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Rosemary extract improves egg quality by altering gut barrier function,intestinal microbiota and oviductal gene expressions in late-phase laying hens

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Journal of Animal Science and Biotechnology 2024年第1期15卷 295-312页

作者： Lianhua Zhang Junwei Ge fei Gao Min Yang Hui Li fei xia Hongtong Bai xiangshu Piao Zhiying Sun Lei Shi Key Laboratory of Plant Resources Institute of BotanyChinese Academy of SciencesBeijing 100093China China National Botanical Garden Beijing 100093China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background Rosemary extract(RE)has been reported to exert antioxidant ***,the application of RE in late-phase laying hens on egg quality,intestinal barrier and microbiota,and oviductal function has not been systematically *** study was investigated to detect the potential effects of RE on performance,egg quality,serum parameters,intestinal heath,cecal microbiota and metabolism,and oviductal gene expressions in late-phase laying hens.A total of 21065-week-old“Jing Tint 6”laying hens were randomly allocated into five treatments with six replicates and seven birds per replicate and fed basal diet(CON)or basal diet supplemented with chlortetracycline at 50 mg/kg(CTC)or RE at 50 mg/kg(RE50),100 mg/kg(RE100),and 200 mg/kg(RE200).Results Our results showed that RE200 improved(P<0.05)Haugh unit and n-6/n-3 of egg yolk,serum superoxide dismutase(SOD)compared with *** significant differences were observed for Haugh unit and n-6/n-3 of egg yolk among CTC,RE50,RE100 and RE200 *** with CTC and RE50 groups,RE200 increased serum SOD activity on d 28 and *** with CON,RE supplementation decreased(P<0.05)total cholesterol(TC)***,RE100 and RE200 decreased(P<0.05)serum interleukin-6(IL-6)content compared with *** and RE200 increased jejunal m RNA expression of ZO-1 and Occludin compared with *** biomarkers of cecal microbiota and metabolite induced by RE 200,including Firmicutes,Eisenbergiella,Paraprevotella,Papillibacter,and butyrate,were closely associated with Haugh unit,n-6/n-3,SOD,IL-6,and ***2 analysis indicated that RE altered carbohydrate and amino acid metabolism of cecal microbiota and increased butyrate synthesizing enzymes,including 3-oxoacid Co A-transferase and butyrate-acetoacetate Co ***,transcriptomic analysis revealed that RE200 improved gene expressions and functional pathways related to immunity and albumen formation in the oviductal *** Dietary supplementation with 2

关键词： Intestinal health Laying hens Microbiota Oviductal function Phytochemicals Production

Adiposity in Chinese people with type 1 diabetes

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World Journal of Diabetes 2024年第7期15卷 1404-1408页

作者： Nian-Wei Wu xia-fei Lyu Zhen-Mei An She-Yu Li Department of Endocrinology and Metabolism West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Guideline and Rapid Recommendation Chinese Evidence-based Medicine CenterCochrane China Center and MAGIC China CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Adiposity,synonymous with obesity,is prevalent among both children and adults with type 1 diabetes in *** literature underscored the pathophysiological and socioeconomic factors associated with adiposity,and consistently highlighted its impact on cardiovascular,kidney,and metabolic diseases among Chinese individuals with type 1 *** and managing adiposity in individuals with type 1 diabetes are complicated and entail comprehensive approaches including lifestyle modifications,cognitive-behavioral therapy,insulin dose titration,and other diabetes treatment *** condition calls for coordination among policymakers,researchers,clinicians,and patients.

关键词： Type 1 diabetes China Metabolic syndrome Obesity Anti-obesity medications

Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery

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Research 2024年第1期2023卷 315-337页

作者： Chong Qiu fei xia Junzhe Zhang Qiaoli Shi Yuqing Meng Chen Wang Huanhuan Pang Liwei Gu Chengchao Xu Qiuyan Guo Jigang Wang Artemisinin Research Center and Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Nephrology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhenGuangdong 518020China

Nanocarriers have therapeutic potential to facilitate drug delivery,including biological agents,smallmolecule drugs,and nucleic ***,their efficiency is limited by several factors;among which,endosomal/lysosomal degradation after endocytosis is the most *** review summarizes advanced strategies for overcoming endosomal/lysosomal barriers to efficient nanodrug delivery based on the perspective of cellular uptake and intracellular transport *** strategies include promoting endosomal/lysosomal escape,using non-endocytic methods of delivery to directly cross the cell membrane to evade endosomes/lysosomes and making a detour pathway to evade endosomes/*** the basis of the findings of this review,we proposed several promising strategies for overcoming endosomal/lysosomal barriers through the smarter and more efficient design of nanodrug delivery systems for future clinical applications.

