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Parallel Light Fields: A Perspective and A Framework

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 542-544页

作者： fei-Yue Wang Yu Shen IEEE State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of ScienceBeijing 100049

Dear Editor,Light fields give relatively complete description of scenes from perspective of angles and positions of rays. At present time, most of the computer vision algorithms take 2D images as input which are simplified expression of light fields with depth information discarded. In theory, computer vision tasks may achieve better performance as long as complete light fields are acquired.

关键词： computer Framework simplified

Regulation of Tumor Microenvironment Under Malignant Conditions:Application of nmoFs in Sonodynamic Therapy

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Chemical Research in Chinese Universities 2024年第4期40卷 611-626页

作者： YANG Yilin YAN fei SHI Zhan State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun130012P.R.China

In this review,we delve into the intricate regulation of the tumor microenvironment(TME)under malignant conditions and explore the transformative potential of nanoscale metal-organic frameworks(nmoFs)in the realm of sonodynamic therapy(SDT).The TME serves as a dynamic milieu influencing tumor progression and therapeutic response,presenting formidable challenges,such as hypoxia,acidity,excess hydrogen peroxide,high expression of glutathione,and *** the exceptional attributes of nmoFs,including their tunable structures and biocompatibility,holds immense promise for enhancing SDT efficacy and reshaping the TME *** integrating nmoFs with SDT,researchers aim to assemble multiple functionalities in a single platform that enhance tumor cell eradication while counteracting unfavorable TME conditions and immune *** potential of nmoFs to revolutionize tumor therapies by precisely targeting TME and overcoming therapeutic barriers is underscored by an in-depth analysis of recent breakthroughs in the use of nmoFs-based sonosensitizers to remodulate TME to amplify the efficacy of SDT.

关键词： Sonodynamic therapy Metal-organic framework Tumor microenvironment modification of sonosensitizer

Electrochemical Biosensor for Multiple Methylation-Locus Analysis Based on DNA-AuNPs and Bienzymatic Dual Signal Amplifications

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American Journal of Analytical Chemistry 2020年第2期11卷 61-74页

作者： Shasha Su Shu Zhang Jiang Huang Xi Chen Yan Li Lichao Fang Jun Deng fei mo Junsong Zheng Department of Clinical and Military Laboratory Medicine College of Medical Laboratory Science Army Medical University Shapingba District Chongqing China Department of Basic Clinical Laboratory Medicine School of Clinical Laboratory Science Guizhou Medical University Yunyan District Guiyang China Department of Clinical Laboratory Affiliated Hospital of Guizhou Medical University Guiyang China Department of Biochemistry Affiliated Hospital of Guizhou Medical University Guiyang China

DNA methylation plays a significant role in various biological events, and its precise determination is vital for the prognosis and treatment of cancer. Here, we proposed an ultrasensitive electrochemical biosensor for the quantitative analysis of multiple methylation-locus in DNA sequence via DNA anchoring the gold nanoparticles (DNA-AuNPs) and bienzyme dual signal amplifications. After the target DNA captured by the DNA-AuNPs of the biosensor, the methyl-CpG binding protein MeCP2 could specifically conjugate to the methylation-loci in the double-stranded DNA. Successively, the glucose oxidase (GOD) and horseradish (HRP) co-labeled antibody captured the His tagged MeCP2, which leads to a cascade enzymatic catalysis of the substrates to yield a detectable electrochemical signal. Both the two strategies, including the high content of DNA-AuNPs and the associated catalysis of bienzyme, dramatically enhanced the sensitivity of the biosensor. The response current elevated with the increasing numbers of methylation-locus, thus the multiple methylated DNA was identified by detecting the corresponding current signals. This method could detect the methylated target as low as 0.1 fM, and showed a wide linear range from 10 - 15 M to 10 - 7 M. Besides, the long-term stability and repeatability of the biosensor were also validated. The prepared electrochemical immunosensor exhibits ultrasensitivity through the bienzyme labeling process, which can be applied for the detection of DNA methylation with low concentration.

