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Recent progress on fluorescent probes for viruses

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Chinese Chemical Letters 2024年第1期35卷 72-83页

作者： Siyang Shen Weilin Xu Jianxiang lu Shuhui Wang Yurou Huang Xiaoyan Zeng Weimin Xiao Jun Yin Key Laboratory of Pesticide and Chemical Biology Ministry of EducationHubei International Scientific and Technological Cooperation Base of Pesticide and Green SynthesisInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Shenzhen Academy of Metrology and Quality Inspection Shenzhen 518109China

Viruses are ubiquitous in human life. Some viruses can be used as vectors of genetic engineering and specific pesticides. Other viruses trigger a variety of diseases in humans, animals and plants, resulting in high infection rates and mortality. Therefore, convenient, accurate and rapid detection of viruses is of great significance for the diagnosis and treatment of subsequent diseases. In contrast to traditional methods of detection, which rely on time-consuming and complex techniques such as polymerase chain reaction (PCR), fluorescent probes and imaging methods generate real-time results, with high specificity, and have been widely used in viral detection. In this review, the application of viral fluorescent probes in analyzing the molecular structure, detection and biological imaging is discussed. In particular, we categorized the probes based on their specificity for human and plant viruses, reviewing the latest findings and analyzing their limitations. The potential of fluorescent molecular probes in the treatment of viral disease and environmental analysis, and their possible combinations with protein and immune technology are discussed.

关键词： Fluorescent probe Detection Bioimaging Virus Health

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基于挠性梁结构的电推进器推力测量方法研究

核技术 2024年第5期47卷 91-101页

作者：王洛麒郑金星刘海洋李飞孟东东陆玉东杜宜凡唐卓尧吴涛史佳明中国科学技术大学合肥230026 中国科学院合肥物质科学研究院合肥230031 中国科学院力学研究所高温气体动力学国家重点实验室北京100190 北京工业大学机械与能源工程学院北京100124

电推进系统在空间任务中相比于传统化学燃料推进工作寿命更长、燃料消耗更低,在近年来备受关注。但基于可控核聚变思想研发的高功率霍尔效应电推进器,其推力很难测量,原因在于这些电推进器需要在高温环境下电离推进剂,所以工作时会产生... 详细信息

电推进系统在空间任务中相比于传统化学燃料推进工作寿命更长、燃料消耗更低,在近年来备受关注。但基于可控核聚变思想研发的高功率霍尔效应电推进器,其推力很难测量,原因在于这些电推进器需要在高温环境下电离推进剂,所以工作时会产生高温等离子体羽流,导致传统推力测试方法无法准确测量其推力。推进器推力的准确测量直接关系到航天器姿态以及轨道保持的控制精度,因此必须在地面测试中准确地测量推力。本文设计并搭建了一套基于挠性梁结构的推力测量平台,可以在高温环境下测量电推进器产生的推力。实验结果表明,以可变比冲磁等离子体火箭为例,在中心磁场强度0.2 T、质量流率为20 mg·s-1的工况下,实时测得电推进器推力为266.5 mN,证明了测量平台的可行性,为后续电推进器推力测量实验提供参考。

关键词：电推进器可控核聚变等离子体挠性梁推力测量

The convergence ball and error analysis of the two-step Secant method

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Applied Mathematics(A Journal of Chinese Universities) 2017年第4期32卷 397-406页

作者： LIN Rong-fei WU Qing-biao CHEN Min-hong KHAN Yasir LIU lu Department of Mathematics Taizhou University Department of Mathematics Zhejiang University Department of Mathematics Zhejiang Sci-Tech University

Under the assumption that the nonlinear operator has Lipschitz continuous divided differences for the first order,we obtain an estimate of the radius of the convergence ball for the two-step secant ***,we also provide an error estimate that matches the convergence order of the two-step secant *** last,we give an application of the proposed theorem.

关键词： two-step secant method estimate of radius convergence ball Lipschitz continuous

Improved computation of pressure coefficient and temperature coefficient of ultrasonic velocity in organic liquids

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Chinese Science Bulletin 1999年第19期44卷 1770-1773页

作者： Yigang lu Jianxin peng Jie Tong Yanwu Dong S China Univ Technol Dept Phys Guangzhou 510641 Peoples R China Shaanxi Normal Univ Appl Acoust Inst Xian 710062 Peoples R China

Based on Jacobson’s molecular free length theory in liquids and the relationship between the ultrasonic velocity and the molecular free length in organic liquids, the equations of pressure coefficient and temperature coefficient of ultrasonic velocity in organic liquids are derived . The calculated pressure coefficient and temperature coefficient of ultrasonic velocity are in good agreement with the measured results.

关键词： organic liquid ultrasonic velocity pressure coefficient of ultrasonic velocity temperature coefficient of ultrasonic velocity.

