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Buckling Properties of Water-Drop-Shaped Pressure Hulls with Various Shape Indices Under Hydrostatic External Pressure

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China Ocean Engineering 2024年第1期38卷 1-17页

作者： DING Xiao-de ZHANG Jian WANG Fang JIAO Hui-feng WANG Ming-lu School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China shanghai Engineering Research Center of Marine Renewable Energy College of Engineering Science and Technol-ogyShanghai Ocean UniversityShanghai 201306China China Ship Scientific Research Center Wuxi 214082China

The water-drop-shaped pressure hull has a good streamline,which has good application prospect in the underwater ***,this study conducted analytical,experimental and numerical investigation of the buckling properties of water-drop-shaped pressure hulls under hydrostatic pressure.A water-drop experiment was conducted to design water-drop-shaped pressure hulls with various shape *** critical loads for the water-drop-shaped pressure hulls were resolved by using Mushtari’s *** numerical simulations including linear buckling analysis and nonlinear buckling analysis including eigenmode imperfections were *** results indicated that the critical loads resolved by Mushtari's formula were in good agreement with the linear buckling loads from the numerical *** formula can be extended to estimate the buckling capacity of water-drop-shaped pressure *** addition,three groups of pressure hulls were fabricated by using stereolithography,a rapid prototyping ***,three groups of the pressure hulls were subjected to ultrasonic measurements,optical scanning,hydrostatic testing and numerical *** experimental results were consistent with the numerical *** results indicate that the sharp end of the water-drop-shaped pressure hulls exhibited instability compared with the blunt *** paper provides a new solution to the limitations of experimental studies on the water-drop-shaped pressure hulls as well as a new configuration and evaluation method for underwater observatories.

关键词： buckling pressure hull water drop underwater observatory

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基于混合边界条件的有限单元法GPR正演模拟

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地球物理学报 2012年第11期55卷 3774-3785页

作者：冯德山陈承申王洪华中南大学地球科学与信息物理学院长沙410083 有色金属成矿预测教育部重点实验室长沙410083 有色资源与地质灾害探查湖南省重点实验室长沙410083

从Maxwell方程组出发,推导了探地雷达(GPR)有限元波动方程.阐述了透射边界条件和Sarma边界条件的原理,推导了这两种边界条件的理论公式;通过在衰减层内加入过渡带优化了Sarma边界条件的加载方法,压制了介质区和衰减层交界面处的人为反射... 详细信息

从Maxwell方程组出发,推导了探地雷达(GPR)有限元波动方程.阐述了透射边界条件和Sarma边界条件的原理,推导了这两种边界条件的理论公式;通过在衰减层内加入过渡带优化了Sarma边界条件的加载方法,压制了介质区和衰减层交界面处的人为反射.考虑到透射边界条件与Sarma边界条件不同的理论机制,提出了一种结合透射边界条件和Sarma边界条件的混合边界条件,它利用Sarma边界条件对到达边界区域的GPR波能量衰减功能和透射边界对GPR波能量的透射功能,使GPR波经过Sarma边界条件的衰减吸收后,再通过透射边界条件将剩余能量透射出去,集成了二者的优势.并以二维均匀模型中的中心脉冲激励源方式为例,通过Matlab程序实现,以GPR的全波场快照的直观方式,对比了有、无边界条件及不同边界条件对人工截断边界的处理效果,说明了该混合边界条件对到达截断边界处的GPR波的处理优于单一边界条件.最后,以基于混合边界条件的有限单元法对两个典型的GPR地电模型进行了正演模拟,指导了GPR数据处理与工程实践.

