检索结果-南通市图书馆

In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging

引用

Nano Research 2024年第5期17卷 4379-4390页

作者： yuzhou Chen Mo Chen Chengxuan yu Huizhu li liman Sai Nguyen T.K.Thanh yueming Wang yan Wo Jian Zhang Xing yang Evgenii l.Guryev Andrei V.Zvyagin Hao De Min Tang Shiyi Chen yunxia li yuefeng Hao Sijia feng Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Department of Physics Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCl Healthcare Biomagnetic and Nanomaterials laboratories London W1S 4BSUK Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mathematical Institute University of OxfordOxford OX26GGUK Institute of Natural Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage *** this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their *** delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)*** Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with *** results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.

关键词： macrophage cell therapy NIR-II in vivo imaging delayed therapy tendon healing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

无人机高光谱遥感和集成深度置信神经网络算法用于密云水库水质参数反演

引用

光谱学与光谱分析 2024年第7期44卷 2066-2074页

作者：乔智姜群鸥律可心高峰北京林业大学水土保持学院北京100038 北京林业大学水土保持与荒漠化防治教育部重点实验室北京100038

随工业化及社会经济迅速发展,水源地面临的水体污染、恶化不断加剧,开展有效的水质监测是水源保护的重要前提。密云水库是北京重要的地表水源地,在保护首都水源安全方面发挥着重要作用。为更精准的监测密云水库水质参数及污染程度,采用... 详细信息

随工业化及社会经济迅速发展,水源地面临的水体污染、恶化不断加剧,开展有效的水质监测是水源保护的重要前提。密云水库是北京重要的地表水源地,在保护首都水源安全方面发挥着重要作用。为更精准的监测密云水库水质参数及污染程度,采用4期无人机高光谱遥感数据,基于随机子空间的集成深度置信神经网络算法(EDBN),构建密云水库水质参数反演模型,对密云水库总氮(TN)、总磷(TP)两项水质参数进行反演。首先,采用基于递归特征消除法对高光谱影像降维处理,将光谱数据与地面水质监测数据进行叠加,通过最小化训练过程中误差来确定隐藏层数、神经节点数等网络结构参数;然后采用由知识源域向网络迁移方式逐步拓展网络,对密云水库总氮和总磷两个水质参数进行训练并对结果进行验证;最后,反演密云水库潮河大坝和白河大坝区域水质参数,揭示其主要水质参数时空演变规律。研究结果显示:(1)构建总氮、总磷反演模型R^(2)分别为0.8355、0.7703,MSE分别为0.0153、0.0008,这表明基于随机子空间的集成深度置信神经网络算法模型对密云水库水质参数反演效果较好;(2)密云水库总氮浓度变化随季节发生一定波动,在夏季浓度较低,秋季相对较高。总磷浓度变化相对平稳,表明密云水库周边区域对磷污染控制效果良好;(3)白河大坝区域水质优于潮河大坝区域,总氮浓度相对偏高,整体处于Ⅲ类水平。而总磷浓度较低,整体处于Ⅱ类水平,较好时可以达到Ⅰ类水平。整体水质可以满足饮用水源的标准,但仍需加强对氮、磷污染物有效监管。研究结果将为密云水库水质高效监测与水源保护提供重要科学依据。

关键词：无人机高光谱深度神经网络算法水质反演密云水库

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Homoclinic Solutions for a Class of Asymptotically Quadratic Second-Order Hamiltonian System

引用

Acta Mathematica Sinica,English Series 2024年

作者： Tie feng yE Wen Bin lIU Hui Xing ZHANG School of Mathematics China University of Mining and Technology Jiangsu Center for Applied Mathematics(CUMT)

In this paper, we study the existence and multiplicity of homoclinic solutions for a class of second-order Hamiltonian system: u″(t)-l(t)u(t) + ΔV(t, u) = 0, where l(t) and V(t, u) are not periodic in t. First, we introduce the definition of index and establish the corresponding index theory. Then, by using the index theory and critical point theory, we prove our main results under the asymptotic quadratic conditions of the potential function.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

耦合条件非线性最优扰动及其在ENSO集合预报研究中的应用

引用

中国科学：地球科学 2024年第3期54卷 845-861页

作者：段晚锁胡蕾冯蓉中国科学院大气物理研究所大气科学和地球流体力学数值模拟国家重点实验室北京100029 中国科学院大学北京100049

考虑到目前集合预报初始扰动方法未能充分刻画地球系统不同圈层相互作用影响的局限性,本研究提出了能够考虑多圈层耦合初始不确定性的耦合条件非线性最优扰动(C-CNOP)方法.将C-CNOP方法应用于热带太平洋典型的海气耦合现象厄尔尼诺-南... 详细信息

