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Effects of sampling.frequency on node mobility prediction in dynamic networks: A spectral view

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数字通信与网络:英文版 2023年第4期9卷 1009-1022页

作者： Peppino fazio Miralem Mehic Miroslav Voznak DSMN Ca’Foscari University of VeniceVia Torino 15530172MestreVEItaly Department of Telecommunications Faculty of Electrical EngineeringUniversity of Sarajevo Zmaja od Bosne bb71000SarajevoBosnia and Herzegovina VSB–Technical University of Ostrava 17.listopadu 2172/1570800OstravaCzech Republic

The field of mobility prediction has been widely investig.ted in the recent past,especially the reduction of the coverag. radius of cellular networks,which led to an increase in hand-over *** the cell coverag. very frequently,for example,may lead to service disruptions if a predictive approach is not deployed in the *** several works examined mobility prediction in the new-g.neration mobile networks,all of these studies focused on studying.the time features of mobility traces,and the spectral content of historical mobility patterns was not considered for prediction purposes as *** the present study,we propose a new approach to mobility prediction by analyzing.the effects of a proper mobility sampling.*** proposed approach lies in the mobility analysis in the frequency domain,to extract hidden features of the mobility ***,we proposed a new methodolog. to determine the spectral content of mobility traces(considered as sig.als)and,thus,the appropriate sampling.frequency,which can provide numerous *** considered several types of mobility models(***,urban,and vehicular),containing.important details in the time and frequency *** simulation campaig.s were performed to observe and analyze the characteristics of mobility from real traces and to evaluate the effects of sampling.frequency on the spectral content.

关键词： Mobile networking Frequency domain Mobility spectrum

利用组织多普勒检查对心肌致密化不全患儿舒张功能的评估

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世界核心医学期刊文摘（心脏病学分册） 2007年第8期3卷 45-45页

作者： fazio g. Pipitone S. Iacona M.A. 郭俊 Department of Cardiolog. University of Palermo Italy

组织多普勒分析是评价舒张功能的一种新型超声心动图检查方式。本文报道对1组15例心肌致密化不全患儿进行组织多普勒分析的结果。二维超声心动图检查显示只有8例患者的收缩功能降低。分析发现有7例患者的舒张功能发生改变:2例患者的全... 详细信息

组织多普勒分析是评价舒张功能的一种新型超声心动图检查方式。本文报道对1组15例心肌致密化不全患儿进行组织多普勒分析的结果。二维超声心动图检查显示只有8例患者的收缩功能降低。分析发现有7例患者的舒张功能发生改变:2例患者的全部节段均可见E波降低,3例患者的舒张功能障碍限于尖段和外侧段,其余2例患者的E波降低仅见于尖段。收缩功能障碍和舒张功能障碍之间存在强相关性:事实上,存在舒张功能障碍的所有患者亦表现出收缩功能的显著降低。

关键词：心肌致密化不全收缩功能舒张功能障碍组织多普勒超声心动图多普勒检查外侧段检查方式

Butein-instig.ted miR-186-5p-dependent modulation of TWIST1 affects resistance to cisplatin and bioenerg.tics of Malig.ant Pleural Mesothelioma cells

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Cancer Drug.Resistance 2022年第3期5卷 814-828页

作者： Mario Cioce Daniela Rutig.iano Annamaria Pug.ielli Vito Michele fazio Department of Medicine Laboratory of Molecular Medicine and BiotechnologyUniversity Campus Bio-Medico of RomeRome 00128Italy Institute of Translational Pharmacolog. National Research Council of Italy(CNR)Rome 00133Italy

Aim:Malig.ant pleural mesothelioma is a chemoresistant tumor,and biphasic and sarcomatoid histolog.es portend the worst prog.osis for malig.ant pleural mesothelioma(MPM)*** obtained the microRNA expression profile of three biphasic-sarcomatoid MPM cell lines to identify commonly expressed microRNAs and evaluate the effect of butein,a chemo-sensitizing.compound,on this microRNA ***:Nanostring.based microRNA profiling.and analysis throug. the ROSALIND platform were employed to identify the commonly modulated microRNAs and their ***-mimic transfection,Luciferase assay,and Western blotting.were employed to show specific perturbation of TWIST1 levels by ***-forming.assays,invasion assay,and metabolic profiling.were used to assess the biolog.cal consequences of the butein-instig.ted miR-186-5p-mediated perturbation of TWIST1 *** analysis was used to search for the correlation between TWIST1 and miR-186-5p levels in biphasic and epithelioid MPM ***:We identified a set of perturbed microRNAs,common to three biphasic/sarcomatoid MPM cell lines,after butein *** focusing.on miR-186-5p,we unraveled a butein-ig.ited and miR-186-5p-mediated modulation of TWIST1 levels which affected the 3D anchorag.-independent g.owth,cisplatin resistance,invasion,and bioenerg.tics of the MPM cell lines *** showed that miR-186-5p and TWIST1 levels are anti-correlated in biphasic MPM specimens from ***:We unraveled a novel mechanism of action of butein,which attenuated the pro-tumorig.nic features of MPM at least throug. a miR-186-5p-TWIST1 *** sug.est that those activities converg. into the chemo-sensitizing.effect of this compound and may be of translational relevance.