关键词：探地雷达有限单元法混合边界条件 Sarma边界条件正演模拟

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Seismic response of a mid-story isolated structure considering SSI in mountainous areas under long-period earthquakes

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 151-161页

作者： Wan feng Qin Shengwu Liu dewen Zhao Tiange Zheng Yanping shan Hang Li Zhiang Peng Fusong Xu Jingran Lei Min College of Construction Engineering Jilin UniversityChangchun 130015China College of Civil Engineering Southwest Forestry UniversityKunming 650024China College of civil engineering Southwest Jiaotong UniversityChengdu 610031China

At present,there is not much research on mid-story isolated structures in mountainous *** this study,a model of a mid-story isolated structure considering soil-structure interaction(SSI)in mountainous areas is established along with a model that does not consider *** long-period earthquake waves and two ordinary earthquake waves are selected as inputs for the dynamic time history analysis of the *** results show that the seismic response of a mid-story isolated structure considering SSI in mountainous areas can be amplified when compared with a structure that does not consider *** structure response under long-period earthquakes is larger than that of ordinary *** structure response under far-field harmonic-like earthquakes is larger than that of near-fault pulse-type *** structure response under near-fault pulse-type earthquakes is larger than that of far-field non-harmonic *** subjected to long-period earthquakes,the displacement of the isolated bearings exceeded the limit value,which led to instability and overturning of the *** structure with dampers in the isolated story could adequately control the nonlinear response of the structure,effectively reduce the displacement of the isolated bearings,and provide a convenient,efficient and economic method not only for new construction but also to retrofit existing structures.

关键词： SSI in mountainous areas long-period earthquakes mid-story isolated structure structural dynamic analysis

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Modern technology-based exploration of mechanism of traditional Chinese medicine in prevention and treatment of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3747-3751页

作者： de-Hui Li Rui-Qi feng Oncology departmentⅡ The First Affiliated Hospital of Hebei University of Chinese Medicine(Hebei Province Hospital of Chinese Medicine)Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology ResearchShijiazhuang 050000Hebei ProvinceChina Graduate School Hebei University of Chinese MedicineShijiazhuang 050000Hebei ProvinceChina

This review comments on the article“To explore the mechanism of Yigong San anti-gastric cancer and immune regulation”.We are interested that the article applied network pharmacology and bioinformatics techniques to elucidate the mechanism of action of Yigong Sang,a traditional Chinese medicine(TCM),in the treatment of gastric cancer(GC).The mechanism of action of Yigong Sang in the treatment of GC has not yet been elucidated because it is composed of multiple Chinese medicines with multiple components and multiple *** emergence of network pharmacology and bioinformatics analysis helps explain the mechanism of action of TCM in preventing and treating GC,and provides a possibility for TCM to transform from empirical to evidence-based *** is of great significance for the application of TCM in oncology,new drug development,formula optimization,and the improvement of clinical efficacy.

关键词： Gastric cancer Traditional Chinese medicine Mechanism Network pharmacology Bioinformatics New technology

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NextPolish2:A Repeat-aware Polishing Tool for Genomes Assembled Using HiFi Long Reads

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 105-109页

作者： Jiang Hu Zhuo Wang Fan Liang shan-Lin Liu Kai Ye de-Peng Wang School of Automation Science and Engineering Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China GrandOmics Biosciences Beijing 102206China department of Entomology College of Plant ProtectionChina Agricultural UniversityBeijing 100193China

The high-fidelity(HiFi)long-read sequencing technology developed by PacBio has greatly improved the base-level accuracy of genome ***,these assemblies still contain base-level errors,particularly within the error-prone regions of HiFi long *** genome polishing tools usually introduce overcorrections and haplotype switch errors when correcting errors in genomes assembled from HiFi long ***,we describe an upgraded genome polishing tool-NextPolish2,which can fix base errors remaining in those“highly accurate”genomes assembled from HiFi long reads without introducing excessive overcorrections and haplotype switch *** believe that NextPolish2 has a great significance to further improve the accuracy of telomere-to-telomere(T2T)***2 is freely available at https://***/Nextomics/NextPolish2.

