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A 2-bp frameshift deletion at GhDR,which encodes a B-BOX protein that co-segregates with the dwarf-red phenotype in Gossypium hirsutum L.

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Journal of Integrative Agriculture 2023年第7期22卷 2000-2014页

作者： WANG Xue-feng SHAO Dong-nan LIANG Qian feng xiao-kang ZHU Qian-hao YANG Yong-lin LIU feng ZHANG Xin-yu LI Yan-jun SUN Jie XUE Fei Key Laboratory of Oasis Eco-Agriculture College of AgricultureShihezi UniversityShihezi 832000P.R.China CSIRO Agriculture and Food CanberraACT 2601Australia Cotton Research Institute Shihezi Academy of Agriculture SciencesShihezi 832000P.R.China

Plant architecture and leaf color are important factors influencing cotton fiber *** this study,based on genetic analysis,stem paraffin sectioning,and phytohormone treatments,we showed that the dwarf-red(DR)cotton mutant is a gibberellin-sensitive mutant caused by a mutation in a single dominant locus,designated *** bulked segregant analysis(BSA)and genotyping by target sequencing(GBTS)approaches,we located the causative mutation to a~197-kb genetic interval on chromosome A09 containing 25 annotated *** on gene annotation and expression changes between the mutant and normal plants,GH_A09G2280 was considered to be the best candidate gene responsible for the dwarf and red mutant phenotypes.A 2-nucleotide deletion was found in the coding region of GhDR/GH_A09G2280 in the DR mutant,which caused a frameshift and truncation of *** is a homolog of Arabidopsis AtBBX24,and encodes a B-box zinc finger *** frameshift deletion eliminated the C-terminal nuclear localization domain and the VP domain of GhDR,and altered its subcellular localization.A comparative transcriptome analysis demonstrated downregulation of the key genes involved in gibberellin biosynthesis and the signaling transduction network,as well as upregulation of the genes related to gibberellin degradation and the anthocyanin biosynthetic pathway in the DR *** results of this study revealed the potential molecular basis by which plant architecture and anthocyanin accumulation are regulated in cotton.

关键词： cotton BBX dwarf anthocyanin gibberellin

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The Hilbert expansion of the Boltzmann equation in the incompressible Euler level in a channel

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Science China Mathematics 2025年第1期68卷 39-88页

作者： Feimin Huang Weiqiang Wang Yong Wang feng xiao Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education) School of Mathematics and StatisticsHunan Normal University

The study of the hydrodynamic limit of the Boltzmann equation with physical boundary is a challenging problem due to the appearance of the viscous and Knudsen boundary *** this paper,the hydrodynamic limit from the Boltzmann equation with the specular reflection boundary condition to the incompressible Euler equations in a channel is *** on the multi-scaled Hilbert expansion,the equations with boundary conditions and compatibility conditions for interior solutions,and viscous and Knudsen boundary layers are derived under different scaling,***,some uniform estimates for the interior solutions,and viscous and Knudsen boundary layers are *** the help of the L2-L∞framework and the uniform estimates obtained above,the solutions to the Boltzmann equation are constructed by the truncated Hilbert expansion with multiscales,and hence the hydrodynamic limit in the incompressible Euler level is justified.

关键词： Boltzmann equation incompressible Euler equations hydrodynamic limit Hilbert expansion specular reflection boundary condition viscous boundary layer Knudsen boundary layer

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： xiao Xiang feng Gao Yu-Gui Peng Peng Wu Zong-Lin Li Xue-feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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手电筒开关座成形工艺与级进模设计

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模具工业 2008年第4期34卷 16-19页

作者：冯小康南华大学机械工程学院湖南衡阳421001

分析了手电筒开关座的成形工艺,在排样设计和模具结构设计中采取了针对性措施,有效地解决了在级进模中进行拉深时条料发生收缩变形的问题,完成了该零件的级进模设计,取得了良好的效益。

关键词：手电筒开关座级进模收缩变形预拉深

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High-dense nanocrystalline W-based alloy prepared by hot isostatic pressing with uniform microstructure, ultrahigh hardness and good thermal stability

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Tungsten 2025年第1期7卷 120-136页

