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Effects of anti-diabetic drugs on sarcopenia: Best treatment options for elderly patients with type 2 diabetes mellitus and sarcopenia

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World Journal of Clinical Cases 2021年第33期9卷 10064-10074页

作者： Xiao-Yu Ma fen-Qin chen Department of Geriatrics The First Affiliated HospitalChina Medical UniversityShenyang 110001Liaoning ProvinceChina

Human life expectancy increases as society becomes more *** increased life expectancy poses challenges associated with the rapid aging of the ***,an age-related disease,has become a worldwide health *** with sarcopenia experience decreases in muscle mass and function,becoming frail and eventually *** 2 diabetes mellitus(T2DM)is also a major health issue;the incidence of T2DM increases with aging.T2DM is associated with reduced muscle strength and poor muscle quality and may contribute to acceleration of the aging process,augmenting age-related *** studies indicate that elderly patients with diabetes are at an increased risk for ***,these older diabetic patients with sarcopenia need specific anti-diabetic therapies targeting not only glycemic control but also sarcopenia,with the goal of preventing sarcopenia in presarcopenic ***,various types of hypoglycemic drugs are available,but which hypoglycemic drugs are better suited for geriatric T2DM patients with sarcopenia remains *** this review,we discuss the association between diabetes and sarcopenia in geriatric patients,and how anti-diabetic drugs may influence sarcopenia *** review will guide clinical workers in the selection of drugs best suited for this patient population.

关键词： Type 2 diabetes mellitus Sarcopenia Anti-diabetic drugs Geriatric

Numerical Solution of Steady-State Free Boundary Problems using the Singular Boundary Method

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Advances in Applied Mathematics and Mechanics 2021年第1期13卷 163-175页

作者： fen chen Bin Zheng Ji Lin Wen chen College of Civil Engineering Hefei University of TechnologyHefeiAnhui 230009China College of Civil Engineering Taizhou UniversityTaizhouZhejiang 318000China College of Mechanics and Materials Hohai UniversityNanjingJiangsu 211100China

In this paper,the recently-developed singular boundary method is applied to address free boundary *** mesh-less numerical method is based on the use of the origin intensity factors with fundamental *** numerical examples and their results are compared with the results obtained using traditional *** comparisons indicate that the proposed scheme yields good results in determining the position of the free boundary.

关键词： Seepage flow singular boundary method mesh-less origin intensity factors

Copper- and Silver-Mediated Cyanation of Aryl Iodides Using DDQ as Cyanide Source

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Chinese Journal of Chemistry 2013年第4期31卷 449-452页

作者： Kui Zheng Peng Yu Shuyou chen fen chen Jiang cheng College of Chemistry & Materials Engineering Wenzhou University Wenzhou Zhejiang 325035 China School of Petrochemical Engineering Changzhou University Changzhou Jiangsu 213164 China

A new copper and silver-mediated cyanation of aryl iodides with DDQ as a cyanide source is achieved, provid- ing nitriles with good yields. This new approach represents a safe method leading to aryl nitriles.

关键词： copper silver cyanation aryl iodides DDQ

Infinitely Many Periodic Solutions for a Class of Second-order Hamiltonian Systems

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Acta Mathematicae Applicatae Sinica 2016年第1期32卷 231-238页

作者： Ming-hai YANG Yue-fen chen Yan-fang XUE Department of Mathematics Xinyang Normal University

In this paper we study the existence of infinitely many periodic solutions for second-order Hamiltonian systems{ü（t）＋A（t）u（t）＋▽F（t,u（t））=0,u（0）-u（T）=u^·（0）-u^·（T）=0,where F（t,u） is even in u,... 详细信息

关键词： second-order Hamiltonian systems periodic solutions Fountain theorem

Preparation and photocatalytic activity of Cu^(2+)-doped TiO_2/SiO_2

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International Journal of Minerals,Metallurgy and Materials 2009年第2期16卷 220-225页

作者： Ru-fen chen Cui-xuan Zhang Juan Deng Guo-qiang Song College of Chemistry and Material Science Hebei Normal University Shijiazhuang 050016 China

Cu^2＋-doped nanostructured TiO2-coated SiO2 （TiO2/SiO2） particles were prepared by the layer-by-layer assembly technique and their photocatalytic property was studied. TiO2 colloids were synthesized by the sol-gel method using TiOSO4 as a precursor. The experimental results showed that TiO2 nanopowders on the surface of SiO2 particles were well distributed and compact. The amount of TiO2 increased with the increase in coating layers. The shell structure appeared to be composed of anatase titania nanocrystals at 550℃. The 2-layer coated TiO2 particles on the surface showed a higher degradation rate compared with all the different-layer samples. The photocatalytic activity of Cu^2＋-doped TiO2/SiO2 was higher than that ofundoped TiO2/SiO2. The optimum dopant content was about 0.10wt%.