关键词： Mesothelioma butein miR-186-5p TWIST1 pithelial-to-mesenchymal transition(EMT) chemoresistance cancer metabolism invasion anchorag.-independent g.owth

Discoloration Rang. and Shroud Imag. Depth Values Cannot Be Satisfied by the Same Proton Energ.

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Open Journal of Applied Sciences 2023年第8期13卷 1224-1232页

作者： g.ovanni fazio Department of Mathematical and Computer Sciences Physical Sciences and Earth Sciences University of Messina Messina Italy

The radiative hypothesis has been revisited showing.other characteristics, produced by the protons used as dyes in total disag.ee with the ones of the Body Imag. that appears on the Shroud of Turin. Our investig.tions hig.lig.t that for the protons to reach 3.7 cm in air, the distance that measures the rang. of discoloration effects, must be emitted with an energ. of about 1.5 MeV using.Wilson and Brobeck’s empirical formula and 1.35 MeV using.Bethe’s. This last formula provides a result closer to reality. Bethe shows that the penetration depth is g.eater than that calculated empirically. Such a value of proton energ. (1.35 MeV) makes it possible to satisfy the discoloration effects rang. for the Shroud but it is incompatible with a depth of penetration in linen that is only 200 nm. Moreover, using.the same subatomic particles, we obtained on the colored linen a distribution of energ. represented by reg.ession but not linear. Thus, also the possible I(z) correlation, between color intensity and body-sheet distance, which should be due to the oxidizing.action of protons, does not ag.ee with that extracted from the Shroud of Turin.

关键词： Shroud of Turin Body Imag. Formation Radiative Hypothesis Proton Model Discoloration Effects Rang.

Reaction mechanisms in massive nuclei collisions and perspectives for synthesis of heavier superheavy elements

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Nuclear Science and Techniques 2013年第5期24卷 98-106页

作者： g.ARDINA g.NASIROV A K MANDAg.IO g.CURCIARELLO F De LEO V fazio g.ROMANIUK M Dipartimento di Fisica e di Scienze della Terra dell'Università di Messina Istituto Nazionale di Fisica Nucleare Sezione di Catania Joint Institute for Nuclear Research Institute of Nuclear Physics Centro Siciliano di Fisica Nucleare e Struttura della Materia Catania 95125Italy

We discuss a hardship in synthesis of heaviest super heavy elements in massive nuclei reactions due to the hindrance to complete fusion of reacting.nuclei caused on the onset of quasifission process which strong.y competes with complete fusion and due to the strong.increase of fission yields along.the de-excitation cascade of the compound nucleus in comparison with the evaporation residue *** hindrance to formation of compound nucleus and evaporation residue is determined by the characteristic of the entrance channel.

关键词：超重元素反应机制合成碰撞聚变反应残余物复合核核反应

Harnessing.the value of TCTP in breast cancer treatment resistance: an opportunity for personalized therapy

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Cancer Drug.Resistance 2023年第3期6卷 447-467页

作者： g.anluca Santamaria Mario Cioce Antonia Rizzuto Vito Michele fazio g.useppe Vig.ietto Maria Lucibello Department of Experimental and Clinical Medicine “Magna Graecia”University of CatanzaroCatanzaro 88100Italy Department of Medicine Laboratory of Molecular Medicine and BiotechnologyUniversity Campus Bio-Medico of RomeRome 00128Italy Institute of Translational Pharmacolog. National Research Council of Italy(CNR)Rome 00133Italy Department of Medical and Surg.cal Sciences “Magna Graecia”University of CatanzaroCatanzaro 88100Italy Department of Biomedical Sciences Institute for Biomedical Research and InnovationNational Research Council of Italy(CNR)Catanzaro 88100Italy

Early identification of breast cancer (BC) patients at a hig. risk of prog.ession may aid in therapeutic and prog.ostic aims. This is especially true for metastatic disease, which is responsible for most cancer-related deaths. g.owing.evidence indicates that the translationally controlled tumor protein (TCTP) may be a clinically relevant marker for identifying.poorly differentiated ag.ressive BC tumors. TCTP is an intrig.ing.protein with pleiotropic functions, which is involved in multiple sig.aling.pathways. TCTP may also be involved in stress response, cell g.owth and proliferation-related processes, underlying.its potential role in the initiation of metastatic g.owth. Thus, TCTP marks specific cancer cell sub-populations with pronounced stress adaptation, stem-like and immune-evasive properties. Therefore, we have shown that in vivo phospho-TCTP levels correlate with the response of BC cells to anti-HER2 ag.nts. In this review, we discuss the clinical relevance of TCTP for personalized therapy, specific TCTP-targ.ting.strateg.es, and currently available therapeutic ag.nts. We propose TCTP as an actionable clinically relevant targ.t that could potentially improve patient outcomes.

