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中国抗生素杂志 2008年第6期33卷 321-324,332页

作者：罗威顾觉奋中国药科大学生命科学与技术学院南京210009

本文概述了以β-酮脂酰-ACP合成酶(Fab)为靶点的新型抗生素的开发背景、筛选模型的构建以及最新筛选成果。并对一种很有希望用于临床的Fab抑制剂platensimycin进行了详细介绍。

关键词： β-酮脂酰-ACP合成酶反义RNA 双平板鉴定耐药菌 Platensimycin

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重症手足口病并发心肺衰竭321例临床分析

临床儿科杂志 2017年第4期35卷 264-267页

作者：谷芬湖南省儿童医院感染科湖南长沙410007

目的分析重症手足口病(HFMD)并发心肺衰竭患儿的临床及流行病学特点,并寻找重症相关危险因素。方法回顾分析2014年1月至2014年12月因手足口病住院,且临床分期为2期及以上患儿的临床资料。结果共入选321例重症手足口病住院患儿,普通组(... 详细信息

目的分析重症手足口病(HFMD)并发心肺衰竭患儿的临床及流行病学特点,并寻找重症相关危险因素。方法回顾分析2014年1月至2014年12月因手足口病住院,且临床分期为2期及以上患儿的临床资料。结果共入选321例重症手足口病住院患儿,普通组(临床分期2期)306例,无死亡病例;心肺衰竭组(临床分期3、4期)15例,7例死亡,两组病死率差异有统计学意义(P<0.001)。心肺衰竭组中位年龄9个月(6~20月龄),低于普通组的24月龄(3月龄~12岁),差异有统计学意义(P<0.01)。心肺衰竭组患儿热峰(39.44±0.23)℃、热程(5.01±0.94)d,高于普通组的(39.12±0.20)℃、(3.93±0.47)d,差异有统计学意义(P均<0.05)。心肺衰竭组呕吐、意识障碍、外周循环障碍、呼吸节律不齐以及肺水肿的发生率均高于普通组,差异有统计学意义(P均<0.001)。心肺衰竭组肠道病毒71型(EV71)阳性率85.7%,高于普通组的61.4%,差异有统计学意义(P<0.01);心肺衰竭组N末端脑钠肽前体(NT-pro BNP)水平均增高(100.0%),普通组35.3%增高,差异有统计学意义(P<0.001)。结论儿童HFMD出现呕吐、意识障碍、循环障碍、呼吸节律紊乱,以及EV71阳性和NT-pro BNP水平升高,存在发生心肺衰竭的风险,需重点监测病情变化。

关键词：手足口病心肺衰竭危险因素儿童

Analysis of Changes in BDNF Levels Before and After Bariatric Surgery in Obese Patients

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Journal of Clinical and Nursing Research 2023年第5期7卷 169-174页

作者： Xiaoxu Zhang Bei Xu Chaofan Liu Bing Wang fen gu Nursing Department of Shanghai Ninth People's Hospital Shanghai Jiaotong University School of MedicineShanghai 200011China Tongji University School of Medicine ShanghaiChina General Surgery Department of Shanghai Ninth People's Hospital Shanghai Jiaotong University School of MedicineShanghai 200011China

Objectives:The rate of obesity has been increasing globally,so is the number of obese patients undergoing bariatric *** relationship between brain-derived neurotrophic factor(BDNF)and body weight has been highlighted in recent years,but there are few related studies in *** purpose of this study was to investigate the changes of BDNF in obese patients before and after bariatric surgery and to provide evidence for obesity-related ***:The BDNF levels in 44 obese patients who underwent bariatric surgery were measured by enzyme-linked immunosorbent assay(ELISA)before and 4.5 months after *** 27.0 was used for statistical ***:Among the 44 patients,30 were female and 14 were *** body mass index(BMI)decreased significantly after bariatric surgery(P0.05).There were no significant differences in BMI and BDNF levels between different sexes before and after surgery(P>0.05).Conclusion:The BDNF levels of obese patients increased significantly after bariatric surgery,which proved that bariatric surgery has an effect on BDNF levels.

