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Mechanical environment for in vitro cartilage tissue engineering assisted by in silico models

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Biomaterials Translational 2023年第1期4卷 18-26页

作者： Rob Jess Tao Ling Yi Xiong Chris J.Wright feihu zhao Department of Computing Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

Mechanobiological study of chondrogenic cells and multipotent stem cells for articular cartilage tissue engineering(CTE)has been widely *** mechanical stimulation in terms of wall shear stress,hydrostatic pressure and mechanical strain has been applied in CTE in *** has been found that the mechanical stimulation at a certain range can accelerate the chondrogenesis and articular cartilage tissue *** review explicitly focuses on the study of the influence of the mechanical environment on proliferation and extracellular matrix production of chondrocytes in vitro for *** multidisciplinary approaches used in previous studies and the need for in silico methods to be used in parallel with in vitro methods are also *** information from this review is expected to direct facial CTE research,in which mechanobiology has not been widely explored yet.

关键词： cartilage tissue engineering in silico modelling mechanical stimulation mechanobiology

Establishment and application of a surrogate model for human Ebola virus disease in BSL-2 laboratory

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Virologica Sinica 2024年第3期39卷 434-446页

作者： Wanying Yang Wujian Li Wujie Zhou Shen Wang Weiqi Wang Zhenshan Wang Na Feng Tiecheng Wang Ying Xie Yongkun zhao feihu Yan Xianzhu Xia Hebei Key Lab of Laboratory Animal Science Department of Laboratory Animal ScienceHebei Medical UniversityShijiazhuang050017China Key Laboratory of Jilin Province for Zoonosis Prevention and Control Changchun Veterinary Research InstituteChinese Academy of Agricultural SciencesChangchun130122China College of Veterinary Medicine Jilin UniversityChangchun130062China College of Veterinary Medicine Jilin Agricultural UniversityChangchun130118China

The Ebola virus(EBOV)is a member of the Orthoebolavirus genus,Filoviridae family,which causes severe hemorrhagic diseases in humans and non-human primates(NHPs),with a case fatality rate of up to 90%.The development of countermeasures against EBOV has been hindered by the lack of ideal animal models,as EBOV requires handling in biosafety level(BSL)-4 ***,accessible and convenient animal models are urgently needed to promote prophylactic and therapeutic approaches against *** this study,a recombinant vesicular stomatitis virus expressing Ebola virus glycoprotein(VSV-EBOV/GP)was constructed and applied as a surrogate virus,establishing a lethal infection in *** infection with VSV-EBOV/GP,3-week-old female Syrian hamsters exhibited disease signs such as weight loss,multi-organ failure,severe uveitis,high viral loads,and developed severe systemic diseases similar to those observed in human EBOV *** animals succumbed at 2–3 days post-infection(dpi).Histopathological changes indicated that VSV-EBOV/GP targeted liver cells,suggesting that the tissue tropism of VSV-EBOV/GP was comparable to wild-type EBOV(WT EBOV).Notably,the pathogenicity of the VSV-EBOV/GP was found to be species-specific,age-related,gender-associated,and challenge ***,equine anti-EBOV immunoglobulins and a subunit vaccine were validated using this ***,this surrogate model represents a safe,effective,and economical tool for rapid preclinical evaluation of medical countermeasures against EBOV under BSL-2 conditions,which would accelerate technological advances and breakthroughs in confronting Ebola virus disease.

关键词： Ebola virus(EBOV) Recombinant vesicular stomatitis virus Pathogenicity Syrian hamster Surrogate models Vaccine evaluation and drug screening

Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model

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Medicine in Novel Technology and Devices 2023年第2期18卷 267-271页

作者： Husham Ahmed Matthew Bedding-Tyrrell Davide Deganello Zhidao Xia Yi Xiong feihu zhao Zienkiewicz Centre for Computational Engineering and Department of Biomedical Engineering Faculty of Science&EngineeringSwansea UniversitySwanseaSA18ENUK Welsh Centre for Printing and Coating Faculty of Science and EngineeringSwansea UniversitySwanseaSA18ENUK Centre for Nanohealth Swansea University Medical School and Faculty of MedicineHealth and Life ScienceSwansea UniversitySwanseaSA35AUUK School of System Design and Intelligent Manufacturing Southern University of Science and TechnologyShenzhen518055China

