural gas,and wind[1].The strong momentum of the PV industry comes from its rapidly decreased levelized cost of electricity due to technological improvement and large-scale application.

关键词： Solar momentum neutral

Integrative Multi-omics Landscape of Non-structural Protein 3 of Severe Acute Respiratory Syndrome Coronaviruses

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Genomics, Proteomics & Bioinformatics 2021年第5期19卷 707-726页

作者： Ruona Shi Zhenhuan feng Xiaofei Zhang CAS key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineCenter for Cell Lineage and DevelopmentGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China University of Chinese Academy of Sciences Beijing 100049China Center for Cell Lineage and Atlas Bioland LaboratoryGuangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510530China

The coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is currently a global *** investigations have been performed to study the clinical and cellular effects of SARS-CoV-2 *** spectrometry-based proteomics studies have revealed the cellular changes due to the infection and identified a plethora of interactors for all SARS-CoV-2 components,except for the longest non-structural protein 3(NSP3).Here,we expressed the full-length NSP3 proteins of SARS-CoV and SARS-CoV-2 to investigate their unique and shared functions using multi-omics *** conducted interactome,phosphoproteome,ubiquitylome,transcriptome,and proteome analyses of NSP3-expressing *** found that NSP3 plays essential roles in cellular functions such as RNA metabolism and immune response(e.g.,NF-κB signal transduction).Interestingly,we showed that SARS-CoV-2 NSP3 has both endoplasmic reticulum and mitochondrial *** addition,SARS-CoV-2 NSP3 is more closely related to mitochondrial ribosomal proteins,whereas SARS-CoV NSP3 is related to the cytosolic ribosomal *** summary,our integrative multi-omics study of NSP3 improves the understanding of the functions of NSP3 and offers potential targets for the development of anti-SARS strategies.

关键词： NSP3 SARS-CoV-2 SARS-CoV Multi-omics Mitochondria

Quantitative attribution of Northern Hemisphere temperatures over the past 2000 years

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Frontiers of Earth Science 2023年第2期17卷 632-641页

作者： feng SHI Mingfang TING Zhengtang GUO key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044China Lamont-Doherty Earth Observatory Columbia UniversityPalisadesNY 10964USA University of Chinese Academy of Sciences Beijing 100049China

Quantitative assessment of natural internal variability and externally forced responses of Northern Hemisphere(NH)temperatures is necessary for understanding and attributing climate change signals during past warm and cold ***,it remains a challenge to distinguish the robust internally generated variability from the observed ***,largeensemble(70 member)simulations,Energy Balance Model simulation,temperature ensemble reconstruction,and three dominant external forcings(volcanic,solar,and greenhouse gas)were combined to estimate the internal variability of NH summer(June–August)temperatures over the past 2000 years(1–2000 CE).Results indicate that the Medieval Climate Anomaly was predominantly attributed to centennial-scale internal oscillation,accounting for an estimated 104%of the warming *** contrast,the Current Warm Period is influenced mainly by external forcing,contributing up to 90%of the warming *** temperature variability offsets cooling by volcanic eruptions during the Late Antique Little Ice *** findings have important implications for the attribution of past climate variability and improvement of future climate projections.

关键词： Common Era Internal variability Dark Ages Cold Period Medieval Climate Anomaly Current Warm Period

Morphology,microstructure and decomposition behavior of M2C carbides in high speed steel

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Journal of Iron and Steel Research International 2017年第1期24卷 43-49页

作者： Xue-feng Zhou Di Liu Wang-long Zhu feng Fang Yi-you Tu Jian-qing Jiang Jiangsu key Laboratory of Advanced Metallic Materials School of Materials Science and EngineeringSoutheast University Nanjing 211189JiangsuChina Jiangsu Engineering Research Center of Tool and Die Steel Danyang 212312JiangsuChina Nanjing University of Information Science and Technology Nanjing 210044JiangsuChina

The morphology,microstructure and decomposition behavior of M2C carbides in high speed steels with different chemical compositions have been investigated by scanning electron microscopy,transmission electron microscopy,electron backscatter diffraction and X-ray *** results show that the morphology and substructure of M2C carbides are very sensitive to chemical compositions of high speed steels.M2C carbides present the plate-like shape in tungsten-molybdenum steel and present the polycrystal orientation in the eutectic *** contrast,they show the fibrous shape in molybdenum-base steel and exhibit the monocrystal ***-like and fibrous M2C carbides are both metastable and decompose into M6 C together with MC at high *** nucleates inside the plate-like M2C while it is formed at the fibrous M2C/matrix interface during the decomposition *** differences are expected to arise from different compositions of plate-like and fibrous M2C carbides.

