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Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients

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World Journal of Gastroenterology 2014年第12期20卷 3327-3334页

作者： Ana Teresa P carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis felipe Ribeiro-Pinto Heitor S P de Souza Disciplina de Gastroenterologia e Endoscopia Digestiva Universidade do Estado do Rio de Janeiro Programa de Carcinogênese Molecular Instituto Nacional de Cancer Laboratório de Toxicologia e Biologia Molecular Universidade do Estado do Rio de Janeiro Servi?o de Gastroenterologia Departamento de Clínica MédicaUniversidade Federal do Rio de Janeiro

AIM: To analyze the prevalence of thiopurine-methyltransferase (TPMT) genotypes and their association with drug toxicity in inflammatory bowel disease (IBD) patients from southeastern Brazil.

关键词： Inflammatory bowel disease Thiopurine-methyl-transferase Azathioprine Drug toxicity Pancreatitis

A decade without diagnosis: Sheehan’s syndrome

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Case Reports in Clinical Medicine 2013年第8期2卷 490-493页

作者： Fábio A. Nascimento Juliane Nery Gustavo Lenci Marques felipe Dunin dos Santos Mauricio de carvalho Department of Internal Medicine Federal University of Paraná Curitiba Brazil Faculty of Medicine Federal University of Paraná Curitiba Brazil

Sheehan’s Syndrome (SS) occurs as a result of ischemic pituitary necrosis due to severe post-partum hemorrhage. We report a 41-year-old woman with a history of severe postpartum hemorrhage 18 years prior to presentation. During this period of time, she experienced severe fatigue. Three months prior to being admitted to our hospital, the patient started to notice alopecia, generalized edema and cognitive impairment. After proper investigation, laboratory tests and clinical findings indicated panhypopituitarism. In addition to neuroimaging and past medical history, SS was diagnosed and treatment started. We emphasize the importance of thorough investigation, further diagnosis and management of this condition (especially in third world countries), since SS is a neurological and endocrinological emergency and potentially life threatening.

关键词： Sheehan’s Syndrome Pituitary Insufficiency Empty Sella

Pain management for the Nuss procedure: comparison between erector spinae plane block, thoracic epidural, and control

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World Journal of Pediatric Surgery 2022年第4期5卷 223-228页

作者： Lisgelia Santana John Driggers Norman F carvalho Department of Anesthesiology and Pain Management Nemours Children's HospitalOrlandoFloridaUSA Anesthesiology University of Central FloridaOrlandoFloridaUSA

Objective Pectus excavatum is a congenital deformity characterized by a caved-in chest *** requires *** less invasive Nuss procedure is very successful,but postoperative pain management is challenging and *** pain management techniques to reduce opioid reliance include the erector spinae plane(ESP)*** retrospectively examined opioid consumption after Nuss procedure comparing three pain management techniques:ESP block,thoracic epidural(TE),and patient-controlled analgesia(PCA).Methods This retrospective cohort study compared pain management outcomes of three patient ***-eight subjects aged 10–18 years underwent Nuss procedure at our institution between January 2014 and January *** primary outcome measure was opioid consumption measured in morphine milligram *** measures included pain ratings and length of stay(LOS).Pain was quantified using the Numeric Pain Rating *** of variance was performed on all outcome *** Average cumulative opioid use was significantly lower in the ESP block(67 mg)than the TE(117 mg)(p=0.0002)or the PCA group(172 mg)(p=0.0002).The ESP block and PCA groups both had a significantly shorter average LOS(3.3 and 3.7 days,respectively)than the TE group(4.7 days).ESP block performed best for reducing opioid consumption and *** opioid consumption is key for limiting side *** study supports use of ESP block as a superior choice when choosing among the three postoperative pain management options that were *** ESP resulted in reduced opioid consumption postoperatively and shorter LOS than TE or PCA for patients undergoing the Nuss procedure for surgical repair of pectus excavatum.

关键词： shorter ESP comparison

Optical clearing mechanisms characterization in muscle

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Journal of Innovative Optical Health Sciences 2016年第5期9卷 82-100页

作者： Luís Oliveira M.Inês carvalho Elisabete Nogueira Valery V.Tuchin Physics Department–Polytechnic Institute of Porto School of Engineering Rua Dr.Antonio Bernardino de Almeida 4314200-072 PortoPortugal FEUP–University of Porto Rua Dr.Roberto Frias 4200-465 PortoPortugal CIETI–Centre of Innovation in Engineering and Industrial Technology ISEP Rua Dr.Antonio Bernardino de Almeida4314200-072 PortoPortugal DEEC/FEUP and INESC TEC University of Porto Rua Dr.Roberto Frias 4200-465 PortoPortugal Research-Education Institute of Optics and Biophotonics Saratov National Research State University 83 Astrakhanskaya street Saratov 410012Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision Mechanics and Control RAS 24 Rabochaya street Saratov 410028Russia Interdisciplinary Laboratory of Biophotonics Tomsk National Research State University 36 Lenin's avenue Tomsk 634050Russia

