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Current status of anaplastic thyroid carcinoma

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World Journal of Clinical Oncology 2024年第6期15卷 684-686页

作者： Abrahams Ocanto Lisselott Torres felipe couñago Department of Radiation Oncology San Francisco de Asís University HospitalGenesis CareMadrid 28002Spain Department of Radiation Oncology Vithas La Milagrosa University HospitalGenesis CareMadrid 28010Spain

In this editorial we comment on the article by Pavlidis et al,published in the recent issue of the World Journal of *** focus on the recent contributions in the management of anaplastic thyroid carcinoma,highlighting the importance of surgery and radiotherapy as first line therapies in its management and the introduction of new systemic therapies beyond chemotherapy,focused on molecular alterations,an essential step in the diagnosis and included in clinical guidelines for the selection of the ideal *** contrast to other neoplasms,immunotherapy,is still beginning in studies of this pathology with encouraging ***,multimodal management of the pathology together with new drugs seems to be the logical step to increase the survival of this neoplasm.

关键词： Anaplastic carcinoma Thyroid diseases Surgery Radiotherapy Immunoth-erapy

Hyoid metastasis an unusual location from lung cancer

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World Journal of Clinical Oncology 2024年第7期15卷 796-798页

作者： Miguel Montijano Abrahams Ocanto felipe couñago Department of Radiation Oncology San Francisco de Asís University HospitalGenesis CareMadrid 28002Spain Department of Radiation Oncology Vithas La Milagrosa University HospitalGenesis CareMadrid 28010Spain National Director Genesis CareMadrid 28043Spain

Bone metastases from lung cancer account for 8.5%,with those located in the hyoid bone being extremely *** this editorial,we made a review about Hsu et al case report highlighted the importance of palliative radiotherapy,even with an unusual but effective scheme in pain control in a patient with non-small cell lung cancer in stage IV.

关键词： Lung cancer Metastases Radiotherapy Palliative care Chemotherapy

Bridging the gap: Predicting brain metastasis in breast cancer

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World Journal of Clinical Oncology 2024年第2期15卷 356-359页

作者： Daniela Gonsalves Raquel Ciérvide felipe couñago Department of Radiation Oncology GenesisCare MadridMadrid 28043Spain Facultad de Medicina Salud y Deporte Universidad Europea de MadridMadrid 28670Spain Department of Radiation Oncology HM HospitalesMadrid 28050Spain

Chen et al explored clinicopathological features and prognostic factors,revealing advanced tumor stage,lung metastases,HER-2 overexpression,and triple-negative status as key *** research connects astrocytes'role in brain metastasis with signaling pathways and the impact of Trastuzumab on HER-2 tumor *** such as positive HER2 status,lack of estrogen receptor expression,and liver metastasis are identified as additional risk *** routine use of magnetic resonance imaging,insights into gene mutations associated with metastasis,and the role of radiotherapy,including prophylaxis possibilities,is controversial in clinical *** these risk factors in a multidisciplinary collaboration is precise for local treatments and targeted therapies,particularly for HER2+tumors,impacting directly on longer survival.

关键词： Brain metastases Breast cancer Clinicopathological features High-risk factors

Management of lateral pelvic lymph nodes in rectal cancer:Is it time to reach an Agreement?

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World Journal of Clinical Oncology 2024年第4期15卷 472-477页

作者： Sigfredo E Romero-Zoghbi Fernando López-Campos felipe couñago Department of Radiation Oncology GenesisCareTalavera de la Reina 45600ToledoSpain Department of Radiation Oncology Hospital Universitario Ramón Y CajalMadrid 28034Spain Department of Radiation Oncology GenesisCare-Hospital Universitario Vithas Madrid La MilagrosaMadrid 28010Spain

In this editorial,we proceed to comment on the article by Chua et al,addressing the management of metastatic lateral pelvic lymph nodes(mLLN)in stage II/III rectal cancer patients below the peritoneal *** treatment of this nodal area sparks significant controversy due to the strategic differences followed by Eastern and Western physicians,albeit with a higher degree of convergence in recent *** dissection of lateral pelvic lymph nodes without neoadjuvant therapy is a standard practice in Eastern *** contrast,in the West,preference leans towards opting for neoadjuvant therapy with chemoradiotherapy or radiotherapy,that would cover the treatment of this area without the need to add the dissection of these nodes to the total mesorectal *** the presence of high-risk nodal characteristics for mLLN related to radiological imaging and lack of response to neoadjuvant therapy,the risk of lateral local recurrence increases,suggesting the appropriate selection of strategies to reduce the risk of recurrence in each patient *** the heterogeneous and retrospective nature of studies addressing this area,an international consensus is necessary to approach this clinical scenario uniformly.