作者： Zao-Ming Wu Lin He Lin-Sen Ye xiao-feng Yang Jia-Jia Zhang Hong-Bo Lei Institute of Materials China Academy of Engineering Physics

High-density uniform microstructure nanocrystalline W-10wt.% Cr-5wt.% Y（W-10Cr-5Y） alloy with an average grain size of 85 nm and a relative density of 99.8% was successfully prepared.W-Cr-Y alloys with different amounts of second-phase particles were prepared by high-energy ball milling and hot isostatic pressing *** effects of composition design,ball milling parameters,and sintering parameters on the microstructure of W-Cr-Y alloys were studied.A feasible technology for controlling the synthesis of high-density nanocrystalline W-based alloys has been *** microstructure analysis of nanocrystalline W-10Cr-5Y alloy shows that there are two types of doping in the second phase:intergranular doping and intragranular *** "uniform distribution YOx-rich particles" effectively suppresses the grain growth of W and leads to the formation of nanocrystalline W-10Cr-5Y alloy.W-10Cr-5Y has an ultra-high hardness,with a Vickers hardness of 1312±12 kgf·***-temperature annealing treatment shows that W-10Cr-5Y has good thermal stability at 1000 and1100℃,as demonstrated by the comparison of Vickers hardness and grain size between annealed and unannealed alloys.

关键词： Hot isostatic pressing Microstructure Nanocrystalline tungsten Thermal stability Vickers hardness

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Genes and proteins expressed at different life cycle stages in the model protist Euplotes vannus revealed by both transcriptomic and proteomic approaches

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Science China Life Sciences 2025年第1期68卷 232-248页

作者： Yaohan Jiang xiao Chen Chundi Wang Liping Lyu Saleh A.Al-Farraj Naomi A.Stover feng Gao Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity Ocean University of China Marine College Shandong University Zoology Department College of ScienceKing Saud University Department of Biology Bradley University Laboratory for Marine Biology and Biotechnology Qingdao Marine Science and Technology Center

Sexual reproduction first appeared in unicellular protists and has continued to be an essential biological process in almost all *** protists, which contain both germline and somatic genomes within a single cell, have evolved a special form of sexual reproduction called conjugation that involves mitosis, meiosis, fertilization, nuclear differentiation, genome rearrangement, and the development of unique cellular structures. The molecular basis and mechanisms of conjugation vary dramatically among ciliates, and many details of the process and its regulation are still largely unknown. In order to better comprehend these processes and mechanisms from an evolutionary perspective, this study provides the first comprehensive overview of the transcriptome and proteome profiles during the entire life cycle of the newly-established marine model ciliate Euplotes vannus. Transcriptome analyses from 14 life cycle stages(three vegetative stages and 11 sexual stages) revealed over 26,000 genes that are specifically expressed at different stages, many of which are related to DNA replication,transcription, translation, mitosis, meiosis, nuclear differentiation, and/or genome rearrangement. Quantitative proteomic analyses identified 338 proteins with homologs associated with conjugation and/or somatic nuclear development in other ciliates, including dicer-like proteins, Hsp90 proteins, RNA polymerase Ⅱ and transcription elongation factors, ribosomal-associated proteins, and ubiquitin-related proteins. Four of these homologs belong to the PIWI family, each with different expression patterns identified and confirmed by RT-qPCR,which may function in small RNA-mediated genome rearrangement. Proteins involved in the nonhomologous end-joining pathway are induced early during meiosis and accumulate in the developing new somatic nucleus, where more than 80% of the germline sequences are eliminated from the somatic genome. A number of new candidate genes and proteins likely t

关键词： sexual reproduction transcriptomic proteomic genome rearrangement PIWI NHEJ

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支架件精密级进模设计与制造

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模具工业 2007年第6期33卷 20-23页

作者：冯小康谢袁飞南华大学机械工程学院湖南衡阳421001 湘南学院物理系湖南郴州423000

分析了支架零件的工艺性和排样设计方案,介绍了模具结构及特点,并简要介绍了模具主要制造工艺。该模具结构不但解决了倒U形弯曲件出模困难问题,而且模具的可靠性、安全性及使用寿命显著提高。

关键词：支架件精密级进模结构特点

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Searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways

