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Metabolic syndrome, intracranial arterial stenosis and cerebral small vessel disease in community- dwelling populations

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Stroke & Vascular Neurology 2021年第4期6卷 589-594,I0055-I0059页

作者： Mei-Jun Shu fei-fei zhai Ding-Ding Zhang fei Han Lixin Zhou Jun Ni Ming Yao Shu-Yang Zhang Li-Ying Cui Zheng-Yu Jin Hui-Juan Zhu Yi-Cheng Zhu Department of Neurology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina Medical Research Center State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina Department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina Department of Radiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina Department of Endocrinology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina

Background and purpose This study aimed to investigate the association of metabolic syndrome(MetS)with both intracranial atherosclerotic stenosis(ICAS)and imaging markers of cerebral small vessel disease(CSVD)in a community-based *** This study included 943 participants(aged 55.6±9.2 years,36.1%male)from the community-based Shunyi cohort *** was defined according to the joint interim criteria and quantified by the MetS severity *** was evaluated by brain magnetic resonance *** MRI markers of CSVD,including white matter hyperintensities(WMHs),lacunes,cerebral microbleeds(CMBs)and enlarged perivascular spaces(EPVS),were *** regression models were used to investigate the association of MetS severity Z-score with ICAS and these CSVD *** We found that risk of ICAS(OR=1.75,95%CI 1.39 to 2.21,p<0.001)increased consistently with MetS *** severity was significantly associated with higher risks of WMH volume(β=0.11,95%CI 0.01 to 0.20,p=0.02)and lacunes(OR=1.28,95%CI 1.03 to 1.59,p=0.03)but not the presence of CMBs(OR=0.93,95%CI 0.74 to 1.16,p=0.51)and PVS severity(EPVS in basal ganglia:OR=0.96,95%CI 0.84 to 1.09,p=0.51 and EPVS in white matter:OR=1.09,95%CI 0.96 to 1.23,p=0.21).Conclusions Our findings suggest that WMH and lacunes share risk factors with atherosclerosis of the cerebral artery,whereas the impact of glucose and lipid metabolic disorder to CMB or EPVS might be weak.

关键词： cerebral severity stenosis

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Effect of Iron on the Stability of Rhodochrosite at the Topmost Lower Mantle Conditions

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Journal of Earth Science 2024年第2期35卷 504-513页

作者： Tianlei zhai fei Qin Shengxuan Huang Shan Qin Yu Gong Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing100871China School of Earth Sciences and Resources China University of GeosciencesBeijing100083China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China

Carbonates are viewed as the principal oxidized carbon carriers during subduction,and thus the stability of subducted carbonates has significant implications for the deep carbon *** we investigate the high pressure-temperature behaviors of rhodochrosite in the presence of iron up to∼34 GPa by in-situ X-ray diffraction and ex-situ Raman *** relatively low temperature below∼1500 K,MnCO_(3)breaks down into MnO and CO_(2).Upon heating to∼1800 K,however,the MnCO_(3)-Fe^(0)reactions occur with the formation of Mn_(3)O_(4),Fe^(O)and reduced carbon.A'three-stage'reaction mechanism is proposed to understand the kinetics of the carbon-iron-manganese redox *** results suggest that Fe^(0)can serve as a reductant to greatly affect the stability of rhodochrosite,which implies that the effect of Fe-metal should be seriously considered for the high pressure-temperature behaviors of other predominant carbonates at Earth's mantle conditions,particularly at depths greater than∼250 km.

关键词： deep carbon cycle rhodochrosite reduced mantle diamond formation high pressure tectonics geochemistry

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Association between large artery stenosis,cerebral small vessel disease and risk of ischemic stroke

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Science China(Life Sciences) 2021年第9期64卷 1473-1480页

作者： fei Han Ding-Ding Zhang fei-fei zhai Jun Xue Jiang-Tao Zhang Shuang Yan Li-Xin Zhou Jun Ni Ming Yao Meng Yang Ming-Li Li Zheng-Yu Jin Qing Dai Shu-Yang Zhang Li-Ying Cui Yi-Cheng Zhu Department of Neurology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Echocardiography China Emergency General HospitalBeijing 100730China Department of Ultrasound Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100005China

