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Radiological features of traumatic vertebral endplate fracture:an analysis of 194 cases with 263 vertebral fractures

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Chinese Medical Journal 2020年第22期133卷 2696-2702页

作者： Xiao-rong Wang fei-rong xu Qiu-Li Huang Yi Xiang J.Wang Department of Radiology Ningbo First HospitalNingboZhejiang 315010China Department of Imaging and Interventional Radiology Faculty of MedicinePrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Radiology Ningbo Women and Children's HospitalNingboZhejiang 315012China

Background:The importance of identifying osteoporotic vertebral endplate or/and cortex fracture(ECF),which primarily includes endplate fracture(EPF)and vertebral anterior cortex buckling,has been ***,some old traumatic ECFs with healing process in the elderly may be mistaken as *** study analyzes the radiological features of traumatic ***:This was a retrospective analysis of 194 spine trauma patients with 263 vertebral fractures(mean age:42.11±9.82 years,118 males and 76 females).All patients had traumatic EPF identified by X-ray/CT/***:The involved vertebra was mostly L1(29.7%),followed by T12 and *** EPFs involved both superior and inferior endplates(12.6%),only 1.9%involved inferior endplate alone,with the majority involved superior *** each endplate was divided into five segments of equal lengths(from anterior to posterior:a1,a2,m,p2,p1),the most depressed point of superior EPFs was mostly at segment-a2(approximately 45%),followed by segment-a1(approximately 20%)or segment-m(approximately 20%),and very rarely at *** upper 1/3 of anterior vertebral wall was more likely to fracture,followed by middle 1/3 of anterior *** posterior vertebral wall fracture,68.5%broke the bony wall surrounding the basivertebral vain.58.6%,30.0%,and 11.4%of vertebral fractures had1/3 vertebral body height *** the extent of vertebral height loss increased,the chance of having both superior and inferior EPFs also increased;however,the chance of having inferior EPF alone did not ***:Traumatic EPF features are characterized,which may help the differentiation of traumatic and osteoporotic EPFs.

关键词： Spine Vertebral fracture Endplate Traumatic Vertebral cortex

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Recent Advances in Artificial Sensory Neurons: Biological Fundamentals, Devices, Applications, and Challenges

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NANO-MICRO LETTERS 2025年第1期17卷 1-49页

作者： Zhong, Shuai Su, Lirou xu, Mingkun Loke, Desmond Yu, Bin Zhang, Yishu Zhao, rong Guangdong Inst Intelligence Sci & Technol Zhuhai 519031 Hengqin Peoples R China Zhejiang Univ Coll Integrated Circuits Hangzhou 3112000 Peoples R China ZJU Hangzhou Global Sci & Technol Innovat Ctr Hangzhou 310027 Peoples R China Singapore Univ Technol & Design Dept Sci Math & Technol Singapore 487372 Singapore Tsinghua Univ Dept Precis Instruments Beijing 100084 Peoples R China Tsinghua Univ Ctr Brain Inspired Comp Res Beijing 100084 Peoples R China Tsinghua Univ IDG McGovern Inst Brain Res Beijing 100084 Peoples R China

Biological fundamentals and recent progress of artificial sensory neurons are systematically *** device, performance metrics, and potential applications of artificial sensory neurons are *** for the future development of artificial sensory neurons are discussed. Spike-based neural networks, which use spikes or action potentials to represent information, have gained a lot of attention because of their high energy efficiency and low power consumption. To fully leverage its advantages, converting the external analog signals to spikes is an essential prerequisite. Conventional approaches including analog-to-digital converters or ring oscillators, and sensors suffer from high power and area costs. Recent efforts are devoted to constructing artificial sensory neurons based on emerging devices inspired by the biological sensory system. They can simultaneously perform sensing and spike conversion, overcoming the deficiencies of traditional sensory systems. This review summarizes and benchmarks the recent progress of artificial sensory neurons. It starts with the presentation of various mechanisms of biological signal transduction, followed by the systematic introduction of the emerging devices employed for artificial sensory neurons. Furthermore, the implementations with different perceptual capabilities are briefly outlined and the key metrics and potential applications are also provided. Finally, we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

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Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第01期 377-384页

作者： Shiwen Liu xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian xu rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian xu fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Distributed State and Fault Estimation for Cyber-Physical Systems Under DoS Attacks

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 261-263页

作者： Limei Liang rong Su Haotian xu the School of Control Science and Engineering Shandong University IEEE the School of Electrical and Electronic Engineering Nanyang Technological University

Dear Editor,The letter deals with the distributed state and fault estimation of the whole physical layer for cyber-physical systems(CPSs) when the cyber layer suffers from DoS attacks. With the advancement of embedded computing, communication and related hardware technologies, CPSs have attracted extensive attention and have been widely used in power system, traffic network, refrigeration system and other fields.

