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Temporal gradients limit the accumulation of neutrophils toward sources of chemoattractant

Microsystems & Nanoengineering 2017年第1期3卷 455-462页

作者： Arvind Chandrasekaran felix ellett Julianne Jorgensen Daniel Irimia Department of Surgery BioMEMS Resource CenterMassachusetts General HospitalHarvard Medical SchoolShriners Burns HospitalBostonMA 02129USA

Neutrophil trafficking during inflammation is a highly orchestrated process,coordinating neutrophil recruitment,sterilization of the wound,and inflammation *** the chemotactic signals guiding neutrophil recruitment to sites of inflammation are relatively well understood,our knowledge of mechanisms controlling cessation of neutrophil recruitment and return to normal tissue physiology remains *** gain insights into these processes,we designed a microfluidic device with an array of chemoattractant reservoirs,which mimics the microenvironment in infected tissues,when multiple clusters of microbes are *** monitored the temporal dynamics of neutrophil recruitment toward the chemoattractant reservoirs at single cell resolution,for 3 *** observed robust neutrophil recruitment that reached a plateau after 1.5 h,despite the continuous presence of strong chemoattractant gradients around the *** timing of the plateau was dependent on the geometry of the devices and was independent from the number of *** the basis of these observations,we ruled out sub-population sensitivity,chemoattractant scavenging,and production of a self-limiting stop signal as potential mechanisms underpinning the plateau in neutrophil *** found a strong correlation between the temporal stabilization of concentration changes and the plateau in neutrophils *** results suggest that dynamic aspects of chemoattractant gradients are key for maximizing recruitment during the acute phase of infections and limiting the accumulation of neutrophils as soon as the infection is contained.

关键词： chemotaxis leukocyte microfluidic relay signaling scavenging

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