关键词： Obesity BDNF Bariatric surgery

Measurement of macular pigment optical density among healthy Chinese people and patients with early-stage age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1190-1195页

作者： Xue-Tao Ren Hong gu Xu Han Jun-Yan Zhang Xue Li Xiu-fen Yang Jun Xu Torkel Snellingen Xi-Pu Liu Ning-Li Wang Ning-Pu Liu Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical University Beijing Ophthalmology and Visual Sciences Key Laboratory Sekwa Eye Hospital Department of Ophthalmology the First Hospital of Tsinghua University

AIMTo measure the macular pigment optical density (MPOD) in healthy Chinese people and patients with early age-related macular degeneration (AMD).METHODSCross-sectional population based study. Demographic and lifestyle characteristics were ascertained by questionnaire. A food frequency questionnaire was completed for all participants. Participants underwent general physical and ophthalmic examinations and MPOD was measured by heterochromatic flicker photometry. Foveal architecture was measured by optical coherence *** of 225 participants (122 healthy and 103 early AMD) was 0.48±0.18. Patients with early AMD (0.52±0.19) tended to have higher MPOD levels than healthy people (0.47±0.17), but the difference was not statistically significant (P=0.06). Participants with carrot or corn oil intake every week tended to have higher levels of MPOD (P=0.002 and 0.008 respectively) while those with corn intake had relatively lower level of MPOD (P=0.01). MPOD increased with the center foveal thickness (P=0.01).CONCLUSIONOur findings show that there is no statistically significant association between MPOD and early AMD in the studied population. MPOD is related to center foveal thickness and diets would influence MPOD levels.

关键词： age-related macular degeneration diets foveal architecture macular pigment optical density

Identification of Dominant Climate Variables on Spatiotemporal Variation in Reference Evapotranspiration on the Loess Plateau,China

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Chinese Geographical Science 2022年第4期32卷 620-642页

作者： LI Xiaofei LIANG Wei JIAO Lei YAN Jianwu ZHANG Weibin WANG fengjiao GOU fen WANG Chengxi SHAO Quanqin School of Geography and Tourism Shaanxi Normal UniversityXi’an 710119China National Demonstration Center for Experimental Geography Education Shaanxi Normal UniversityXi’an 710119China Xi’an gu Bo Electronic Intelligent Technology Co. LtdXi’anChina Key Laboratory of Terrestrial Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Reference evapotranspiration(ET_(0))is a vital component in hydrometeorological research and is widely applied to various aspects,such as water resource management,hydrological modeling,irrigation deployment,and understanding and predicting the influence of hydrologic cycle variations on future climate and land use *** the influence of various meteorological variables on ET_(0) is not only helpful for predicting actual evapotranspiration but also has important implications for understanding the impact of global climate change on regional water *** on daily data from 69 meteorological stations,the present study analyzed the spatiotemporal pattern of ET_(0) and major contributing meteorological variables to ET_(0) from 1960 to 2017 by the segmented re-gression model,Mann-Kendall test,wavelet analysis,generalized linear model,and detrending *** results showed that the annual ET_(0) declined slightly because of the combined effects of the reduction in solar radiation and wind speed and the increase in vapor pressure deficit(VPD)and average air temperature in the Loess Plateau(LP)during the past 58 *** change points were detected in 1972,1990,1999,and 2010,and the annual ET_(0) showed a zigzag change trend of‘increasing-decreasing-increasing-decreasing-increasing’.Wind speed and VPD played a leading role in the ET_(0) changes from 1960 to 1990 and from 1991 to 2017,*** study confirms that the dominant meteorological factors affecting ET_(0) had undergone significant changes due to global climate change and vegetation greening in the past 58 years,and VPD had become the major factor controlling the ET_(0) changes on the *** data presented herein will contribute to increasing the accuracy of predictions on future changes in ET_(0).

关键词： reference evapotranspiration(ET0) change points generalized linear model dominant factors vapor pressure deficit(VPD) Loess Plateau(LP)

X射线荧光光谱法同时测定煤灰中的12种成分

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光谱学与光谱分析 2008年第6期28卷 1430-1434页

作者：宋义郭芬谷松海天津出入境检验检疫局天津300456

采用熔融制样法,用X射线荧光光谱法同时测定煤灰中的常量、少量和微量成分SiO2,Al2O3,Fe2O3,CaO,SO3,TiO2,K2O,Na2O,P2O5,MgO,MnO,BaO。选用混合熔剂并加入氧化剂的方式降低熔融温度,解决了硫的准确测量问题。同时通过选用土壤等标准样... 详细信息

采用熔融制样法,用X射线荧光光谱法同时测定煤灰中的常量、少量和微量成分SiO2,Al2O3,Fe2O3,CaO,SO3,TiO2,K2O,Na2O,P2O5,MgO,MnO,BaO。选用混合熔剂并加入氧化剂的方式降低熔融温度,解决了硫的准确测量问题。同时通过选用土壤等标准样品解决了煤灰成分标准样品不足的问题。应用可变理论α系数及固定α系数法进行基体效应校正,所得结果与化学法的分析结果相符合。

关键词： X射线荧光光谱 XRF 煤灰元素

Site-directed mutagenesis identified the key active site residues of alcohol acyltransferase PpAAT1 responsible for aroma biosynthesis in peach fruits