We aimed to assess the associations of large artery stenosis(LAS)and cerebral small vessel disease(CSVD)with the risk of ischemic stroke and to investigate their respective and combined *** the prospective population-based Shunyi Study,1,082 stroke-free participants aged 55.9±9.1 years were *** were followed for incident stroke throughout the study period(2013-2019).Total small vessel disease score was used to measure CSVD ***-cerebral large artery stenosis was evaluated via brain magnetic resonance angiography and carotid *** estimated the risk of ischemic stroke in relation to LAS and CSVD with Cox regression *** a mean follow-up of 4.2 years,34 participants(3.1%)experienced at least one ischemic *** LAS(≥50% stenosis versus no stenosis:HR=3.27(95%CI:1.31-8.18))and high CSVD burden(total small vessel disease score 2-4 versus 0 point:HR=12.73(4.83-33.53))were associated with increased stroke risk *** multivariate models,CSVD burden(7.72%)explained a larger portion of the variation in stroke risk than severity of LAS(3.49%).Our findings identified that both LAS and CSVD were associated with future ischemic stroke in asymptomatic subjects,while those with high CSVD burden deserve more attention in primary prevention of stroke.

关键词： large artery stenosis cerebral small vessel disease ischemic stroke cohort study

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Inflammatory biomarkers and cerebral small vessel disease:a community-based cohort study

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Stroke & Vascular Neurology 2022年第4期7卷 302-309,I0009-I0014页

作者： Ding-Ding Zhang Yuan Cao Jing-Yu Mu Yi-Ming Liu Feng Gao fei Han fei-fei zhai Li-Xin Zhou Jun Ni Ming Yao Ming-Li Li Zheng-Yu Jin Shu-Yang Zhang Li-Ying Cui Yong Shen Yi-Cheng Zhu Central Research Laboratory State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Neurology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Division of Life Sciences and Medicine Institute on Aging and Brain DisordersThe First Affiliated Hospital of USTCUniversity of Science and Technology of ChinaHefeiChina Department of Radiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background and purpose Although inflammation has been proposed to be a candidate risk factor for cerebral small vessel disease(CSVD),previous findings remain largely inconclusive and vary according to disease status and study *** present study aimed to investigate possible associations between inflammatory biomarkers and MRI markers of *** A group of 15 serum inflammatory biomarkers representing a variety of those putatively involved in the inflammatory cascade was grouped and assessed in a cross-sectional study involving 960 stroke-free *** biomarker panel was grouped as follows:systemic inflammation(high-sensitivity C reactive protein(hsCRP),interleukin 6 and tumour necrosis factorα),endothelial-related inflammation(E-selectin,P-selectin,intercellular adhesion molecule 1,vascular cell adhesion molecule 1(VCAM-1),CD40 ligand,lipoprotein-associated phospholipase A2,chitinase-3-like 1 protein and total homocysteine(tHCY))and media-related inflammation(matrix metalloproteinases 2,3 and 9,and osteopontin).The association(s)between different inflammatory groups and white matter hyperintensity(WMH),lacunes,cerebral microbleeds(CMBs),enlarged perivascular space(PVS)and the number of deep medullary veins(DMVs)were *** High levels of serum endothelial-related inflammatory biomarkers were associated with both increased WMH volume(R^(2)=0.435,p=0.015)and the presence of lacunes(R^(2)=0.254,p=0.027).Backward stepwise elimination of individual inflammatory biomarkers for endothelial-related biomarkers revealed that VCAM-1 was significant for WMH(β=0.063,p=0.005)and tHCY was significant for lacunes(β=0.069,p<0.001).There was no association between any group of inflammatory biomarkers and CMBs or *** inflammatory biomarkers were associated with fewer DMVs(R^(2)=0.032,p=0.006),and backward stepwise elimination of individual systemic-related inflammatory biomarkers revealed that hsCRP(β=−0.162,p=0.007)was *** WM

关键词： inflammation cerebral stepwise

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3D printed modular Bouligand dissipative structures with adjustable mechanical properties for gradient energy absorbing

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Materials Futures 2024年第2期3卷 104-116页

作者： Junfeng Xiao Mengxing Zhang fei zhai Hongrui Wei Sen Liu Peng Wang Zhiyang Liu Zhongying Ji Xiaolong Wang Shenzhen Institute of Information Technology Shenzhen 518172People’s Republic of China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai Zhongke Research Institute of Advanced Materials and Green Chemical EngineeringYantai 264006People’s Republic of China School of Chemistry and Chemical Engineering Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous RegionShihezi UniversityShihezi 832003People’s Republic of China School of Transportation Engineering Shandong Jianzhu UniversityJinan 250101People’s Republic of China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518061People’s Republic of China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesGansu Lanzhou 730000People’s Republic of China