Mechanical stimulation,such as fluid-induced wall shear stress(WSS),is known that can influence the cellular ***,in some tissue engineering experiments in vitro,mechanical stimulation is applied via bioreactors to the cells in cell culturing to study cell physiology and *** 3D cell culturing,porous scaffolds are used for housing the *** is known that the scaffold porous geometries can influence the scaffold permeability and internal WSS in a bioreactor(such as perfusion bioreactor).To calculate the WSS generated on cells within scaffolds,usually computational fluid dynamics(CFD)simulation is ***,the limitations of the computational method for WSS calculation are:(i)the high time cost of the CFD simulation(in particular for the highly irregular geometries);(ii)accessibility to the CFD model for some cell culturing experimentalists due to the knowledge *** address these limitations,this study aims to develop an empirical model for calculating the WSS based on scaffold *** model can allow the tissue engineers to efficiently calculate the WSS generated within the scaffold and/or determine the bioreactor loading without performing the computational simulations.

关键词： Wall shear stress Permeability Empirical model Tissue engineering scaffold Bioreactor

舱口下开盖重力平衡机构力学性能分析与优化设计

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船舶工程 2022年第8期44卷 66-72页

作者：赵飞虎宋强王瑞中国船舶科学研究中心江苏无锡214082 深海技术科学太湖实验室江苏无锡214082 深海载人装备国家重点实验室江苏无锡214082

建立舱口下开盖的扭转弹簧平衡机构和连杆弹簧平衡机构的力学模型,对比分析这2种平衡机构的力矩与反向重力矩的匹配程度,结果发现,连杆弹簧平衡机构对舱口下开盖的重力平衡效果更优。为减小舱口下开盖启闭过程中人员的操作力矩,将连杆... 详细信息

建立舱口下开盖的扭转弹簧平衡机构和连杆弹簧平衡机构的力学模型,对比分析这2种平衡机构的力矩与反向重力矩的匹配程度,结果发现,连杆弹簧平衡机构对舱口下开盖的重力平衡效果更优。为减小舱口下开盖启闭过程中人员的操作力矩,将连杆弹簧平衡机构作为优化设计对象,建立以操作力矩最大值最小为目标的优化数学模型。为适应工程设计的要求,通过添加整数约束,采用变量映射的方法将优化变量转换为连续整数,并采用遗传算法求取某型舱口下开盖重力平衡机构的最优解。

关键词：舱口下开盖重力平衡机构遗传算法优化设计

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O形圈水下吸附状态及脱落现象分析与计算

润滑与密封 2023年第3期48卷 113-119页

作者：赵飞虎许可赵国良齐新中国船舶科学研究中心江苏无锡214082 深海技术科学太湖试验室江苏无锡214082 深海载人装备国家重点实验室江苏无锡214082

安装于舱口盖锥形密封面上的O形圈,在水下开盖初始阶段处于吸附状态并存在开盖后脱落的风险。为保证开盖后O形圈不会发生脱落,采用有限元仿真的方法分析O形圈在密封槽内的吸附移动状态,通过受力分析确定O形圈发生脱落时相应的临界位置;... 详细信息

安装于舱口盖锥形密封面上的O形圈,在水下开盖初始阶段处于吸附状态并存在开盖后脱落的风险。为保证开盖后O形圈不会发生脱落,采用有限元仿真的方法分析O形圈在密封槽内的吸附移动状态,通过受力分析确定O形圈发生脱落时相应的临界位置;结合赫兹接触理论提出O形圈临界参数的计算方法,并通过对O形圈多个相关变量的灵敏度分析,确定选型设计中临界参数最适合的变量。结果表明:对于锥形密封面舱口盖,若水下开盖时O形圈两侧存在压差,则必然存在吸附状态,若O形圈保持吸附状态移动并与密封槽棱圆角接触后,则开盖后密封圈会发生脱落现象;为了避免脱落现象的发生,在O形圈选型设计时必须考虑其临界参数,并根据其数值大小调整O形圈相关参数;其中,O形圈内径参数对压差变化的灵敏度最低,因此在O形圈设计过程中可通过调整内径参数来确保O形圈不会发生脱落。通过水下开盖试验,验证临界参数值的可信度和计算方法的合理性。