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Horticulture Research 2021年第1期8卷 368-377页

作者： Zhi-Zhong Song Bin Peng Zi-Xia gu Mei-Ling Tang Bei Li Mei-Xia Liang Li-Min Wang Xiao-Tong guo Jian-Ping Wang Yu-fen Sha Hong-Xia Zhang The Engineering Research Institute of Agriculture and Forestry Ludong University186 Hongqizhong RoadYantai 264025China Key Laboratory of Molecular Module-Based Breeding of High Yield and Abiotic Resistant Plants in Universities of Shandong(Ludong University) 186 Hongqizhong RoadYantai 264025China Institute of Botany Jiangsu Province and Chinese Academy of Sciences1 QianhuhoucunNanjing 210014China Yantai Academy of Agricultural Science 26 Gangcheng West StreetYantai 265500China

The aroma of peach fruit is predominantly determined by the accumulation of γ-decalactone and ester compounds.A previous study showed that the biosynthesis of these aroma compounds in peach fruit is catalyzed by PpAAT1,an alcohol *** this work,we investigated the key active site residues responsible for γ-decalactone and ester biosynthesis.A total of 14 candidate amino acid residues possibly involved in internal esterification and 9 candidate amino acid residues possibly involved in esterification of PpAAT1 were assessed via site-directed *** of the in vitro enzyme activities of PpAAT1 and its site-directed mutant proteins(PpAAT1-SMs)with different amino acid residue mutations as well as the contents of γ-decalactone in transgenic tobacco leaves and peach fruits transiently expressing PpAAT1 and PpAAT1-SMs revealed that site-directed mutation of H165 in the conserved HxxxD motif led to lost enzymatic activity of PpAAT1 in both internal esterification and its reactions,whereas mutation of the key amino acid residue D376 led to the total loss ofγ-decalactone biosynthesis activity of *** of 9 and 7 other amino acid residues also dramatically affected the enzymatic activity of PpAAT1 in the internal esterification and esterification reactions,*** findings provide a biochemical foundation for the mechanical biosynthesis ofγ-decalactone and ester compounds catalyzed by PpAAT1 in peach fruits,which could be used to guide the molecular breeding of new peach species with more favorable aromas for consumers.

关键词： residues directed alcohol

硝化后熔融制样法——X射线荧光光谱同时测定锰矿中主、次元素

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光谱学与光谱分析 2007年第2期27卷 404-407页

作者：宋义郭芬谷松海天津出入境检验检疫局化矿实验室天津塘沽300456

采用X射线荧光光谱法同时测定锰矿中Mn,SiO2,Fe,P,Al2O3,CaO,MgO和S等8个组分。因锰矿熔融制样过程中产生气泡现象严重,影响到测定的准确性和重现性,文章提出了先加硝酸破坏锰矿样品中的有机物,然后用12∶22混合熔剂在1000℃熔融制样的... 详细信息

采用X射线荧光光谱法同时测定锰矿中Mn,SiO2,Fe,P,Al2O3,CaO,MgO和S等8个组分。因锰矿熔融制样过程中产生气泡现象严重,影响到测定的准确性和重现性,文章提出了先加硝酸破坏锰矿样品中的有机物,然后用12∶22混合熔剂在1000℃熔融制样的方法,解决了锰矿熔融制样过程中有机物挥发产生大量的气泡导致熔剂飞溅的问题,消除了试样的粒度效应和矿物效应,同时也解决了硫元素在制样过程中容易挥发的难题。对熔剂、熔融时间、硝酸加入量等制样条件进行了选择,并采用可变理论α系数法校正基体的吸收增强效应,扩大了测定线形范围,进行了方法的精密度及准确度试验。与化学法对比,本法测定锰矿中各组分的定量分析结果令人满意,方法准确、快速、简便。

关键词： X射线荧光光谱锰矿硝化后熔融制样制样

糖皮质激素联合抗结核药物治疗对结核性浆膜炎有效性、不良反应及病死率的Meta分析

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中国防痨杂志 2025年第1期47卷 77-86页

作者：石宜林顾岩内蒙古医科大学附属医院呼吸与危重症医学科A区呼和浩特010030 内蒙古自治区第四医院急诊科呼和浩特010000

目的:系统评价糖皮质激素联合抗结核药物治疗结核性浆膜炎有效率、不良反应及病死率的变化。方法:采用主题词与自由词相结合的方式,从中国知网、万方、维普、中国生物医学文献数据库、PubMed和Web of Science中检索糖皮质激素联合抗结... 详细信息

