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System dynamics in structural strength and vibration fatigue life assessment of the swing bar for high‐speed maglev train

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International Journal of Mechanical System Dynamics 2022年第2期2卷 178-189页

作者： Feng Guo feifei hu Shengchuan Wu Feng He Jianxin Liu Xingwen Wu State Key Laboratory of Traction Power Southwest Jiaotong UniversitySichuanChengduChina School of Mechanical Engineering Southwest Jiaotong UniversitySichuanChengduChina

High‐speed maglev trains are subjected to severe dynamic loads,thus posing a failure *** is necessary to account for the vehicle dynamics to improve the structural strength and fatigue life assessment approach under harsh routes and super high‐speed *** the most critical load‐carrying part between the vehicle body and levitation frames,the swing bar was taken as an example to demonstrate the significance of vehicle dynamics to integrate classical structural strength and fatigue life with the service conditions.A multiphysics‐coupled dynamic model of an alpha improvement scheme for an electromagnetic suspension maglev train capable of 600 km/h was established to investigate the complex dynamic loads and fatigue *** this model,the structural strength and fatigue life of the wrought swing bars were *** show only a slight effect on the structural strength and fatigue life of swing bars by the super high‐speed *** nonaxial bending moments caused by the uncompensated relative displacement between the vehicle body and bolsters are identified as the decisive *** minimum safety factor of the structural strength for wrought swing bars is 1.33,while the minimum fatigue life is 34 *** match the design requirements but are not conservative ***,further verification and optimization are recommended to improve the design of swing bars.

关键词： vibration fatigue life dynamic strength levitation frame high‐speed maglev train time‐domain stepwise fatigue assessment(TSFA)

TECC Applied in Geopark for a Case Study of Qixia Planning National Geopark

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地学前缘 2009年第S1期16卷 295-296页

作者： feifei hu,Mingzhong Tian School of the Earth Sciences and Resources,China University of Geosciences(Beijing),Beijing 100083,China.

This paper applied the theory of TECC(Tourism Environmental Carrying Capacity) into the case of Qixia Planning National *** adopt new planning framework to do the planning of TECC。

关键词： TECC geoheritages basic environment Qixia Planning National Geopark

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin feifei Yuan Hongbin Lu Jianzhong hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

革命科学与社会转向——马克思的社会关系理论初探

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广东社会科学 2006年第6期 90-94页

作者：胡飞飞北京大学社会学系

与以往社会理论不同,面对现代性危机,马克思转向社会生活的分析从而发现人的社会关系本质。在经济、社会和历史三个向度中,马克思对现实关系的批判正是基于社会关系的本质,社会关系构成了马克思革命科学的基础。社会转向产生了真正意义... 详细信息

与以往社会理论不同,面对现代性危机,马克思转向社会生活的分析从而发现人的社会关系本质。在经济、社会和历史三个向度中,马克思对现实关系的批判正是基于社会关系的本质,社会关系构成了马克思革命科学的基础。社会转向产生了真正意义上的社会学分析,在这个意义上,马克思主义的方法是与时俱进的革命科学。

关键词：社会转向社会关系革命科学

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UV/Fe^0处理对硝基苯胺废水的研究

工业水处理 2012年第10期32卷 51-53页

作者：胡菲菲长江大学城市建设学院湖北荆州434023

对UV/Fe0协同降解对硝基苯胺废水进行了研究,分别考察了铁粉量、pH、对硝基苯胺初始浓度以及反应时间等影响因素对废水降解效果的影响。结果表明,对于50 mg/L对硝基苯胺废水溶液,pH=3时,当加入30 mg/L的铁粉量,反应180 min后,对硝基苯... 详细信息

对UV/Fe0协同降解对硝基苯胺废水进行了研究,分别考察了铁粉量、pH、对硝基苯胺初始浓度以及反应时间等影响因素对废水降解效果的影响。结果表明,对于50 mg/L对硝基苯胺废水溶液,pH=3时,当加入30 mg/L的铁粉量,反应180 min后,对硝基苯胺降解率达到了93%。通过对比实验,发现UV/Fe0体系较UV/Fe2+体系对对硝基苯胺具有更好的降解效果。

