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Effect of modifying matrix microstructures and nanosized precipitates on strengthening mechanisms and ductile-to-brittle-transitiontemperature in a 1000 MPa Ni-Cr-Mo-Cu steel

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Journal of Iron and Steel Research(International) 2022年第8期29卷 1257-1276页

作者： fei Zhu Li Yang Feng chai Xiao-bing Luo Cai-fu Yang Zheng-yan Zhang Department of Structural Steels Central Iron and Steel Research InstituteBeijing 100081China Material Digital R&D Center China Iron and Steel Research Institute GroupBeijing 100081China

A superior combination of yield strength(1001 MPa)and-20℃ impact toughness(166 J)was obtained in Nb-V-Timicroalloyed Ni-Cr-Mo-Cu steel treated by direct quenching and tempering route(DQT).The tested steels treated by DQT route and re-austenitization and tempering route(QT)were compared with each other in terms of mechanical properties and microstructures characterized by optical microscopy,transmission electron microscopy,X-ray diffraction,electron back-scattered diffraction method and so *** and Vickers hardness of the tested steel treated by the above two routes vary with isothermal aging temperature(400-600℃),shown as under-aged state,peak-aged state and overaged *** DQT specimens show higher strength and Vickers hardness than QT specimens with the same aging ***,the largest difference of yield strength between DQT and QT specimens was shown in DQT600 and QT600 ***600 or QT600 specimens refers to direct quenched(DQ)or quenched(Q)specimens isothermally aged at 600℃.The main disparities in quenched microstructure between DQ and Q specimens are mainly in morphology of prior austenite grains,dislocation density of martensite matrix and solution amount of Nb and Mo elements dissolving in martensite matrix,which play key roles in affecting microstructure and mechanical properties of DQT and QT *** dislocation density of matrix and finer average diameter of both MC(M is any combination of Nb,Mo and V)and Cu-rich particles were shown in DQT600 specimens than in QT600 *** from dislocations and nanosized MC and Cu-rich particles mainly leads to the largest difference of yield strength between DQT600 and QT600 *** addition,strong dislocation strengthening and precipitation strengthening in DQT600 specimen also elevated its ductile-to-brittle-transition-temperature,compared with QT600 specimen.

关键词： Cu-bearing high-strength low-alloy steel Direct quenching Nanosized precipitate Strengthening Ductile-to-brittle-transition-temperature

300 MW机组直流燃烧器二次风在线测量系统研究

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仪表技术 2018年第10期 32-33页

作者：柴飞虎崔锐京能山西漳山发电有限责任公司

为了深入挖掘机组的节能和环保潜力、提高机组运行安全稳定性,必须通过更加精细化的操作运行方式实现。以漳山电厂300 MW机组二次风测量装置为研究对象,提出了一种非常规的测量方案,即采用多值测量与流场分布规律相结合的方案,实现对燃... 详细信息

为了深入挖掘机组的节能和环保潜力、提高机组运行安全稳定性,必须通过更加精细化的操作运行方式实现。以漳山电厂300 MW机组二次风测量装置为研究对象,提出了一种非常规的测量方案,即采用多值测量与流场分布规律相结合的方案,实现对燃烧器二次风的精确控制以及二次风门的自动调节。

关键词：直流燃烧器二次风测量精度

高校出版人才培养模式创新下的学生就业探索——以北京印刷学院为例

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中国大学生就业 2019年第15期 39-43页

作者：翟阳李柴非北京印刷学院

受移动互联网、媒介融合技术快速发展的影响,我国出版产业对复合型应用人才的需求日益增大。面对传统出版的转型升级与数字出版的飞速前进,加快培养出版应用型人才以迎合当前出版就业趋势,是现阶段摆在各个高校面前的一道必答题。高校... 详细信息

受移动互联网、媒介融合技术快速发展的影响,我国出版产业对复合型应用人才的需求日益增大。面对传统出版的转型升级与数字出版的飞速前进,加快培养出版应用型人才以迎合当前出版就业趋势,是现阶段摆在各个高校面前的一道必答题。高校人才培养模式理应随着行业的整体发展变化不断优化创新,人才培养模式的方向与路径亦对学生的就业产生影响。