关键词： Rectal cancer Lateral pelvic lymph node metastases Pelvic lymph node dissection Total neoadjuvant therapy Selective management of the lateral pelvic nodes Prophylactic management of the lateral pelvic nodes Chemoradiotherapy Total mesorectal excision

Pembrolizumab autoimmune related diabetes:Moving forward,keep learning

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World Journal of Clinical Oncology 2024年第5期15卷 576-579页

作者： Jose Angel Garcia Diego Alcaraz Esther Holgado felipe couñago Department of Medical Oncology GenesisCare Spain-San Francisco de Asis University HospitalMadrid 28002Spain Department of Chief of Medical Oncology GenesisCare Spain-San Francisco de Asis University HospitalMadrid 28002Spain Department of Chief of Radiation Oncology GenesisCare-Vithas La Milagrosa HospitalMadrid 28010Spain

Immune checkpoint inhibitors(and more specifically programmed cell death 1/programmed cell death ligand 1 inhibitors as Pembrolizumab)initiated a revolution in the field of melanoma and have now expanded to several tumor subtypes and in increasingly broader clinical contexts,including the adjuvant and neoadjuvant setting,with potentially curable patients and prolonged *** side effects related to these drugs include a wide spectrum of manifestations,with endocrinological adverse events being some of the most ***-induced type 1 diabetes mellitus is an infrequent but potentially serious and not clearly reversible side effect that possesses characteristic clinical features and has high morbidity and mortality,with a chronic impact on quality of *** etiopathogenesis of this phenomenom needs to be further investigated and a collaborative effort through the involvement of oncologists and other medical specialists is necessary for the correct identification and management of patients at risk.

关键词： Immune checkpoints Pembrolizumab Immunotherapy Side effects Endocrine system Diabetes mellitus

Neoadjuvant treatment of rectal cancer: Where we are and where we are going

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World Journal of Clinical Oncology 2024年第7期15卷 790-795页

作者： Elísabet González Del Portillo felipe couñago Fernando López-Campos Department of Radiation Oncología Hospital Universitario La PazMadrid 28046Spain Department of Radiation Oncology GenesisCare MadridMadrid 28010Spain Department of Radiation Oncology Hospital Universitario Ramón Y CajalMadrid 28034Spain

Locally advanced rectal cancer requires a multidisciplinary approach based on total neoadjuvant treatment with radiotherapy(RT)and chemotherapy(ChT),followed by deferred ***,alternatives to the standard total neoadjuvant therapy(TNT)are being explored,such as new ChT regimens or the introduction of *** standard TNT,up to a third of patients may achieve a complete pathological response(CPR),potentially avoiding ***,as of now,we lack predictive markers of response that would allow us to define criteria for a conservative organ *** presence of muta-tions,genes,or new imaging tests is helping to define these *** example of this is the diffusion coefficient in the diffusion-weighted sequence of magnetic resonance imaging and the integration of this imaging technique into RT *** allows for the monitoring of the evolution of this coefficient over successive RT sessions,helping to determine which patients will achieve CPR or those who may require intensification of neoadjuvant therapy.

关键词： Locally advanced rectal cancer Total neoadyuvant treatment Radiotherapy Biomarker Magnetic resonance imaging Conservative organ strategy Watch and wait

COVID-19 and information and communication technology in radiation oncology:A new paradigm

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World Journal of Clinical Oncology 2020年第12期11卷 968-975页

作者： Castalia Fernández Virginia Ruiz felipe couñago Department of Radiation Oncology GenesisCare MadridMadrid 28043Spain Department of Radiation Oncology Hospital Universitario de BurgosBurgos 09006Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridMadrid 28028Spain Department of Radiation Oncology Hospital La LuzMadrid 28028Spain Department of Radiation Oncology Universidad Europea de MadridMadrid 28028Spain

Due to coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus 2,there has been a major reallocation of resources that has impacted the treatment of many diseases,including *** growing use of information and communication technologies(ICT),together with a new approach to work aimed at ensuring the safety of health care professionals and patients alike,has allowed us to maintain the quality of care while ensuring *** application of ICT to health care(eHealth)aims to significantly improve the quality,access to,and effectiveness of medical *** fact,the expanded use of ICT has been recognized as a key,cost-effective priority for health care by the World Health *** medical speciality of radiation oncology is closely linked to technology and as a consequence of coronavirus disease 2019,ICT has been widely employed by radiation oncologists worldwide,providing new opportunities for interaction among professionals,including telemedicine and e-learning,while also minimizing treatment *** research should concentrate on this emerging paradigm,which offers new opportunities,including faster and more diverse exchange of scientific knowledge,organizational improvements,and more efficient ***,these efficiencies will allow professionals to dedicate more time to patient care,with a better work-life *** the present editorial,we discuss the opportunities provided by these digital tools,as well as barriers to theirimplementation,and a vision of the future.

