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Hepatocellular carcinoma metastatic to the kidney mimicking renal oncocytoma

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Hepatobiliary & Pancreatic Diseases International 2010年第5期9卷 550-552页

作者： antonio D'antonio Alessia Caleo Oliviero Caleo Maria Addesso Amedeo Boscaino Department of Pathologic Anatomy A.O."San Giovanni di Dio e Ruggi d'Aragona"via S.LeonardoSalernoItaly Department of Biomorphological and Functional Science University of Medicine "Federico II"NaplesItaly Department of Pathologic Anatomy ASL SA1Hospital "Scarlato"Scafati(SA) Unit of Pathologic Anatomy A.O.R.N."Cardarelli"via A.Cardarelli 980131 NaplesItaly

BACKGROUND:Renal metastases of hepatocellular carcinoma(HCC) are very *** our knowledge only five cases have been reported to the present;all had a well-known primary ***:We describe the clinico-pathological features of a rare case of HCC metastatic to the kidney in which the renal mass was the clinical debut of *** patient was a 54-year-old woman previously submitted to orthotopic liver transplantation,who underwent left nephrectomy for a renal ***:Histologically,the tumor was composed mainly of epithelioid cells with homogeneous acidophilic cytoplasm resembling oncocytoma or primary renal carcinoma with oncocytic features.A correct diagnosis was made on the basis of positive immunostaining for hepatocyte paraffin ***:Metastasis to the kidney is a rare complication that should be considered whenever a renal mass is present in patients with *** HCC may histologically resemble primary renal tumors such as oncocytoma,pathologists must be aware of this possibility above all in patients referred for liver transplantation and treated with immunosuppressant *** is particularly helpful to establish a precise diagnosis in cases of doubt.

关键词： renal metastasis hepatocellular carcinoma immunohistochemistry differential diagnosis

Role of brain-derived neurotrophic factor during the regenerative response after traumatic brain injury in adult zebrafish

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Neural Regeneration Research 2018年第6期13卷 941-944页

作者： Pietro Cacialli antonio Palladino Carla Lucini Department of Veterinary Medicine University of Naples Federico Ⅱ

Several mammalian animal models of traumatic brain injury have been used, mostly rodents. However, reparative mechanisms in mammalian brain are very limited, and newly formed neurons do not survive for long time. The brain of adult zebrafish, a teleost fish widely used as vertebrate model, possesses high regenerative properties after injury due to the presence of numerous stem cells niches. The ventricular lining of the zebrafish dorsal telencephalon is the most studied neuronal stem cell niche because its dorso-lateral zone is considered the equivalent to the hippocampus of mammals which contains one of the two constitutive neurogenic niches of mammals. To mimic TBI, stab wound in the dorso-lateral telencephalon of zebrafish was used in studies devoted to fish regenerative properties. Brain-derived neurotrophic factor, which is known to play key roles in the repair process after traumatic brain lesions, persists around the lesioned area of injured telencephalon of adult zebrafish. These results are extensively compared to reparative processes in rodent brain. Considering the complete repair of the damaged area in fish, it could be tempting to consider brain-derived neurotrophic factor as a factor contributing to create a permissive environment that enables the establishment of new neuronal population in damaged brain.

关键词： brain-derived neurotrophic factor neurotrophins neurotrophic factors brain telencephalon teleost fish traumatic brain injury lesion neurons

Role of capsule endoscopy in suspected celiac disease: A European multi-centre study

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World Journal of Gastroenterology 2017年第4期23卷 703-711页

作者： Marisol Luján-Sanchis Enrique Pérez-Cuadrado-Robles Javier Garcia-Lledo José-Francisco Juanmartinena Fernandez Luca Elli Victoria-Alejandra Jiménez-García Juan Egea-Valenzuela Julio Valle-Munoz Cristina Carretero-Ribón Ignacio Fernández-Urién-Sainz antonio López-Higueras Noelia Alonso-Lazaro Mileidis Sanjuan-Acosta Francisco Sanchez-Ceballos Bruno Rosa Santiago González-Vázquez Federica Branchi Lucía Ruano-Díaz César Prieto-de-Frías Vicente Pons-Beltrán Pilar Borque-Barrera Begona González-Suárez Sofía Xavier federico Argüelles-Arias Juan-Manuel Herrerías-gutiérrez Enrique Pérez-Cuadrado-Martínez Javier Sempere-García-Argüelles Digestive Diseases Unit General University Hospital of Valencia Small Bowel Unit Hospital Morales Meseguer Digestive Diseases Unit General University Gregorio Maranón Unit of Gastroenterology and Endoscopy Complejo Hospitalario de Navarra Center for prevention and Diagnosis of Celiac Disease Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico Unit of Gastroenterology and Endoscopy University Hospital Virgen Macarena Gastroenterology department Hospital Virgen de la Arrixaca Department of Gastroenterology Complejo Hospitalario de Toledo Department of Gastroenterology University of Navarra Clinic1 Endoscopy Digestive Unit Digestive Diseases AreaUniversitari i Politècnic La Fe Hospital1 Digestive Diseases Unit University Hospital Nuestra Senora de Candelaria1 Digestive Diseases Unit Clinical Hospital San Carlos1 Digestive Diseases Unit Hospital da Senhora da Oliveira-Guimaraes1 Endoscopy Digestive Unit Hospital Clinic de Barcelona

