检索结果-南通市图书馆

Prognostic model for esophagogastric variceal rebleeding after endoscopic treatment in liver cirrhosis: A Chinese multicenter study

引用

World Journal of Gastroenterology 2025年第2期31卷 85-101页

作者： Jun-Yi Zhan Jie Chen Jin-Zhong Yu fei-Peng Xu fei-fei xing De-Xin Wang Ming-Yan Yang Feng xing Jian Wang Yong-Ping Mu Cell Biology Laboratory Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Liver Diseases Shanghai Academy of Chinese MedicineShanghai 201203China Clinical Key Laboratory of Traditional Chinese Medicine of Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Key Laboratory of Liver and Kidney Disease of the Ministry of Education Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Gastroenterology and Hepatology Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Institute of Liver Disease Fudan UniversityShanghai 200032China Evidence-Based Medicine Center Fudan UniversityShanghai 200032China Department of Gastrointestinal Endoscopy Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Hepatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Rebleeding after recovery from esophagogastric variceal bleeding(EGVB)is a severe complication that is associated with high rates of both incidence and *** its clinical importance,recognized prognostic models that can effectively predict esophagogastric variceal rebleeding in patients with liver cirrhosis are *** To construct and externally validate a reliable prognostic model for predicting the occurrence of esophagogastric variceal *** This study included 477 EGVB patients across 2 cohorts:The derivation cohort(n=322)and the validation cohort(n=155).The primary outcome was rebleeding events within 1 *** least absolute shrinkage and selection operator was applied for predictor selection,and multivariate Cox regression analysis was used to construct the prognostic *** validation was performed with bootstrap *** assessed the discrimination,calibration and accuracy of the model,and performed patient risk *** Six predictors,including albumin and aspartate aminotransferase concentrations,white blood cell count,and the presence of ascites,portal vein thrombosis,and bleeding signs,were selected for the rebleeding event prediction following endoscopic treatment(REPET)*** predicting rebleeding within 1 year,the REPET model ex-hibited a concordance index of 0.775 and a Brier score of 0.143 in the derivation cohort,alongside 0.862 and 0.127 in the validation ***,the REPET model revealed a significant difference in rebleeding rates(P<0.01)between low-risk patients and intermediate-to high-risk patients in both *** We constructed and validated a new prognostic model for variceal rebleeding with excellent predictive per-formance,which will improve the clinical management of rebleeding in EGVB patients.

关键词： Esophagogastric variceal bleeding Variceal rebleeding Liver cirrhosis Prognostic model Risk stratification Secondary prophylaxis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

General synthesis of hollow mesoporous conducting polymers by dual-colloid interface co-assembly for high-energy-density micro-supercapacitors

引用

Journal of Energy Chemistry 2021年第11期30卷 145-152,I0004页

作者： Jing Cui fei-fei xing Hao Luo Jie-Qiong Qin Yan Li Yonghui Zhong Facai Wei Jianwei Fu Chengbin Jing Jiangong Cheng Zhong-Shuai Wu Shaohua Liu State Key Laboratory of Precision Spectroscopy and Department of Materials School of Physics and Electronic ScienceEast China Normal University500 Dongchuan RoadShanghai 200241China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of Sciences457 Zhongshan RoadDalian 116023LiaoningChina Dalian National Laboratory for Clean Energy Chinese Academy of Sciences457 Zhongshan RoadDalian 116023LiaoningChina University of Chinese Academy of Sciences 19 A Yuquan RoadShijingshan DistrictBeijing 100049China School of Chemistry and Molecular Engineering East China Normal University500 Dongchuan RoadShanghai 200241China School of Materials Science and Engineering Zhengzhou University100 Science AvenueZhengzhou 450002HenanChina State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences865 Changning RoadShanghai 200050China Shanghai Academy of Quality Management 258 Wuyi RoadShanghai 200050China

