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Epidemiological and Hemato-Biochemical Profiles of Diabetic Patients at the Diabetology, Endocrinology, and Metabolic Diseases Department of the Alpha Oumar Diallo Regional Hospital, Kindia (Republic of Guinea)

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Journal of Diabetes Mellitus 2024年第2期14卷 108-121页

作者： fatoumata bah Cé Camara Ousmane Sangare Elhadji Saidou Balde Karamo Toure Taliby Dos Camara Mariama Kourouma César Hagassou Biology Laboratory Department of Biology Faculty of Sciences Gamal Abdel Nasser University Conakry (Commune of Dixinn) Guinea Higher School of Tourism and Hospitality of Guinea Conakry Guinea Faculty of Pharmaceutical and Medical Sciences Gamal Abdel Nasser University Conakry Guinea

This study aims to enhance the healthcare services for diabetic patients in the administrative region of Kindia by suggesting dietary interventions to assist diabetics in better managing their condition. Conducted over a period of six months, from February 18 to July 18, 2021, this prospective and descriptive cross-sectional study involved 220 diabetic patients. Among these, 48 patients (22%) maintained balanced glucose levels (2 g/l). Positive glycosuria was observed in 54% of the patients, whereas 46% demonstrated normal glycosuria. An analysis of urinary parameters revealed that 15% of the patients had abnormal Ketone Bodies. Normal HbA1c levels (9%) HbA1c levels. Hematological assessments indicated significant variation: 56% of the patients had low hemoglobin levels, 4% suffered from hyper-eosinophilia, and 1% each from hyper-basophilia and hyper-hemoglobinemia. The anemic profile was characterized as mild anemia in 75%, moderate anemia in 20%, and severe anemia in 5%. Furthermore, 25% of patients were affected by Microcytic anemia and 75% by Normocytic anemia. Demographically, women constituted 65% of the study group compared to 35% of men. The most represented age bracket was 41 to 60 years, accounting for 52% of the patients, while those between 61 and 80 years comprised 36%. Every district in Kindia was impacted by diabetes.

关键词： Epidemiology Diabetes Glucose Levels Glycosuria Metabolic Disorders Kindia

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Evaluation of the Living Conditions and Health Perceptions of Waste Electrical and Electronic Equipment Handlers in the Informal Sector in Dakar

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Occupational Diseases and Environmental Medicine 2024年第2期12卷 115-129页

作者： Robert Faomowe Foko Awa Ndong Marius Kedote fatoumata bah Absa Lam Cheikh Diop Aminata Toure Mathilde Cabral Mamadou Fall Laboratoire de Toxicologie et d’ Hydrologie Facult&#233 de M&#233decine Pharmacie et Odontostomalogie Universit&#233 Cheikh Anta Diop de Dakar Dakar S&#233n&#233gal Unité Mixte de Recherche d&#8217Exploration et de Diagnostic Unit&#233 de Formation et de Recherche des Sciences de la Sant&#233 Universit&#233 Iba Der Thiam de Thi&#232s Thi&#232s S&#233n&#233gal Institut Ré gional de Sant&#233 Publique Universit&#233 d&#8217Abomey-Calavi Ouidah B&#233nin

Electrical and electronic devices are becoming an increasingly important part of our society. In Africa, and in Senegal in particular, the handling and management of electronic and electrical equipment (EEE) that has reached the end of its life is mainly informal. This professional environment is characterized by the disintegration of the sector and the social heterogeneity that can be found there. The objective of this study is to assess the standard of living of electrical and electronic equipment waste handlers in the Dakar region, as well as their perception of their health. A survey was used to obtain information on sociodemographic background, living arrangements, perception of health status, and good practices to be implemented in case of work-related health problems. Life style, perception of general health and health problems were ranged as excellent, very good, good, average and poor. Informal recyclers in the Dakar region lived mainly in rooms and buildings as tenants (49.1%), or in family homes (48.4%) before starting this activity, and 51.2% continue to live in rooms and buildings as tenants compared to 41.4% who still live in a family home. The perception of health status ranged from poor to excellent, and 4.9% believe that they are limited in work due to a disability or health problem. Informal work is a heterogeneous phenomenon that makes research and policymaking particularly complex. There are several external factors within informal WEEE re-cyclers that can cause health problems or functional disability. However, the living conditions and the perception they have of their state of health are contradictory to the working conditions and the social environment to which they belong. A biomedical approach would consolidate these achievements by confirming or invalidating them.