关键词： somal drugs finding

Machine learning and bioinformatics to identify biomarkers in response to Burkholderia pseudomallei infection in mice

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BIOCELL 2024年第4期48卷 613-621页

作者： YAO FANG fei xia feifei TIAN L EI QU FANG YANG JUAN FANG ZHENHONG HU HAICHAO LIU Department of Respiratory and Critical Care Medicine General Hospital of Center Theater of PLAWuhan430070China School of Medicine Wuhan University of Science and TechnologyWuhan430065China School of Life Science and Engineering Southwest Jiaotong UniversityChengdu611756China

Objective:In the realm of Class I pathogens,Burkholderia pseudomallei(BP)stands out for its propensity to induce severe *** the intricate interactions between BP and host cells is imperative for comprehending the dynamics of BP infection and discerning biomarkers indicative of the host cell response ***:mRNA extraction from BP-infected mouse macrophages constituted the initial step of our *** gene expression arrays,the extracted RNA underwent conversion into digital *** percentile shift method facilitated data processing,with the identiﬁcation of genes manifesting signiﬁcant differences accomplished through the application of the ***,a comprehensive analysis involving Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway was conducted on the differentially expressed genes(DEGs).Leveraging the ESTIMATE algorithm,gene signatures were utilized to compute risk scores for gene expression *** vector machine analysis and gene enrichment scores were instrumental in establishing correlations between biomarkers and macrophages,followed by an evaluation of the predictive power of the identiﬁed ***:The functional and pathway associations of the DEGs predominantly centered around G protein-coupled receptors.A noteworthy positive correlation emerged between the blue module,consisting of 416 genes,and the ***4,identiﬁed through support vector machine analysis among intersecting genes,indicated a robust interaction with macrophages,suggesting its potential as a robust ***4 exhibited commendable predictive efﬁcacy,with BP infection inducing its expression in both macrophages and mouse lung *** blotting in macrophages conﬁrmed a signiﬁcant upregulation of FZD4 expression from 0.5 to 24 h *** mouse lung tissue,FZD4 manifested higher expression in the cytoplasm of pulmonary epithelial cells in BP-infected lungs than in the

关键词： Burkholderia pseudomallei Microarray assay Machine learning Bioinformatics FZD4

Ten-year observation of corneal densitometry and associated factors following small incision lenticule extraction

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 485-490页

作者： xiao-Song Han fei xia Zhuo-Yi Chen Pei-Jun Yao Dong-Mei Yang Jing Zhao Xing-Tao Zhou Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghai 200031China NHC Key Laboratory of Myopia(Fudan University) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghai 200031China Shanghai Research Center of Ophthalmology and Optometry Shanghai 200031China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care(20DZ2255000) Shanghai 200031China

●AIM:To investigate the long-term changes of corneal densitometry(CD)and its contributing elements after small incision lenticule extraction(SMILE).●METHODS:Totally 31 eyes of 31 patients with mean spherical equivalent of-6.46±1.50 D and mean age 28.23±7.38y were ***-scale examinations were conducted on all patients preoperatively and during *** acuity,manifest refraction,axial length,corneal thickness,corneal higher-order aberrations,and CD were evaluated.●RESULTS:All surgeries were completed successfully without complications or adverse ***-year safety index was 1.17±0.20 and efficacy 1.04±*** value of 0–6 mm zones in central layer was statistically significantly lower 10y postoperatively,compared with preoperative values(0–2 mmΔ=-1.62,2–6 mmΔ=-1.24,P<0.01).There were no correlations between CD values and factors evaluated.●CONCLUSION:SMILE is a safe and efficient procedure for myopia on a long-term *** values get lower 10y postoperatively,whose mechanism is to be further discussed.