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World Journal of Clinical Cases 2025年第1期13卷 22-28页

作者： Hua Bai xiao-feng feng Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina Department of Neurology Wulong Branch of the People's Hospital Affiliated to Chongqing UniversityWulong 408500ChongqingChina Department of Neurology Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

Dementia is a group of diseases,including Alzheimer's disease(AD),vascular dementia,Lewy body dementia,frontotemporal dementia,Parkinson's disease dementia,metabolic dementia and toxic *** treatment of dementia mainly includes symptomatic treatment by controlling the primary disease and accompanying symptoms,nutritional support therapy for repairing nerve cells,psychological auxiliary treatment,and treatment that improves cognitive function through *** them,drug therapy to improve cognitive function is *** review focuses on introducing and commenting on some recent progress in exploring drugs to improve cognitive function,especially the new progress in drug treatment for *** mainly discuss the opportunities and challenges in finding and developing new therapeutic drugs from the aspects of acetylcholinesterase,N-methyl-D-aspartate glutamate receptor,amyloid protein,tau protein and chronic immune inflammation.

关键词： Alzheimer's disease Dementia Cholinesterase inhibitor Beta amyloid Tau protein

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生产者服务业与制造业的互动演化研究——基于我国投入产出表的实证分析

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华东经济管理 2010年第1期24卷 54-59页

作者：陈伟达冯小康东南大学经济管理学院江苏南京210096

文章基于我国1987、1992、1997和2002年的投入产出表,选取13个制造业细分行业和历年的生产者服务业细分行业,运用完全消耗系数对我国生产者服务业与制造业的互动演化规律进行实证分析。研究表明,我国生产者服务业与制造业互动演化的工... 详细信息

文章基于我国1987、1992、1997和2002年的投入产出表,选取13个制造业细分行业和历年的生产者服务业细分行业,运用完全消耗系数对我国生产者服务业与制造业的互动演化规律进行实证分析。研究表明,我国生产者服务业与制造业互动演化的工业化阶段已基本完成,信息化阶段正在逐步深入。相比于美国,我国生产者服务业对制造业的中间投入率较低,而制造业对生产者服务业的中间投入率却偏高。在此基础上,本文提出了促进我国生产者服务业与制造业良性互动发展的相关建议。

关键词：生产者服务业制造业投入产出分析互动演化

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基于最优排序的局部敏感哈希索引

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计算机学报 2020年第5期43卷 930-947页

作者：冯小康彭延国崔江涛刘英帆李辉西安电子科技大学计算机科学与技术学院西安710071 香港中文大学系统工程与工程管理系香港999077 西安电子科技大学网络与信息安全学院西安710071 社会安全风险感知与防控大数据应用国家工程实验室北京100084

针对外存环境中海量高维数据近似最近邻(Approximate Nearest Neighbor,ANN)查询面临的"维度灾难"和I/O性能瓶颈难题,本文提出了一种基于最优排序的局部敏感哈希(Locality-Sensitive Hashing,LSH)索引方案O2LSH(Optimal Order LSH).通过引入空间填充曲线为复合哈希键值建立线序并排序,使近邻候选点更多地分布在相同或相邻磁盘页面,实现用少量顺序I/O加载到足够多的候选点.本文对多种常用空间曲线技术进行了量化分析,发现:(1)基本排序方案SK-LSH使用的row-wise曲线具有"维度优先遍历"的特性,容易对ANN查询造成多种局限;(2)另一类"邻域优先遍历"特性的曲线能够产生更好的候选点局部分布,且排序性能更加稳定.通过对比,我们选取了一种最优的"邻域优先遍历"曲线构造线序,该线序能够最大程度地改善近邻候选点的局部分布,进一步提升磁盘访问效率和查询精度.在多个真实多媒体数据集上进行了对比实验,证实了O2LSH相对于先进LSH方案(包括C2LSH、SK-LSH、SRS以及QALSH)在查询精度和I/O效率上的优越性.特别地,O2LSH克服了基本排序方案SK-LSH对LSH关键参数的敏感性,算法实用性进一步提升.

关键词：近似最近邻高维索引局部敏感哈希空间线序局部分布

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