Rational design and precise regulation over the morphology, structure, and pore size of functional conducting mesoporous polymers with enriched active sites and shorten electron–ion transport pathway are extremely important for developing high-performance micro-supercapacitors (MSCs), but still remain a great challenge. Herein, a general dual-colloid interface co-assembly strategy is proposed to fabricate hollow mesoporous polypyrrole nano-bowls (mPPy-nbs) for high-energy-density solid-state planar MSCs. By simply adjusting the size of block copolymer micelles, the diameter of polystyrene nanospheres and the amount of pyrrole monomer, mesopore size of the shell, void and shell thickness of mPPy-nbs can be simultaneously controlled. Importantly, this strategy can be further utilized to synthesize other hollow mesoporous polymers, including poly(tris(4-aminophenyl)amine), poly(1,3,5-triaminobenzene) and their copolymers, demonstrative of excellent universality. The structurally optimized mPPy-nb exhibits high specific surface area of 122 m^(2) g^(−1)and large capacitance of 225 F g^(−1) at 1 mV s^(−1). Furthermore, the MSCs assembled by mPPy-nbs deliver impressive volumetric capacitance of 90 F cm^(−3) and energy density of 2.0 mWh cm^(−3), superior to the most reported polymers-based MSCs. Also, the fabricated MSCs present excellent flexibility with almost no capacitance decay under varying bending states, and robust serial/parallel self-integration for boosting voltage and capacitance output. Therefore, this work will inspire the new design of mesoporous conducting polymer materials toward high-performance microscale supercapacitive devices.

关键词： Interface co-assembly Dual-colloids Mesopore Hollow nano-bowl Micro-supercapacitors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

转化生长因子βⅠ型受体抑制剂的体外筛选及构效关系分析

引用

国际药学研究杂志 2017年第6期44卷 544-550页

作者：龙隆李菲菲李行舟陈伟李微王莉莉军事医学科学院毒物药物研究所抗毒药物与毒理学国家重点实验室北京100850 北京师范大学生命科学学院北京100875

目的筛选转化生长因子(TGF-β)信号通路Ⅰ型受体抑制剂,并探讨活性化合物的结构特征。方法利用SMAD3荧光素酶报告系统对靶向TGF-β信号通路Ⅰ型受体激活素受体样激酶(ALK)设计合成的170个化合物进行活性初筛;通过分子水平激酶活性分析... 详细信息

目的筛选转化生长因子(TGF-β)信号通路Ⅰ型受体抑制剂,并探讨活性化合物的结构特征。方法利用SMAD3荧光素酶报告系统对靶向TGF-β信号通路Ⅰ型受体激活素受体样激酶(ALK)设计合成的170个化合物进行活性初筛;通过分子水平激酶活性分析评价初筛活性化合物对ALK4、ALK5或ALK7激酶的选择性抑制活性;采用EGFP-SMAD2荧光蛋白转核模型,对筛选结果进行确证;参照SB431542与ALK5分子对接情况,对活性化合物进行构效关系的分析。结果初筛发现15个化合物对TGF-β引起的SMAD3荧光素酶报告基因表达达到≥25%的抑制程度;在分子水平对ALK4、ALK5或ALK7也具有抑制活性,并表现出一定的选择性。其中,化合物63对ALK4和ALK7的IC50值分别为0.234和0.370μmol/L,对ALK5选择性较差,化合物64对ALK4、ALK5和ALK7的IC50值分别为10、6和85 nmol/L。这两个化合物在TGF-β1诱导EGFP-SMAD2核转位中同样表现出浓度依赖性抑制活性,IC50值分别为0.45和6.30μmol/L。MTT细胞增殖抑制实验表明,63和64在有效浓度下均无细胞毒性。构效关系分析表明,1,2,4-三芳基-1H-咪唑母核、1,3,5-三芳基-1H-吡唑母核、3,4-亚甲二氧基苯基、6-甲基-吡啶-2基和4-氨基羧基取代基团的化合物预计具有更好的活性。结论筛选得到2个与阳性化合物SB431542活性相当的TGF-β信号通路Ⅰ型受体抑制剂,其中63对ALK4和ALK7具有选择性,64对ALK4、ALK5和ALK7均有抑制活性。

关键词：激活素受体样激酶激酶抑制剂分子水平筛选模型 SMAD2/3

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Joint toxicity of methamidophos and cadmium acting on Abelmoschus manihot

引用

Journal of Environmental Sciences 2005年第3期17卷 379-383页

作者： WANGXiao-fei ZHOUQi-xing KeyLaboratoryofTerrestrialEcologicalProcess InstituteofAppliedEcologyChineseAcademyofSciencesShenyang110016China／／GraduateSchooloftheChineseAcademyofSeiences.Beijing100039China

Joint toxicity of methamidophos and cadmium(Cd) on the ornamental Abelmoschus manihot was firstly examined and compared with single-factor effects of the two pollutants using ecotoxicological indexes including the inhibitory rate of seed germination, root elongation and inhibitory concentration 50%(IC_ 50). The results indicated that methamidophos and Cd had unobvious(p>0.05) effects on seed germination of the ornamental. There were significant(p20 mg/L). However, the analysis of joint effects indicated that there were antagonistic effects between Cd and methamidophos under all the treatments. At the high concentration of Cd, joint toxicity of methamidophos and Cd was more dependent on concentration of Cd.

