检索结果-南通市图书馆

Compa.tmenta.ized necroptosis a.tiva.ion in excitotoxicityinduced a.ona. degenera.ion: a.novel mecha.ism implica.ed in neurodegenera.ive disea.e pa.hology

引用

Neura. Regenera.ion Resea.ch 2019年第8期14卷 1385-1386页

作者： Ma.a.ena.S. a.ra.ola.felipe a. court Center for Integra.ive Biology Faculty of Sciences Universidad Mayor de Chile Santiago CnileFONDAP Center for Geroscience Brain Health and Metabolism Santiago Chile Buck Institute for Resea.ch on a.eing Novato San Francisco CA USA

Excitotoxicity a.d neurona. cell dea.h: Gluta.a.e is the ma.n excita.ory neurotra.smitter of the centra. nervous system a.d functiona.ly involved in most bra.n a.tivities, including bra.n development, syna.tic pla.ticity, lea.ning a.d memory. Exc让a.ory syna.tic tra.smission is prima.ily media.ed by liga.a.ga.ed ion cha.nels, including a.a.ino-3-hydroxy-5-methylisoxa.oIe-4-propionic a.id (a.Pa., N-methyl-D-a.pa.ta.e (NMDa. a.d ka.na.e receptors. a.tiva.ion of gluta.a.e receptors, pa.ticula.ly NMDa.receptors, usua.ly lea.s to ca.cium influx, whicn ca. a.t a. a.second messenger for severa. processes to media.e syna.tic a.tivity a.d bra.n function. Nevertheless, excessive relea.e of gluta.a.e neurotra.smitter ma. produce intra.ellula. ca.cium overloa., lea.ing to a.ca.ca.e of events media.ing cytoskeleton da.a.e a.compa.ied w让h rea.tive oxygen species (ROS) genera.ion, mitochondria. dysfunction a.d ultima.ely neurona. cell dea.h. These toxic effects of gluta.a.e a.e known a. excitotoxicity. Neurona. excitotoxicity ha. been linked to severa. a.ute a.d chronic bra.n disea.es, such a. stroke/ischemia. epilepsy a.d a.ra.ge of neurodegenera.ive disorders, including a.zheimer's disea.e (a.), Huntingtons disea.e, a.yotrophic la.era. sclerosis (a.S) a.d Pa.kinsons disea.e (PD), contributing to the neurona. lost in different bra.n regions. Unfortuna.ely, trea.ing nervous system disorders with genera. gluta.a.e receptor blockers ha. been a.socia.ed with undesira.le side effects, becoming increa.ingly necessa.y to unra.el downstrea. effectors in the excitotoxicity-dependent cell dea.h pa.hwa. in order to develop novel thera.eutic stra.egies.

关键词： Compa.tmenta.ized necroptosis a.tiva.ion excitotoxicityinduced a.ona. neurodegenera.ive disea.e

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New insights on the molecula. mecha.isms of colla.era. sprouting a.ter periphera. nerve injury

引用

Neura. Regenera.ion Resea.ch 2021年第9期16卷 1760-1761页

作者： Dominique Lema.tre felipe a.court Universida. del Desa.rollo Facultad de MedicinaCentro de Fisiología Celular e IntegrativaSantiagoChile Center for Integra.ive Biology Faculty of SciencesUniversidad MayorSantiagoChile Geroscience Center for Bra.n Hea.th a.d Meta.olism(GERO) SantiagoChile The Buck Institute for Resea.ch on a.ing NovatoCAUSA

a.ona. regenera.ion a.ter injuries to the nervous system ha. been extensively studied due to its implica.ion in motor a.d sensory functiona. recovery. Distinct types of regenera.ion ha. been identified, such a. ca.onica. a.ona. regenera.ion, defined a. the growth of a.ons from the tra.sected a.ona. stump to reinnerva.e the origina. ta.get, or regenera.ive sprouting, in which the growth occurs from a.region of the da.a.ed a.on either close or fa. from the injury site(Tuszynski a.d Stewa.d, 2012).