AIMTo analyze the diagnostic yield (DY), therapeutic impact (TI) and safety of capsule endoscopy (CE).METHODSThis is a multi-centre, observational, analytical, retrospective study. A total of 163 patients with suspicion of celiac disease (CD) (mean age = 46.4 ± 17.3 years, 68.1% women) who underwent CE from 2003 to 2015 were included. Patients were divided into four groups: seronegative CD with atrophy (Group-I, n = 19), seropositive CD without atrophy (Group-II, n = 39), contraindication to gastroscopy (Group-III, n = 6), seronegative CD without atrophy, but with a compatible context (Group-IV, n = 99). DY, TI and the safety of CE were *** overall DY was 54% and the final diagnosis was villous atrophy (n = 65, 39.9%), complicated CD (n = 12, 7.4%) and other enteropathies (n = 11, 6.8%; 8 Crohn’s). DY for groups I to IV was 73.7%, 69.2%, 50% and 44.4%, respectively. Atrophy was located in duodenum in 24 cases (36.9%), diffuse in 19 (29.2%), jejunal in 11 (16.9%), and patchy in 10 cases (15.4%). Factors associated with a greater DY were positive serology (68.3% vs 49.2%, P = 0.034) and older age (P = 0.008). On the other hand, neither sex nor clinical presentation, family background, positive histology or HLA status were associated with DY. CE results changed the therapeutic approach in 71.8% of the cases. Atrophy was associated with a greater TI (92.3% vs 45.3%, P < 0.001) and 81.9% of the patients responded to diet. There was one case of capsule retention (0.6%). Agreement between CE findings and subsequent histology was 100% for diagnosing normal/other conditions, 70% for suspected CD and 50% for complicated *** has a high DY in cases of suspicion of CD and it leads to changes in the clinical course of the disease. CE is safe procedure with a high degree of concordance with histology and it helps in the differential diagnosis of CD.

关键词： Capsule endoscopy Celiac disease Anti-transglutaminase antibodies Gluten-free diet Non-celiac gluten sensitivity

Loss of efficacy and safety of the switch from infliximab original to infliximab biosimilar(CT-P13)in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2018年第46期24卷 5288-5296页

作者： María Fernanda Guerra Veloz federico Argüelles-Arias Luisa Castro Laria Belén Maldonado Pérez antonio Benítez Roldan Raúl Perea Amarillo Vicente Merino Bohórquez Miguel Angel Calleja Angel Caunedo Alvarez Angel Vilches Arenas Department of Gastroenterology University Hospital Virgen MacarenaSeville 41007Spain Pharmacy Unit University Hospital Virgen MacarenaSeville 41007Spain Preventive Medicine and Public Health University Hospital Virgen MacarenaSeville 41007Spain

BACKGROUND Infliximab original has changed the natural history of inflammatory bowel diseases(IBD) over the past two decades. However, the recent expiration of its patent has allowed the entry of the first Infliximab biosimilar into the European and Spanish markets. Currently switching drugs data in IBD are limited. AIM To compare the efficacy of infliximab biosimilar, CT-P13, against infliximab original, analyzing the loss of response of both at the 12 mo follow-up in patients with *** An observational study of two cohorts has been conducted. One retrospective cohort that included patients with IBD treated with Infliximab original, and a prospective cohort of patients who were switching from infliximab original to infliximab biosimilar(CT-P13). We had analyzed the overall efficacy and loss of efficacy in patients in remission at the end of one year after treatment with the original drug compared to the results of the year of treatment with the ***98 patients(CD 67, CU 31) were included in both cohorts. The overall efficacy for infliximab original per year of treatment was 71% vs 68.2% for infliximab biosimilar(P = 0.80). The loss of overall efficacy at 12 mo for infliximab original was 6.6% vs 14.5% for infliximab biosimilar(P = 0.806). The loss of efficacy in patients who were in basal remission was 16.3% for infliximab original vs 27.1% for infliximab biosimilar. Adverse events were 9.2% for infliximab original vs 11.2% for infliximab biosimilar. CONCLUSION The overall efficacy and loss of treatment response with infliximab biosimilar(CT-P13) is similar to that observed with infliximab original in patients who were switching at the 12 mo follow-up. There is no difference in the rate of adverse events.