考虑到目前集合预报初始扰动方法未能充分刻画地球系统不同圈层相互作用影响的局限性,本研究提出了能够考虑多圈层耦合初始不确定性的耦合条件非线性最优扰动(C-CNOP)方法.将C-CNOP方法应用于热带太平洋典型的海气耦合现象厄尔尼诺-南方涛动(ENSO)事件的集合预报研究,表明了C-CNOP方法能够产生ENSO集合预报的更恰当考虑海气耦合不确定性的快速增长初始扰动(CPs);从Nino3.4海表温度距平(SSTA)时间变率的预报和ENSO成熟位相SSTA空间变率的预报两方面,揭示了CPs能够有效促进ENSO集合平均预报的水平,尤其从春、夏季开始的预报,即使该季节热带太平洋海气耦合强度最弱, CPs也能够捕捉到该弱海气耦合信息的不确定性,从而大大抑制了ENSO预报误差在该季节由于最强海气耦合不稳定性导致的快速增长,有效延长了ENSO的预报时效.因此, C-CNOP方法是一个能够产生集合预报的更充分考虑初始耦合不确定性的初始扰动的方法,期望未来在继续研究的基础上,使C-CNOP在地球气候系统预测中发挥重要作用.

关键词：集合预报多圈层相互作用初始扰动 ENSO

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Keplerate polyoxomolybdate nanoball mediated controllable preparation of metal-doped molybdenum disulfide for electrocatalytic hydrogen evolution in acidic and alkaline media

引用

Chinese Chemical letters 2024年第7期35卷 524-528页

作者： Ping Wang Ting Wang Ming Xu Ze Gao Hongyu li Bowen li yuqi Wang Chaoqun Qu Ming feng Key.l.boratory of Functional Materials Physics and Chemistry of the Ministry of Education Jilin Normal UniversityChangchun 130103China School of Science Changchun University of Science and TechnologyChangchun 130022China

Rationally designed novel cost-effective hydrogen evolution reaction(HER)electrocatalysts with controlled surface composition and advanced structural superiority is extremely critical to optimize the HER ***(POMs)with structural diversity and adjustable element compositions represent a promising precursor for rational design and preparation of HER ***,a series of transition metal-doped MoS_(2)materials with different surface engineered structures(Fe,Cr,V doping and S vacancies)(M-MoS_(2)/CC,M=Fe,Cr and V)were fabricated by a simple hydrothermalvulcanization strategy using Keplerate polyoxomolybdate nanoball({Mo_(72)Fe_(30)},{Mo_(72)Cr_(30)},{Mo_(72)V_(30)},{Mo_(132)})as *** enlarged interlayer spacing as well as the integration of homogeneous transition metal doping and abundant sulfur vacancies endows prepared M-MoS_(2)/CC with superior HER electrocatalytic performance and excellent long-term working stability in both acidic and alkaline *** optimized Fe-MoS_(2)/CC afford current densities of 10 and 50 mA/cm^(2)at overpotentials of 188/272 mV and 194/394 mV in 0.5 mol/l H_(2)SO_(4)and 1.0 mol/l KOH aqueous solution,respectively,outperforming most of reported typical transition metal sulfide-based *** work represents an important breakthrough for POMs-mediated highly efficient transition metal sulfide-based HER electrocatalysts with wide range pH activity and may provide new options for the rational design of promising HER electrocatalysts and beyond.

关键词： Polyoxometalate Electrocatalytic Hydrogen evolution reaction Doping MoS_(2)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Novel long QT Syndrome Type 2-associated F129I Mutation in the KCNH2 Gene Significantly Affects IKr Through the hERG1 Homomeric and Heteromeric Potassium Channels

引用

Cardiology Discovery 2024年第2期4卷 174-182页

作者： li feng Kejuan Ma Xin li Nian liu Deyong long Changsheng Ma Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityNational Clinical Research Center for Cardiovascular DiseasesBeijing 100029China Community Health Service Center of Beijing Nomal University Beijing 100875China.