关键词： myopia small incision lenticule extraction corneal densitometry

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饱和岩石循环冻融蠕变力学特性及损伤分析

科学技术与工程 2024年第18期24卷 7584-7591页

作者：郭夏飞李伟煤炭科学技术研究院有限公司北京100013 煤矿灾害防控全国重点实验室北京100013

为研究饱和岩石循环冻融条件下的蠕变力学特性,开展了不同饱和冻融次数三轴蠕变力学试验。根据试样变形特征建立了弹黏塑性蠕变模型,计算了蠕变模型相关参数,研究了饱和循环冻融相关参数变化特征。分析了随冻融次数增加裂隙扩展发育规律... 详细信息

为研究饱和岩石循环冻融条件下的蠕变力学特性,开展了不同饱和冻融次数三轴蠕变力学试验。根据试样变形特征建立了弹黏塑性蠕变模型,计算了蠕变模型相关参数,研究了饱和循环冻融相关参数变化特征。分析了随冻融次数增加裂隙扩展发育规律,提出了循环冻融蠕变损伤模型,基于试验数据对损伤模型进行了验证。研究表明:饱和循环冻融蠕变过程分为过渡蠕变阶段,稳定蠕变阶段和加速蠕变阶段3个阶段,冻融次数增加蠕变各个阶段均呈缩短趋势。建立弹黏塑性蠕变模型基础上,总结相关蠕变参数随加载应力增加均呈现增大趋势,随冻融次数增加,相同应力条件下蠕变参数逐渐减小。冻融过程中裂隙发育主要分为两种:沿原有裂隙扩展和独立发育的裂隙。原有裂隙扩展速度大于独立发育裂隙产生速度。试样循环冻融过程中裂隙发育速度逐渐增大。考虑冻融次数对蠕变参数的影响,同时引入损伤系数对其影响结果修正,建立蠕变损伤模型解释了循环冻融蠕变损伤过程,模型理论曲线与试验数据对比显示具有较好的相关性,验证了蠕变损伤模型的正确性。

关键词：饱和循环冻融蠕变力学特性蠕变模型裂隙发育规律损伤模型

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不同衣藻光合作用响应汞胁迫的比较研究

水生生物学报 2024年第6期48卷 1040-1050页

作者：夏亦雪艾晓寒朱飞霞毕永红中国科学院水生生物研究所淡水生态与生物技术国家重点试验室武汉430072 中国科学院大学北京100049 大连海洋大学水产与生命学院大连116023

为筛选耐受汞胁迫的衣藻(Chlamydomonas reinhardtii)藻株,研究不同衣藻光合作用过程响应汞胁迫的差异,比较了不同汞浓度下11株衣藻的生长、叶绿素a含量及叶绿素荧光活性。结果表明,随着汞离子浓度升高,叶绿素a含量显著下降且生长受抑制... 详细信息

为筛选耐受汞胁迫的衣藻(Chlamydomonas reinhardtii)藻株,研究不同衣藻光合作用过程响应汞胁迫的差异,比较了不同汞浓度下11株衣藻的生长、叶绿素a含量及叶绿素荧光活性。结果表明,随着汞离子浓度升高,叶绿素a含量显著下降且生长受抑制,叶绿素荧光活性参数W_(k)、V_(j)和M_(o)快速增加,ψ_(o)和φEo快速下降,表明光合系统Ⅱ(PSⅡ)反应中心的供体侧和受体侧的电子传递受阻,光合活性被抑制。在11株衣藻中,衣藻FACHB-889(EC_(50)为0.762 mg/L)对汞耐受能力最弱,衣藻FACHB-2217对汞耐受能力最强(EC_(50)为2.848 mg/L)。与对照相比,在低浓度汞(1.0 mg/L)胁迫下,衣藻FACHB-889光合活性受抑制,单位面积活性反应中心数量(RC/CS_(o))显著下降(P<0.05),单位活性反应中心吸收的能量(ABS/RC)持续增加,单位反应中心耗散的能量(DIo/RC)和单位反应中心捕获的用于电子传递的能量(ET_(o)/RC)呈下降趋势,表明吸收的能量不能被光合作用有效利用,且无法通过热耗散释放,导致能量的非正常积累,使细胞失活甚至死亡;衣藻FACHB-2217单位活性反应中心吸收的能量(ABS/RC)、用于还原Q_(A)的能量(TR_(o)/RC)及用于电子传递的能量(ET_(o)/RC)均显著升高,细胞通过有活性的单位反应中心光合能力的增强,有效转化吸收的能量,消除部分反应中心失活的负面影响。研究表明,光合活性及其能量分配的差异是衣藻对汞敏感/耐受的重要原因。