关键词： Radiation oncology COVID-19 Telemedicine Telehealth Distance learning Medical education Patient care Information technology Social media

New perspectives in the management of small cell lung cancer

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World Journal of Clinical Oncology 2022年第6期13卷 429-447页

作者： Cristina Pangua Jacobo Rogado Gloria Serrano-Montero JoséBelda-Sanchís BeatrizÁlvarez Rodríguez Laura Torrado Nuria Rodríguez De Dios Xabier Mielgo-Rubio Juan Carlos Trujillo felipe couñago Department of Medical Oncology Hospital Universitario Infanta LeonorMadrid 28031Spain Department of Thoracic Surgery Hospital de la Santa Creu i Sant Pau&Hospital de MarUniversitat Autònoma de BarcelonaBarcelona 08041CataloniaSpain Department of Radiation Oncology Hospital Universitario HM SanchinarroHM HospitalesHM CIOCC Centro Integral Oncológico Clara CampalMadrid 28050Spain Department of Radiation Oncology Hospital Universitario Lucus Augusti&Instituto de Investigación Sanitaria Santiago de Compostela(IDIS)Lugo 27003Spain Department of Radiation Oncology Hospital Del Mar&Hospital Del Mar Medical Research Institute(IMIM)&Pompeu Fabra UniversityBarcelona 08003CataloniaSpain Department of Medical Oncology Alcorcón Foundation University HospitalAlcorcón 28922MadridSpain Department of Thoracic Surgery Hospital de la Santa Creu i Sant PauBarcelona 08029Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28223Spain

The treatment of small cell lung cancer(SCLC)is a challenge for all specialists *** treatments have been added to the therapeutic armamentarium in recent months,but efforts must continue to improve both survival and quality of *** in surgery and radiotherapy have resulted in prolonged survival times and fewer complications,while more careful patient selection has led to increased staging *** in the field of systemic therapy have resulted in changes to clinical guidelines and the management of patients with advanced disease,mainly with the introduction of *** this article,we describe recent improvements in the management of patients with SCLC,review current treatments,and discuss future lines of research.

关键词： Small cell lung cancer Whole-brain radiotherapy Prophylactic cranial irradiation Stereotactic body radiotherapy Immunotherapy Atezolizumab Durvalumab

Stereotactic body radiation therapy:A good dance partner of oligometastatic non-small cell lung cancer to the sound of SINDAS study

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World Journal of Clinical Oncology 2020年第12期11卷 983-989页

作者： Xabier Mielgo-Rubio Javier Garde-Noguera Oscar Juan felipe couñago Department of Medical Oncology Hospital Universitario Fundación AlcorcónMadrid 28922Spain Department of Medical Oncology Hospital Arnau de VilanovaC/Sant ClimentValencia 46015Spain Department of Medical Oncology La Fe University HospitalValencia 46026Comunitat ValencianaSpain School of Medicine Catholic University San Vicente MartirValencia 46001Comunitat ValencianaSpain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28028Spain

The European Organization for Research on Treatment of Cancer Research published a consensus statement to establish the key criteria to define oligometastatic disease(OMD).According to those criteria,all lesions(both primary and metastatic)should be amenable to radical intent treatment with acceptable *** retrospective studies have shown that adding local ablative therapy to the treatment of OMD improves outcomes;however,due to the diverse selection criteria and treatment strategies used in those studies,it is difficult to compare directly results to draw definitive *** recent years,prospective phase II trials,such as the SABR-COMET and"Oligomez"trials,have shown that stereotactic body radiation therapy(SBRT)improves outcomes in patients with *** recently,interim results of the randomised phase 3 SINDAS trial were reported at the annual meeting of the American Society of Clinical Oncology 2020 demonstrating that upfront SBRT added to systemic treatment with tyrosine kinase inhibitors yielded a significant benefit in both progression-free survival and overall survival in patients with epidermal growth factor receptor-mutant oligometastatic non-small cell lung *** the present editorial,we review the definition and historical context of advanced non-small cell lung cancer with *** addition,we review the scientific evidence for local ablative therapy and SBRT and discuss the results of recently published prospective *** also discuss in depth the results of the SINDAS study,including the strengths and weaknesses of the study and the barriers to extrapolating these results to routine clinical practice.

关键词： Oligometastatic Non-small cell lung cancer Stereotactic body radiation therapy SINDAS Local ablative therapy Epidermal growth factor receptor mutations Epidermal growth factor receptor-mutated