关键词：出版人才培养学生就业

七氟烷吸入复合瑞芬太尼麻醉在小儿腹腔镜疝修补术中的效果

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中华疝和腹壁外科杂志（电子版） 2024年第2期18卷 223-227页

作者：郭建丽珠娜宋飞柴国东鄂尔多斯市中心医院麻醉科内蒙古017000 内蒙古自治区妇幼保健院麻醉科呼和浩特010000

目的探究七氟烷吸入复合瑞芬太尼麻醉在小儿腹腔镜腹股沟疝修补术中的应用效果。方法选取2020年6月至2022年12月,鄂尔多斯市中心医院收治的100例行小儿腹股沟疝修补术患者,随机数字表法将患儿分为对照组与观察组,各50例。2组患儿均接受... 详细信息

目的探究七氟烷吸入复合瑞芬太尼麻醉在小儿腹腔镜腹股沟疝修补术中的应用效果。方法选取2020年6月至2022年12月,鄂尔多斯市中心医院收治的100例行小儿腹股沟疝修补术患者,随机数字表法将患儿分为对照组与观察组,各50例。2组患儿均接受腹腔镜腹股沟疝修补术治疗,对照组患儿予以丙泊酚复合瑞芬太尼麻醉,观察组患儿予以七氟烷吸入复合瑞芬太尼麻醉。比较2组患儿入室前(T0)、切皮时(T1)、手术开始5 min(T2)、10 min(T3)及术毕即刻(T4)的血流动力学指标[心率、平均动脉压(MAP)],术前、术后的应激指标[皮质醇、促肾上腺糖皮质激素(ACTH)、C反应蛋白(CRP)]变化,术后6、12、24、48 h疼痛程度(NRS评分法)、Ramsay镇静量表评分(RSS),以及躁动情况。结果与T0时刻比较,对照组在T1、T2、T3时的心率均显著降低(P0.05)。2组患者的心率水平比较,差异有统计学意义(F_(组间)=446.800,P_(组间)0.05),2组患者MAP水平比较,差异有统计学意义(F_(组间)=62.540,P_(组间)0.05)。结论小儿腹股沟疝修补术应用七氟烷复合瑞芬太尼麻醉利于患儿血流动力学平衡,降低患儿应激反应。

关键词：儿童疝疝修补术七氟烷瑞芬太尼血流动力学应激反应躁动

局部进展期肾癌患者术后预后列线图的建立与验证

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现代泌尿外科杂志 2024年第4期29卷 334-341页

作者：李飞问晓东柴红强吴明庞磊山西医科大学第五临床医学院泌尿外科山西太原030012

目的基于SEER数据库构建局部进展期肾癌患者列线图生存预测模型,为未来局部进展期肾癌患者术后预后研究提供参考。方法从SEER数据库中下载相关病例数据(n=7893),采用简单随机分组法将数据按7∶3的比例分为实验组和验证组,利用统计学方... 详细信息

目的基于SEER数据库构建局部进展期肾癌患者列线图生存预测模型,为未来局部进展期肾癌患者术后预后研究提供参考。方法从SEER数据库中下载相关病例数据(n=7893),采用简单随机分组法将数据按7∶3的比例分为实验组和验证组,利用统计学方法分析数据中所包含的临床病例信息,筛选影响患者预后的独立危险因素,并绘制局部进展期肾癌患者总体生存时间(OS)及肿瘤特异性生存时间(CSS)列线图模型。运用一致性指数、曲线下面积、内外部验证以及校准曲线评估模型效能。结果患者年龄、肿瘤大小、疾病进展类型、TNM分期、阳性淋巴结数目、婚姻状态以及病理类型与患者OS及CSS显著相关(P<0.001),利用上述预测因子,构建患者OS列线图模型并内部验证1、3、5年受试者工作特征曲线下面积(AUC)分别为0.809、0.721及0.715,构建CSS列线图模型并内部验证1、3、5年AUC分别为0.802、0.745和0.735;患者OS列线图模型外部验证1、3、5年AUC分别为0.792、0.628及0.620,CSS列线图外部验证1、3、5年AUC分别为0.943、0.803和0.737,模型区分度与准确度良好。结论本列线图模型预测性能良好,对临床个体化治疗具有一定指导意义。