关键词： nanostructured TiO2 SiO2 particles layer-byqayer assembly Cu^2+ -doped photocatalytic activity

Pollution and health risk assessment of heavy metals in soils of Guizhou,China

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Ecosystem Health and Sustainability 2021年第1期7卷 6-17页

作者： Gao Yu fen chen Hongli Zhang Zuhua Wang College of Agroforestry Engineering and Planning Tongren UniversityTongrenPeople’s Republic of China Key Laboratory of Original Agro-Environmental Pollution Prevention and Control Ministry of Agriculture and Rural Affairs/Tianjin Key Laboratory of Agro-environment and Safe-productTianjinPeople’s Republic of China Remote Sensing Monitoring Department Geo-Compass Information Technology CompanyLTDBeijingPeople’s Republic of China

Mining of minerals in Guizhou,China,where it is enriched with reserves,may lead to soil contamination with heavy *** assessed the risk of eight typical heavy metals in Guizhou soils by collecting province-wide data available in the literature and using the geo-accumulation index method,the ecological risk assessment method,and the USEPA health risk assessment *** concentrations of eight heavy metals,except for Pb and Cr,were above the background *** heavy metal pollution evaluation results showed that As,Cu,Zn,Pb,Cr,Cd,and Ni reached the pollution levels,while Hg fell into the category of moderate ***,Cu,Zn,Pb,Cr,and Ni posed low potential ecological risk,while Cd and Hg demonstrated a considerable or a very high potential ecological ***,the integrated potential ecological risk was ranked“very high”.Regarding to health risk,the non-carcinogenic risks caused by heavy metals were insignificant,but the carcinogenic risk caused by As was ***,there appeared serious soil contamination of Hg and As,with the latter also being the greatest potential risk to human *** Hg and As should stay at the highest priory for remediation efforts in Guizhou soils.

关键词： Heavy metals geo-accumulation index potential ecological risk human health risk

Synthesis of high-performance single-crystal Li-rich cathode by self-combustion method

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Rare Metals 2023年第3期42卷 830-837页

作者： Lun-Te Li Ya-fen chen Yan-chen Liu Qi Zhang Jun-Wei Wu Qun-Hui Yuan School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen 518055China

Li-rich manganese-based oxide has been identified as the most promising cathode material for next-generation Li-ion batteries,due to its high capacity,high operating voltage,safety,and low ***,its wide application is restricted by low initial Columbic efficiency,undesirable cycle stability,and poor rate *** tackle these issues,single-crystal Li_(1.2)Mn_(0.54)Co_(0.13)Ni_(0.13)O_(2) is synthesized by a self-combustion *** with the poly-crystal Li-rich cathode,the specific discharge capacity of the single-crystal sample increased from 252.0 to304.6 mAh·g^(-1) at 0.1 C.

关键词： crystal high manganese

Studies on a New Usage of Hypophosphorous Acid-iodine System in N-C Bond Cleavage

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Chinese Chemical Letters 2003年第4期14卷 351-354页

作者： Ge MENG Ling ZHAO You Fu LUO fen Er chen Department of Chemistry Fudan UniversityShanghai 200433

A mixture of hypophosphorous acid (H3PO2) and iodine in acetic acid can cleave the N-alkyl bond in a variety of N-1 substituted pyrimidine derivative in relatively high yields, without any damage to the amido bond in ... 详细信息

关键词： Hypophosphorous acid iodine carbon-nitrogen bond cleavage.

Effect of luteolin on apoptosis and vascular endothelial growth factor in human choroidal melanoma cells

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International Journal of Ophthalmology(English edition) 2021年第2期14卷 186-193页

作者： Meng-Lin Shi Yu-fen chen Hong-Fei Liao Nanchang University Nanchang 330000Jiangxi ProvinceChina Jiangxi Province Blood Center Nanchang 330052Jiangxi ProvinceChina Jiangxi Research Institute of Ophthalmology&Visual Sciences Nanchang 330000Jiangxi ProvinceChina Department of Ophthalmology the Affiliated Eye Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina

AIM:To investigate the effects of luteolin on apoptosis,the cell cycle,and the expression and secretion of vascular endothelial growth factor(VEGF)in human choroidal melanoma cells(C918 and OCM-1).METHODS:C918 and OCM-1 cells cultured in vitro were treated with various concentrations of luteolin(0,5,10,15μmol/L).Cell growth was observed with an inverted microscope,and cell cycle arrest was detected by propidium iodide(PI)staining using flow *** was detected by Hoechst33342 staining,and apoptosis rate was determined by Annexin V-FITC/PI experiments using flow *** expression of apoptosis-related proteins Bcl-2,Bax and VEGF was analyzed using Western *** levels of VEGF secreted by the cells into the supernatant was analyzed using ***:After treating with 5 to 15μmol/L luteolin for 48 h,the fusion degree of C918 and OCM-1 cells decreased,and more floating apoptotic cells *** treatment increased the G0-G1 phase ratio of the C918 and OCM-1 cells,blocked cell cycle progression,and increased the apoptosis rate of the C918 and OCM-1 *** blot showed that luteolin decreased the expression of Bcl-2 and VEGF in the C918 and OCM-1 cells and increased the expression of Bax *** ELISA results showed that 10 to 15μmol/L luteolin decreased the cell secretion of ***:Luteolin may induce apoptosis by regulating the levels of apoptosis-related proteins in C918 and OCM-1 *** can induce cell cycle arrest,decrease the expression of VEGF.

关键词： luteolin human choroidal melanoma cells apoptosis cell cycle vascular endothelial growth factor