Optical immersion clearing is a technique that has been widely studied for more than two decades and that is used to originate a temporary transparency effect in biological *** applied in cooperation with clinical methods it provides optimization of diagnosis and treatment *** technique turns biological tissues more transparent through two main mechanisms-tissue dehydration and refractive index(RI)matching between tissue *** matching is obtained by partial replacement of interstit ial water by a biocompat ible agent that presents higher RI and it can be completely rever sible by natural rehydration in vrivo or by assisted rehydration in ex vivo *** data to characterize and discriminate between the two mechanisms and to find new ones are *** a simple method,based on collimated transmittance and thickness measurements made from muscle samples under treatment,we have estimated the diffusion properties of glucose,ethylene glycol(EG)and water that were used to perform such char acterization and *** these properties with data from literature that characterize their diffusion in water we have observed that musde cell membrane permeability limits agent and water diffusion in the *** same experi-mental data has allowed to calculate the optical dearing(OC)eficiency and make an inter-pretation of the internal changes that occurred in muscle during the *** same methodology can now be used to perform similar studies with other agents and in other tissues in order to solve engineering problems at design of inexpensive and robust technologies for a *** improvement of optical tomogr aphic techmiques with better contrast and in depth imaging.

关键词： Collimated transmittance agent diffusivity tissue dehydration thickness variation refractive index matching glucose ethylene glycol

Synaptic pathology in multiple sclerosis:a role for Nogo-A signaling in astrocytes?

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Neural Regeneration Research 2023年第1期18卷 127-128页

作者： Sheila Espírito-Santo Vinícius Gabriel Coutinho Flávia carvalho Alcantara Gomes Laboratório de Biologia Celular e Tecidual Universidade Estadual do Norte Fluminense Darcy RibeiroCampos dos GoytacazesRJBrazil Laboratório de Neurobiologia Celular Universidade Federal do Rio de JaneiroInstituto de Ciências BiomédicasRio de JaneiroRJBrazil

Multiple sclerosis(MS)is characterized as an inflammatory demyelinating disease that affects the central nervous system(CNS),leading to sensory,motor and cognitive ***,axonal denudation culminates in axonal lesions and *** demyelinating lesions in MS are associated with infiltration of immune cells combined with activation of the resident CNS inflammatory cells,astro-and microglia.

关键词： sclerosis impairment lesions

A comprehensive study on the processing of Co:ZnO nanostructured ceramics:Defect chemistry engineering and grain growth kinetics

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Journal of Materials Science & Technology 2023年第7期138卷 221-232页

作者： R.T.da Silva J.M.Morbec G.Rahman H.B.de carvalho Universidade Federal de Ouro Preto-UFOP Ouro PretoMG 35400-000Brazil School of Chemical and Physical Sciences Keele UniversityKeele ST55BGUnited Kingdom Department of Physics Quaid-i-Azam UniversityIslamabad 45320Pakistan Universidade Federal de Alfenas-UNIFAL Alfenas 37130-000Brazi

In this report,we present a systematic study on the preparation of Co:ZnO ceramics via a standard solid-state route from different Co precursors(Co_(3)O_(4),CoO,and metallic Co)and atmospheres(O_(2)and Ar).Particular emphasis is given to defect chemistry engineering and the sintering growth ***-principles calculations based on density functional theory are employed to determine the formation en-ergy of the main point defects in ZnO and Co:ZnO *** on the theoretical results,a set of chemical reactions is *** microstructural characterization is also performed to determine the degree of Co incorporation into the ZnO *** samples prepared in Ar atmosphere and metal-lic Co present the highest Co solubility limit(lower apparent Co incorporation activation energy)due to the incongruent ZnO *** of the parameters of the sintering growth kinetics reveals that Co_(3)O_(4)is the best sintering additive to achieve larger grain sizes,and possible higher densi-ties,in both sintering atmospheres,while metallic Co is the best to achieve the smallest grain size with higher Co concentration and homogeneous spatial distribution for a subsequent reduction of *** results show that the sintering in O_(2)effectively promotes zinc vacancies in the ZnO structure,while the sintering in Ar promotes zinc interstitial *** findings contribute to understanding the preparation of Co-doped ZnO ceramics and the sintering growth kinetics,which may improve the state of the art in processing the material at both bulk and nanometric scales.

关键词： Multifunctionality Zinc oxide Defect engineering Growth kinetics

Multi-mechanical waves against Alzheimer’s disease pathology:a systematic review

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Translational Neurodegeneration 2021年第3期10卷 459-486页

作者： Francisca Monteiro Ioannis Sotiropoulos Óscar carvalho Nuno Sousa Filipe S.Silva Center for Microelectromechanical Systems(CMEMS) University of MinhoCampus Azurém4800-058 GuimarãesPortugal Life and Health Sciences Research Institute(ICVS) Medical SchoolUniversity of MinhoCampus Gualtar4710-057 BragaPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Institute of Biosciences&Applications NCSR“Demokritos” AthensGreece