关键词：局部进展期肾癌监测流行病学列线图预后因素预测模型总生存时间肿瘤特异性生存时间

Pollution characteristics and health risk assessment of polycyclic aromatic hydrocarbons and nitrated polycyclic aromatic hydrocarbons during heating season in Beijing

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Journal of Environmental Sciences 2023年第1期123卷 169-182页

作者： Xurong Bai Jie Wei Yanqin Ren Rui Gao Fahe chai Hong Li fei Xu Yuxue Kong State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Shandong University Environment Research InstituteQingdao 266237China Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China

Polycyclic aromatic hydrocarbons(PAHs)and their nitrated derivatives(NPAHs)attract continuous attention due to their outstanding carcinogenicity and *** order to investigate the diurnal variations,sources,formation mechanism,and health risk assessment of them in heating season,particulate matter(PM)were collected in Beijing urban area from December 26,2017 to January 17,*** and NPAHs in PM were quantitatively analyzed via gas chromatography-mass spectrometry(GC-MS).Average daily concentrations of PAHs and NPAHs were(78±54)ng/m^(3)and(783±684)pg/m^(3),*** concentrations of them were significantly higher at nighttime than at daytime,and NPAHs concentrations were 1-2 orders of magnitude lower than PAHs *** the heating season,the dominant species of PAHs include benzo[b]fluoranthene,fluoranthene,pyrene,and chrysene,while 9-nitroanthracene,2+3-nitrofluoranthene,and 2-nitropyrene were dominant species for *** were found to have a single peak during heating and to be primarily distributed in the 0.4-0.7μm particle *** emissions such as biomass burning,coal combustion,and traffic emissions were the major sources of *** were produced by the primary source of vehicle emissions and the secondary reaction triggered by OH radicals,as well as biomass burning during *** to the health risk assessment,the total carcinogenic risk was higher in adults than in *** upon oral ingestion,the carcinogenic risk in children was higher than that of adults,but the risk of adults was higher than children through skin contact and respiratory inhalation.

关键词： Heating season Polycyclic aromatic hydrocarbons Nitrated polycyclic aromatic hydrocarbons Pollution characteristics Source Health risk assessment

Anti-inflammatory effects of Abelmoschus manihot(L.)*** LPS-induced cystitis in mice:potential candidate for cystitis treatment based on classic use

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Chinese Journal of Natural Medicines 2022年第5期20卷 321-331页

作者： ZHOU Su FAN Kai-Kai GU Li-fei YU Bo-Yang chai Cheng-Zhi Jiangsu Key Laboratory of TCM Evaluation and Translational Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China Research Center for Traceability and Standardization of TCMs School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

Abelmoschus manihot(L.)Medik.(***)is a traditional Chinese herbal medicine with a variety of pharmacological *** was first recorded in Jiayou Materia Medica dating back to the Song dynasty to eliminate urinary tract irritation by clearing away heat and diuretic ***,its pharmacological action on urinary tract infections has not been *** present study aims to evaluate the anti-inflammatory activity of *** on a mouse model of lipopolysaccharide(LPS)-induced *** results showed that *** decreased white blood cell(WBC)count in urine sediments of the cystitis mice,alleviated bladder congestion,edema,as well as histopathological damage,reduced the expression levels of tumor necrosis factor-α,interleukin-6,and interleukin-1β***,*** administration significantly downregulated the expression levels of TLR4,MYD88,IκBα,p-IκBα,NF-κB p65,and p-NF-κB p65 in LPS-induced cystitis *** findings demonstrated the protective effect of *** against LPS-induced cystitis,which is attributed to its anti-inflammatory profile by suppressing TLR4/MYD88/NF-κB *** results suggest that *** could be a potential candidate for cystitis treatment.