Objective:The long QT syndrome type 2 is caused by the loss-of-function mutations in the KCNH2 gene,which encodes hERG1,the voltage-gated potassium *** hERG1 channels conduct rapid delayed rectifier K^(+)currents(I_(Kr))in the human cardiac ***2 encodes 2 main isoforms-hERG1a and hERG1b,which assemble to form the homomeric or heteromeric hERG1 ***,the functional characteristics of the heteromeric hERG1 channels in long QT syndrome type 2 are not *** this study,a novel mutation in the N-terminus of hERG1a(F129l)was identified in a proband of long QT syndrome type *** purpose of this study was to identify the electrophysiological change of homomeric and heteromeric hERG1 channels with ***:Candidate genes were screened by direct sequencing.F129l-hERG1a was cloned in the pcDNA3.1 vector by site-directed ***,the wild-type(WT)hERG1a and/or F129l-hERG1a were transiently expressed in the HEK293 cells with or without hERG1b *** expression levels of the transgenes,cellular distribution of hERG1a and hERG1b,and the electrophysiological features of the homomeric and the heteromeric hERG1 channels with the WT-hERG1a or F129l-hERG1a were analyzed using whole-cell patch-clamp electrophysiology,western blotting,and immunofluorescence ***:The proband was clinically diagnosed with long QT syndrome type 2 and carried a heterozygous mutation c.385T>A(F1291)in the KCNH2 *** study proved that the F129l substitution in hERG1a significantly decreased I_(Kr) in both the homomeric and heteromeric hERG1channels by 86%and 70%,respectively(WT-hERG1a(54.88±18.74)pA/pF vs.F129l-hERG1a(7.34±1.90)pA/pF,Pl-hERG1a/hERG1b(26.54±9.83)pA/pF,Pltage dependence of I_(Kr) activation(V_(1/2) and k)was not affected by the mutation in both the homomeric and heteromeric hERG1 *** peak current densities and the kinetic charact

关键词： long QT syndrome Arrhythmia lon channels hERG

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

银耳多糖的结构、功能性及应用研究进展

引用

食品工业科技 2024年第4期45卷 362-370页

作者：许欢怡李泉岑郑明锋刘斌吕峰曾峰福建农林大学食品科学学院福建福州350002 福建省亚热带果蔬加工工程技术研究中心福建福州350002 国家菌草工程技术研究中心福建福州350002

银耳富含营养素,银耳多糖是其中最主要的功能活性成分,具有多种生物活性。银耳多糖的制备方法多样,对于其结构的研究多集中在分子量、单糖组分和糖苷键类型等方面。本文综述了银耳多糖的制备、结构和抗氧化、抗肿瘤、调节免疫、改善记... 详细信息

银耳富含营养素,银耳多糖是其中最主要的功能活性成分,具有多种生物活性。银耳多糖的制备方法多样,对于其结构的研究多集中在分子量、单糖组分和糖苷键类型等方面。本文综述了银耳多糖的制备、结构和抗氧化、抗肿瘤、调节免疫、改善记忆、抗炎、降血糖和降血脂等生物活性及其在食品、化妆品和医药方面的开发应用。未来需要优化银耳多糖的制备技术,结合现代分析技术解析银耳多糖的高级结构,对银耳多糖的功能及作用机理进行深入的研究,以期为银耳的精深加工与产品研发提供理论参考。

关键词：银耳多糖结构分子量功能性构效关系

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tungsten pnictides for water electrolysis:advances and perspectives

引用

Tungsten 2024年第4期6卷 675-695页

作者： Xue Kang Xi-Han Tan Ning Han Jian-feng Hou Chen-Min yao Zhi-Jie Chen Bing-Jie Ni Department of Chemistry and Chemical Engineering Lyuliang University Department of Materials Engineering State Key.l.boratory of Oral & Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of Education Hubei Key Laboratory of Stomatology School & Hospital of Stomatology Wuhan University School of Civil and Environmental Engineering The University of New South Wales

Hydrogen fuel is recognized as a promising energy carrier for the sustainable development of global energy system and the green hydrogen production via water electrolysis attracts great *** development of cost-effective electrocatalysts for water electrolysis is important for enhancing green hydrogen production ***,tungsten pnictides(phosphides and nitrides) have emerged as promising catalysts for water electrolysis,and efficient tungsten pnictide-based catalysts with different nanostructures,compositions,and surface chemical properties have been *** this review,recent progress in the design of tungsten pnictide-based electrocatalysts for water electrolysis is comprehensively *** synthesis of tungsten pnictide-based electrocatalysts are discussed ***,current achievements in developing efficient tungsten pnictide electrocatalysts for water electrolysis are detailed,and four key catalyst design strategies(i.e.,nanostructure control,heteroatom doping,defect engineering,and heterostructure design) are *** physicochemical properties-catalytic performance relationship of tungsten pnictide-based electrocatalysts is also *** last,perspectives in this field are put forward for guiding further research on the design and application of high-performance tungsten pnictide-based electrocatalysts.

