检索结果-南通市图书馆

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Feasibility study on buoyancy-weight ratios of a submerged floating tunnel prototype subjected to hydrodynamic loads

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2015年第5期31卷 750-761页

作者： Xu Long fei ge Youshi Hong School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical University State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of Sciences

The research progress of a novel traffic solution,a submerged floating tunnel（SFT）,is reviewed in terms of a study approach and loading *** existing publications,the buoyancy-weight ratio（BWR） is usually ***,BWR is a critical structural parameter that tremendously affects the dynamic behaviour of not only the tunnel tube itself but also the cable *** the context of a SFT prototype（SFTP） project in Qiandao Lake（Zhejiang Province,China）,the importance of BWR is illustrated by finite element analysis and subsequently,an optimized BWR is proposed within a reasonable range in the present *** the numerical model,structural damping is identified to be of *** damping and the corresponding Rayleigh coefficients are attained through a sensitivity study,which shows that the adopted damping ratios are fairly suitable for ***,the human sense of security is considered by quantifying the comfort index,which helps further optimize BWR in the SFTP structural parameter design.

关键词： Submerged floating tunnel Buoyancy-weight ratio Water wave and current loads Dynamic response Human security sense Comfort index

在线全文

学校读者我要写书评

暂无评论

林下仙茅栽培技术研究

现代农业科技 2017年第18期 57-59页

作者：叶生宝何钢刘贤桂席飞飞倪尚格中南林业科技大学生命科学与技术学院湖南长沙410018 中南林业科技大学林学院广东常瑞林业有限公司

[目的]探索林下仙茅栽培模式,实现高效利用林地资源,解决林地、仙茅栽培的突出问题。[方法]采用自然生长模式,只用接近自然化的人工栽培模式,实现最大成活率以及收益效果。[结果]广州从化仙茅种植基地的土壤质量评价为污染程度为安全,... 详细信息

[目的]探索林下仙茅栽培模式,实现高效利用林地资源,解决林地、仙茅栽培的突出问题。[方法]采用自然生长模式,只用接近自然化的人工栽培模式,实现最大成活率以及收益效果。[结果]广州从化仙茅种植基地的土壤质量评价为污染程度为安全,污染水平为清洁,到2016年林下仙茅集约化栽培的成活率为74.7%±1.43%,而林下非集约化栽培成活率为40.70%±1.04%,非林下集约化栽培成活率为45.60%±2.18%,非林下非集约化栽培成活率为38.40%±1.41%。[结论]林下仙茅生长周期长,成活率逐年降低,试验地内生长在林下仙茅成活率明显好于非林下地段,说明林下仙茅成活率与生长环境密切相关;林下集约化栽培可增强与林下其他物种之间的竞争还可以抵抗暴雨的冲刷,从而减少仙茅的死亡率。

关键词：仙茅林下栽培技术

在线全文

学校读者我要写书评

暂无评论

近70年黄河潼关站以下河段冲淤特征分析

水土保持研究 2025年第1期32卷 48-56页

作者：韩超王飞戈文艳陈昊史尚渝刘元昊西北农林科技大学水土保持科学与工程学院中国科学院水利部水土保持研究所

[目的]揭示黄河潼关以下河段冲淤变化过程及分布特征，为未来黄河下游水土保持和调水调沙工作提供参考。[方法]对1952—2022年来潼关—花园口段、下游游荡型河段、过渡型河段、弯曲型河段输沙特征和冲淤过程进行分析，采用趋势分析、突... 详细信息

[目的]揭示黄河潼关以下河段冲淤变化过程及分布特征，为未来黄河下游水土保持和调水调沙工作提供参考。[方法]对1952—2022年来潼关—花园口段、下游游荡型河段、过渡型河段、弯曲型河段输沙特征和冲淤过程进行分析，采用趋势分析、突变检验与回归分析等方法，确定了不同河段的输沙、冲淤变化特征及其相互影响。[结果]潼关以下河段年输沙量在显著减少(p<0.01),1996年后各站输沙量大幅降低，近20年来沙系数均低于0.01,表现冲刷特征。各河段年淤积量呈下降趋势，潼关—花园口段和弯曲型河段仍在持续淤积，花园口—艾山段近20年淤积量则为负值。研究时段内，潼关以下河段累计淤积泥沙186.84亿t,潼关—花园口段、游荡型河段、过渡型河段和弯曲型河段分别淤积了86.75亿t, 49.45亿t, 17.14亿t, 33.49亿t。另外，输沙量和来沙系数变化分别对潼关—花园口、游荡型河段和花园口以下河段淤积影响明显(p<0.01)。[结论]小浪底水利枢纽运行及调水调沙实施后，潼关以下河段年淤积量大幅减少，潼关—花园口和弯曲型河段承载了更多泥沙，花园口—艾山段则已由淤转冲。

关键词：水沙变化黄河下游冲淤过程淤积现状

Highly-efficient quantitative fluorescence resonance energy transfer measurements based on deep learning

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2020年第6期3卷 23-35页

作者： Lin ge fei Liu Jianwen Luo Department of Biomedical Engineering School of Medicine Tsinghua UniversityBeijing100084China Beijing Advanced Information&Industrial Technology Research Institute Beijing Information Science&Technology University Beijing 100192China

Intensity-based quantitative fluorescence resonance energy transfer(FRET)is a technique to measure the distance of molecules in scale of a few nanometers which is far beyond optical diffraction *** widely used technique needs complicated experimental process and manual image analyses to obtain precise results,which take a long time and restrict the application of quantitative FRET especially in living *** this paper,a simplified and automatic quanti-tative FRET(saqFRET)method with high efficiency is *** saqFRET,photo-activatable acceptor PA-mCherry and optimized excitation wavelength of donor enhanced green fluorescent protein(EGFP)are used to simplify FRET crosstalk *** manual image analyses are time consuming when the dataset is *** proposed automatic image analyses based on deep learning can analyze 100 samples within 30 s and demonstrate the same precision as manual image analyses.