关键词：零价铁紫外光对硝基苯胺

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高校文科实验室成果转化模式与路径探索

实验技术与管理 2023年第11期40卷 252-257页

作者：胡菲菲上海交通大学文科建设处上海200240

从成果形式看,文科实验室成果可分为学术性产出、服务性产出和技术性产出三种类型,分别通过政府购买服务、校企合作共同研发、实验室自主开发等渠道进行成果转化。该文详细分析了文科实验室成果转化困境及影响因素,提出面向社会发展需... 详细信息

从成果形式看,文科实验室成果可分为学术性产出、服务性产出和技术性产出三种类型,分别通过政府购买服务、校企合作共同研发、实验室自主开发等渠道进行成果转化。该文详细分析了文科实验室成果转化困境及影响因素,提出面向社会发展需求聚焦“问题域”、面向成果质量提升打造“技术集”、面向产学研一体化形成“转化链”、面向成果转化保障构建“制度圈”,以高效率成果转化提升文科实验室服务社会经济发展的能力。

关键词：文科实验室成果转化模式路径

Generation of B Cell-Deficient Pigs by Highly Efficient CRISPR/Cas9-Mediated Gene Targeting

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Journal of Genetics and Genomics 2015年第8期42卷 437-444页

作者： Fengjiao Chen Ying Wang Yilin Yuan Wei Zhang Zijian Ren Yong Jin Xiaorui Liu Qiang Xiong Qin Chen Manling Zhang Xiaokang Li Lihua Zhao Ze Li Zhaoqiang Wu Yanfei Zhang feifei hu Juan huang Rongfeng Li Yifan Dai State Key Laboratory of Reproductive Medicine and Jiangsu Key Laboratory of Xenotransplantation Nanjing Medical University

Generating B cell-deficient mutant is the first step to produce human antibody repertoires in large animal models. In this study, we applied the clustered regularly interspaced short palindromic repeat （CRISPR）/CRISPR-associated （Cas） system to target the JH region of the pig IgM heavy chain gene which is crucial for B cell development and differentiation. Transfection of IgM-targeting Cas9 plasmid in primary porcine fetal fibroblasts （PFFs） enabled inducing gene knock out （KO） in up to 53.3% of colonies analyzed, a quarter of which harbored biallelic modification, which was much higher than that of the traditional homologous recombination （HR）. With the aid of somatic cell nuclear transfer （SCNT） technology, three piglets with the biallelic lgM heavy chain gene mutation were produced. The piglets showed no antibody-producing B cells which indicated that the biallelic mutation of the lgM heavy chain gene effectively knocked out the function of the IgM and resulted in a B cell-deficient phenotype. Our study suggests that the CRISPR/Cas9 system combined with SCNT technology is an efficient genome-editing approach in pigs.

关键词： CRISPR/Cas9 system lgM heavy chain Pig genome editing B cell-deficiency Somatic cell nuclear transfer

Severe human infection with a novel avian-origin influenza A(H7N4) virus

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Science Bulletin 2018年第16期63卷 1043-1050页

作者： Xiang huo Lun-biao Cui Cong Chen Dayan Wang Xian Qi Ming-hao Zhou Xiling Guo Fengming Wang William J. Liu Weirong Kong Daxin Ni Ying Chi Yiyue Ge Haodi huang feifei hu Chao Li Xiang Zhao Ruiqi Ren Chang-jun Bao George F. Gao Feng-Cai Zhu Key Laboratories of Enteric Pathogenic Microbiology (Ministry of Health) Jiangsu Provincial Center for Disease Control and Prevention. Nanjing 210009 China Chinese Center for Disease Control and Prevention (China CDC) Beijing 102206 China National Institute for Viral Disease Control and Prevention China CDC Beijing 102206 China Changzhou Center for Disease Control and Prevention Changzhou 213022 China Liyang Center for Disease Control and Prevention Liyang 213300 China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences (CA5) Beijing 100101 China Center for Influenza Research and Early-Warning (CASCIRE) Chinese Academy of Sciences Beijing 100101 China Key Laboratory of Infectious Diseases School of Public Health Nanjing Medical University Nanjing 211166 China