关键词： High speed steel Carbide M2C Morphology Substructure Decomposition

A novel user behavioral aggregation method based on synonym groups in online video systems

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Science China(Information Sciences) 2016年第2期59卷 237-239页

作者： Tingting feng Yuchun GUO Yishuai CHEN School of Electronics and Information Engineering Beijing Jiaotong University

Dear editor,Huge commercial interests have arisen as online video service surges,and user demographic information is precious and critical to predict user preferences,make recommendations and increase advertisement *** instance,lady perfume advertisers usually target their advertisement to the ***,many studies predict user demographic information such as gender based on

关键词： OLR A novel user behavioral aggregation method based on synonym groups in online video systems Word

Optimality Conditions for Minimax Optimization Problems with an Infinite Number of Constraints and Related Applications

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Acta Mathematicae Applicatae Sinica 2021年第2期37卷 251-263页

作者： Li-nan ZHONG Yuan-feng JIN Department of Mathematics College of ScienceYanbian UniversityYanji 133002China

This paper is concerned with the study of optimality conditions for minimax optimization problems with an infinite number of constraints,denoted by(MMOP).More precisely,we first establish necessary conditions for optimal solutions to the problem(MMOP)by means of employing some advanced tools of variational analysis and generalized ***,sufficient conditions for the existence of such solutions to the problem(MMOP)are investigated with the help of generalized convexity functions defined in terms of the limiting subdifferential of locally Lipschitz ***,some of the obtained results are applied to formulating optimality conditions for weakly efficient solutions to a related multiobjective optimization problem with an infinite number of constraints,and a necessary optimality condition for a quasiε-solution to problem(MMOP).

关键词： minimax programming problem semi-infinite optimization limiting subdifferential multiobjective optimization approximate solutions

A Scheme for Generating Nonisospectral Integrable Hierarchies and Its Related Applications

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Acta Mathematica Sinica,English Series 2021年第5期37卷 707-730页

作者： Yu feng ZHANG Xiang Zhi ZHANG School of Mathematics China University of Mining and TechnologyXuzhou 221116P.R.China

Under the framework of the complex column-vector loop algebra C^(p),we propose a scheme for generating nonisospectral integrable hierarchies of evolution equations which generalizes the applicable scope of the Tu *** applications of the scheme,we work out a nonisospectral integrable Schrodinger hierarchy and its expanding integrable *** latter can be reduced to some nonisospectral generalized integrable Schrodinger systems,including the derivative nonlinear Schrodinger equation once obtained by Kaup and ***,we obtain the famous Fokker-Plank equation and its generalized form,which has extensive applications in the stochastic dynamic ***,we investigate the Lie group symmetries,fundamental solutions and group-invariant solutions as well as the representation of the tensor of the Heisenberg group H_(3)and the matrix linear group SL(2,R)for the generalized Fokker-Plank equation(GFPE).

关键词： Nonisospectral integrable Schr?dinger hierarchy expanding integrable model symmetry group

Secure Image Hiding Scheme Based on Magic Signet

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Journal of Electronic Science and Technology 2020年第1期18卷 93-101页

作者： Chin-feng Lee Ying-Xiang Wang Department of Information Management Chaoyang University of TechnologyTaichung 41349

Image data hiding technology is secret communications that carry hidden data in such a way that no one except the sender and intended recipients can even realize there is a hidden message. High embedding capacity,good images quality, and security are three important essentials. In this paper, each confidential hexadecimal will be carried by two cover pixels based on a magic matrix generated from a square template to reach the goal of higher embedding capacity while keeping good image visualization. Experimental results reveal that the proposed scheme guarantees higher embedding capacity of 2 bits per pixel and has the peak signal-to-noise ratio(PSNR) of 44.7 dB on average. Moreover, secret keys are used to ensure security consideration.

关键词： Data hiding embedding capacity steganography visual quality