关键词： Electrocatalysts Hydrogen evolution reaction Oxygen evolution reaction Tungsten nitrides Tungsten phosphides

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

High-rate electrochemical H_(2)O_(2) production over multimetallic atom catalysts under acidic–neutral conditions

引用

Carbon Energy 2024年第1期6卷 44-62页

作者： yueyu Tong Jiaxin liu Bing-Jian Su Jenh-yih Juang feng Hou lichang yin Shi Xue Dou Ji liang Key.l.boratory for Advanced Ceramics and Machining Technology of Ministry of Education School of Materials Science and EngineeringTianjin UniversityTianjinChina Institute for Superconducting and Electronic Materials University of WollongongInnovation CampusNorth WollongongNew South WalesAustralia Department of Electrophysics National Chiao Tung UniversityHsinchuTaiwanChina Shenyang National laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyangLiaoningChina Institute of Energy Materials Science University of Shanghai for Science and TechnologyShanghaiChina

Hydrogen peroxide(H_(2)O_(2))production by the electrochemical 2-electron oxygen reduction reaction(2e−ORR)is a promising alternative to the energy-intensive anthraquinone process,and single-atom electrocatalysts show the unique capability of high selectivity toward 2e−ORR against the 4e−*** extremely.l.w surface density of the single-atom sites and the inflexibility in manipulating their geometric/electronic configurations,however,compromise the H_(2)O_(2) yield and impede further performance ***,we construct a family of multiatom catalysts(MACs),on which two or three single atoms are closely coordinated to form high-density active sites that are versatile in their atomic configurations for optimal adsorption of essential*OOH *** them,the Cox–Ni MAC presents excellent electrocatalytic performance for 2e−ORR,in terms of its exceptionally high H_(2)O_(2) yield in acidic electrolytes(28.96 mol l^(−1) gcat.^(−1) h^(−1))and high selectivity under acidic to neutral conditions in a wide potential region(>80%,0–0.7 V).Operando X-ray absorption and density functional theory analyses jointly unveil its unique trimetallic Co2NiN8 configuration,which efficiently induces an appropriate Ni–d orbital filling and modulates the*OOH adsorption,together boosting the electrocatalytic 2e−ORR *** work thus provides a new MAC strategy for tuning the geometric/electronic structure of active sites for 2e−ORR and other potential electrochemical processes.

关键词： hydrogen peroxide production multiatom catalysts operando X-ray adsorption spectrum reaction mechanism tendency structure-property relation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Pearl yangxin Anshen Decoction on HAMD and PTSD-SS Scores, Cytokines and Related Metabolites in Patients with Post-Traumatic Stress Disorder

引用

Journal of Behavioral and Brain Science 2024年第3期14卷 93-102页

作者： yu feng Min Guo Department of Gastroenterology The Fourth People’s Hospital of Haikou Haikou China

Objective: This paper aims to observe the Pearl yangxin Anshen Decoction to influence the score of HAMD and PTSD-SS, the changes of the cytokines and the related metabolic product in patients with PTSD. Methods: From June 2015 to May 2016, in the traditional Chinese medicine clinics of Hainan Province People’s Hospital, there were 50 patients with PTSD, the age were from 30 to 60, they were randomly divided into treatment group (25 cases) and control group (25 cases), then compared the scores of HAMD and PTSD-SS between the two groups, searched the changes of cytokines and the related metabolic product. Results: In the treatment group: before and after treatment the scores of PTSD-SS were 65.64 ± 7.02, 28.32 ± 4.18, and the scores of HAMD were 29.28 ± 1.97, 11.72 ± 2.13;In the control group: before and after treatment the scores of PTSD-SS were 63.24 ± 6.16, 31.40 ± 4.29, the scores of HAMD were 30.24 ± 2.05, 13.08 ± 2.30. After 3 months patients in treatment group the scores of PTSD-SS and HAMD were lower than the control group (t = 2.570, P = 0.013, t = -2.1640, P = 0.035). In the control group: before and after 3 months treatment the Il-2 levels respectively were 79.84 ± 26.46 pg/ml, 56.18 ± 22.67 pg/ml, the Il-6 levels respectively were 110.83 ± 47.65 pg/ml, 59.67 ± 44.68 pg/ml, the Il-8 levels respectively were 73.11 ± 78.51 pg/ml, 55.83 ± 81.94 pg/ml, the NE levels respectively were 420.04 ± 674.75 pg/ml, 185.31 ± 417.91 pg/ml, the MDA levels respectively were 112.35 ± 62.87 ng/ml, 60.42.33 ± 53.64 ng/ml, the NO levels were 126.6 ± 47.4 μmol/l, 78.6 ± 45.7 μmol/l, the VIP levels were 396.6 ± 144.4 pg/ml, 122.4 ± 111.5 pg/ml. In the treatment group: before and after 3 months treatment the Il-2 levels respectively were 86.00 ± 32.29 pg/ml, 53.84 ± 27.01 pg/ml, the Il-6 levels respectively were 108.21 ± 44.60 pg/ml, 42.46 ± 42.16 pg/ml, the Il-8 levels respectively were 81.48 ± 94.19 pg/ml, 54.07 ± 84.15 pg/ml, the NE levels respectively were 392.93 ± 592.84 pg/m

关键词： Post-Traumatic Stress Disorder Psychological Intervention Serological Detection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：