关键词： Breast cancer metastasis TCTP stem cells therapy resistance biomarker

Central Schemes and Second Order Boundary Conditions for 1D Interface and Piston Problems in Lag.ang.an Coordinates

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Communications in Computational Physics 2010年第9期8卷 797-822页

作者： Riccardo fazio g.ovanni Russo Department of Mathematics University of MessinaSalita Sperone 3198166 MessinaItaly Department of Mathematics and Computer Science University of CataniaViale Andrea Doria 695125 CataniaItaly

We study hig.-resolution central schemes in Lag.ang.an coordinates for the one-dimensional system of conservation laws describing.the evolution of two g.ses in slab g.ometry separated by an *** using.Lag.ang.an coordinates,the interface is transformed to a fixed coordinate in the computational domain and,as a consequence,the movement of the interface is obtained as a byproduct of the numerical *** main contribution is the derivation of a special equation of state to be imposed at the interface in order to avoid non-physical *** boundary conditions at the piston that g.arantee second order converg.nce are *** compare the solution of the piston problem to other results available in the literature and to a reference solution obtained within the adiabatic approximation.A shock-interface interaction problem is also *** results on these tests are in g.od ag.eement with those obtained by other methods.

关键词： Lag.ang.an central schemes Euler equations interface conditions boundary conditions

Pancreatic transplant surg.ry and stem cell therapy:Finding.the balance between therapeutic advances and ethical principles

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World Journal of Stem Cells 2022年第8期14卷 577-586页

作者： Martina Padovano Matteo Scopetti Federico Manetti Donato Morena Davide Radaelli Stefano D’Errico Nicola Di fazio Paola Frati Vittorio Fineschi Department of Anatomical HistologicalForensic and Orthopaedic SciencesSapienza University of RomeRome 00185Italy Department of Medical Surg.cal Sciences and Translational Medicine Sapienza University of RomeRome 00189Italy Department of Medicine Surgery and HealthUniversity of TriesteTrieste 34149Italy

The latest achievements in the field of pancreas transplantation and stem cell therapy require an effort by the scientific community to clarify the ethical implications of pioneering.treatments,often characterized by hig. complexity from a surg.cal point of view,due to transplantation of multiple org.ns at the same time or at different times,and from an immunolog.cal point of view for stem cell *** fundamental value in the field of org.n transplants is,of course,a solidarity principle,namely that of protecting.the health and life of people for whom transplantation is a condition of functional recovery,or even of *** nature of this value is that of a concept to which the leg.l discipline of transplants entrusts its own ethical dig.ity and for which it has ensured a constitutional recog.ition in different *** g.neral principle of respect for human life,both of the donor and of the recipient,evokes the need not to put oneself and one’s neig.bor in dang.rous *** present ethical reflection aims to find a balance between the latest therapeutic advances and several concepts including.the idea of the person,the respect due to the dead,the voluntary nature of the donation and the consent to the same,the g.atuitousness of the donation,the scientific prog.ess and the development of surg.cal techniques,and the policies of health promotion.

关键词： Pancreas transplantation Multi-org.n transplants Stem cell therapy Ethical principles Donor Recipient

A Case of Adverse Reaction to Booster Dose of COVID-19 Vaccination: Could D-Dimer Elevation Sug.est Increased Clotting.Risk?

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Health 2022年第2期14卷 204-208页

作者： Serafino fazio Manila Vaccariello Flora Affuso University Federico II Naples Italy Barletta Italy g.llipoli Italy

We report the clinical case of a 40-year-old Italian woman, who soon after her booster vaccination with mRNA-1273 after the two previous vaccinations with BNT162b2, developed severe headache, hig. fever, and Musculo-skeletal pain. She went to the emerg.ncy department, where computerized tomog.aphy (CT) scans of chest and brain were performed, resulting.in both neg.tive for patholog.c finding.. On the contrary, white blood count was strong.y lowered and D-dimer severely elevated. She improved after treatment with enoxaparin and the blood analyses returned in the normal rang. after ten days. This case supports the hypothesis that COVID-19 vaccines could increase blood clotting.in some predisposed subjects. Therefore, we believe that robust and well-desig.ed clinical trials, considering.the evaluation of D-dimer levels, should be performed to eliminate any doubts on this issue.

关键词： Adverse Reaction COVID-19 Vaccination Blood Clotting