目的:系统评价糖皮质激素联合抗结核药物治疗结核性浆膜炎有效率、不良反应及病死率的变化。方法:采用主题词与自由词相结合的方式,从中国知网、万方、维普、中国生物医学文献数据库、PubMed和Web of Science中检索糖皮质激素联合抗结核药物治疗结核性浆膜炎的随机对照实验(RCT)并纳入研究文章中的参考文献,检索时限均从建库至2024年8月1日。中文检索词包括肺外结核、结核性脑膜炎、结核性胸膜炎、结核性心包炎、糖皮质激素、类固醇激素、地塞米松、甲泼尼龙等;英文检索词包括extrapulmonary tuberculosis,tuberculous meningitis,tuberculous pleurisy,tuberculous pericarditis,glucocorticoids,steroid hormones,dexamethasone,methylprednisolone等。由2名研究人员独立筛选文献、提取数据、评价文献质量后,采用Stata 15.1软件对纳入的数据进行异质性检验分析及发表偏倚分析,以对结核性浆膜炎在抗结核治疗的基础上应用糖皮质激素后的有效性、不良反应及病死率等进行综合评价。结果:共检索到相关文献4619篇,排除不符合入组标准的文献后最终纳入31篇文献、2410例患者进行Meta分析,其中,抗结核治疗联合糖皮质激素治疗组患者(观察组)1228例,仅抗结核治疗组患者(对照组)1182例;根据疾病类型将患者再分为结核性脑膜炎组(包括23项研究,观察组876例,对照组876例)、结核性胸膜炎组(包括6项研究,观察组280例,对照组276例)和结核性心包炎组(包括2项研究,观察组72例,对照组30例)。Meta分析结果显示,与对照组相比,联合糖皮质激素对结核性脑膜炎、结核性胸膜炎和结核性心包炎的治疗有效性均更好[OR(95%CI)=4.63(3.48~6.17)、6.62(3.55~12.34)、7.92(2.44~25.66)]、对结核性脑膜炎的病死率更低[OR(95%CI)=0.45(0.23~0.87)],对结核性胸膜炎的不良反应更少[OR(95%CI)=0.31(0.18~0.52)]。结论:糖皮质激素联合抗结核药物治疗可提高结核性脑膜炎、结核性胸膜炎和结核性心包炎治疗有效性,降低结核性脑膜炎病死率和结核性胸膜炎药物不良反应。

关键词：结核浆膜炎抗结核药糖皮质激素类治疗结果 Meta分析(主题)

硒及硒纳米颗粒生物学机制与口腔常见疾病的关系

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中国组织工程研究 2025年第22期29卷 4813-4822页

作者：彭璐瑶顾瑜遵义医科大学珠海校区广东省珠海市519041 贵州省高等学校口腔疾病研究特色重点实验室贵州省遵义市563000

背景:硒作为人体所需的微量非金属元素具有抗炎、抗氧化、抗菌、免疫调节和抗肿瘤等生物活性,已经在生物医学领域得到广泛应用。目的:总结硒及其纳米颗粒在抗炎、抗氧化、抗菌、免疫调节和抗肿瘤方面的功能和作用机制,以及在口腔医学领... 详细信息

背景:硒作为人体所需的微量非金属元素具有抗炎、抗氧化、抗菌、免疫调节和抗肿瘤等生物活性,已经在生物医学领域得到广泛应用。目的:总结硒及其纳米颗粒在抗炎、抗氧化、抗菌、免疫调节和抗肿瘤方面的功能和作用机制,以及在口腔医学领域的研究进展。方法:以“selenium,selenium nanoparticles,oral neoplasms,caries,dental pupal disease,periapical disease,dental implant”为英文检索词,以“硒,硒纳米颗粒,口腔癌,龋病,牙髓病,根尖周病,口腔种植”为中文检索词,分别在PubMed、中国知网、万方数据库进行文献检索,检索文献时限为2000年1月至2024年2月。经过对文献的深入分析和仔细阅读,最后选择74篇文献进行全面综述。结果与结论:(1)硒的生物学特性主要是通过合成硒蛋白,以抗氧化机制为核心,调节各种细胞因子和介导与之相关的信号通路,进而产生抗菌、免疫调节、抗肿瘤等作用;(2)硒除了在口腔癌、龋病、牙髓根尖周病等方面可用于早期诊断、治疗和预后判断外,更多的是可作为新型口腔材料在口腔领域应用,例如:用于开发新型牙科封闭剂或根管系统消毒剂,又或在优化口腔种植材料性能等方面有所应用;(3)生物安全性是影响硒在生物医药领域应用的最重要因素之一,选择合适的剂量和形式才能使其发挥出良好作用。硒在口腔材料学方面展现出了巨大的应用潜力和广阔的发展空间。

关键词：硒硒纳米颗粒口腔癌龋病牙髓根尖周病口腔种植