关键词： Crohn’s disease Ulcerative colitis CT-P13 Inflammatory bowel disease Biosimilar agent Infliximab original Efficacy

Selective excitation and imaging of ultraslow phonon polaritons in thin hexagonal boron nitride crystals

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Light(Science & Applications) 2018年第1期7卷 808-816页

作者： antonio Ambrosio Michele Tamagnone Kundan Chaudhary Luis A.Jauregui Philip Kim William L.Wilson federico Capasso Center for Nanoscale Systems Harvard UniversityCambridgeMA 02138USA Department of Physics Harvard UniversityCambridgeMA 02138USA Harvard John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA

We selectively excite and study two new types of phonon-polariton guided modes that are found in hexagonal boron nitride thin flakes on a gold *** modes show substantially improved confinement and a group velocity that is hundreds of times slower than the speed of light,thereby providing a new way to create slow light in the midinfrared range with a simple structure that does not require *** mode is the fundamental mode in the first Restrahlen band of hexagonal boron nitride thin crystals on a gold substrate;the other mode is equivalent to the second mode of the second Restrahlen band of hexagonal boron nitride flakes that are suspended in *** new modes also couple efficiently with incident light at the hexagonal boron nitride edges,as we demonstrate experimentally using photo-induced force microscopy and scanning near-field optical *** high confinement of these modes allows for Purcell factors that are on the order of tens of thousands directly above boron nitride and a wide band,with new perspectives for enhanced light-matter *** findings demonstrate a new approach to engineering the dispersion of polaritons in 2D materials to improve confinement and light-matter interaction,thereby paving the way for new applications in mid-infrared nano-optics.

关键词： interaction. boron hexagonal

Production of carbonaceous material from avocado peel for its application as alternative adsorbent for dyes removal

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Chinese Journal of Chemical Engineering 2016年第4期24卷 521-528页

作者： Carolyn Palma Lucia Lloret antonio Puen Maira Tobar Elsa Contreras Departamento de Ingenieria Quimica Ambiental Universidad Tecnica Federico Santa Mafia Vicunia Mackenna 3939 Santiago Chile Departamento de Ingenieria Quimica Universidad de Santiago de Chile Alameda 3363 Santiago Chile

Adsorption processes have received special attention for contaminants removal thanks to their capability to gen- erate effluents with high quality as well as their simple design. In the current work, the agro-waste residue avo- cado peel is proposed to be used as alternative to conventional activated carbons whose use is sometimes restricted to high costs, upgraded by their exhausting after long term operations. The carbonization procedure was optimized and analyzed through factorial design and response surface methodology by evaluating temper- ature （400-900 ℃） and time （30-90 min） effects： optimal conditions were found at 900℃ and 65 min, gener- ating an adsorbent with 87.52 m2.g 1 of BET surface area, a mesopore volume of 74% and a zero point charge at 8.6. The feasibility of the carbonaceous material was proved for the removal of a variety of dyes by investigating substrate （10-50 mg.L 1） and solid （0.5-20 g.L-1） concentration effects and statistical significance： complete removal of Naphthol Blue Black and Reactive Black 5 was reached under optimal conditions （10 mg.L 1 and 20g.L 1 of dye and solid, respectively）, while Basic Blue 41 was eliminated by using 13.4 g. L- 1 of the adsorbent. Overall, dyes removal by adsorption on carbonized avocado peel is presented as a promising technology due to the low cost and easy availability of the precursor, as well as the straightforward generation, the satisfactory char- acteristics and the proved adsorption capacity of the adsorbent.

关键词： Avocado peelCarbonizationOptimizationAdsorptionDyes

Is liver biopsy mandatory in children with chronic hepatitis C?

