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Chinese Chemical Letters 2023年第7期34卷 102-106页

作者： Weitao Yan Mingwen Zheng Peihsuan Chuang Hao Sun Shiping Wang Chunfa Xu fen-Er chen Institute of Pharmaceutical Science and Technology College of ChemistryFuzhou UniversityFuzhou 350108China National Engineering Research Center of Chemical Fertilizer Catalyst College of Chemical EngineeringFuzhou UniversityFuzhou 350108China Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs Fudan University.Shanghai 200433China

A highly efficient coupling of glycosyl stannanes and sulfonium salts enabled by synergistic Pd/Cu catalysis is disclosed, facilitating the construction of C-aryl/alkenyl glycals under mild conditions in high *** protocol tolerates a wide scope of functional groups including ketone, cyano, ester, amide, nitro,halide. The one-pot formal C–H glycosylation starting from arene is demonstrated with a reaction sequence of dibenzothiophenylation/Stille coupling. Besides, a gram-scale reaction is performed successfully,showing the high applicability of this protocol.

关键词： C-glycals Sulfonium salts Synergistic catalysis Carbohydrate Glycosyl stannanes Stille coupling

Recent advances using cyclopropanols and cyclobutanols in ring-openingasymmetric synthesis

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Green Synthesis and Catalysis 2022年第3期3卷 219-226页

作者： Hong Yan Gregory S.Smith fen-Er chen Institute of Pharmaceutical Science and Technology College of ChemistryFuzhou UniversityFuzhou 350108China Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs Fudan UniversityShanghai 200433China Department of Chemistry University of Cape TownRondeboschCape Town 7700South Africa

Due to high ring strain energies,cyclopropanols and cyclobutanols have a strong tendency of breaking theendocyclic C–C bonds to participate in versatile organic *** an inherent three-dimensionalstructure,cyclopropanols and cyclobutanols have the advantage of synthesizing linear or cyclic molecules withstereogenic centers via ring-opening asymmetric *** are three strategies for the ring-opening ofcyclopropanols and cyclobutanols usually involved in asymmetric synthesis:1)β-carbon elimination of metalalkoxide;2)radical ring-opening;3)ring-opening via semipinacol *** present review has high-lighted the progress developed in the last five years.

关键词： Cyclopropanol Cyclobutanol Ring-opening C–C bond cleavage Asymmetric synthesis

Clinical and microstructural changes with different iontophoresis-assisted corneal cross-linking methods for keratoconus

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International Journal of Ophthalmology(English edition) 2019年第2期12卷 219-225页

作者： Kai Liao Min Hu fen chen Pei Li Peng Song Qing-Yan Zeng Aier School of Ophthalmology Central South University Hankou Aier Eye Hospital

AIM: To compare the clinical and microstructural changes induced by different transepithelial iontophoresis-assisted corneal cross-linking(I-CXL) methods for keratoconus. METHODS: A total of 42 eyes of 42 patients with progressive keratoconus were divided into two groups. Group A received I-CXL for 5 min, while group B received I-CXL for 10 min. Visual acuity, optical coherence tomography(OCT), specular microscopy and confocal microscopy were evaluated preoperatively and at 1, 3, 6, and 12 mo postoperatively. RESULTS: Twelve months after the operation, uncorrected visual acuity(UCVA) and corrected distance visual acuity(CDVA) were improved in both groups, with a better outcome in the I-CXL 10 min group(P=0.025, 0.021, respectively). Kmax values decreased by 0.94±3.00 D in the I-CXL 10 min group(P=0.033) but increased by 1.87±3.29 D in the I-CXL 5 min group(P=0.012). OCT scans showed that the demarcation line was most visible and substantially deeper in the I-CXL 10 min group. Confocal microscopy showed greater anterior stromal keratocyte decreases in the I-CXL 10 min group than in the I-CXL 5 min group at 3 and 6 mo postoperatively(P<0.001); however, anterior stromal keratocytes and subbasal nerve density were not significantly different between the two groups at 12 mo postoperatively. CONCLUSION: I-CXL for 10 min more effectively halts the progression of keratoconus than I-CXL for 5 min after 12 mo of follow-up. However, long-term studies are needed to evaluate the efficacy and safety of I-CXL.

