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Green Chemical Engineering 2022年第3期3卷 280-287页

作者： felipe de la cruz-martinez Jose A.Castro-Osma Agustin lara-Sanchez Universidad de Castilla-la Mancha Departamento de Quimica InorganicaOrganica y Bioquimica-Centro de Innovacion en Quimica Avanzada(ORFEO-CINQA)Facultad de Ciencias y Tecnologias QuimicasCiudad Real13071Spain Instituto de Investigaciones Quimicas(IIQ) Departamento de Quimica Inorganica and Centro de Innovacion en Quimica Avanzada(ORFEO-CINQA)Consejo Superior de Investigaciones Cientificas(CSIC)and University of SevillaSevilla41092Spain Universidad de Castilla-la Mancha Departamento de Quimica InorganicaOrganica y Bioquimica-Centro de Innovacion en Quimica Avanzada(ORFEO-CINQA)Facultad de FarmaciaAlbacete02071Spain

Novel mono-and bimetallic scorpionate aluminum compounds have been designed and characterized by spec-troscopic *** organometallics complexes,in combination with tetrabutylammonium bromide as cocatalyst,displayed good catalytic activity for the cycloaddition of styrene oxide and CO_(2) under ambient *** the compounds tested,monometallic complex 3 featuring diethylamino groups showed the highest catalytic *** catalytic system catalyzed the formation of cyclic carbonate products from their corresponding epoxides at room temperature and 1 bar of CO_(2) pressure in the absence of a solvent in good yields and excellent selectivities.

关键词： CO_(2) Epoxides Cyclic carbonates Aluminum complexes

Exploring alternative treatments for Helicobacter pylori infection

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World Journal of Gastroenterology 2014年第6期20卷 1450-1469页

作者： Guadalupe Ayala Wendy Itzel Escobedo-Hinojosa Carlos felipe de la cruz-Herrera Irma Romero Centro de Investigación sobre Enfermedades Infecciosas Instituto Nacional de Salud Pública INSP departamen-to de Bioquímica Facultad de Medicina Universidad Nacional Autónoma de México

Helicobacter pylori(H. pylori) is a successful pathogen that can persist in the stomach of an infected person for their entire life. It provokes chronic gastric inflammation that leads to the development of serious gastric diseases such as peptic ulcers, gastric cancer and Mucosa associated lymphoid tissue lymphoma. It is known that these ailments can be avoided if the infection by the bacteria can be prevented or eradicated. Currently, numerous antibiotic-based therapies are available. However, these therapies have several inherent problems, including the appearance of resistance to the antibiotics used and associated adverse effects, the risk of re-infection and the high cost of antibiotic therapy. The delay in developing a vaccine to prevent or eradicate the infection has furthered research into new therapeutic approaches. This review summarises the most relevant recent studies on vaccine development and new treatments using natural resources such as plants, probiotics and nutraceuticals. In addition, novel alternatives based on microorganisms, peptides, polysaccharides, and intragastric violet light irradiation are presented. Alternative therapies have not been effective in eradicating the bacteria but have been shown to maintain low bacterial levels. Nevertheless, some of them are useful in preventing the adverse effects of antibiotics, modulating the immune response, gastroprotection, and the general promotion of health. Therefore, those agents can be used as adjuvants of allopathic anti-H. pylori eradication therapy.

关键词： Helicobacter pylori Treatment Natural products Probiotics Nutraceuticals

Early-onset colorectal cancer:A separate subset of colorectal cancer

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World Journal of Gastroenterology 2014年第46期20卷 17288-17296页

作者： Irene Osorio Silla Daniel Rueda Yolanda Rodríguez Juan Luis García felipe de la cruz Vigo José Perea department of Surgery 12 de Octubre University HospitalMadrid 28041Spain Molecular Biology laboratory 12 de Octubre University HospitalMadrid 28041Spain department of Pathology 12 de Octubre University HospitalMadrid 28041Spain Centre for Cancer Research Medical University of SalamancaSalamanca 37008Spain

Colorectal cancer(CRC)has a great impact on the world *** increasing frequency,CRC is described according to the presenting phenotype,based on its molecular *** of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized ***-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of *** molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial ***,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular *** purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular ***,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC.

关键词： Chromosomal instability CpG island methylator phenotype Early-onset colorectal cancer Lynch syndrome Microsatellite instability

GLOBAL SOLUTIONS TO A HYDRODYNAMIC MOdeL FOR SEMICONDUCTORS WITH VELOCITY RElaXATION

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Acta Mathematica Scientia 2023年第2期43卷 975-980页

作者：王先婷陆云光 Richard de la cruz 尤国桥 department of Mathematics Wuxi Institute of TechnologyWuxi 214121China School of Mathematics Hangzhou Normal UniversityHangzhou 311121China Escuela de Matematicas y Estadistica Universidad Pedagógica y Tecnológica de Colombia 999076Colombia School of Mathematics Nanjing Audit UniversityNanjing 210000China

In this paper,we apply the method given in the paper“Zero relaxation time limits to a hydrodynamic model of two carrier types for semiconductors”(Mathematische Annalen,2022,382:1031–1046)to study the Cauchy problem for a one dimensional inhomogeneous hydrodynamic model of two-carrier types for semiconductors with the velocity relaxation.

