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Investigation on Azoospermia Factor (AZF) Microdeletion and Sex-determining Region Y (SRY) of the Y Chromosome in Male Infertility

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Journal of Reproduction and Contraception 2013年第2期24卷 88-94页

作者： Li-hua LU fei-xue hu song GE Laboratory of Genetics Deptment of Laboratory Medicine Peking University Shenzhen Hospital

Objective To determine the incidence of azoospermia faetor （AZF） microdeletions of Y chromosome in male infertility and to investigate the mechanism of sex-determining region Y （SRY） in sex differentiation. Methods The mierodeletion of AZF was detected by multiplex polymerase chain reaction （PCR） using Y-chromosome specific sequence tagged sites （STSs）, and SRY was analyzed by PCR and sequencing. Results There were 100 cases with AZF microdeletion and the ratio of AZF microdeletion was 6.8% over all 1 474 cases. The ratios of AZF microdeletion of azoospermia group and severe oligozoospermia group were 9.0% and 7.1%, respectively, which was significantly different from oligozoospermia group （P〈 0. 05）. There were 67 cases with 5 STSs mierodeletion of sY152, sY239, sY243, sY254 and sY255. There were 20 cases with long fragment deletion more than 10 STSs, and the patterns of AZF microdeletion in other 13 cases were rare. In all 9 patients with disorders of sex differentiation, there were 6patients with SRY-absent and AZF-absent. There was no mutation of SRY gene by sequencing in other 3 patients with SRY-positive. Conclusion Deletions in AZF region of Y chromosome are specific with diagnoses with spermatogenesis disorder. Deletions of sY152, sY239, sY243, sY254 and sY255 occur the most frequently. SRY was an important candidate gene of testis-determining factor （TDF） gene.

关键词： sex-determining region Y (SRY) azoospermia factor (AZF) sex differentiation spermatogenesis

A wide-linear-range and low-hysteresis resistive strain sensor made of double-threaded conductive yarn for human movement detection

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Journal of Materials Science & Technology 2024年第5期172卷 202-212页

作者： fei huang Jiyong hu Xiong Yan Shanghai Frontier Science Research Center for Modern Textiles Donghua UniversityShanghai 201620China

Yarn-based flexible strain sensors with advantages in wearability and integrability have attracted wide ***,it is still a big challenge to achieve yarn-based strain sensors with a wide linear strain range,low hysteresis,and durability synchronously that can be used for full range detection of human body ***,a new structure,double-threaded conductive yarn with rhythmic strain distribu-tion,is reported to markedly widen the linear strain range of microcrack-based stretchable strain sensors.A new method of winding and thermally adhering hot-melt filaments on the surface of the elastic fiber is used to achieve double-threaded yarn(DTY)with rhythmic strain *** proposed strategy,the integration of heterogeneous materials,is reported to significantly reduce the mechanical hysteresis of composite *** strain distribution of the DTY during stretching causes multi-level micro-cracks in different regions of the carbon nanotube(CNT)conductive layer deposited on the surface of the ***,the sensing performance of DTY-based strain sensor can be adjusted by designing the structural *** final prepared flexible strain sensor has the advantages of a wide linear strain range(100%),great sensitivity(GF=12.43),low hysteresis,rapid response(158 ms),high repeatability(>2000 cycles at 50%strain),and hydrophobicity,*** sensor can monitor human motion repeatedly and stably well,and shows great advantages in flexible wearable devices.

关键词： Double-threaded yarn Strain redistribution Hysteresis human motion monitoring

Enhancing adhesive bond strength of CFRP/titanium joints through NaOH anodising and resin pre-coating treatments with optimised anodising conditions

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Chinese Journal of Aeronautics 2024年第2期37卷 511-523页

作者： Yunsen hu Jingheng ZHANG Lin WANG fei CHENG Xiaozhi hu School of Materials and Chemistry Southwest University of Science and TechnologyMianyang 621000China School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Engineering Research Center of Biomass Materials Ministry of EducationSouthwest University of Science and TechnologyMianyang 621010China Department of Mechanical Engineering University of Western AustraliaPerthWA 6009Australia