关键词： Resonance energy transfer fluorescence living cells photoactivatable deep network

Synthesis and Optical Properties of ZnO Nanoparticles in Submicron PS Hollow Reactors

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Physics 2012年第6期25卷 719-724,I0004页

作者： Xue-feng Huang fei-fei Ju Mo-zhen Wang Xue-wu ge CAS Key Laboratory of Soft Matter Chemisry Department of Polymer Science and EngineeringUniversity of Science and Technology of China Hefei 230026 China

ZnO nanoparticles were first encapsulated in submicron PS hollow microspheres through two-step swelling process of core-shell structured PMMA/PS （PMMA： polymethyl methao- rylate） microspheres in acid-alkali solution, and the ZnO precursors, i.e. the ethanol solu- tions of （CHaCOO）2Zn and LiOH. The transmission electron microscope, X-ray diffraction, and thermogravimetric analysis results show that the feeding order of ethanol solutions of （CH3COO）2Zn and LiOH in the second swelling step has great influence on the loading efficiency and the size of ZnO nanoparticles, but little on their crystal form. The photolumi- nescence and UV-Vis absorption behavior of ZnO/PS microspheres show that the PS shell can effectively avoid the fluorescence quenching effect.

关键词： ZnO/PS hybrid material Core-shell polymer Swelling PS hollow microsphere Optical property

New U-Pb zircon ages document Late Triassic Tianqiaoling flora of eastern Jinlin,NE China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2021年第5期64卷 807-812页

作者： Yuhui FENG Tao YANG fei LIANG ge SUN Key Lab of Evolution of Past Life in NE Asia Ministry of Natural ResourcesShenyang Normal UniversityShenyang 110034China College of Paleontology Shenyang Normal UniversityShenyang 110034China Key Lab for Evolution of Past Life and Environment in NE Asia Ministry of EducationJilin UniversityChangchun 130026China

The Late Triassic Tianqiaoling flora is well-known in China,and its discovery has changed our understanding of Chinese Late Triassic phytogeographical *** broadly,this flora has great significance for the study of phytogeography in East Asia during this ***,the previous dating of this flora was only evidenced by plant fossils and stratigraphic correlation,and the accurate dating has still not been *** this study,rhyolite samples were collected from the bottom of the Tianqiaoling Formation,which is conformally contacted the Tianqiaoling flora-bearing *** results of new U-Pb dating gave ages for the rhyolites of 212.8±2.5 Ma,indicating the end of Malugou Formation and initial Tianqiaoling Formation in deposition occurred in the late Norian(~227–208.5 Ma),which is contemporaneous with the peak of the Tianqiaoling flora in *** radiometric dating results are basically consistent with paleobiological *** new age provides a key anchor point for regional stratigraphic correlation of the Tianqiaoling flora with its related Late Triassic floras,and contribute to a better understanding of the geology and phytogeography in the East Asia,particularly in the"triangle region"covering the eastern Jilin(China),South Primorye(Russia)and Southwest Japan,during the Late Triassic.

关键词： Late Triassic Tianqiaoling flora U-Pb zircon NE China

Reliability analysis of excavated slopes in undrained clay

在线全文

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2023年第11期17卷 1760-1775页

作者： Shuang SHU Bin ge Yongxin WU fei ZHANG Key Laboratory of the Ministry of Education for geomechanics and Embankment Engineering College of Civil and Transportation EngineeringHohai UniversityNanjing 210098China

A novel approach based on the upper bound theory is proposed to assess the stability of excavated slopes with spatially variable clay in undrained *** proposed random limit analysis is a combination of the deterministic slope stability limit analysis together with random field theory and Monte Carlo simulation.A series of analyses is conducted to verify the potential application of the proposed method and to investigate the effects of the soil undrained shear strength gradient and the spatial correlation length on slope *** groups of potential sliding surfaces are identified and the occurrence probability of each sort of failure mechanism is quantified for various slope *** proposed method is found to be feasible for evaluating slope *** obtained results are helpful in understanding the slope failure mechanism from a quantitative point of *** paper could provide guidance for slope targeted local reinforcement.

关键词： slope stability spatial variability limit analysis random field clay

An experimental investigation of dual-resonant and non-resonant responses for vortex-induced vibration of a long slender cylinder

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2014年第2期57卷 321-329页

作者： WU XiaoDong ge fei HONG YouShi College of Mechanics Taiyuan University of Technology State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of Sciences

Experimental results of the dual-resonant and non-resonant responses are presented for vortex-induced vibrations(VIV)of a long slender *** cylinder has a diameter of 10mm and a length of 3.31 m,giving an aspect ratio of *** cylinder was towed by a carriage with the velocity up to 1.5 m/s,with the Reynolds number varying from 2500 to *** different weights were used to provide the initial *** resonance means that resonance occurs simultaneously in both the cross-flow(CF)and in-line(IL)*** experiments were conducted in two *** the first stage,dual-resonant dynamic features of the cylinder subjected to vortex-induced excitation were *** features of CF and IL vibration amplitude,motion orbits,phase angle differences,dominant frequencies and mode order numbers are *** the second stage of the experiments,particular emphasis was placed on non-resonant dynamic *** variation of multi-mode modal displacement amplitudes was investigated in detail.

关键词： vortex-induced vibrations long slender cylinder dual-resonant responses non-resonant responses