关键词： global L solution hydrodynamic model two-carrier types velocity relaxation

Corneal topography in keratoconus: state of the art

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Eye and Vision 2016年第1期3卷 37-48页

作者： F.Cavas-martinez E.de la cruz Sanchez J.Nieto martinez F.J.Fernandez Canavate D.G.Fernandez-Pacheco department of Graphical Expression Technical University of CartagenaC/Doctor Fleming s/nCartagena 30202MurciaSpain Faculty of Sports Science C/Santa Alicia s/nSantiago de la Ribera30720 MurciaSpain

The morphological characterization of the cornea using corneal topographers is a widespread clinical practice that is essential for the diagnosis of *** current state of this non-invasive exploratory technique has evolved with the possibility of achieving a great number of measuring points of both anterior and posterior corneal surfaces,which is possible due to the development of new and advanced measurement *** these data are later used to extract a series of topographic valuation indices that permit to offer the most exact and reliable clinical *** paper describes the technologies in which current corneal topographers are based on,being possible to define the main morphological characteristics that the keratoconus pathology produces on corneal ***,the main valuation indices,which are provided by the corneal topographers and used for the diagnosis of keratoconus,are also defined.

关键词： Placido disc detection system Topographer Diagnosis

Sustainable transit vehicle tracking service,using intelligent transportation system services and emerging communication technologies:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第6期7卷 729-747页

作者： Ricardo Salazar-Cabrera álvaro Pachón de la cruz Juan Manuel Madrid Molina Telematics Engineering Research Group(GIT) Telematics DepartmentUniversidad del CaucaPopayanColombia Information Technology and Telecommunications Research Group(I2T) ICT DepartmentUniuersidad IcesiCaliColombia

The most salient problems of transit vehicle service in latin American intermediate cities include:the high number of passengers involved in traffic accidents;traffic congestion caused by transit vehicles,and pollution generated by these vehicles,which increases in high congestion *** improve upon this situation,a research was conducted on the transit vehicle tracking service,which is a basic service for implementing mobility solutions for the aforementioned problems,the most relevant characteristics of this service for the context of latin American intermediate cities were identified,and an implementation was *** paper presents the four stages of the study:(a)a review of the state-of-the-art of services or systems related to vehicle tracking,including wireless communications technologies,implemented sustainability approaches,usage of special algorithms for efficiency improvement,and the intelligent transportation system(ITS)architecture used as a basis;(b)the process of identifying relevant characteristics of the service for a given context;(c)proposal of an ITS architecture for this service in an intermediate city,its requirements and the suggested technologies;and(d)development of experiments for validating usage of the key suggested *** review allowed to identify the main service characteristics,with regard to vehicle positioning technologies,the recommended wireless communication technology(long range,LoRa),energy consumption considerations,and use of artificial intelligence(AI)to calculate waiting time of users at bus ***,an ITS architecture for the city of Popayan(Colombian city)considering the aforementioned characteristics is proposed,and the experiments related to the use of these technologies are described in detail.

关键词： Transportation engineering Intelligent transportation systems Transit vehicle ITS architecture Tracking Long range

In silico analysis of lncRNA-miRNA-mRNA signatures related to Sorafenib effectiveness in liver cancer cells

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World Journal of Gastroenterology 2025年第3期31卷 84-102页

作者： Patricia de la cruz-Ojeda Ester Parras-Martínez Raquel Rey-Pérez Jordi Muntané Functional Genomics of Solid Tumors laboratory Centre de Recherche des CordeliersParis 75006France department of Oncology Surgery Cell Therapy and Organ TransplantationInstitute of Biomedicine of SevilleVirgen del Rocio University HospitalSeville 41013Spain Biomedical Research Center for Hepatic and Digestive Diseases CIBERehdMadrid 28029Spain department of Medical Physiology and Biophysics University of SevilleSeville 41009Spain