Alzheimer’s disease(AD)is the most common cause of dementia,afecting approximately 40 million people *** inefectiveness of the available pharmacological treatments against AD has fostered researchers to focus on alternative strategies to overcome this *** vibrations delivered in diferent stimulation modes have been associated with marked improvements in cognitive and physical performance in both demented and nondemented *** of the mechanical-based stimulation modalities in eforts are earlier whole-body vibration,transcranial ultrasound stimulation with microbubble injection,and more recently,auditory ***,there is a huge variety of treatment specifcations,and in many cases,conficting results are *** this review,a search on Scopus,PubMed,and Web of Science databases was performed,resulting in 37 *** studies suggest that mechanical vibrations delivered through diferent stimulation modes are efective in attenuating many parameters of AD pathology including functional connectivity and neuronal circuit integrity defcits in the brains of AD patients,as well as in subjects with cognitive decline and non-demented older *** the evolving preclinical and clinical evidence on these therapeutic modalities,their translation into clinical practice is not consolidated ***,this comprehensive and critical systematic review aims to address the most important gaps in the reviewed protocols and propose optimal regimens for future clinical application.

关键词： Alzheimer’s disease Auditory stimulation Mechanical vibrations Ultrasounds Whole-body vibration

Mechanical stimulation devices formechanobiology studies:a market,literature,and patents review

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Bio-Design and Manufacturing 2023年第3期6卷 340-371页

作者： F.Melo-Fonseca O.carvalho M.Gasik G.Miranda F.S.Silva Center for MicroElectroMechanical Systems University of Minho(CMEMS-UMinho)Campus de Azurém4800-058 GuimarãesPortugal LABBELS–Associate Laboratory BragaGuimarãesPortugal International Iberian Nanotechnology Laboratory(INL) 4715-330 BragaPortugal School of Chemical Engineering Aalto University Foundation00076 EspooFinland Seqvera Ltd. HelsinkiFinland Department of Materials and Ceramic Engineering CICECOAveiro Institute of MaterialsUniversity of Aveiro3810-193 AveiroPortugal

Significant advancements in various research and technological fields have contributed to remarkable findings on the physiological dynamics of the human *** closely mimic the complex physiological environment,research has moved from two-dimensional(2D)culture systems to more sophisticated three-dimensional(3D)dynamic *** bioreactors or microfluidic-based culture models,cells are typically seeded on polymeric substrates or incorporated into 3D constructs which are mechanically stimulated to investigate cell response to mechanical stresses,such as tensile or *** review focuses on the working principles of mechanical stimulation devices currently available on the market or custom-built by research groups or protected by patents and highlights the main features still open to *** are the features which could be focused on to perform,in the future,more reliable and accurate mechanobiology studies.

关键词： Biomaterials Polymers Actuators Mechanical stress Mechanotransduction

Duration and intensity of rainfall events with the same erosivity change sediment yield and runoff rates

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International Soil and Water Conservation Research 2021年第1期9卷 69-75页

作者： Wilk Sampaio de Almeida Steffen Seitz Luiz Fernando Coutinho de Oliveira Daniel Fonseca de carvalho Agronomy Department Federal Institute of EducationScience and Technology of RondôniaCampus AriquemesRO 257km 13AriquemesRO76870-000Brazil Department of Geosciences University of TübingenTübingenGermany Federal University of Lavras Department of Water Resources and Sanitation37200-000LavrasMGBrazil Federal Rural University of Rio de Janeiro Engineering DepartmentBR 465km 723897-000SeropédicaRJBrazil

The effect of different rainfall patterns on surface runoff,infiltration and thus soil losses and sediment concentrations are still in the focus of current *** most simulated rainfall experiments,pre-cipitation is applied at a fixed intensity for a fixed ***,the impact of rainfall patterns on soil erosion processes may be different varying the rainfall duration and intensity that produces an event with similar rainfall erosivity ***-five rainfall events were applied on micro-scale runoff plots in a soil covered with corn straw to evaluate the sediment yield and runoff *** different rainfall types were composed by association of duration(Dur)and intensity(IP)with the same erosivity *** Dur varied from 38 to 106 min and the IP varied from 75.0 to 44.6 mm h^(-1).The sediment yield varied from 1.89±1.26 g m^(-2) to 4.02±2.66 g m^(-2) and runoff ranged from 16.9±8.74 mm to 32.63±10.67 mm with highest rates occurring with high intensity and low *** highest rainfall intensity provides the maximum sediment yield(0.138 g m^(-2) min^(-1))and runoff rates(0.87 mm min^(-1)).The time to start surface runoff varied from 14 to 19.2 min and it was longer in treatments with longer durations and low precipitation *** difference was found in the amount of sediments applying rain with the same erosivity and different associations of duration and ***,the intensity and duration of the rain,with the same erosivity,altered the amount and time of *** rainfall experiments with con-stant intensity and fixed time,the erosion rates depend on the duration of the applied ***,the results of this study can contribute to the development of new perspectives in the design of water erosion experiments with simulated rain considering the duration,intensity and also the association of these variables to produce rainfall that delivery the same soil erosion capacity.

关键词： Simulated rainfall Rainfall pattern Water erosion Soil loss