关键词：汞光系统Ⅱ 毒性效应衣藻

公共卫生事件下我国风险与避险资产溢出效应——基于收益与风险分析的视角

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管理科学学报 2024年第6期27卷 127-148页

作者：魏宇李霞飞梁超云南财经大学金融学院昆明650221 西南交通大学经济管理学院成都610031

始于2019年末的重大公共卫生事件对我国实体经济和各类资产市场带来了前所未有的冲击,也引发了对我国各类资产间溢出效应的广泛讨论.本研究利用基于时变参数向量自回归(TVP-VAR)模型的动态溢出指数框架及其频域扩展,探讨了该事件影响下... 详细信息

始于2019年末的重大公共卫生事件对我国实体经济和各类资产市场带来了前所未有的冲击,也引发了对我国各类资产间溢出效应的广泛讨论.本研究利用基于时变参数向量自回归(TVP-VAR)模型的动态溢出指数框架及其频域扩展,探讨了该事件影响下我国股市这一风险资产市场与四种潜在避险资产(国债、外汇、黄金和原油)市场间收益和波动溢出的时域和频域特征.实证结果表明:首先,在该事件冲击下,我国资产系统的总收益和总波动溢出指数及其三个频域成分都出现了前所未有的增加;其次,资产收益溢出的短期成分最大,而波动溢出则以长期成分为主;第三,系统的主要收益和波动溢出来源会因该事件的国内外发展趋势的变化而发生改变,且一些资产所扮演的角色在该事件期间产生了明显的周期性转变.具体来说,在收益溢出方面,国债和原油分别是中期和后期除股票以外的净收益的溢出来源,且在该事件中期,黄金虽然是短期收益溢出的净接收者,却是中长期收益溢出的净传递者.在波动溢出方面,股票和国债是严重时期和舒缓时期除原油以外的额外波动溢出来源,且此时股票和原油虽然是长期净波动溢出来源,却是中短期波动溢出的净接受者.随着该事件逐渐可控,原油仍是波动溢出的净传递者,而国债则成为了中短期波动溢出的净传递者和长期波动溢出的净接收者.最后,在严重时期,国债,外汇和黄金市场是股票市场风险较好的避风港,同时,持有原油资产空头也可以较好地对冲股票市场风险.

关键词：重大公共卫生事件股票市场避险资产收益溢出波动溢出

失败的刑事司法?--性侵犯罪警察侦查比较研究

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青少年犯罪问题 2024年第3期 56-73页

作者：夏菲华东政法大学

负责性侵犯罪案件立案、侦查工作的警察,在性侵犯罪实际案发数、犯罪嫌疑人与被害人关系以及被害人报假案等问题上容易出现认知错误,导致其在案件处置过程中倾向于怀疑报案的被害人、不积极侦查或者采取错误的侦查措施。最终结果是性侵... 详细信息

负责性侵犯罪案件立案、侦查工作的警察,在性侵犯罪实际案发数、犯罪嫌疑人与被害人关系以及被害人报假案等问题上容易出现认知错误,导致其在案件处置过程中倾向于怀疑报案的被害人、不积极侦查或者采取错误的侦查措施。最终结果是性侵犯罪案件在刑事司法系统中的不当耗损情况严重,被害人遭遇二次伤害,刑事司法正义价值的实现大打折扣。警察部门应当构建以被害人为中心的立案、侦查模式,细化工作规则,有效开展犯罪侦查,切实保护性侵犯罪被害人获得刑事司法救济的权利。

关键词：性侵犯罪侦查案件损耗被害人中心警察文化