关键词： E-Waste Informal Work Living Arrangements Health Perception Occupational Exposure

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Lipid Profile of Patients Seen in Consultation at the Cardiology Department at the Ignace DEEN National Hospital (City of Conakry, Republic of Guinea)

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Open Journal of Endocrine and Metabolic Diseases 2024年第8期14卷 143-163页

作者： fatoumata bah Cé Camara Ousmane Sangare Ahmadou Sadio Diallo Taliby Dos Camara Karamo Toure N’Dankassa Akolbel Saidou Balde Demba Magassouba Biology Laboratory Department of Biology Faculty of Sciences Gamal Abdel Nasser University Conakry Guinea Department of Food Sciences and Nutrition Higher School of Tourism and Hospitality of Guinea Conakry Guinea

The study addressed a crucial public health concern of dyslipidemia and its management, with a focus on the Ignace DEEN National Hospital patients, filling a research gap in the Republic of Guinea. It contributed valuable epidemiological data on dyslipidemia in the studied population, emphasizing gender, age, and socio-professional categories, which could inform tailored prevention and management strategies in improving the health care of dyslipidemia patients by proposing diets to help these patients better manage their disease and a food system for preventing dyslipidemia. The study focused on the lipid profile of patients seen at the cardiology department at the Ignace DEEN National Hospital Republic of Guinea (Conakry). This was a prospective, descriptive study lasting six (6) months from January 24 to July 23, 2021;aimed at determining the frequency of lipid abnormalities and pathologies related to the lipid profile. A total of 523 people were included in this study with a female predominance of 59.34% compared to 40.66% of males for a ratio of 1.5 in favor of women. The age groups of 45 - 54 and 55 - 65 were the most affected with respective frequencies of 45.42% and 30.03%. The most represented socio-professional category was that of housewives, i.e. 45.78%, followed by traders 18.68%. Our series was dominated by the married couple, i.e. 77.29%. Dyslipidemia constitutes a modifiable cardiovascular risk factor in patients seen in the cardiology department at the Ignace DEEN Hospital;its control must be strict through the use of hygienic and dietary rules and hypolipidemia medications.

关键词： Dyslipidemia Profile Lipid Lipid Abnormalities

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Long-Term Impact of Acute Retinoic Acid Supplementation at the Young Age on Testicular Architecture of Wistar Albino Rats

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Advances in Reproductive Sciences 2024年第1期12卷 1-13页

作者： Mama Sy Racha Kamenda Ibondou fatoumata bah Robert Foko Ndiaga Diop Mame Vénus Abdoulaye Séga Cheikh Diop Mamadou Fall Oumar Faye Laboratory of Histology Embryology and Cytogenetics Faculty of Medecine Cheikh Anta Diop University Dakar Senegal

Introduction: Inappropriate and excess vitamin supplementation, particularly for vitamin A, is increasingly recognized as a public health problem in developed countries. On the other hand, blind supplementation of vitamin A, for children in developing countries is a subject of controversy in the literature. The crucial role of vitamin A in the process of spermatogenesis in adult rodents is well established, but only a few publications are consecrated to the long-term effect of vitamin A intake at a young age on testicular development and differentiation. Objectives: Our study aimed to evaluate the long-term effects of acute supplementation at an early age, in the post-natal period, on spermatogenesis and testicular trophicity at adult age. Material and Methods: Young Wistar Albinos rats of 22 days received an acute high dose of supplementation of vitamin A (retinyl palmitate). The control group, group 1, received only extra virgin olive oil, Group 2 a dose of 7000 IU/kg of retinyl palmitate, group 3, 14,000 IU/kg, and Group 4 a dose of 28,000 IU/kg. At 10 weeks of age, the testes’ testosterone levels were measured by ELISA. For histological assessment, sections were stained with Hematoxylin eosin, and the Johnsen score was used to evaluate spermatogenesis in the seminiferous tubules. Results: The average testicular weights of rats were significantly lower in group 4 (p < 0.05), and so was the testosterone level in the testis compared to the control group (p .01). Most of the seminiferous tubules were concerned by an arrest of spermatogenesis and the Johnsen score was decreased with a mean score of 5.96 ± 1.60 (p .001) in that Group. In Group 3, Johnsen’s score was significantly better than the one obtained with the control. Conclusion: We observed a negative effect in the long term with a high acute dose of supplementation of retinyl palmitate at a young age, on testicular development and differentiation. Despite a return to normal diet after that supplementation, d