关键词： Telomere-to-telomere Genome assembly Genome polishing Error correction HiFi long read

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Expression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 670-686页

作者： Ye Yang Wu Wen feng-Lin Chen Ying-Jie Zhang Xiao-Cong Liu Xiao-Yan Yang shan-shan Hu Ye Jiang Jing Yuan Digestive Diseases Chengdu Qingbaijiang District People's HospitalChengdu 610300Sichuan ProvinceChina Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate School Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND The incidence and mortality of colorectal cancer(CRC)are among the highest in the world,and its occurrence and development are closely related to tumor *** the balance between pigment epithelium-derived factors(PEDF)that inhibit angiogenesis and vascular endothelial growth factors(VEGF)that stimulate angiogenesis is broken,angiogenesis is out of control,resulting in tumor ***,it is very necessary to find more therapeutic targets for CRC for early intervention and later *** To investigate the expression and significance of PEDF,VEGF,and CD31-stained microvessel density values(CD31-MVD)in normal colorectal mucosa,adenoma,and *** In this case-control study,we collected archived wax blocks of specimens from the Digestive Endoscopy Center and the General Surgery department of Chengdu Second People's Hospital from April 2022 to October *** cases of specimen wax blocks were selected as normal intestinal mucosa confirmed by electronic colonoscopy and concurrent biopsy(normal control group),50 cases of specimen wax blocks were selected as colorectal adenoma confirmed by electronic colonoscopy and pathological biopsy(adenoma group),and 50 cases of specimen wax blocks were selected as CRC confirmed by postoperative pathological biopsy after inpatient operation of general surgery(CRC group).An immunohistochemical staining experiment was carried out to detect PEDF and VEGF expression in three groups of specimens,analyze their differences,study the relationship between the two and clinicopathological factors in CRC group,record CD31-MVD in the three groups,and analyze the correlation of PEDF,VEGF,and CD31-MVD in the colorectal adenoma group and the CRC *** F test or adjusted F test is used to analyze measurement data ***-Wallis rank sum test was used between groups for ranked *** chi-square test,adjusted chi-square test,or Fisher's exact test were used to compare the rates betwe

关键词： Pigment epithelium-derived factors Vascular endothelial growth factor Microvessel density Colorectal adenoma Colorectal cancer Targeted therapy

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综合物探方法在堤防质量检测中的应用

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地球物理学进展 2006年第4期21卷 1328-1331页

作者：石明冯德山戴前伟昆明理工大学国土资源工程学院中南大学信息物理工程学院长沙410083

在堤防质量检测中,地球物理方法能够实现快速、无损的探测,但采用单一物探方法对堤防隐患的判别易形成多解,也很难对堤防质量做出准确分类.本文中应用探地雷达、高密度电法、地震勘探等综合物探方法对大源渡堤防质量进行检测,并以龙荫... 详细信息

在堤防质量检测中,地球物理方法能够实现快速、无损的探测,但采用单一物探方法对堤防隐患的判别易形成多解,也很难对堤防质量做出准确分类.本文中应用探地雷达、高密度电法、地震勘探等综合物探方法对大源渡堤防质量进行检测,并以龙荫港以例,通过综合三种物探方法互相参照、相互验证,互为补充,查明了堤防隐患的分布位置与埋深,为堤防质量检测提供一种新的工作方法.

关键词：综合物探堤防质量检测地震勘探地质雷达高密度电法

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TSP-203在隧道超前预报中的应用

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地球物理学进展 2005年第2期20卷 460-464页

作者：戴前伟何刚冯德山湖南长沙中南大学信息物理工程学院长沙410083

TSP203系统是瑞士Amberg工程技术公司最新研制并拥有专利的隧道地震探测仪,专门为隧道超前地质预报而设计的.该系统从数据采集、处理和成果评估高度智能化,采用该系统可以预报隧道工作面前方100m左右围岩地质体的性质、位置和规模,并可... 详细信息

TSP203系统是瑞士Amberg工程技术公司最新研制并拥有专利的隧道地震探测仪,专门为隧道超前地质预报而设计的.该系统从数据采集、处理和成果评估高度智能化,采用该系统可以预报隧道工作面前方100m左右围岩地质体的性质、位置和规模,并可推算出其岩石物理力学参数,为确定合理的支护参数提供依据,确保隧道施工安全和质量.本文对TSP203系统、工作原理、数据采集及资料解释方面做了系统的阐述.