关键词： joint toxicity cadmium methamidophos ornamental

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Anisotropic optical and electric properties of β-gallium oxide

引用

Journal of Semiconductors 2023年第7期44卷 8-22页

作者： Yonghui Zhang fei xing School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255000China

The anisotropic properties and applications ofβ-gallium oxide(β-Ga_(2)O_(3))are comprehensively *** the anisotropic properties are essentially resulted from the anisotropic crystal *** process flow of how to exfoliate nanoflakes from bulk material is *** optical properties,including optical bandgap,Raman and photolumines-cence characters are comprehensively *** measurement configurations of angle-resolved polarized Raman spec-tra(ARPRS)are reviewed,with Raman intensity formulas calculated with Raman tensor *** method to obtain the Raman tensor elements of phonon modes through experimental fitting is also *** addition,the anisotropy in elec-tron mobility and affinity are *** applications,especially polarization photodetectors,based onβ-Ga_(2)O_(3)were summa-rized *** kinds of polarization detection mechanisms based on material dichroism,1D morphology and metal-grids are discussed *** review paper provides a framework for anisotropic optical and electric properties ofβ-Ga_(2)O_(3),as well as the applications based on these characters,and is expected to lead to a wider discussion on this topic.

关键词： gallium oxide anisotropic dichroism polarization monoclinic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Improvements in Long-Lead Prediction of Early-Summer Subtropical Frontal Rainfall Based on Arctic Sea Ice

引用

Journal of Ocean University of China 2019年第3期18卷 542-552页

作者： xing Wen HUANG fei Key Laboratory of Physical Oceanography Ocean University of China Qingdao 266100 China Laboratory for Ocean and Climate Dynamics Pilot National Laboratory for Marine Science and Technology (Qingdao) Qingdao 266100 China Ningbo Collaborative Innovation Center of Nonlinear Harzard System of Ocean and Atmosphere Ningbo University Ningbo 315211 China

Seasonal prediction of East Asia(EA) summer rainfall, especially with a longer-lead time, is in great demand, but still very challenging. The present study aims to make long-lead prediction of EA subtropical frontal rainfall(SFR) during early summer(May-June mean, MJ) by considering Arctic sea ice(ASI) variability as a new potential predictor. A MJ SFR index(SFRI), the leading principle component of the empirical orthogonal function(EOF) analysis applied to the MJ precipitation anomaly over EA, is defined as the predictand. Analysis of 38-year observations(1979-2016) revealed three physically consequential predictors. A stronger SFRI is preceded by dipolar ASI anomaly in the previous autumn, a sea level pressure(SLP) dipole in the Eurasian continent, and a sea surface temperature anomaly tripole pattern in the tropical Pacific in the previous winter. These precursors foreshadow an enhanced Okhotsk High, lower local SLP over EA, and a strengthened western Pacific subtropical high. These factors are controlling circulation features for a positive SFRI. A physical-empirical model was established to predict SFRI by combining the three predictors. Hindcasting was performed for the 1979-2016 period, which showed a hindcast prediction skill that was, unexpectedly, substantially higher than that of a four-dynamical models’ ensemble prediction for the 1979-2010 period(0.72 versus 0.47). Note that ASI variation is a new predictor compared with signals originating from the tropics to mid-latitudes. The long-lead hindcast skill was notably lower without the ASI signals included, implying the high practical value of ASI variation in terms of long-lead seasonal prediction of MJ EA rainfall.