关键词： keratoconus transepithelial corneal crosslinking iontophoresis anterior stromal keratocyte subbasal nerve density

Targeting metabolism:A potential strategy for hematological cancer therapy

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World Journal of Clinical Cases 2022年第10期10卷 2990-3004页

作者： Xue Tang fen chen Li-Chun Xie Si-Xi Liu Hui-Rong Mai Department of Hematology and Oncology Shenzhen Children’s HospitalShenzhen 518038Guangdong ProvinceChina

Most hematological cancer-related relapses and deaths are caused by metastasis;thus,the importance of this process as a target of therapy should be *** cancer is a type of cancer in which metabolism plays an essential role in ***,we are required to block fundamental metastatic processes and develop specific preclinical and clinical strategies against those biomarkers involved in the metabolic regulation of hematological cancer cells,which do not rely on primary tumor *** understand progress in this field,we provide a summary of recent developments in the understanding of metabolism in hematological cancer and a general understanding of biomarkers currently used and under investigation for clinical and preclinical applications involving drug *** signaling pathways involved in cancer cell metabolism are highlighted and shed light on how we could identify novel biomarkers involved in cancer development and *** review provides new insights into biomolecular carriers that could be targeted as anticancer biomarkers.

关键词： Metabolism Metastasis Hematological cancer Biomarker Cancer Anticancer

Asymmetric catalytic hydrogenation of imines and enamines in natural product synthesis

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Green Synthesis and Catalysis 2020年第1期1卷 26-41页

作者： Pei Tang Huijing Wang Wen Zhang fen-Er chen Sichuan Research Center for Drug Precision Industrial Technology West China School of PharmacySichuan UniversityChengdu 610041China Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs Shanghai 200433China

Asymmetric catalytic hydrogenations of imines and enamines with chiral transition-metal complexes bearing chiral ligands are among the most green and powerful approaches for the elaboration of chiral amine structures in organic *** review focuses on recent applications of asymmetric hydrogenations of imine and enamine substrates in the total syntheses of natural *** applications include diverse processes involving asymmetric transfer hydrogenation(ATH)and asymmetric hydrogenation(AH)to form key chiral amine motifs in natural products with good efficiency and high-level enantiocontrol.

关键词： Asymmetric catalytic hydrogenation Imine substrates Enamine substrates Natural product synthesis Enantioselectivity

Risk of critical limb ischemia in long-term uterine cancer survivors:A population-based study

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World Journal of Clinical Cases 2022年第36期10卷 13293-13303页

作者： Min-Chi chen Jung-Jung Chang Miao-fen chen Ting-Yao Wang Cih-En Huang Kuan-Der Lee Chao-Yu chen Department of Public Health Chang Gung UniversityTaoyuan 333Taiwan Department of Obstetrics and Gynecology Chang Gung Memorial HospitalChiayi 612Taiwan Division of Cardiovascular Disease Department of Internal MedicineChang Gung Memorial HospitalChiayi 612Taiwan Department of Radiation Oncology Change Gung Memorial HospitalLinkouTaoyuan 333Taiwan Division of Hematology and Oncology Department of Internal MedicineChang Gung Memorial HospitalChiayi 612Taiwan Graduate Institute of Clinical Medical Sciences College of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Medicine Taipei Medical University HospitalTaipei 100Taiwan Department of Medical Research Taichung Veterans General HospitalTaichung 407Taiwan Department of Post-Baccalaureate Medicine College of MedicineNational Chung Hsing UniversityTaichung 402Taiwan Department of Early Childhood Care and Education Shu-Zen Junior College of Medicine and ManagementKaohsiung 821Taiwan