Three-dimensional(3D)printing allows for the creation of complex,layered structures with precise micro and macro architectures that are not achievable through traditional *** designing 3D structures with geometric precision,it is possible to achieve selective regulation of mechanical properties,enabling efficient dissipation of mechanical *** this study,a series of modular samples inspired by the Bouligand structure were designed and produced using a direct ink writing system,along with a classical printable polydimethylsiloxane *** altering the angles of filaments in adjacent layers(from 30◦to 90◦)and the filament spacing during printing(from 0.8 mm to 2.4 mm),the mechanical properties of these modular samples can be *** mechanical testing revealed that the 3D printed modular Bouligand structures exhibit stress-strain responses that enable multiple adjustments of the elastic modulus from 0.06 MPa to over 0.8 *** mechanical properties were adjusted more than 10 times in printed samples prepared using uniform *** gradient control mechanism of mechanical properties during this process was analyzed using finite element ***,3D printed customized modular Bouligand structures can be assembled to create an array with Bouligand structures displaying various orientations and interlayer details tailored to specific *** decomposing the original Bouligand structure and then assembling the modular samples into a specialized array,this research aims to provide parameters for achieving gradient energy absorption structures through modular 3D printing.

关键词： 3D printing additive manufacturing Bouligand structure energy absorbing structures

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Simultaneous control of ferromagnetism and ferroelasticity by oxygen octahedral backbone stretching

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Chinese Physics B 2024年第9期33卷 186-192页

作者： Genhao Liang Hui Cao Long Cheng Junkun Zha Mingrui Bao fei Ye Hua Zhou Aidi Zhao Xiaofang zhai Department of Physics University of Science and Technology of ChinaHefei 230026China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Materials Science Division Argonne National LaboratoryLemontIL 60439USA X-ray Science Division Advanced Photon SourceArgonne National LaboratoryLemontIL 60439USA

Coexistence of ferromagnetism and ferroelasticity in a single material is an intriguing phenomenon,but has been rarely *** we studied both the ferromagnetism and ferroelasticity in a group of LaCoO3 films with systematically tuned atomic *** found that all films exhibit ferroelastic domains with four-fold symmetry and the larger domain size(higher elasticity)is always accompanied by stronger *** performed synchrotron x-ray diffraction studies to investigate the backbone structure of the CoO6 octahedra,and found that both the ferromagnetism and the elasticity are simultaneously enhanced when the in-plane Co–O–Co bond angles are *** the study demonstrates the inextricable correlation between the ferromagnetism and ferroelasticity mediated through the octahedral backbone structure,which may open up new possibilities to develop multifunctional materials.

关键词： perovskite oxide film ferromagnetism ferroelasticity twin domain

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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

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Military Medical Research 2024年第1期11卷 34-49页

作者： Yi-Qun Li Fang-Zhou Sun Chun-Xiao Li Hong-Nan Mo Yan-Tong Zhou Dan Lv Jing-Tong zhai Hai-Li Qian fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background Triple negative breast cancer(TNBC),the most aggressive subtype of breast cancer,is characterized by a high incidence of brain metastasis(BrM)and a poor *** the most lethal form of breast cancer,BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment *** evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis(BCBrM),but the underlying mechanisms are far from being fully *** Through analysis of BCBrM transcriptome data from mice and patients,and immunohistochemical validation on patient tissues,we identified and verified the specific down-regulation of retinoic acid receptor responder 2(RARRES2),a multifunctional adipokine and chemokine,in BrM of *** investigated the effect of aberrant RARRES2 expression of BrM in both in vitro and in vivo *** signaling pathway components were evaluated using multi-omics *** were performed to elucidate the regulation of lipid metabolic reprogramming of *** We found that downregulation of RARRES2 is specifically associated with BCBrM,and that RARRES2 deficiency promoted BCBrM through lipid metabolic ***,reduced expression of RARRES2 in brain metastatic potential TNBC cells resulted in increased levels of glycerophospholipid and decreased levels of triacylglycerols by regulating phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway to facilitate the survival of breast cancer cells in the unique brain *** Our work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of ***2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM.