human infections with influenza H7 subtypes, such as H7Ng, have raised concerns worldwide. Here, we report a human infection with a novel influenza A（HTN4） virus. A 68 years-old woman with cardiovascular and cholecystic comorbidities developed rapidly progressed pneumonia with influenza-like-illness as initial symptom, recovered after 23 days-hospitalization including 8 days in ICLI. Laboratory indicators for liver and blood coagulation dysfunction were observed. Oseltamivir phosphate, glucocorticoids and antibiotics were jointly implemented, with nasal catheterization of oxygen inhalation for this patient. We obtained the medical records and collected serial respiratory and blood specimens from her. We col- lected throat, cloacal and/or feces samples of poultry and wild birds from the patient＇s backyard, neigh- borhood, local live poultry markets （LPMs） and the nearest lake. All close contacts of the patient were followed up and sampled with throat swabs and sera. Influenza viruses and other respiratory pathogens were tested by real-time RT-PCR, viral culturing and/or sequencing for human respiratory and bird sam- ples. Micro-neutralizing assay was performed for sera. A novel reassortant wild bird-origin H7N4 virus is identified from the patient and her backyard poultry （chickens and ducks） by sequencing, which is dis- tinct from previously-reported avian H7N4 and H7N9 viruses. At least four folds increase of neutralizing antibodies to H7N4 was detected in her convalescent sera. No samples from close contacts, wild birds or other poultry were tested positive for H7N4 by real-time RT-PCR.

关键词： Avian influenza virus (AIV) human infection HTN4 Epidemiology Pneumonia

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低压静电场辅助冷藏对牛肉品质的影响

食品科学 2021年第1期42卷 132-138页

作者：胡斐斐钱书意李侠江峰胡海梅张春晖中国农业科学院农产品加工研究所农业农村部农产品加工综合性重点实验室北京100193 长虹美菱股份有限公司安徽合肥230000

为研究低压静电场辅助冷藏对牛肉品质的影响,采用牛背最长肌作为实验材料,探究其在静电场(实验组)和非静电场环境下(对照组)冷藏过程中的品质变化。对比分析了肉样在贮藏期间菌落总数、总挥发性盐基氮(total volatile basic nitrogen,TV... 详细信息

为研究低压静电场辅助冷藏对牛肉品质的影响,采用牛背最长肌作为实验材料,探究其在静电场(实验组)和非静电场环境下(对照组)冷藏过程中的品质变化。对比分析了肉样在贮藏期间菌落总数、总挥发性盐基氮(total volatile basic nitrogen,TVB-N)含量、色泽、贮藏损失率、蒸煮损失率和剪切力的变化,并通过扫描电子显微镜、透射电子显微镜分别观察肌肉的微观结构和超微结构。结果表明:与静电板隔距10、30 cm和50 cm处肉样在贮藏第7天时菌落总数分别为5.11、5.54、5.27(lg(CFU/g)),显著低于对照组(6.41(lg(CFU/g)))(P<0.05)。贮藏期内,实验组肉样维持了较高的新鲜度,其TVB-N含量均显著低于对照组(P<0.05)。此外,贮藏期内与对照组相比,实验组肉样贮藏损失率更低,且剪切力显著下降(P<0.05),L*值、a*值显著升高(P<0.05),肉样的持水力、嫩度较高,色泽更亮。扫描电子显微镜、透射电子显微镜观察结果显示,实验组肉样贮藏期间肌纤维束排列相对紧密,较好地维持了肌肉微观结构。综上,低压静电场辅助冷藏可有效延长牛肉贮藏期,缓解其在贮藏期间的品质劣变,肉样与静电板的有效隔距为10~50 cm。

关键词：低压静电场牛背最长肌品质冷藏