关键词： Abelmoschus manihot(L.)Medik.(A.manihot) Cystitis Lipopolysaccharide(LPS) Inflammation TLR4/MYD88/NF-κB

Screening of immune cell activators from Astragali Radix using a comprehensive two-dimensional NK-92MI cell membrane chromatography/C18 column/time-of-flight mass spectrometry system

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Journal of Pharmaceutical Analysis 2022年第5期12卷 725-732页

作者： Xinyi chai Yanqiu Gu Lei Lv Chun Chen fei Feng Yan Cao Yue Liu Zhenyu Zhu Zhanying Hong Yifeng chai Xiaofei Chen School of Pharmacy Shanghai Key Laboratory for Pharmaceutical Metabolite ResearchNaval Medical University(Second Military Medical University)Shanghai 200433China Department of Pharmacy Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai201999China Department of Pharmacy Shanghai Eastern Hepatobiliary Surgery HospitalNaval Medical University(Second Military Medical University)Shanghai200438China

Astragali Radix(AR)is a clinically used herbal medicine with multiple immunomodulatory activities that can strengthen the activity and cytotoxicity of natural killer(NK)***,owing to the complexity of its composition,the specific active ingredients in AR that act on NK cells are not clear *** membrane chromatography(CMC)is mainly used to screen the active ingredients in a complex system of herbal *** this study,a new comprehensive two-dimensional(2D)NK-92MI CMC/C18 column/time-of-flight mass spectrometry(TOFMS)system was established to screen for potential NK cell *** obtain a higher column efficiency,3-mercaptopropyltrimethoxysilane-modified silica was synthesized to prepare the NK-92MI CMC *** total,nine components in AR were screened from this system,which could be washed out from the NK-92MI/CMC column after 10 min,and they showed good affinity for NK-92MI/CMC *** representative active compounds of AR,isoastragaloside Ⅰ and astragaloside IV,promoted the killing effect of NK cells on K562 cells in a dose-dependent *** can thus suggest that isoastragaloside Ⅰ and astragaloside Ⅳ are the main immunomodulatory components of *** comprehensive 2D NK-92MI CMC analytical system is a practical method for screening immune cell activators from other herbal medicines with immunomodulatory effects.

关键词： NK cell activators Cell membrane chromatography Immunomodulatory herbal medicine Covalent bonding

基于ISIGHT平台的GFRP托盘结构优化设计

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林产工业 2024年第5期61卷 32-38页

作者：郑妮华于宝磊殷震柴东何金牛杜艺飞刘可洋北京建筑材料科学研究总院有限公司北京102402 北京瑞和伟创控股有限公司北京101149 北京建筑材料检验研究院股份有限公司北京102402 北京林业大学材料科学与技术学院北京102402 四川师范大学服装与设计艺术学院四川成都610101

托盘是货物运输中的重要工具,其生产原料也呈现出多样化的发展趋势。本文针对废弃玻璃纤维增强塑料(GFRP)托盘进行结构设计,使用ABAQUS进行静力分析,并通过ISIGHT对托盘进行DOE全因子试验优化。将托盘结构参数作为变量,托盘质量、最大... 详细信息

托盘是货物运输中的重要工具,其生产原料也呈现出多样化的发展趋势。本文针对废弃玻璃纤维增强塑料(GFRP)托盘进行结构设计,使用ABAQUS进行静力分析,并通过ISIGHT对托盘进行DOE全因子试验优化。将托盘结构参数作为变量,托盘质量、最大应力作为优化目标,进而得到局部最优解。将DOE试验结果通过RBF模型进行拟合,得到近似模型,并通过NSGA-Ⅱ算法对其进行优化,进而得到最优结构。结果表明,DOE优化后,托盘质量增加了9.2%,最大应力降低了18.2%;通过NSGA-Ⅱ算法优化后,托盘质量减小了1.2%,最大应力降低了15.3%,实现了对托盘结构的优化设计。

关键词： GFRP托盘托盘结构力学仿真近似模型优化设计