BACKGROUND The risk of critical limb ischemia(CLI)which causes ischemic pain or ischemic loss in the arteries of the lower extremities in long-term uterine cancer(UC)survivors remains unclear,especially in Asian patients,who are younger at the diagnosis of UC than their Western *** To conduct a nationwide population-based study to assess the risk of CLI in UC long-term *** UC survivors,defined as those who survived for longer than 5 years after the diagnosis,were identified and matched at a 1:4 ratio with normal *** Cox models were used to assess the risk of *** From 2000 to 2005,1889 UC survivors who received surgery alone or surgery combined with radiotherapy(RT)were classified into younger(onset age65 years,aHR=2.48,P=0.011),had hypertension(aHR=2.18,P=0.008)or received HRT(aHR=3.52,P=0.020)were at a higher risk of *** In this nationwide study,we found that the risk factors associated with CLI were similar in both cohorts except for adjuvant RT that was negligible in the younger group,but positive in the older *** the survivors,hypertension,advanced age,and HRT were more hazardous than *** prevention should include CLI as a late complication in UC survivorship programs.

关键词： Uterine cancer Critical limb ischemia Radiotherapy Survivorship

Recent advances in remote C(sp^(3))-H functionalization via chelating group-assisted metal-catalyzed chain-walking reaction

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Chinese Chemical Letters 2024年第11期35卷 99-110页

作者： Jian Han Li-Li Zeng Qin-Yu Fei Yan-Xiang Ge Rong-Hui Huang fen-Er chen School of Pharmacy Changzhou UniversityChangzhou 213164China Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shenzhen Research Institute of Nanjing University Shenzhen 518057China

Aliphatic C(sp^(3))-H moieties are ubiquitous in numerous organic *** functionalization of inert C(sp^(3))-H bonds is a powerful and straightforward approach for the efficient construction of diverse carbon-carbon or carbon-heteroatom *** group directed metal-catalyzed remote functionalization of readily available alkenes has emerged as an appealing strategy for rapidly accessing various value-added aliphatic *** the aid of directing groups,variousα-,β-andγ-functionalized alkanes could be synthesized smoothly with excellent *** preferred formation of a stable five-or six-membered metallacycle intermediate terminates the chain-walking at a specific methylene site,which serves as the driving force for excellent site-selective migratory *** review herein is aimed at summarizing the recent progress on the metal-catalyzed regiodivergent functionalization of unactivated alkenes by merging alkene isomerization and cross-coupling with the assistance of directing *** but not least,the current situations and future directions in this field are highlighted and discussed.

关键词： Chelating group Chain-walking Regiodivergent Unactivated alkenes C(sp^(3))-H functionalization Transition-metal catalysis

Novel Efficient Method for Synthesis of N_(1,4)-Disubstituted-1,4-benzodiazepine-2,5-diones

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Chemical Research in Chinese Universities 2009年第3期25卷 312-316页

作者： WANG Qiu-yan YU Jing-jun LU Cui-fen chen Zu-xing YANG Gui-chun Key Laboratory for the Synthesis and Application of Organic Functional Molecules of Ministry of Education School of Chemistry and Chemical Engineering Hubei University Wuhan 430062 P. R. China

A novel and efficient method was developed for the liquid-phase synthesis of Nj,4-disubstitutedbenzodiazepine-2,5-diones with 2-chloro-5-nitrobenzoic acid as initiating material via 4 step reactions containing esterifieation, ＂Ulmn reaction＂, acylation, alkylation and cyclization. The reaction conditions were mild and the overall yields of the products ranged from 45% to 71%.

关键词： 1,4-Benzodiazepine-2,5-dione Liquid-phase Dipeptides

Maximal methane potential of different animal manures collected in northwest region of China

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International Journal of Agricultural and Biological Engineering 2017年第1期10卷 202-208页

作者： chen fen Yu Gao Li Wei Liu fenwu Zhang Wuping Bu Yushan Li Xiaomei College of Resource and Environment Science Shanxi Agricultural UniversityTaiguShanxi 030801China Environmental Planning Institute of Shanxi Province TaiyuanShanxi 030024China Alberta Innovates–Energy and Environment Solutions EdmontonAlbertaT5J 3G2Canada