Adhesively Bonded Carbon Fibre Reinforced Plastic(CFRP)and titanium alloy have been extensively used as a hybrid structure in modern aircrafts due to their excellent combination of mechanical properties and chemical *** study utilised NaOH anodising method to create micro-rough titanium surfaces for enhancing adhesive bonding between titanium alloy and CFRP laminates.A special and simple technique named Resin Pre-Coating(RPC)was also employed to improve the surface wetting of anodised titanium and grinded CFRP *** influences of anodising temperature and duration on the surface morphology,wettability and adhesive bond strength were *** single lap shear test results showed that the bond strength of specimens anodised at 20℃for 15 min improved by 135.9%and 95.4%,respectively,in comparison with that of acid pickled and grinded specimens(without RPC treatment).Although increasing the anodising temperature and duration produced rougher titanium surfaces,the adhesively bonded joints were not strong enough due to relatively friable titanium oxide layers.

关键词： Carbon Fibre Reinforced Polymer(CFRP) Titanium alloy Anodising Resin pre-coating Adhesive joints

Trial application of the envelope method to the potential ambiguity problem

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Nuclear Science and Techniques 2024年第1期35卷 73-80页

作者： Li-Yuan hu Yu-Shou song Fundamental Science on Nuclear Safety and Simulation Technology Laboratory Harbin Engineering UniversityHarbin 150001China College of Nuclear Science and Technology Harbin Engineering UniversityHarbin 150001China Key Laboratory of Nuclear Safety and Advanced Nuclear Energy Technology Ministry of Industry and Information TechnologyHarbin 150001China

The optical potential ambiguity is a long-standing problem in the analysis of elastic scattering *** a specific collid-ing system,ambiguous potential families can lead to different behaviors in the nearside and farside scattering *** contrast,the envelope method can decompose the experimental data into two components with negative and positive deflection angles,***,a question arises as to whether the comparison between the calculated nearside(or farside)component and the derived positive-deflection-angle(or negative-deflection-angle)component can help analyze the potential ambiguity *** this study,we conducted a trial application of the envelope method to the potential ambiguity *** envelope method was improved by including uncertainties in the experimental *** colliding systems of 16O+28Si at 215.2 MeV and 12C+12C at 1016 MeV were considered in the *** each colliding system,the angular distribution experimental data were described nearly equally well by two potential sets,one of which is“surface transpar-ent”and the other is *** calculated angular distributions were decomposed into nearside and farside scattering *** the improved envelope method,the experimental data were decomposed into the positive-deflection-angle and negative-deflection-angle components,which were then compared with the calculated nearside and farside *** capability of the envelope method to analyze the potential ambiguities was also discussed.

关键词： Elastic scattering Optical potential ambiguities Envelope method Nearside/farside decomposition

A Novel Scalable Fault-Tolerant Control Design for DC Microgrids With Nonuniform Faults

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1886-1888页

作者： Aimin Wang Minrui fei Dajun Du Yang song Shanghai Key Laboratory of Power Station Automation Technology the School of Mechatronic Engineering and AutomationShanghai UniversityShanghai 200072China

Dear Editor,The existing control schemes for microgrids(MGs)face challenges in effectively addressing plugging in/out operations under uncertain power lines and *** tackle this issue,this letter proposes a novel scalable fault-tolerant control(FTC)strategy for DC *** developing a structured Lyapunov matrix(SLM),a decoupled FTC method is introduced to mitigate the adverse effects of uncertain lines and nonuniform ***,global stability is ensured by deriving local rules expressed as linear matrix inequalities(LMIs)that solely depend on local *** new distributed generation unit(DGU)introduces only one additional condition of this nature,allowing the stability rules to scale with topology ***,the effectiveness of the proposed scheme is illustrated through simulations conducted using the MATLAB/SimPowerSystems toolbox.

关键词： stability letter operations

Boundary Regularity of Isometries Between Infinitely Flat Complex Domains

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1375-1387页

作者： Jin song LIU fei TAO Hong Yu WANG Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190P.R.China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049P.R.China Beijing International Center for Mathematical Research Peking UniversityBeijing 100871P.R.China School of Science Beijing University of Posts and TelecommunicationsBeijing 100876P.R.China Key Laboratory of Mathematics and Information Networks(Beijing University of Posts and Telecommunications) Ministry of EducationBeijing 100876P.R.China

In this paper we prove that isometries with respect to the Kobayashi metric between certain domains having boundary points at which the boundary is infinitely flat extend continuously to the *** strategy is to reestab... 详细信息