关键词： East Asia subtropical frontal rainfall long-lead seasonal prediction Arctic sea ice Physical-empirical model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lithiophilic interface guided transient infiltration of molten lithium for stable 3D composite lithium anodes

引用

Nano Research 2023年第6期16卷 8297-8303页

作者： Lan-xing Li Yun-Nuo Li fei-fei Cao Huan Ye College of Science Huazhong Agricultural UniversityWuhan 430070China

Fabricating three-dimensional(3D)composite lithium anodes via thermal infusion effectively addresses uncontrollable Li deposition and large volume ***,potential risks due to the long wetting time and high melting point remain a critical yet unconsidered ***,we report a stable 3D composite Li anode by infusing molten Li into a 3D scaffold within 3 s at 220℃.The key-enabling technique is the growth of a lithiophilic Mg-Al double oxide(LDO)nanosheet array layer on the *** in-situ formed lithiophilic alloy,combined with the capillary forces from the nanosheet arrays,enabled the transient infiltration of molten *** addition,the formed high ionic-conductivity Li phase can help construct a robust solid electrolyte interphase(SEI),stabilize the Li anode/electrolyte interface,and guide uniform Li *** 3D composite anode exhibited a long cycling life of 1,000 h under a current density of 1 mA·cm^(−2)and over 1,600 h under a current density of 2 mA·cm^(−2)with a high areal capacity of 4 mAh·cm^(−2)in Li/Li symmetric *** 3D composite anodes paired with high areal capacity LiFePO_(4)(LFP)and S cathodes demonstrate its practical application feasibility.

关键词： lithium metal battery composite Li anode interfacial layer thermal infusion long cycling life

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

QoE-driven resource allocation for mobile IP services in wireless network

引用

Science China(Information Sciences) 2015年第1期58卷 222-231页

作者： fei ZeSong xing ChengWen LI Na School of Information Science and Engineering Beijing Institute of Technology

In this study, quality of experience(QoE)-driven resource allocation for multi-applications in Internet Protocol(IP)-based wireless networks is studied. Considering that the mean opinion score(MOS) summation maximization problem is not fair to satisfy heterogeneous users' QoE with various mobile applications, we apply multi-objective optimization method to maximize each user's MOS utility. At the beginning of this work, the relationship between MOS utility and user transmission rate for three multimedia applications, that is, File Download, Internet Protocol Television, and Voice over Internet Protocol are discussed. However, the relations under diverse evaluation models are quite different and users in various mobile applications have different requirements, which make the optimization problem difficult to solve. To meet each user's minimum rate requirement,the idea of Nash bargaining solution is applied in the Hungarian-based subcarrier assignment problem. Then to simplify the power allocation problem, the concept of equivalent channel is introduced. Further by applying the tolerance membership function, we develop a fuzzy Max-Min decision model for generating an optimal power allocation solution. Simulation results demonstrate the satisfying characteristics of the proposed algorithm in terms of MOS utility and average data rate.

关键词： quality of experience mean opinion score tolerance membership function fuzziness multi-objective optimization

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Adsorption Behavior of CH2 and CH3 on Metal Clusters CUn （n=1-6）

引用

Chinese Journal of Chemical Physics 2008年第5期21卷 445-450页

作者： Xi-hui Cheng Ming-xing Jin Zhan Hu fei-fei Hu Da-jun Ding Institute of Atomic and Molecular Physics Jilin University Changchun 130012 China

Using density functional theory with generalized gradient approximation and hybrid functional, we studied the properties of energy, charge population, and vibration of CH2 and CH3 adsorbed on Cun （n=1-6） clusters. The results show that the DFT calculation with the hybrid functional matches the experimental results better in both cases. The calculation results indicate that the adsorption of CH2 is stronger than that of CH3. During adsorption, the charges transfer from Cu to CH2 or CH3. The obtained vibrational frequencies for different modes of CH2 and CH3 adsorbed on Cun agree well with the experimental results for the adsorption on Cu（111） surface.

关键词： Adsorption CH2 CH3 Cu cluster

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Convergence to the Rarefaction Wave for a Model of Radiating Gas in One-dimension

引用

Acta Mathematicae Applicatae Sinica 2016年第2期32卷 239-256页

作者： fei-min HUANG xing LI Academy Mathematics and Systems Science the Chinese Academy of Sciences College of Mathematics and Statistics Shenzhen University

In this paper, a sequence of solutions to the one-dimensional motion of a radiating gas are con- structed. Furthermore, when the absorption coefficient a tends to oo, the above solutions converge to the rarefaction wa... 详细信息

关键词： rarefaction wave compressible euler system radiating gas, hyperbolic-elliptic system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：