检索结果-南通市图书馆

Molecular pathogenesis of acute myeloid leukemia: A diversedisease with new perspectives

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2010年第4期4卷 356-362页

作者： felicitas THOL Arnold GANSER Department of Hematology HemostasisOncologyand Stem Cell TransplantationHannover Medical SchoolHannover 30625Germany

Acute myeloid leukemia(AML)is a very heterogeneous neoplasm of the hematopoietic stem *** important achievements in the treatment of AML,the long term survival of patients with the disease remains *** the pathogenesis of AML better is crucial forﬁnding new treatment *** AML development,hematopoietic precursor cells undergo clonal transformation in a multistep process through acquisition of chromosomal rearrangements and/or different gene *** recent years,novel gene mutations have been found in patients with *** mutations can be divided into two important categories,class I mutations that confer a proliferation advantage and class II mutations that inhibit myeloid *** for some of these mutations is now part of the initial diagnostic work-up in newly diagnosed AML *** about the mutation status of speciﬁc genes is useful for risk-stratiﬁcation,minimal residual disease(MRD)monitoring and increasingly also for targeted therapy,especially for patients with cytogenetically normal AML(CN-AML).Besides chromosomal rearrangements and gene mutations,epigenetic regulation of genes–meaning changes in gene expression by mechanisms other than changes in the underlying DNA sequence–also represents an important mechanism of *** article reviews some of the most common mutations in CN-AML and gives a perspective of the translation of these discoveries from bench to bedside.

关键词： acute myeloid leukemia mutations risk stratiﬁcation

Mosaic theory revised:inflammation and salt play central roles in arterial hypertension

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2022年第5期19卷 561-576页

作者： felicitas E.Hengel Jean-Pierre Benitah Ulrich O.Wenzel Ⅲ.Department of Medicine University Hospital Hamburg-EppendorfHamburgGermany Inserm UMR-S 1180 Faculty of PharmacyUniversity Paris SaclayGif-sur-YvetteFrance

The mosaic theory of hypertension was advocated by Irvine Page~80 years ago and suggested that hypertension resulted from the close interactions of different *** evidence indicates that hypertension and hypertensive end-organ damage are not only mediated by the proposed mechanisms that result in hemodynamic *** plays an important role in the pathophysiology and contributes to the deleterious consequences of arterial *** intake is indispensable for normal body function but can be detrimental when it exceeds dietary *** data show that sodium levels also modulate the function of monocytes/macrophages,dendritic cells,and different T-cell *** of these effects are mediated by changes in the microbiome and metabolome due to high-salt *** purpose of this review is to propose a revised and extended version of the mosaic theory by summarizing and integrating recent advances in salt,immunity,and hypertension *** and inflammation are placed in the middle of the mosaic because both factors influence each of the remaining pieces.

关键词： Arterial hypertension salt innate and adaptive immunity renin angiotensin aldosterone system mineralocorticoid receptor angiotensinⅡreceptor

Time-domain Dynamic State Estimation for Unbalanced Three-phase Power Systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2023年第2期11卷 446-454页

作者： Martin Pfeifer felicitas Mueller Steven de Jongh Frederik Gielnik Thomas Leibfried Sören Hohmann Institute of Control Systems(IRS) KarlsruheGermany Institute of Electrical Energy Systems and High Voltage Technology(IEH)at the Karlsruhe Institute of Technology(KIT) 76131 KarlsruheGermany

In this paper,we present a time-domain dynamic state estimation for unbalanced three-phase power *** dynamic nature of the estimator stems from an explicit consideration of the electromagnetic dynamics of the network,i.e.,the dynamics of the electrical *** enables our approach to release the assumption of the network being in quasi-steady ***,based on the line dynamics,we derive a graphbased dynamic system *** handle the large number of interacting variables,we propose a port-Hamiltonian modeling *** on the port-Hamiltonian model,we then follow an observer-based approach to develop a dynamic *** estimator uses synchronized sampled value measurements to calculate asymptotic convergent estimates for the unknown bus voltages and *** design and implementation of the estimator are illustrated through the IEEE 33-bus *** simulations verify the estimator to produce asymptotic exact estimates,which are able to detect harmonic distortion and sub-second transients as arising from converterbased resources.