关键词： TSP-203 隧道掌子面超前地质预报

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基于深度学习的隧道衬砌结构物探地雷达图像自动识别

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地球物理学进展 2020年第4期35卷 1552-1556页

作者：冯德山杨子龙中南大学地球科学与信息物理学院长沙410083 有色资源与地质灾害探查湖南省重点实验室长沙410083

传统探地雷达图像识别方法中存在识别准确率不高,复杂目标体识别难度大,识别流程较为繁琐,不能实现端到端识别等问题,不能准确的识别实测数据.本文将深度学习中Faster R-CNN、YOLOv3这两种具有代表性的目标检测算法运用到探地雷达的图... 详细信息

传统探地雷达图像识别方法中存在识别准确率不高,复杂目标体识别难度大,识别流程较为繁琐,不能实现端到端识别等问题,不能准确的识别实测数据.本文将深度学习中Faster R-CNN、YOLOv3这两种具有代表性的目标检测算法运用到探地雷达的图像识别当中.选择隧道的衬砌结构作为探测识别研究目标,制作了包含钢拱架、钢筋网、施工缝三类结构物标注的实测数据集.从准确率、召回率、平均准确率,准确率-召回率曲线等评价指标,分析了这两种算法在实测数据集上的表现.并对照典型的识别结果,结合这两种算法的原理说明了其运用到探地雷达图像自动识别上的特点.在测试集上,Faster R-CNN在钢拱架、钢筋网、施工缝三类结构物的识别中分别取得了95.5%、90.5%、96.8%平均准确率,YOLOv3则分别取得了90.0%、16.6%、95.3%平均准确率.实验结果表明两种深度学习目标检测方法在隧道衬砌探地雷达图像的识别上取得了良好的效果,其中Faster R-CNN整体效果更好,但会将多次波误识别为有效信号,YOLOv3较少误识别多次波,但是对钢筋网识别效果不好,两种方法搭配使用会形成优势互补.

关键词：深度学习探地雷达自动识别 Faster R-CNN YOLOv3

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Converting“cold”to“hot”:epigenetics strategies to improve immune therapy effect by regulating tumor-associated immune suppressive cells

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Cancer Communications 2024年第6期44卷 601-636页

作者： Yijia Tang Guangzu Cui Haicong Liu Ying Han Changjing Cai Ziyang feng Hong Shen shan Zeng department of Oncology Xiangya HospitalCentral South UniversityChangshaHunanP.R.China National Clinical Resaerch Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunanChina

Significant developments in cancer treatment have been made since the advent of immune ***,there are still some patientswithmalignant tumors who do not benefit from *** without immunogenicity are called“cold”tumors which are unresponsive to immunotherapy,and the opposite are“hot”*** suppressive cells(ISCs)refer to cells which can inhibit the immune response such as tumor-associated macrophages(TAMs),myeloid-derived suppressor cells(MDSCs),regulatory T(Treg)cells and so *** more ISCs infiltrated,the weaker the immunogenicity of the tumor,showing the characteristics of“cold”*** dysfunction of ISCs in the tumor microenvironment(TME)may play essential roles in insensitive therapeutic *** studies have found that epigeneticmechanisms play an important role in the regulation of *** ISCs may be a new approach to transforming“cold”tumors into“hot”***,we focused on the function of ISCs in the TME and discussed how epigenetics is involved in regulating *** addition,we summarized the mechanisms by which the epigenetic drugs convert immunotherapy-insensitive tumors into immunotherapy-sensitive tumors which would be an innovative tendency for future immunotherapy in“cold”tumor.

关键词： DNA methylation epigenetics strategy histone modification immune suppressive cell noncoding RNA

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