关键词： Vitamin A Retinyl Palmitate Spermatogenesis Testis-Wistar Albino Rats

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Respiratory Flow Rates of Metal Welders Compared to a Population Not Exposed to Metal Welding Dust

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Open Journal of Respiratory Diseases 2024年第2期14卷 51-59页

作者： Robert Faomowe Foko Abdou Khadir Sow Awa Ba Mor Diaw fatoumata bah Mame Saloum Coly Absa Lam Cheikh Diop Aminata Toure Abdoulaye Ba Abdoulaye Samb Arame Mbengue Mathilde Cabral Mamadou Fall Laboratory of Toxicology and Hydrology Faculty of Medicine Pharmacy and Odontostomatology Cheikh Anta Diop University of Dakar Dakar-Fann Senegal Laboratory of Physiology and Functional Exploration Faculty of Medicine Pharmacy and Odontostomatology Cheikh Anta Diop University of Dakar Dakar-Fann Senegal Laboratory of Physiology and Functional Exploration Alioune DIOP University of Bambey Bambey Senegal Laboratory of Physiology UFR of Health Sciences Functional Exploration Department Thies Regional Hospital Center Thies Senegal

Background: The welding trade includes many industrial activities in both the formal and informal sectors. Workers in this professional environment do not have access to individual and collective means of protection adapted to the activity, which exposes them to the dust emitted during their activity and therefore contributes to increasing the risk of developing respiratory disorders in this population. Objective: Our study aimed to evaluate the ventilatory function of metal welders in the city of Dakar. Method: This was a comparative study based on the analysis of the spirometric parameters of metal welders working in the city of Dakar (Senegal) with those of a control group of the same kind, selected from the general population. Measurements of forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF) and maximum mid expiratory flow (MMEF) were measured. Results: A total of 75 men between the ages of 19 and 61 were recruited and divided into two groups (43 controls and 32 welders). The welding population had more frequent distal and central obstructions and pulmonary restriction compared to the control group. The metals most commonly used by welders were aluminum for welders who had an obstruction, while for those who had a restriction, iron was the most used metal. Signs of metal fever were frequently found in welders, especially those with ventilatory disorders. Conclusion: The prevalence of respiratory disorders observed is close to that observed in industrial environments, where exposure levels are the highest. The lack of personal protective equipment could also be a significant risk factor in the development of these disorders.

关键词： Welder Occupational Exposure Spirometric Disorder Metal Fever Dakar

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Generation of Gata-1 Tissue-specific Knockout Mouse Model Using CRISPR/Cas9 System

Generation of Gata-1 Tissue-specific Knockout Mouse Model Us...

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作者： fatoumata BINTA MACI bah 东北师范大学

学位级别：硕士

转录因子Gata1对类红细胞的发育至关重要。因此Gata1突变体胚胎由于严重的贫血而死于子宫中。通常认为除了造血系统外,Gata1只表达于组织的支持细胞中。但是我们实验室最近表述了Gata1在脂肪组织中也有表达。为了研究Gata1在脂肪组织发... 详细信息

转录因子Gata1对类红细胞的发育至关重要。因此Gata1突变体胚胎由于严重的贫血而死于子宫中。通常认为除了造血系统外,Gata1只表达于组织的支持细胞中。但是我们实验室最近表述了Gata1在脂肪组织中也有表达。为了研究Gata1在脂肪组织发育过程中的作用,我们运用CRISPR/Cas9系统构建了脂肪组织特异的Gata1敲除的小鼠模型。CRISPR/Cas9系统是一种有效的基因打靶技术并能够实现多种基因的编辑。在我们的研究中,我们分别针对人及小鼠的GATA-1基因设计了四种sg RNAs(Sg2,Sg3,Sg4,Sg5)和3种sg RNAs(Sg1,Sg2,Sg3)。我们经过细胞水平验证有效的Sg RNAs,在ap2启动子介导下形成脂肪组织特异的基因敲除小鼠。转基因小鼠之间相互交配来维持繁殖。这个仍在研究。我们发现依赖于CRISPR的基因编辑是序列特异的并且可以同时引入多个g RNAs,并实现靶位点有效的多种编辑。我们分别在小鼠和人的GATA-1基因中得到606bp和多于1kb的缺失片段。我们建立了一种容易并且多样的RNA-指导的基因编辑工具。