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World Journal of Gastroenterology 2007年第29期13卷 4025-4026页

作者： Raffaele Iorio antonio Verrico Antonietta Giannattasio Department of Pediatrics University "Federico Ⅱ" Naples Italy

Liver biopsy is considered the most accurate means to estimate the necroinflammatory activity and the extent of fibrosis. However, histology evaluation is an invasive procedure associated with risk to the patient, risk of sampling error and diagnostic inconsistencies due to inter- and intra-observer error. On the basis of histological studies performed so far, chronic hepatitis C in children appears morphologically benign in the majority of cases. At the Pediatric Liver Unit of our university, a total of 67 children with chronic hepatitis C underwent liver biopsy. Liver biopsy was repeated 5.5 years after the initial histological evaluation in 21 children. On a total number of 88 liver biopsies, micronodular cirrhosis was detected only in one genotype 1b-infected obese child. Since liver histology investigation of a child with chronic hepatitis C has few chances to highlight severe lesions, we question how liver biopsy helps in the management of children with chronic hepatitis C.

关键词： Liver fibrosis Cirrhosis Natural history Liver biopsy Children

liver and the defects of cholesterol and bile acids biosynthesis: rare disorders many diagnostic pitfalls

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World Journal of Gastroenterology 2017年第29期23卷 5257-5265页

作者： Gaetano Corso antonio Dello Russo Monica Gelzo Department of Clinical and Experimental Medicine University of Foggia Department of Molecular Medicine and Medical Biotechnology University of Naples Federico Ⅱ

In recent decades, biotechnology produced a growth of knowledge on the causes and mechanisms of metabolic diseases that have formed the basis for their study, diagnosis and treatment. Unfortunately, it is well known that the clinical features of metabolic diseases can manifest themselves with very different characteristics and escape early detection. Also, it is well known that the prognosis of many metabolic diseases is excellent if diagnosed and treated early. In this editorial we briefly summarized two groups of inherited metabolic diseases, the defects of cholesterol biosynthesis and those of bile acids. Both groups show variable clinical manifestations but some clinical signs and symptoms are common in both the defects of cholesterol and bile acids. The differential diagnosis can be made analyzing sterol profiles in blood and/or bile acids in blood and urine by chromatographic techniques(GC-MS and LC-MS/MS). Several defects of both biosynthetic pathways are treatable so early diagnosis is crucial. Unfortunately their diagnosis is made too late, due either to the clinical heterogeneity of the syndromes(severe, mild and very mild) that to the scarcity of scientific dissemination of these rare diseases. Therefore, the delay in diagnosis leads the patient to the medical observation when the disease has produced irreversible damages to the body. Here, we highlighted simple clinical and laboratory descriptions that can potentially make you to suspect a defect in cholesterol biosynthesis and/or bile acids, as well, we suggest appropriate request of the laboratory tests that along with common clinical features can help to diagnose these defects.

关键词： Cholesterol Bile acids Liver metabolism Gas chromatography coupled to mass spectrometry Liquid chromatography coupled to tandem mass spectrometry

Adenocarcinoma of the third duodenal portion:Case report and review of literature

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World Journal of Gastrointestinal Surgery 2012年第1期4卷 23-26页

作者： federico Sista Giuseppe De Santis antonio Giuliani Emanuela Marina Cecilia Federica Piccione Laura Lancione Sergio Leardi Gianfranco Amicucci General Surgery Department of SurgeryUniversity of L’Aquila

We focus on the diagnostic and therapeutic problems of duodenal adenocarcinoma, reporting a case and reviewing the literature. A 65-year old man with adenocarcinoma in the third duodenal portion was successfully treated with a segmental resection of the third part of the duodenum, avoiding a duodeno-cephalo-pancreatectomy. This tumor is very rare and frequently affects the III and IV duodenal portion. A precocious diagnosis and the exact localization of this neoplasia are crucial factors in order to decide the surgical strategy. Given a non-specificity of symptoms, endoscopy with biopsy is the diagnostic gold standard. Duodeno-cephalo-pancreatectomy (DCP) and segmental resection of the duodenum (SRD) are the two surgical options, with overlapping morbidity (27% vs 18%) and post operative mortality (3% vs 1%). The average incidence of postoperative long-term survival is 100%, 73.3% and 31.6% of cases after 1, 3 and 5 years from surgery, respectively. Long-term survival is made worse by two factors: the presence of metastatic lymph nodes and tumor localization in the proximal duodenum. The two surgical options are radical: DCP should be used only for proximal localizations while SRD should be chosen for distal localizations.

关键词： Duodenal carcinoma Duodeno-cephalo-pancreatectomy Segmental resection Survival III duodenal portion Duodenal embryological development