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早产儿医院感染直接经济损失及其影响因素

中华医院感染学杂志 2024年第3期34卷 426-431页

作者：卢婉婷施春兰林志鹏洪雅芳黄素玲泉州市第一医院院内感染控制科福建泉州362000 泉州市第一医院院新生儿重症监护室福建泉州362000

目的分析早产儿医院感染直接经济损失的影响因素.方法回顾性收集泉州市第一医院2018年1月-2022年12月新生儿重症监护室早产儿的资料,采用递归系统模型分析各因素对早产儿医院感染直接经济损失的影响.结果共纳入1205例早产儿,医院感染124... 详细信息

目的分析早产儿医院感染直接经济损失的影响因素.方法回顾性收集泉州市第一医院2018年1月-2022年12月新生儿重症监护室早产儿的资料,采用递归系统模型分析各因素对早产儿医院感染直接经济损失的影响.结果共纳入1205例早产儿,医院感染124例,感染率为10.29%;经倾向指数匹配法共成功匹配121对;早产儿医院感染组和非感染组住院天数中位数分别为34 d和7 d,医院感染组较非医院感染组住院时间延长27 d(P<0.001);医院感染组住院费用中位数为39636.94元,非医院感染组为8982.02元,医院感染组住院费用较非医院感染组多支出30654.92元(P<0.001);在增加的费用中,以药费、治疗费和检查费为主;出生体质量对早产儿医院感染直接经济损失既存在直接效应又存在间接效应,影响最大;住院天数、胃管留置和气管插管仅有直接效应;胎龄和抗菌药物使用天数仅有间接效应.结论临床实践中需重点关注出生体质量<1500 g和胎龄<32周的早产儿、尽可能缩短住院天数、减少侵入性操作、控制抗菌药物使用天数,从而控制住院费用,减少患儿经济负担.

关键词：早产儿医院感染直接经济损失递归系统模型影响因素影响效应

Mapping the antiparallel aligned domain rotation by microwave excitation

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Chinese Physics B 2024年第9期33卷 599-605页

作者： Jing Zhang Yuanzhi Cui Xiaoyu Wang Chuang Wang Mengchen Liu Jie Xu Kai Li Yunhe Zhao Zhenyan lu Lining Pan Chendong Jin Qingfang Liu Jianbo Wang Derang Cao College of Physics Qingdao UniversityQingdao 266071China National Demonstration Center for Experimental Applied Physics Education Qingdao UniversityQingdao 266071China SKLSM Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbin 150040China Hunan Provincial Key Laboratory of Intelligent Sensors and Advanced Sensor Materials School of Physics and ElectronicsHunan University of Science and TechnologyXiangtan 411201China CAS Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Key Laboratory of Optic-Electronic Information and Materials of Hebei Province Research Center for Computational PhysicsCollege of Physics Science and TechnologyHebei UniversityBaoding 071002China Key Laboratory for Magnetism and Magnetic Materials of Ministry of Education Lanzhou UniversityLanzhou 730000China Key Laboratory of Special Functional Materials and Structural Design Ministry of EducationLanzhou UniversityLanzhou 730000China

The evolution process of magnetic domains in response to external fields is crucial for the modern understanding and application of *** this study,we investigated the domain rotation in stripe domain films of varying thicknesses by examining their response to microwave excitation in four different *** resonance spectra indicate that the rotation field of stripe domain film under an applied magnetic field approaches the field where the resonance mode of sample *** saturation field of the stripe domain film corresponds to the field where the resonance mode disappears when measured in the stripe direction parallel to the microwave magnetic *** results are reproducible and consistent with micromagnetic simulations,providing additional approaches and techniques for comprehending the microscopic mechanisms of magnetic domains and characterizing their rotation.

关键词： stripe domain magnetic film microwave excitation micromagnetic simulation

Chlorogenic acid alters the voltage-gated potassium channel currents of trigeminal ganglion neurons

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International Journal of Oral Science 2014年第4期6卷 233-240页

作者： Yu-Jiao Zhang Xiao-Wen lu Ning Song Liang Kou Min-Ke Wu fei Liu Hang Wang Jie-fei Shen State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Ningbo Dental Hospital