关键词： DNA Methylation Electrochemistry Biosensor AuNPs Bienzyme

MIXED DISCONTINUOUS GALERKIN METHOD FOR QUASI-NEWTONIAN STOKES FLOWS

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Journal of Computational Mathematics 2024年第3期42卷 885-910页

作者： Yanxia Qian fei Wang Wenjing Yan School of Mathematics and Statistics Xi'an Jiaotong UniversityXi'an 710049China School of Mathematics and Statistics&State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong UniversityXi'an 710049China

In this paper,we introduce and analyze an augmented mixed discontinuous Galerkin(MDG)method for a class of quasi-Newtonian Stokes *** the mixed formulation,the unknowns are strain rate,stress and velocity,which are approximated by a discontinuous piecewise polynomial triplet ■for k≥***,the discontinuous piecewise polynomial function spaces for the field of strain rate and the stress field are designed to be *** addition,the pressure is easily recovered through simple *** the benefit of the analysis,we enrich the MDG scheme with the constitutive equation relating the stress and the strain rate,so that the well-posedness of the augmented formulation is obtained by a nonlinear functional *** k≥0,we get the optimal convergence order for the stress in broken ■(div)-norm and velocity in L^(2)-***,the error estimates of the strain rate and the stress in-norm,and the pressure in L^(2)-norm are optimal under certain ***,several numerical examples are given to show the performance of the augmented MDG method and verify the theoretical *** evidence is provided to show that the orders of convergence are sharp.

关键词： Quasi-Newtonian fows Mixed discontinuous Galerkin method Symmetric strain rate Symmetric stress Optimal convergence orders

Impacts of pancreatic exocrine insufficiency on gut microbiota

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 271-279页

作者： Yulin GUO Feng CAO fei LI Department of General Surgery Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Acute Pancreatitis Clinical Center of Capital Medical University Beijing 100053China

Pancreatic exocrine insufficiency(PEI)can be induced by various kinds of diseases,including chronic pancreatitis,acute pancreatitis,and *** main pathogenetic mechanism of PEI involves the decline of trypsin synthesis,disorder of pancreatic fluid flow,and imbalance of secretion *** studies have shown that PEI could induce gut bacterial overgrowth and dysbiosis,with the abundance of Lactobacillus and Bifidobacterium increasing the most,which could be partially reversed by pancreatic enzyme replacement *** studies have also confirmed the association between PEI and the dysbiosis of gut *** exocrine secretions and changes in duodenal p H as well as bile salt malabsorption brought about by PEI may affect and shape the abundance and composition of gut *** turn,the gut microbiota may impact the pancreatic exocrine acinus through potential bidirectional *** forward,more and higher-quality studies are needed that focus on the mechanism underlying the impact of PEI on the gut microbiota.

关键词： Pancreatic exocrine insufficiency Gut microbiota Gut microbiome Pancreatic enzyme replacement therapy

RNA modifications in cellular metabolism:implications for metabolism-targeted therapy and immunotherapy

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1565-1594页

作者： Wei-Wei Liu Si-Qing Zheng Tian Li Yun-fei fei Chen Wang Shuang Zhang fei Wang Guan-Min Jiang Hao Wang Department of Laboratory Medicine The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina School of Clinical Medicine Shandong UniversityJinanChina Core Unit of National Clinical Research Center for Laboratory Medicine HefeiChina Neurosurgical Department The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Department of Clinical Laboratory The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiChina

Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of *** studies have been constantly making inroads in our understanding of pathophysiology,and inspiring development of *** a crucial component of epigenetics at post-transcription level,RNA modification significantly determines RNA fates,further affecting various biological processes and cellular *** be noted,immunometabolism defines the metabolic alterations occur on immune cells in different stages and immunological *** this review,we characterize the distribution features,modifying mechanisms and biological functions of 8 RNA modifications,including N6-methyladenosine(m6A),N6,2'-O-dimethyladenosine(m6Am),N1-methyladenosine(m1A),5-methylcytosine(m5C),N4-acetylcytosine(ac4C),N7-methylguanosine(m7G),Pseudouridine(V),adenosine-to-inosine(A-to-l)editing,which are relatively the most studied *** regulatory roles of these RNA modification on metabolism in diverse health and disease contexts are comprehensively described,categorized as glucose,lipid,amino acid,and mitochondrial *** we highlight the regulation of RNA modifications on immunometabolism,further influencing immune *** all,we provide a thorough discussion about clinical implications of RNA modification in metabolism-targeted therapy and immunotherapy,progression of RNA modification-targeted agents,and its potential in RNAtargeted ***,we give legitimate perspectives for future researches in this field from methodological requirements,mechanistic insights,to therapeutic applications.