关键词： injuries injury colla.era.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Commenta.y on"Pa.optosis-like cell dea.h in ischemia.reperfusion injury of retina. neurons"

引用

Neura. Regenera.ion Resea.ch 2023年第2期18卷 341-341页

作者： Ma.a.ena.S.a.rázola.felipe a.court Center for Integra.ive Biology Faculty of SciencesUniversidad Mayor Geroscience Center for Bra.n Hea.th a.d Meta.olism(GERO) SantiagoChile Buck Institute for Resea.ch on a.ing NovatoCAUSA

See rela.ed a.ticle,pp 357-363Severa. deca.es ha.e pa.sed since progra.medcell dea.h(PCD)wa. *** wa. first defined by Kerr in 1972,a.d la.er described by the Nobel Prices in Physiology or Medicine 2002,Sydney Brenner,John Sulston a.d Robert Horwitz,who defined genetic regula.ors of a.optosis(Dia.a.tis et a..,2008).However,it wa. in 1858 when the Germa. pa.hologist a.d biologist Rudolf Virchow identified for the first time the phenomenon of a.optosis,which he na.ed necrobiosis,a.guing tha. this form of cell dea.h wa. completely different from the uncontrolled necrosis,suggesting the existence of two different types of cell ***,the knowledge in the field of cell dea.h regula.ion is extensive,but still under continuous expa.sion.

关键词： expa.sion dea.h Sydney

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ma.netic a.d superconducting pha.e dia.ra.s a.d tra.sition tempera.ures predicted using text mining a.d ma.hine lea.ning

引用

npj Computa.iona. Ma.eria.s 2020年第1期6卷 1521-1529页

作者： Ca.lum J.court Ja.queline M.Cole Ca.endish La.ora.ory Department of PhysicsUniversity of CambridgeJ.J.Thomson AvenueCambridge CB30HEUK ISIS Neutron a.d Muon Source STFC Rutherford Appleton LaboratoryHarwell Science and Innovation CampusDidcotOxfordshire OX110QXUK a.gonne Na.iona. La.ora.ory 9700 South Cass AvenueArgonneIL 60439USA Depa.tment of Chemica. Engineering a.d Biotechnology University of CambridgeWest Cambridge SitePhilippa Fawcett DriveCambridge CB30FSUK

Predicting the properties of ma.eria.s prior to their synthesis is of grea. importa.ce in ma.eria.s *** a.d superconducting ma.eria.s exhibit a.number of unique properties tha. ma.e them useful in a.wide va.iety of a.plica.ions,including solid oxide fuel cells,solid-sta.e refrigera.ts,photon detectors a.d metrology *** a.l these a.plica.ions,pha.e tra.sitions pla. a. importa.t role in determining the fea.ibility of the ma.eria.s in ***,we present a.pipeline for fully integra.ing da.a.extra.ted from the scientific litera.ure into ma.hine-lea.ning tools for property prediction a.d ma.eria.s *** a.va.ced na.ura. la.gua.e processing(NLP)a.d ma.hine-lea.ning techniques,we successfully reconstruct the pha.e dia.ra.s of well-known ma.netic a.d superconducting compounds,a.d demonstra.e tha. it is possible to predict the pha.e-tra.sition tempera.ures of compounds not present in the *** provide the tool a. a. online open-source pla.form,forming the ba.is for further resea.ch into ma.netic a.d superconducting ma.eria.s discovery for potentia. device a.plica.ions.

关键词： pha.e tra.sition superconducting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ma.ING Ma.OR RETa.L ESTa.LISHMENTS SUSTa.Na.LE:THE Ca.E OF THE Ma.L a. ROBINSON

引用

Journa. of Green Building 2007年第4期2卷 14-22页

作者： Ma.thew M.Meha.ik court Gould Beth Edwa.ds Susta.na.le Pittsburgh 425 Sixth AvenueSuite 1335PittsburghPA 15261 Susta.na.le Pittsburgh The Ma.l a. Robinson

INTRODUCTION This ca.e serves a. a.lea.ership exa.ple of wha. is initia.ly possible for existing ma.l reta.l esta.lishments rega.ding *** discussion consists of a.ca.e study of how a.multidisciplina.y tea. of Pittsburgh-regiona. experts conducted a.comprehensive a.a.ysis using a.systems a.proa.h[1]to identify a.d provide recommenda.ions for susta.na.le business solutions to benefit a.la.ge reta.l shopping ma.l in the Pittsburgh Region,The Ma.l a. *** convening orga.iza.ion for this project wa. Susta.na.le *** from the a.sessment include solutions tha. will sa.e or ma.e money a.d increa.e the ma.l’s effectiveness a.d resource *** impa.ts include recommenda.ions for becoming better stewa.ds of the environment a.d community a.d increa.ing the ma.l’s public *** project a.proa.h ha. been to focus on opportunities for continuous improvement where the interests of people,business,a.d environment meet.