关键词： Dynamic state estimation power system harmonic observer port-Hamiltonian system static state estimation transient

Absent MicroRNAs in Different Tissues of Patients with Acquired Cardiomyopathy

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2016年第4期14卷 224-234页

作者： Christine S. Siegismund Maria Rohde Uwe Kiihl felicitas Escher Heinz Peter Schultheiss Dirk Lassner Institute for Cardiac Diagnostics and Therapy(IKDT) 12203 BerlinGermany Department of Cardiology Campus VirchowCharite-University Hospital Berlin13353 BerlinGermany

MicroRNAs （miRNAs） can be found in a wide range of tissues and body fluids, and their specific signatures can be used to determine diseases or predict clinical courses. The miRNA profiles in biological samples （tissue, serum, peripheral blood mononuelear cells or other body fluids） differ significantly even in the same patient and therefore have their own specificity for the presented condition. Complex profiles of deregulated miRNAs are of high interest, whereas the importance of non-expressed miRNAs was ignored. Since miRNAs regulate gene expression rather negatively, absent miRNAs could indicate genes with unaltered expression that therefore are normally expressed in specific compartments or under specific disease situations. For the first time, non-detectable miRNAs in different tissues and body fluids from patients with different diseases （cardiomyopathies, Alzheimer＇s disease, bladder cancer, and ocular cancer） were analyzed and compared in this study, miRNA expression data were generated by microarray or TaqMan PCR-based platforms. Lists of absent miRNAs of primarily cardiac patients （myocardium, blood cells, and serum） were clustered and analyzed for potentially involved pathways using two prediction platforms, i.e., miRNA enrichment analysis and annotation tool （miEAA） and DIANA miRPath. Extensive search in biomedical publication databases for the relevance of non-expressed miRNAs in predicted pathways revealed no evidence for their involvement in heart-related pathways as indicated by software tools, confirming proposed approach.

关键词： Cardiomyopathy Heart muscle biopsy Absent mi RNAs Peripheral blood mononuclear cell Serum

Small mammal community composition impacts bank vole (Clethrionomys glareolus) population dynamics and associated seroprevalence of Puumala orthohantavirus

在线全文

学校读者我要写书评

暂无评论

Integrative Zoology 2024年第1期19卷 52-65页

作者： felicitas Maria BUJNOCH Daniela REIL Stephan DREWES Ulrike MROSENFELD Rainer G.ULRICH Jens JACOB Christian IMHOLT Julius Kühn-Institute Federal Research Centre for Cultivated PlantsInstitute for Epidemiology and Pathogen DiagnosticsRodent ResearchMünsterGermany University of Münster Institute for Evolution and BiodiversityMünsterGermany Friedrich-Loeffler-Institut Federal Research Institute for Animal HealthInstitute of Novel and Emerging Infectious DiseasesGreifswald-Insel RiemsGermany

Rodents are important reservoirs for zoonotic pathogens that cause diseases in *** is hypoth-esized to be closely related to pathogen prevalence through multiple direct and indirect *** example,the presence of non-host species can reduce contact rates of the main reservoir host and thus reduce the risk of transmission(“dilution effect”).In addition,an overlap in ecological niches between two species could lead to increased interspecific competition,potentially limiting host densities and reducing density-dependent pathogen transmission *** this study,we investigated the relative impact of population-level regulation of direct and indirect drivers of the prevalence of Puumala orthohantavirus(PUUV)in bank voles(Clethrionomys glareolus)during years with high *** compiled data on small mammal community composition from four regions in Germany between 2010 and *** equation modeling revealed a strong seasonality in PUUV control mechanisms in bank *** abundance of shrews tended to have a negative relationship with host abundance,and host abundance positively influenced PUUV seroprevalence,while at the same time increasing the abundance of competing non-hosts like the wood mouse(Apodemus sylvaticus)and the yellow-neckedfield mouse(Apodemusflavicollis)were associated with reduced PUUV seroprevalence in the *** results indicate that for PUUV in bank voles,dilution is associated with increased interspecific *** pressures leading to the decline of Apodemus *** a specific habitat could lead to the amplification of mechanisms promoting PUUV transmission within the host populations.

关键词： bank vole biodiversity Puumala orthohantavirus small mammals

Impact of donor-specific antibodies on long-term graft survival with pediatric liver transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2021年第6期13卷 673-685页

作者： felicitas Leonie Schotters Jan Beime Andrea Briem-Richter Thomas Binder Uta Herden Enke Freya Grabhorn Department of Pediatric Hepatology and Liver Transplantation Universitätsklinikum Hamburg-EppendorfHamburg 20246Germany Department of Transfusion Medicine Human Leucocyte Antigen LaboratoryUniversity Medicine RostockRostock 18057Germany Department of Hepatobiliary&Transplant Surgery Universitätsklinikum Hamburg-EppendorfHamburg 20246Germany

BACKGROUND In a previous paper,we reported a high prevalence of donor-specific antibody(DSA)in pediatric patients with chronic rejection and expressed the need for confirmation of these findings in a larger *** To clarify the importance of DSAs on long-term graft survival in a larger cohort of pediatric *** We performed a retrospective analysis of 123 pediatric liver transplantation(LT)recipients who participated in yearly follow-ups including Luminex testing for DSA at our *** cohort was split into two groups according to the DSA status(DSA-positive n=54,DSA-negative n=69).Groups were compared with regard to liver function,biopsy findings,graft survival,need for re-LT and immunosuppressive *** DSA-positive pediatric patients showed a higher prevalence of chronic rejection(P=0.01),fibrosis(P<0.001)and re-transplantation(P=0.018)than DSA-negative *** II DSAs particularly influenced graft *** DQ2,DQ7,DQ8 and DQ9 might serve as indicators for the risk of chronic rejection and/or allograft *** fluorescence intensity levels and DSA number did not impact graft *** episodes of chronic rejection might lead to DSA *** DSA prevalence significantly affected long-term liver allograft performance and liver allograft survival in our cohort of pediatric *** for class II DSAs in combination with assessment of protocol liver biopsies for chronic antibodymediated rejection improved early identification of patients at risk of graft loss.