Maximum methane potential(B0)is an important parameter used in assessing suitability of a substrate for biogas *** study examined maximum methane potential of different manures generated from three major Chinese livestock,namely chicken,hog and cattle,and evaluated the important factors that affect the maximum methane potential of a *** livestock manures collected from the local farms were incubated under a thermophilic anaerobic condition(55℃).The results showed that the maximum methane potential(B0)of cattle,hog and chicken manures were 292.0 mL/g VS,272.0 mL/g VS and 266.4 mL/g VS,*** B0 value decreases with increasing contents of crude protein and crude fat,while increases with increasing the contents of carbohydrates and crude fiber in *** content of NH4+-N in chicken manure was significantly higher during the digestion period,reached as high as 1962.5 mg/L by the end of incubation *** metals of Cu and Zn in the manure also affect the *** relationships that describe the B0 decrease in response to increase of Zn and Cu contents in manure were developed and used as a simple tool to assess the effects of these metals on the *** was concluded that the protein,Cu and Zn contents of manure are most important chemical compositions that negatively affect maximum methane *** on the three experimental manures,the maximum methane potential was limited by either ammonium content or Cu and Zn content in the *** a commercial biogas production facility using these manures as main feedstock,one should consider to add co-substrate or co-substrates to reduce concentration of these chemicals to maximize biogas production.

关键词： anaerobic digestion manure compositions biomethane potential volatile solid degradation

Perioperative and long-term results of ultrasonography-guided single-and multiple-tract percutaneous nephrolithotomy for staghorn calculi

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World Journal of Clinical Cases 2024年第7期12卷 1243-1250页

作者： Rui-Xiang cheng Ni Dai Yan-Min Wang Pei Qi fen chen Department of Urology Wuhan Ninth HospitalWuhan 430081Hubei ProvinceChina Department of Urinary Pain Wuhan Hankou HospitalWuhan 430000Hubei ProvinceChina Pre-hospital Emergency Department Wuhan Puren HospitalWuhan 430081Hubei ProvinceChina Department of Orthopedic Trauma Surgery Wuhan Hankou HospitalWuhan 430000Hubei ProvinceChina Department of Ultrasound Hubei Provincial Hospital of Integrated Traditional Chinese and Western MedicineWuhan 430015Hubei ProvinceChina

BACKGROUND It is possible that this condition will lead to urosepsis and progressive deterioration of renal function in the absence of surgical *** recent clinical studies have shown that multi-tract percutaneous nephrolithotomy(MPCNL)has a similar stone free rate(SFR)as standard percutaneous nephrolithotomy(S-PCNL).As a result,M-PCNL was also recommended as a treatment option for staghorn *** To examine the perioperative and long-term results of ultrasonography-guided single-and *** This was a retrospective cohort *** March 2021 and January 2022,the urology department of our hospital selected patients for the treatment of staghorn calculi using percutaneous *** primary outcomes were com plication rate and SFR,and the characteristics of patients,operative parameters,laboratory measurements were also *** In total,345 patients were enrolled in the study(186 in the S-PCNL group and 159 in the M-PCNL group).The SFR in the M-PCNL group was significantly higher than that in the S-PCNL group(P=0.033).Moreover,the incidence rates of hydrothorax(P=0.03)and postoperative infection(P=0.012)were higher in the M-PCNL group than in the S-PCNL *** regression analysis demonstrated that post-operative white blood cell count(OR=2.57,95%CI:1.90-3.47,P<0.001)and stone size(OR=1.59,95%CI:1.27-2.00,P<0.001)were associated with a higher overall complication rate in the S-PCNL *** mass index(OR=1.22,95%CI:1.06-1.40,P=0.004)and stone size(OR=1.70,95%CI:1.35-2.15,P<0.001)were associated with increased overall complications in the M-PCNL *** Multiple access tracts can facilitate higher SFR while slightly increasing the incidence of acceptable complications.

关键词： Single-tract percutaneous nephrolithotomy Multiple-tract percutaneous nephrolithotomy Staghorn calculi Ultrasonography