关键词： RARRES2 Lipid metabolic reprogramming Brain metastasis(BrM) Breast cancer

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金代西北路招讨司驻地考论

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中国边疆史地研究 2024年第2期34卷 63-74,222,223页

作者：翟飞陕西师范大学历史文化学院 710119

金代西北路招讨司作为北部边疆重要的军政管理机构,正式建置于金太宗天会三年(1125),起初权治于辽代的燕子城(今河北省张北县老城);金世宗大定八年(1168),北迁至新桓州城;金章宗明昌七年(1196),因翰里札河之战对西北路招讨司军队的巨大... 详细信息

金代西北路招讨司作为北部边疆重要的军政管理机构,正式建置于金太宗天会三年(1125),起初权治于辽代的燕子城(今河北省张北县老城);金世宗大定八年(1168),北迁至新桓州城;金章宗明昌七年(1196),因翰里札河之战对西北路招讨司军队的巨大冲击,致使其管区军政格局突变,驻地遂再度由新桓州城南迁至抚州城(金初燕子城);金卫绍王崇庆元年(1212),西北路招讨司全境被蒙古军队占据,其建制遂不复存在。

关键词：金代西北路招讨司燕子城桓州抚州

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近距离煤层群拦截钻孔瓦斯抽采技术研究

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矿业研究与开发 2024年第8期44卷 165-172页

作者：翟鑫王飞太原理工大学安全与应急管理工程学院山西太原030024 山西煤矿安全研究生教育创新中心山西太原030024

针对近距离煤层群瓦斯治理难题,以杜儿坪煤矿某工作面为研究对象,模拟开采后覆岩裂隙发育情况。根据近距离煤层群瓦斯抽采机理,利用FLUENT软件模拟采空区在布置顶板高位钻孔前后和“顶板高位+底板拦截”钻孔后的瓦斯运移情况,对比分析... 详细信息

针对近距离煤层群瓦斯治理难题,以杜儿坪煤矿某工作面为研究对象,模拟开采后覆岩裂隙发育情况。根据近距离煤层群瓦斯抽采机理,利用FLUENT软件模拟采空区在布置顶板高位钻孔前后和“顶板高位+底板拦截”钻孔后的瓦斯运移情况,对比分析抽采效果和工作面上隅角CH_(4)体积分数。结果表明:覆岩垮落带高度为16m,裂隙带高度为58m;将顶板高位钻孔布置在垂直位置距顶板38.5~57.25 m,水平位置距回风巷20~50m范围内,底板拦截钻孔布置在距底板正下方5m,距回风巷侧10~15m时,工作面上隅角的CH4体积分数降低至0.32%,瓦斯抽采效率高;对工作面采空区高位定向钻孔联合底板拦截钻孔技术进行现场应用,取得了良好的瓦斯治理和抽采效果。

关键词：近距离煤层群瓦斯抽采顶板高位钻孔底板拦截钻孔数值模拟

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猕猴桃果实无损检测技术研究进展

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食品与发酵工业 2024年第12期50卷 396-403页

作者：曲东徐娜翟晨利燕飞陕西理工大学生物科学与工程学院陕西省资源生物重点实验室陕西汉中723000 陕南秦巴山区生物资源综合开发协同创新中心陕西汉中723001 秦巴生物资源与生态环境省部共建国家重点实验室陕西汉中723001

猕猴桃果实富含维生素C和膳食纤维,具有抗氧化等功能,倍受消费者的青睐。中国是全球猕猴桃栽培和出口的主要国家之一,果实品质检测技术及评价是助推产业发展的关键保障之一。无损检测技术是近年来在工业、农业领域广泛应用的一项新技术... 详细信息

猕猴桃果实富含维生素C和膳食纤维,具有抗氧化等功能,倍受消费者的青睐。中国是全球猕猴桃栽培和出口的主要国家之一,果实品质检测技术及评价是助推产业发展的关键保障之一。无损检测技术是近年来在工业、农业领域广泛应用的一项新技术。猕猴桃果实无损检测,是在不损坏果实的情况下,完成果实采摘期品质、果实分级和贮藏期品质的检测,是保障高品质果实供应的重要方法之一。该文总结了基于声学特性、介电性质、光学性质等猕猴桃果实无损检测技术的原理、比较不同技术类型的优缺点,并对猕猴桃果实无损检测技术研究方向进行了展望,以期为猕猴桃果实无损检测技术研究及应用提供参考。

关键词：猕猴桃果实品质无损检测技术研究进展

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