关键词： Donor-specific antibodies Graft rejection Liver transplantation Fluoroimmunoassay Pediatrics Graft dysfunction Fibrosis

The Human PsB-ATPase ATP13A2 Is Not a Ca2＊ Transporting Pump

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Life Sciences 2011年第1期5卷 1-6页

作者： felicitas de Tezanos Pinto Gerardo Raul Corradi Hugo Pedro Adamo IQUIFIB-Facultad de Farmacia y Bioquimica Universidad de Buenos Aires Junin 956 1113 Buenos Aires Argentina

The human gene ATP 13A2 has been proposed to code for an ATP powered ion transporter of the PsB subfamily. Mutations of the human gene ATP1 3A2 were found to underlie an autosomal recessive form of early-onset parkinsonism （PD） with pyramidal degeneration and dementia. The ion transported by the ATP13A2 pump is not known, but several studies have shown that the Ps-ATPases influence the homeostasis of intracellular Ca2＋, and thus it has been suggested that they transport Ca2＋. In order to evaluate this possibility Chinese hamster ovary （CHO） cells stably expressing the human ATP13A2 protein have been obtained and the Ca2＋ transport activity of ATP 13A2 was assessed by measuring the ATP-dependent uptake of Ca2＋ into microsomal vesicles. As a positive control vesicles containing the human plasma membrane Ca2＋ pump （PMCA） were used. No significant differences were found between vesicles containing the ATP 13A2 protein and the control. Moreover, Ca2＋ was unable to induce the formation of the P-ATPase acylphosphate intermediate in vesicles containing the expressed ATPl3A2. These results favor the idea that the ATPI3A2 does not transport Ca2＋.

关键词： PSB-ATP13A2 calcium uptake CHO cells overexpression.

DEVELOPING YOUNG CHILDREN'S LITERACY: FAMILY LITERACY PRACTICES

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Applied Linguistics 2006年第1期29卷 93-98,129页

作者： felicitas E.Pado 菲律宾大学

This paper will present two researches on family literacy and how they develop the children's early literacy behaviors. The first research looked into the literacy behaviors of preschool-age children with ages ranging from three to five years and what home environment factors influenced the acquisition of these literacy behaviors. The second research looked into the training of urban poor families into literacy and numeracy through training modules, and looked into how these parents can develop and enhance their own literacy and numeracy and then teach these to their children.

关键词： young children literacy family literacy practices

Sonographic Estimation of Visceral Adipose Tissue in an African Population

在线全文

学校读者我要写书评

暂无评论

Health 2015年第5期7卷 653-658页

作者： Thomas Adejoh Idigo felicitas Ugochinyere Sobechukwu Warric Iwene Onwuzu Nkubli Flavious Bobouin Alhamdu Sila Moi Radiology Department Nnamdi Azikiwe University Teaching Hospital Nnewi Nigeria Department of Medical Radiography and Radiological Sciences University of Nigeria Enugu Campus Enugu Nigeria Medical Imaging Unit Department of Medical Center University of Nigeria Nsukka Nigeria Department of Medical Radiography College of Medical Sciences University of Maiduguri Maiduguri Nigeria

Purpose: To establish normal values of sonographically-quantified visceral adipose tissue (VAT) in an African population and to correlate results with biomarkers. Patients and Methods: 100 male and 150 female volunteers were scanned for intra-abdominal adipose tissue thickness. Other parameters obtained include BMI, WC, and blood pressure (BP). Pearson correlation coefficient (r) was used to estimate the degree of relationship in VAT, BMI, WC, and blood pressure. Results: The mean VAT thickness was 25.36 ± 16.42 mm. VAT correlated positively and linearly with age (r = 0.651;p < 0.05), BMI (males: r = 0.745, p < 0.05, and females: r = 0.736;p < 0.05), WC (males: r = 0.797, p < 0.05;females: r = 0.779, p < 0.05), and systolic and diastolic blood pressure. (Systolic: r = 0.524, p < 0.05, and diastolic: r = 0.535, p <0.05). Conclusion: Ultrasound is a useful tool in assessing VAT during routine scans to identify patients at risk of increased blood pressure and cardiac diseases associated with obesity.

关键词： Adipose Tissue Blood Pressure Viscera Ultrasound