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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li xu Huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

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Correlation analysis of PCB and comparison of test-analysis model reduction methods

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Chinese Journal of Aeronautics 2014年第4期27卷 835-845页

作者： xu fei Li Chuanri Jiang Tongmin rong Shuanglong School of Reliability and Systems Engineering Beihang University

The validity of correlation analysis between finite element model（FEM） and modal test data is strongly affected by three factors, i.e., quality of excitation and measurement points in modal test,FEM reduction methods, and correlation check techniques. A new criterion based on modified mode participation（MMP） for choosing the best excitation point is presented. Comparison between this new criterion and mode participation（MP） criterion is made by using Case 1 with a simple printed circuit board（PCB）. The result indicates that this new criterion produces better results. In Case 2, 35 measurement points are selected to perform modal test and correlation analysis while 9 selected in Case *** equivalent reduction expansion process（SEREP）, modal assurance criteria（MAC）, coordinate modal assurance criteria（CoMAC）, pseudo orthogonality check（POC） and coordinate orthogonality check（CORTHOG） are used to show the error introduced by modal test in Cases 2 and 3. Case 2 shows that additional errors which cannot be identified by using CoMAC can be found by using *** both Cases 2 and 3, Guyan reduction, improved reduced system（IRS） method, SEREP and Hybrid reduction are compared for accuracy and robustness. The results suggest that the quality of the reduction process is problem dependent. However, the IRS method is an improvement over the Guyan reduction, and the Hybrid reduction is an improvement over the SEREP reduction.

关键词： Correlation analysis Excitation and measurementpoint Finite element method Modal analysis Model reduction PCB

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Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： Guo-Fu xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

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Establishment and verification of theoretical model for underwater light-sheet Scheimpflug LiDAR system

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Science China Technological Sciences 2025年第1期 54-61页

作者： fei FENG Guojun WU Bo LIU xu ZHAO Yafeng WU Jinghan xu Xi'an Institute of Optics and Precision Mechanics Chinese Academy of Sciences University of Chinese Academy of Sciences

The Scheimpflug imaging in the air can increase the depth-of-view and has been well studied with an accurate Scheimpflug imaging model. However, there is no corresponding underwater light-sheet Scheimpflug(ULSS) imaging *** a result, imaging accuracy cannot be ensured in the design phase, which mainly relies on the post-calibration. In this paper,the ULSS imaging model is firstly established, which gives the relationship between the pixel number and target distance, as well as that between the target distance and range resolution. A new experimental bracket and an underwater Scheimflug imaging lens were designed and developed. Based on this new device, several experiments were carried out in a pool to study the range resolution of this ULSS LiDAR, by which the correctness of the imaging model was verified. It also shows that the newly designed ULSS LiDAR can achieve a millimeter-level resolution within 8 m.

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Characterizations of Weighted Besov Spaces with Variable Exponents

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Acta Mathematica Sinica,English Series 2024年第11期40卷 2855-2878页

作者： Sheng rong WANG Peng fei GUO Jing Shi xu School of Mathematics and Statistics Hainan Normal UniversityHaikou571158P.R.China Center for Applied Mathematics of Guangxi Guangxi Colleges and Universities Key Laboratory of Data Analysis and ComputationSchool of Mathematics and Computing ScienceGuilin University of Electronic TechnologyGuilin541004P.R.China

In this paper,we first give characterizations of weighted Besov spaces with variable exponents via Peetre’s maximal *** we obtain decomposition characterizations of these spaces by atom,molecule and *** an applicatio... 详细信息

关键词： Besov space Muckenhoupt weight variable exponent Peetre’s maximal function atom molecule wavelet pseudo-differential operator

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