BACKGROUND Hepatocellular carcinoma(HCC)is the most common subtype of primary liver cancer with varied incidence and epidemiology *** is still a recommended treatment for a large proportion of patients with advanced *** patterns of treatment responsiveness have been identified in differentiated hepatoblastoma HepG2 cells and metastatic HCC SNU449 *** To define the long non-codingRNA-microRNA-mRNA(lncRNA-miRNA-mRNA)predicted signatures related to selected hallmarks of cancer(apoptosis,autophagy,cell stress,cell dedifferentiation and invasiveness)in RNAseq studies using Sorafenib-treated HepG2 and SNU449 *** available software analyses allowed us to establish the lncRNA-miRNA-mRNA regulatory axes following treatment in HepG2 and SNU449 *** HepG2 and SNU449 cells were treated with Sorafenib(10μmol/L)for 24 *** RNA,including small and long RNA,was extracted with a commercial miRNeasy *** was carried out for the identification of changes in lncRNA-miRNA-mRNA regulatory *** MAlaT,THAP9-AS1 and SNGH17 appeared to coordinately regulate miR-374b-3p and miR-769-5p that led to upregulation of SMAD7,TIRARP,TFAP4 and FAXDC2 in HepG2 ***12,EPB41 L4A-AS1,LINC01578,SNHG12 and GAS5 interacted with let-7b-3p,miR-195-5p and VEGFA in SNU449 *** axes MAlaT1/hsamir-374b-3p/SMAD7 and MAlaT1/hsa-mir-769-5p/TFAP4 were of high relevance for Sorafenib response in HepG2 cells,whereas PVT1/hsa-miR-195-5p/VEGFA was responsible for the differential response of SNU449 cells to Sorafenib *** Critical lncRNAs acting as sponges of miRNA were identified that regulated mRNA expression,whose proteins mainly increased the antitumor effectiveness of the treatment(SMAD7,TIRARP,TFAP4,FAXDC2 and ADRB2).However,the broad regulatory axis leading to increased VEGFA expression may be related to the side effect of Sorafenib in SNU449 cells.

关键词： Cell culture Hepatocellular carcinoma Non-coding RNA RNAseq Sorafenib

Experimental study of friction dissipators for seismic protection of building structures

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Earthquake Engineering and Engineering Vibration 2011年第4期10卷 475-486页

作者： F. López-Almansa S.T. de la cruz C. Taylor Technical University of Catalonia Architecture Structures Department Universidad Autónoma de Ciudad Juárez Civil and Environmental Engineering Department Civil Engineering department University of Bristol

This paper presents the results from unidirectional shaking table tests of two reduced scale steel models of a building frame, with one and two floors, respectively. These frames incorporate friction dissipators at every floor. The inputs are sine-dwells and artificial and registered earthquakes. This study is part of a larger research project aiming to assess the seismic efficiency of friction dissipators by means of an integrated numerical and experimental approach. Inside this framework, the main objectives of these experiments are to：（i） collect a wide range of results to calibrate a numerical model derived within the project, （ii） clarify some of the most controversial issues about friction dissipators （including behavior for inputs containing pulses, capacity to reduce resonance peaks, introduction of high frequencies in the response, and self- generated eccentricities）, （iii） better understand their dynamic behavior, （iv） provide insight on the feasibility and reliability of using simple friction dissipators for seismic protection of building structures and （v） characterize the hysteretic behavior of these devices. Most of these objectives are satisfactorily reached and relevant conclusions are stated.

关键词： building structures earthquake engineering passive control friction energy dissipators experimentalverification shaking table tests

Intelligent collision risk detection in medium-sized cities of developing countries,using naturalistic driving:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第6期9卷 912-929页

作者： Juan Jose Paredes Santiago felipe Yepes Ricardo Salazar-Cabrera Alvaro Pachon dela cruz Juan Manuel Madrid Molina Telematics Engineering Research Group(GIT) Telematics DepartmentUniversidad Del CaucaPopayanColombia Information Technology and Telecommunications Research Group(12T) Universidad IcesiCaliColombia

Traffic accidents are one of the most serious problems worldwide,being one of the leading causes of death and economic loss in the ***-and middle-income countries,mainly their medium-sized cities,are among the most affected by this problem.93%of traffic accidents occur in low and middle-income countries,even though these countries have approximately 60%of the world’s *** occurs mainly because in these types of countries,especially in medium-sized cities(target context),there are no ideal conditions for driving,such as adequate road infrastructure,good condition of vehicles,and rigorous safety *** data analysis techniques including machine learning(ML)have increasingly been used to solve this *** driving(ND)can be applied as a data collection method that provides information on traffic *** commonly uses a vehicle’s kinematic data to detect high-risk driving behaviors that could cause an *** objectives of this document are to present a review of different alternatives that help in data collection and creation of intelligent solutions related to detection of possible traffic accidents,principally using ND;and to propose an intelligent collision risk detection system(ICRDS)for identification of areas with a high probability of TA in the target *** the review,it was possible to analyze and evaluate the devices,variables and algorithms that help characterize a risk event in driving,considering the target *** development of a prototype of an ICRDS for a medium-sized city in a developing country is considered viable,considering the identified components,with the aim of identifying risk events in driving,and areas of high probability of accidents in the city.

关键词： Naturalistic driving Near-crash Traffic accident Vehicle data collection

Femtosecond laser-assisted cataract surgery(FlaCS)in resident training

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Annals of Eye Science 2018年第1期3卷 393-402页

作者： Carmen Somavilla Bueno Jose de la cruz department of Ophthalmology and Visual Sciences University of Illinois at ChicagoChicagoILUSA

This article reviews the history of the femtosecond laser in ophthalmology and its subsequent introduction into the field of cataract *** discusses the innovations that this technology has brought to the *** article also describes the current system of teaching cataract surgery to ophthalmology residents in the United States and then examines how femtosecond laser-assisted cataract surgery(FlaCS)can be a beneficial part of residency education.

关键词： Femtosecond laser cataract surgery capsulorhexis optical coherence tomography