Chlorogenic acid（5-caffeoylquinic acid, CGA） is a phenolic compound that is found ubiquitously in plants, fruits and vegetables and is formed via the esterification of caffeic acid and quinic acid. In addition to its notable biological functions against cardiovascular diseases, type-2 diabetes and inflammatory conditions, CGA was recently hypothesized to be an alternative for the treatment of neurological diseases such as Alzheimer＇s disease and neuropathic pain disorders. However, its mechanism of action is ***-gated potassium channel（Kv） is a crucial factor in the electro-physiological processes of sensory neurons. Kv has also been identified as a potential therapeutic target for inflammation and neuropathic pain disorders. In this study, we analysed the effects of CGA on the two main subtypes of Kv in trigeminal ganglion neurons, namely, the IK,Aand IK,Vchannels. Trigeminal ganglion（TRG）neurons were acutely disassociated from the rat TRG, and two different doses of CGA（0.2 and 1 mmol·L21） were applied to the ***-cell patch-clamp recordings were performed to observe alterations in the activation and inactivation properties of the IK,Aand IK,Vchannels. The results demonstrated that 0.2 mmol·L21CGA decreased the peak current density of IK,A. Both 0.2 mmol·L21and1 mmol·L21CGA also caused a significant reduction in the activation and inactivation thresholds of IK,Aand IK,V. CGA exhibited a strong effect on the activation and inactivation velocities of IK,Aand IK,V. These findings provide novel evidence explaining the biological effects of CGA, especially regarding its neurological effects.

关键词： chlorogenic acid trigeminal ganglion neuron voltage-gated potassium channel whole-cell patch clamp

Temperature-dependent synergistic evolution mechanism of rhenium and irradiation defects in tungsten-rhenium alloys

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Journal of Materials Science & Technology 2023年第14期145卷 221-234页

作者： Yu-Hao Li Fang-Ya Yue Zhong-Zhu Li peng-Wei Hou Yu-Ze Niu Hui-Zhi Ma Ying Zhang Xun-Xiang Hu Hui-Qiu Deng Hong-Bo Zhou fei Gao Guang-Hong lu Department of Physics Beihang UniversityBeijing 100191China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China College of Physics Sichuan UniversityChengdu 610065China School of Physics and Electronics Hunan UniversityChangsha 410082China Department of Nuclear Engineering and Radiological Science University of MichiganAnn ArborMI 48109USA

We have systemically investigated the synergistic evolution of rhenium(Re)and irradiation defects in tungsten(W)-Re alloys under different temperatures and irradiation doses using object Kinetic Monte Carlo *** results revealed the underlying mechanism for the transition of Re effect on W from beneficial to harmful during the Re-defects evolution with the increase of irradiation dose,in which tem-perature always plays a critical *** the one hand,Re will significantly promote the defect annihila-tion at low irradiation doses and high temperatures,thereby effectively reducing their sizes and number *** is due to the formation of stable Re-SIAs complexes that can be eliminated by the mobile vacancy-type defects,whereas the transition of the migration pattern of SIAs only plays a weak role in the defect recombination in W-Re *** the other hand,with the increase of irradiation dose,Re will aggregate to form Re-rich clusters or even ***,the formation mechanism of Re-rich clusters is also dependent on *** low temperatures,the interstitial-mediated mech-anism plays a crucial role in the Re-rich cluster formation,while at high temperatures,both SIA-type and vacancy-type defects will act as the transport carriers of Re to promote their ***,the critical conditions for the transition of Re from beneficial to harmful and the formation of Re-rich clusters at different tem peratures and irradiation doses are given with the help of the phase *** work presents the temperature dependence of the synergy of Re and irradiation defects in W-Re in fusion-relevant environment,which provides a good reference for the development of radiation-resistant materials and the prediction of W performance in fusion reactors.

关键词： Synergistic evolution Irradiation defects Defects recombination Rhenium-rich clusters Tungsten-rhenium alloys

Phonon engineering in Yb:La_(2)CaB_(10)O_(19)crystal for extended lasing beyond the fluorescence spectrum

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Light(Science & Applications) 2023年第9期12卷 1921-1929页

作者： Yanling Cheng fei Liang Dazhi lu Jingcheng Feng Guochun Zhang Haohai Yu Huaijin Zhang Yicheng Wu State Key Laboratory of Crystal Materials and Institute of Crystal Materials Shandong UniversityJinan 250100China Key Lab Functional Crystals and Laser Technology Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Since the first invention of the laser in 1960,direct lasing outside the fluorescence spectrum is deemed impossible owing to the“zero-gain”***,when electron-phonon coupling meets laser oscillation,an energy modulation by the quantized phonon can tailor the electronic transitions,thus directly creating some unprecedented lasers with extended wavelengths by phonon ***,we demonstrate a broadband lasing(1000-1280 nm)in a Yb-doped La_(2)CaB_(10)O_(19)(Yb:LCB)crystal,far beyond its spontaneous fluorescence *** calculations and in situ Raman verify that such a substantial laser emission is devoted to the multiphonon coupling to lattice vibrations of a dangling“quasi-free-oxygen”site,with the increasing phonon numbers step-by-step(n=1–6).This new structural motif provides more alternative candidates with strong-coupling laser ***,the quantitative relations between phonon density distribution and laser wavelength extension are *** results give rise to the search for on-demand lasers in the darkness and pave a reliable guideline to study those intriguing electron-phonon-photon coupled systems for integrated photonic applications.

关键词： beyond lasing spectrum