关键词：水下吸附脱落现象锥形密封面 O形圈

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煤矿综采工作面采煤机线缆联动智能化设计

机械管理开发 2020年第11期35卷 235-236,265页

作者：赵飞虎同煤集团同家梁矿山西大同037025

为了解决综采工作面采煤机在行走环节中出现的电缆夹多次重叠、互相刮卡、线缆被磨损等故障,提出了使用智能系统拖行线缆的观点.通过设计出一种应用动力牵引采煤机拖缆架行走的智能采煤机线缆联动系统,同时通过配置电控系统以检测和引... 详细信息

为了解决综采工作面采煤机在行走环节中出现的电缆夹多次重叠、互相刮卡、线缆被磨损等故障,提出了使用智能系统拖行线缆的观点.通过设计出一种应用动力牵引采煤机拖缆架行走的智能采煤机线缆联动系统,同时通过配置电控系统以检测和引导采煤机线缆联动系统的工作状态,以保障采煤机线缆的顺畅运行.

关键词：线缆联动电缆夹拖缆综采

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生态建筑与城市发展的协调

中国科技信息 2010年第9期 330-331页

作者：赵飞虎中国人民解放军95588部队后勤部机营科

文章从建设领域实施可持续发展战略的角度阐述了生态建筑的特征,设计目标,设计原则;在可持续发展原则的基础上,探讨生态建筑与城市发展的协调问题。

关键词：生态建筑设计目标设计原则城市发展

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真空耙式干燥器机械密封的设计

润滑与密封 2014年第11期39卷 118-120页

作者：朱军赵飞虎刘龙全成都一通密封有限公司四川成都610100

对真空耙式干燥工艺及设备特点进行分析,以轴径为320 mm的某型号真空耙式干燥器为例,设计其密封结构,探讨其冲洗方案及摩擦副、辅助密封和结构件的选材。模拟实际工况对设计的样机进行的运转试验,结果表明该密封结构密封效果良好。

关键词：真空干燥器机械密封泄漏

(Pb,Sr)Nb_2O_6-NaNbO_3薄膜的制备与介电性能研究

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稀有金属 2017年第7期41卷 826-830页

作者：谭飞虎赵鸿滨于军洋张庆猛魏峰杜军北京有色金属研究总院先进电子材料研究所北京100088 北京有色金属研究总院智能传感功能材料国家重点实验室北京100088

采用脉冲激光技术(PLD)在p+-Si上沉积了(Pb,Sr)Nb2O6-Na Nb O3介质薄膜,介质薄膜在氧化气氛下进行不同温度的热处理,进行光刻图形化、磁控溅射沉积电极之后,形成Al/p+-Si/(Pb,Sr)Nb2O6-Na Nb O3/Au结构的MIM(金属-绝缘体-金属)电容器。... 详细信息

采用脉冲激光技术(PLD)在p+-Si上沉积了(Pb,Sr)Nb2O6-Na Nb O3介质薄膜,介质薄膜在氧化气氛下进行不同温度的热处理,进行光刻图形化、磁控溅射沉积电极之后,形成Al/p+-Si/(Pb,Sr)Nb2O6-Na Nb O3/Au结构的MIM(金属-绝缘体-金属)电容器。通过X射线衍射(XRD)、原子力显微镜(AFM)和高分辨透射电子显微镜(HRTEM)对介质薄膜的微观形貌及结构进行分析。通过测试不同温度热处理后薄膜电容器的I-V和C-V电学特性,研究了不同温度热处理对薄膜电容器漏电流密度、电容、介电损耗及物相的影响,并对电容器电容和损耗的偏压特性进行了分析,结果表明,800℃热处理能显著提高薄膜的介电常数并降低漏电流密度。在偏压为-1 V,频率为1 k Hz的测试环境下,其介电常数为33,漏电流密度约为4.104×10-9A·cm-2,满足微电子领域内对漏电流小于1×10-8A·cm-2的要求;对薄膜电容器特性曲线拟合后得到其二次项电压系数为188,符合国际半导体技术蓝图(ITRS)对未来MIM电容提出的要求,具有良好的应用前景,是制备无机薄膜电容器理想的介质材料。

关键词： (Pb,Sr)Nb2O6-NaNbO3薄膜脉冲激光沉积法微晶玻璃薄膜 MIM 介电性能