关键词： GATA-1转录因子 VEGF-A CRISPR/Cas9 脂肪组织肥胖

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Histopathological study of the kidney after administration of methanolic extract of roots of <i>Leptadenia hastata</i>in the Albino Wistar rat

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Open Journal of Pathology 2020年第2期10卷 67-75页

作者： Mama Sy Diallo fatoumata bah Chérif Mouhamed Dial Cheikh Diop Oumar Faye Matar Seck Laboratory of Histology Embryology and Cytogenetics Faculty of Medicine Pharmacy and Odonto-Stomatology University Cheikh Anta Diop Dakar Senegal Laboratory of Toxicology and Hydrology Faculty of Medicine Pharmacy and Odonto-Stomatology University Cheikh Anta Diop Dakar Senegal Laboratory of Pathology Faculty of Medicine Pharmacy and Odonto-Stomatology University Cheikh Anta Diop Dakar Senegal Organic and Therapeutic Chemistry Laboratory Faculty of Medicine Pharmacy and Odonto-Stomatology University Cheikh Anta Diop Dakar Senegal

Introduction: the roots of Leptadenia hastata, (L hastata) are remedies from the Senegalese pharmacopoeia and are as widely used as the leaves. However, few researchers have devoted themselves to their toxicity, unlike the leaves. However, in the traditional pharmacopoeia, the indications for use are very different. The aim of our study was to study the effect of the administration of methanolic extracts of roots of L hastata on renal tissue, using an animal model. Materials and Methods: a cohort of 18 rats was studied with a random distribution of the animals in 3 groups (n = 6). The first group was the control group. The treated groups (Group II and III) received the methanolic extract of L. hastata with an administration of 500 mg / kg / day and 1000 mg / kg / day respectively, for 28 days. Results: The dose of 1000 mg / kg / day was lethal in group III, from the first week in females. Serum creatinine was significantly higher in rats given the root extract. There was kidney damage with vacuolar degeneration starting at 500 mg / kg / day. The lesions were more severe in group III with glomerular involvement characterized by retraction in the renal corpuscles. Conclusion: If the leaves of L hastata seem to be safe for consumption according to the majority of authors in the literature, the roots of this same plant could be harmful. In addition to the lethality observed at the doses tested, the lesions in the renal parenchyma would be dose-dependent.

关键词： Leptadenia hastata Renal Toxicity Phytotherapy Vacuolar Degeneration

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Atypical Coarctation of the Aorta Revealed by Arterial Hypertension in a 22-Year-Old Young Man

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World Journal of Cardiovascular Diseases 2023年第7期13卷 359-365页

作者： Mamadou Bassirou bah Elhdj Yaya Balde Thierno Hamidou Balde fatoumata Biro bah Aissatou Tiguidanké Balde Amadou Diouldé Doumbouya Mamadou Diallo Alpha Kone Ibrahima Sory Sylla Thierno Siradjo Balde Abdoulaye Camara Mamadou Dadhi Balde Cardiology Department Ignace Deen Hospital Conakry Guinea Department of Imaging Ignace Deen Hospital Conakry Guinea Cardiology Department Donka Hospital Conakry Guinea

Non-isthmic coarctation of the aorta is a rare congenital malformation in adults. Arterial hypertension is a frequent circumstance of discovery. We reported the case of a 22-year-old Guinean man who had been followed for 5 years for hypertension. Clinically, he presented with hypertension of the upper limbs with a systolic pressure gradient of 100 mmHg. The diagnosis was confirmed by thoracic angioscan, which showed a 65.8% coarctation of the abdominal aorta. He was on triple antihypertensive therapy combining Atenolol 100 mg, Amlodipine 10 mg and Perindopril 10 mg. He is awaiting interventional treatment. His blood pressure is stable at around 140/90 mmHg.