关键词： metabolism targeted alterations

Impacts of proppant distribution on development of tight oil reservoirs with threshold pressure gradient

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Petroleum Science 2024年第1期21卷 445-457页

作者： Ming Yue Wei-Yao Zhu fei-fei Gou Tian-Ru Song Yu-Chun You Qi-Tao Zhang State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development Beijing102206China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing100083China

Field evidence indicates that proppant distribution and threshold pressure gradient have great impacts on well *** at the development of unconventional oil reservoirs in Triassic Chang-7 Unit,Ordos Basin of China,we presented an integrated workflow to investigate how(1)proppant placement in induced fracture and(2)non-linear flow in reservoir matrix would affect well productivity and fluid flow in the *** with our research before(Yue et al.,2020),here we extended this study into the development of multi-stage fractured horizontal wells(MFHWs)with large-scale complicated fracture *** integrated workflow is based on the finite element method and consists of simulation models for proppant-laden fluid flow,fracture flow,and non-linear seepage flow,*** results indicate that the distribution of proppant inside the induced cracks significantly affects the productivity of the *** we assign an idealized proppant distribution instead of the real distribution,there will be an overestimation of 44.98%in daily oil rate and 30.63%in cumulative oil production after continuous development of 1000 ***,threshold pressure gradient(TPG)also significantly affects the well performance in tight oil *** we simply apply linear Darcy’s law to the reservoir matrix,the overall cumulative oil production can be overrated by 77%after 1000 days of *** general,this research provides new insights into the development of tight oil reservoirs with TPG and meanwhile reveals the significance of proppant distribution and non-linear fluid flow in the production scenario design.

关键词： Proppant distribution Tight oil reservoir Multi-stage fractured horizontal well Threshold pressure gradient moving boundary

Homoclinic Solutions for a Class of Perturbed Fractional Hamiltonian Systems with Subquadratic Conditions

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1177-1196页

作者： Ying LUO fei GUO Yan LIU School of Mathematics Tianjin UniversityTianjin 300354P.R.China Tianjin Key Laboratory of Brain-Inspired Intelligence Technology Tianjin300354P.R.China

In this paper,we consider the following perturbed fractional Hamiltonian systems{tD_(∞)^(α)(_(-∞)D_(t)^(α)u(t))+L(t)u(t)=■_(u)W(t,u(t))+■(u)G(t,u(t)),t∈R,u∈H^(α)(R,R^(N)),whereα∈(1/2,1],L∈C(R,R^(N×N))is symmetric and not necessarily required to be positive definite,W∈C1(R×R^(N,R))is locally subquadratic and locally even near the origin,and perturbed term G∈C1(R×R^(N,R))maybe has no parity in *** the perturbed method improved by the authors,a sequence of nontrivial homo clinic solutions is obtained,which generalizes previous results.

关键词： Perturbed fractional Hamiltonian systems subquadratic condition perturbed method homoclinic solutions multiplicity

大菱鲆CD55负调控补体激活及其广谱细菌结合能力

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海洋科学 2022年第7期46卷 24-31页

作者：吴蒙李墨非孙黎中国科学院海洋研究所山东青岛266071 中国科学院大学北京100049 天津师范大学生命科学学院天津市动植物抗性重点实验室天津300387

CD55蛋白在哺乳动物中是一种补体调控因子,但其在鱼类中的功能未知。本研究探索了大菱鲆(Scophthalmus maximus)CD55(SmCD55)蛋白的功能。结果表明,SmCD55蛋白由344个氨基酸残基构成,含有一个N端信号肽和3个补体调控蛋白(CCP)功能域。Sm... 详细信息

CD55蛋白在哺乳动物中是一种补体调控因子,但其在鱼类中的功能未知。本研究探索了大菱鲆(Scophthalmus maximus)CD55(SmCD55)蛋白的功能。结果表明,SmCD55蛋白由344个氨基酸残基构成,含有一个N端信号肽和3个补体调控蛋白(CCP)功能域。SmCD55基因在大菱鲆多种组织中均有表达,其中,在肌肉中表达量最低,在脑组织的表达量最高。通过原核表达获得了重组的SmCD55(rSmCD55)蛋白,发现rSmCD55蛋白能够抑制大菱鲆血清的溶血活性和杀菌活性,表明其负调控补体系统的激活。此外,本研究还发现rSmCD55蛋白可以结合包括重要水产病原菌迟缓爱德华氏菌(Edwardsiella tarda)、荧光假单胞杆菌(Pseudomonas fluorescens)、鳗弧菌(Vibrio anguillarum)、哈维氏弧菌(Vibrio harveyi)和海豚链球菌(Streptococcus iniae)在内的多种细菌,其中与哈维氏弧菌的结合能力最强。以上这些研究结果丰富了鱼类补体系统的理论知识,加深了对鱼类补体激活调控的了解。

关键词：大菱鲆(Scophthalmus maximus) CD55蛋白补体激活细菌结合