关键词： Boundary extension Kobayashi metric isometries

Asymmetric Drying and Wetting Trends in Eastern and Western China

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Advances in Atmospheric Sciences 2024年第2期41卷 221-232页

作者： Wen WU fei JI Shujuan hu Yongli HE College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Collaborative Innovation Center for Western Ecological Safety Lanzhou UniversityLanzhou 730000China

As an important factor that directly affects agricultural production, the social economy, and policy implementation,observed changes in dry/wet conditions have become a matter of widespread concern. However, previous research has mainly focused on the long-term linear changes of dry/wet conditions, while the detection and evolution of the non-linear trends related to dry/wet changes have received less attention. The non-linear trends of the annual aridity index, obtained by the Ensemble Empirical Mode Decomposition(EEMD) method, reveal that changes in dry/wet conditions in China are asymmetric and can be characterized by contrasting features in both time and space in China. Spatially, most areas in western China have experienced transitions from drying to wetting, while opposite changes have occurred in most areas of eastern China. Temporally, the transitions occurred earlier in western China compared to eastern China. Research into the asymmetric spatial characteristics of dry/wet conditions compensates for the inadequacies of previous studies, which focused solely on temporal evolution;at the same time, it remedies the inadequacies of traditional research on linear trends over centennial timescales. Analyzing the non-linear trend also provides for a more comprehensive understanding of the drying/wetting changes in China.

关键词： aridity index EEMD dry/wet conditions asymmetric evolution

Effects of the urban landscape on heatwave-mortality associations in Hong Kong: comparison of different heatwave definitions

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 145-156页

作者： Jinglu song Yi Lu Thomas Fischer Kejia hu Department of Urban Planning and Design Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Department of Architecture and Civil Engineering City University of Hong KongKowloon TongHong Kong 999077China Environmental Assessment and Management Research Centre School of Environmental SciencesUniversity of LiverpoolLiverpool L35TRUK Research Unit for Environmental Sciences and Management Faculty of Natural and Agricultural SciencesNorth West UniversityPotchefstroom 31750South Africa Institute of Big Data in Health Science School of Public HealthZhejiang UniversityZijingang CampusHangzhou 310058China

Despite increased attention given to potential modifiers of temperature-mortality associations, evidence for variations between different urban landscape characteristics remains limited. It is in this context that in this paper effect modifications of multiple urban landscape characteristics are explored under different heatwave definitions for different age groups and gender in Hong Kong, China. Daily meteorological data and heatwave-related mortality counts from 2008 to 2017 were collected from the Hong Kong Census and Statistics Department, China. A case-only design was adopted, combined with logistic regression models to examine the modification effects of five urban landscape characteristics under six heatwave definitions. Stratified analyses were conducted to investigate age- and gender-specific effect modifications. It is found that individuals living in greener areas experienced lower levels of mortality during or immediately after heatwaves. In contrast, a higher building density and nighttime land surface temperature (LST) were associated with a higher heatwave-related mortality risk. Pronounced effect modifications of these urban landscape characteristics were observed under hotter and longer heatwaves, and in older adults (age ≥ 65 years) and males. The findings provide a scientific basis for policymakers and practitioners when considering measures for coping with hotter, longer, and more frequent heatwaves in the context of global climate change.

关键词： Urban landscape Heatwave Mortality Effect modification Intra-urban differences Health risk reduction

Stochastic LQ Control with Extra Measurability Restriction

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Journal of Systems Science & Complexity 2024年第3期37卷 1003-1022页

作者： WANG Hongxia hu Yuxi LI Zixing song Lianfeng College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China

Different from the standard linear quadratic(LQ)problem for stochastic systems,the LQ problem considered in the paper has extra measurability *** problem also appears in the LQ control problem for stochastic systems with delays,rational expectations problems,asymmetric information control,and so *** essential difficulty lies in that one has to optimize the input and its conditional expectations *** stochastic maximum principle(SMP)and orthogonal decomposition technique are the key ***,the authors establish the SMP and convert the original problem into forward and backward stochastic difference equations(FBSDEs)with extra measurability ***,the authors resolve the FBSDEs by using the orthogonal decomposition technique and obtain the analytical solution to the underlying ***,the authors explore the essential distinction between the problem and the standard stochastic LQ control ***,numerical examples are given to illustrate the obtained results.

关键词： Multiplicative noise systems optimal control stochastic maximum principle stochastic systems