关键词： Abdominal Aortic Coarctation Arterial Hypertension Young Subject Congenital Malformation

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Platypnea-Orthodeoxia Syndrome in an Elderly Patient Treated with Percutaneous Patent Foramen Ovale Closure: Report of a Case and Review of the Literature

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World Journal of Cardiovascular Diseases 2023年第8期13卷 470-476页

作者： Doumbouya Amadou Diouldé bah Abdoul Mazid Mariama Diallo Mamadou Madiou Baldé Aissatou Tiguidanké Diallo Alpha Oumar Bouroure Guissé Mamadou Cellou Sow Mariama Oury Diallo Mariama Djalakhan bah fatoumata Biro Condé Bakary Koïvogui Kokoulo Camara Alseny bah Mamadou Bassirou Balde Elhadj Yaya Baldé Mamadou Dadhi Cardiology Department of the Ignace Deen Hospital Conakry Guinea

Introduction: Platypnea-Orthodeoxia syndrome is characterized by dyspnea and hypoxia in the upright position, usually improving in the supine position. Two components are required: an interatrial or intrapulmonary shunt, and a functional component. Diagnosis is made by contrast ultrasonography. We report a case of Platypnea-Orthodeoxia syndrome revealed by positional dyspnea in an 87-year-old patient. The aim of this study is to describe the clinical, therapeutic and evolutionary profile of this syndrome. Case Presentation: This is an 87-year-old patient with a history of pulmonary embolism (PE) and stroke. He was seen for dyspnea and desaturation in orthostatism, revealing a patent foramen ovale (PFO). Progression was favorable after closure of the PFO. Conclusion: Platypnea-Orthodeoxia syndrome may be presented as simple exertional dyspnea. The clinician should check for improvement in symptoms and/or oxygenation during decubitus. Definitive treatment consists of percutaneous closure of the shunt.

关键词： Syndrome Platypnea-Orthodeoxia Patent Foramen Ovale

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Prostatic Adenomectomy and Comorbidities: Frequency and Management at the Urology Department of the Ignace Deen National Hospital in Conakry

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Open Journal of Urology 2024年第4期14卷 217-226页

作者： Demba Cisse Alpha Oumar Barry Morlaye fatoumata Bangoura Alimou Diallo Mamadou Dian bah Youssouf Keita Daouda Kanté Thierno Mamadou Oury Diallo Mamadou Bissiriou bah Mamadou Diawo bah Abdoulaye Bobo Diallo Oumar Raphiou bah Maitre-Assistant à la Facult&#233 des Sciences et Techniques de la Sant&#233 Universit&#233 Gamal Abdel Nasser de Conakry Conakry Guin&#233e

Goal: To determine the type of comorbidity and highlight the complications of adenomectomy and comorbidities. Material and Methods: This is a prospective, descriptive, cross-sectional study lasting six (6) months, from July 1, 2022 to December 31, 2022. Patients with BPH on comorbidity condition taken care of during the study period AND have agreed to participate in the study. Results: During our study, 49 cases of benign prostatic hypertrophy with comorbidities were collected, representing a frequency of 29%. The average age ranges for the patients were 43 - 70 years. The age group most affected was 70 to 79 years old (38.80%). Nocturnal urinary frequency was the main reason for consultation present in all our patients. The most frequent comorbidity was hypertension, i.e. 83.70%. The PSA rate between 4 and 10 was the most represented, i.e. 42.86%. The prostate volume was between 61 and 100 ml in 40.82% of patients. Histology showed that it was a benign adenomatous hypertrophy of the prostate in 85.70% and a prostatic adenomyoma in 14.29%. Trans-bladder adenomectomy alone was the most performed technique, i.e. 49%, followed by trans urethral resection of the prostate, i.e. 38.80%. Retention of urine after removal of the catheter was the most observed complication, i.e. 12.20%. Conclusion: Benign prostatic hypertrophy with comorbidities constitutes a frequent association. Because their presence can affect effectiveness and lead to complications.

关键词： Prostatic Hypertrophy Comorbidities Conakry University Hospital

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