关键词： Susta.na.le Ca.E shopping

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ULTRa.OUND INDUCED a.D La.ER ENHa.CED COLD FUSION CHEMISTRY

引用

Nuclea. Science a.d Techniques 1995年第4期6卷 198-203页

作者： T. V. Prevenslik (2/E Greenery court, Discovery Ba., Hong Kong)

The sta.da.d model of sonoluminescence suggests tha. the Coulomb ba.rier to deuterium fusion ma. be overcome by high bubble ga. tempera.ures ca.sed by compression hea.ing if the bubble dia.eter rema.ns spherica. during bubble ***, in the more likely colla.se geometry of a.pa.ca.e sha.e, the tempera.ure rise in the bubbles is negligible. But the colla.sing pa.ca.e bubble is found to significa.tly increa.e the frequency of the infra.ed energy a.a.la.le in the vibra.iona. sta.e of the wa.er molecules a. a.bient tempera.ure. For a.colla.se to liquid density, ultra.iolet ra.ia.ion a. a.out 10eV is found. a.though the ultra.iolet ra.ia.ion is of a.low intensity, higher intensities ma. be possible if the bubble colla.se is enha.ced by visible a.d infra.ed la.ers. Neither hot nor cold fusion is predicted in bubble colla.se,but the ultra.iolet energy a. a.out 10eV developed in the bubble is sufficient to provide the ba.is for a.new field of chemistry ca.led ultra.ound induced a.d la.er enha.ced cold fusion chemistry.

关键词： Cold fusion Ultra.ound Ultra.iolet Theory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sonoluminescence a.d the proba.ility of isotherma. bubble colla.se

引用

Nuclea. Science a.d Techniques 1997年第4期8卷 236-238页

作者： Thoma. V Prevenslik ( 2E Greenery court, Discovery Ba., Hong Kong) 2EGreenerycourt DiscoveryBayHongKong

ＳｏｎｏｌｕｍｉｎｅｓｃｅｎｃｅａｎｄｔｈｅｐｒｏｂａｂｉｌｉｔｙｏｆｉｓｏｔｈｅｒｍａｌｂｕｂｂｌｅｃｏｌａｐｓｅＴｈｏｍａｓＶＰｒｅｖｅｎｓｌｉｋ（２ＥＧｒｅｎｅｒｙＣｏｕｒｔ，ＤｉｓｃｏｖｅｒｙＢａｙ，Ｈｏｎｇ... 详细信息

ＳｏｎｏｌｕｍｉｎｅｓｃｅｎｃｅａｎｄｔｈｅｐｒｏｂａｂｉｌｉｔｙｏｆｉｓｏｔｈｅｒｍａｌｂｕｂｂｌｅｃｏｌａｐｓｅＴｈｏｍａｓＶＰｒｅｖｅｎｓｌｉｋ（２ＥＧｒｅｎｅｒｙＣｏｕｒｔ，ＤｉｓｃｏｖｅｒｙＢａｙ，ＨｏｎｇＫｏｎｇ）ＡｂｓｔｒａｃｔＣｏｍｐ...

关键词：冷聚变声致发光等温泡消失

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Providing Strong Judicia. Gua.a.tees for Innova.ion-Driven Development

引用

Qiu Shi 2021年第2期13卷 30-37页

作者： The Intellectua. Property court of the Supreme People's court The Intellectua. Property court of the Supreme People’s court

In his speech a. the 25th Group Study Session of the Politica. Burea. of the 19th CPC Centra. Committee,Genera. Secreta.y Xi Jinping thoroughly exa.ined a.series of theoretica. a.d pra.tica. issues concerning our direction,principles,a.d underpinning for reform a.d development in the field of intellectua. property(IP)*** speech provides a.funda.enta. a.d pra.tica. guide for the work of strengthening IP protection in *** the a.judica.ion of IP ca.es.

关键词： Strong thoroughly concerning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Extra.tion of physica. Schottky pa.a.eters using the La.bert function in Ni/a.Ga./Ga. HEMT devices with defined conduction phenomena

引用

Journa. of Semiconductors 2017年第1期38卷 95-99页

作者： O.La.ry a.Diva. D.Fa.il P.Dherbécourt Norma.die Université URGPM CNRS UMR 663476801 St-Etienne-du-RouvrayFrance

Electrica. cha.a.teriza.ion a.a.yses a.e proposed in this work using the La.bert function on Schottky junctions in Ga. wide ba.d ga. semiconductor devices for extra.tion of physica. *** La.bert function is used to give a. explicit expression of the current in the Schottky *** function is a.plied with defined conduction phenomena.wherea. other work presented a.bitra.y（or undefined）conduction mecha.isms in such pa.a.eters＇ *** upon a.Ga./Ga. HEMT structures,extra.tions of pa.a.eters a.e undergone in order to provide physica. *** work highlights a.new expression of current with defined conduction phenomena.in order to qua.tify the physica. properties of Schottky conta.ts in a.Ga./Ga. HEMT tra.sistors.

关键词： Ga. Schottky junction conduction mecha.isms La.bert function pa.a.eters extra.tion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Twenty-first century clima.e cha.ge a.d submerged a.ua.ic vegeta.ion in a.tempera.e estua.y:the ca.e of Chesa.ea.e Ba.

引用

Ecosystem Hea.th a.d Susta.na.ility 2017年第7期3卷 14-34页

作者： Thoma. M.a.nold Richa.d C.Zimmerma. Ka.ha.ina.a.M.Engelha.dt J.court Stevenson Depa.tments of Biology a.d Environmenta. Studies Dickinson CollegeCarlislePAUSA Depa.tment of Ocea. Earth and Atmospheric SciencesOld Dominion UniversityNorfolkVAUSA a.pa.a.hia. La.ora.ory University of Maryland Center for Environmental ScienceFrostburgMDUSA Horn Point La.ora.ory University of Maryland Center for Environmental ScienceCambridgeMDUSA

Introduction:The Chesa.ea.e Ba. wa. once renowned for expa.sive mea.ows of submerged a.ua.ic vegeta.ion(Sa.).However,only 10%of the origina. mea.ows *** restora.ion effortswill be complica.ed by a.celera.ing clima.e cha.ge,including physiologica. stressors such a. a.predicted mea. tempera.ure increa.e of 2-6℃a.d a.50-160%increa.e in CO_(2)***:a. the Chesa.ea.e Ba. begins to exhibit cha.a.teristics of a.subtropica. estua.y,summer hea. wa.es will become more frequent a.d *** a.one would eventua.ly elimina.e eelgra.s(Zostera.ma.ina.from the *** will fa.or na.ive hea.-tolera.t species such a. widgeon gra.s(Ruppia.ma.itima.while fa.ilita.ing coloniza.ion by non-na.ive sea.ra.ses(e.g.,Ha.odule spp.).Intensifying huma. a.tivity will a.so fuel coa.ta. zone a.idifica.ion a.d the resulting high CO_(2)/low pH conditions ma. benefit Sa. via.a.CO_(2)fertiliza.ion effect.”Discussion:a.idifica.ion is known to offset the effects of therma. stress a.d ma. ha.e simila. effects in estua.ies,a.suming wa.er cla.ity is sufficient to support CO_(2)-stimula.ed photosynthesis a.d pla.ts a.e not overgrown by ***,coa.ta. zone a.idifica.ion is va.ia.le,driven mostly by loca. biologica. processes tha. ma. or ma. not a.wa.s counterba.a.ce the effects of regiona. *** preca.ious equipoise between two forces-therma. stress a.d a.idifica.ion-will be critica.ly importa.t beca.se it ma. ultima.ely determine the fa.e of cool-wa.er pla.ts such a. Zostera.ma.ina.in the Chesa.ea.e ***:The combined impa.ts of wa.ming,coa.ta. zone a.idifica.ion,wa.er cla.ity,a.d overgrowth of competing a.ga. will determine the fa.e of Sa. communities in ra.idly cha.ging tempera.e estua.ies.

关键词： Submerged a.ua.ic vegeta.ion clima.e tempera.ure coa.ta. a.idifica.ion Chesa.ea.e Ba.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：