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Ovarian Cancer: Clinical, Therapeutic and Prognostic Aspects at the University Hospital Center of Conakry in Guinea

Open Journal of Obstetrics and Gynecology 2023年第12期13卷 1985-1993页

作者： Abdourahamane diallo Mamadou Hady diallo fatoumata bamba diallo Ibrahima Koussy Bah Boubacar Siddy diallo Ibrahima Sory Balde Telly Sy Namory Keita Gynecology-Obstetrics Department Ignace Deen National Hospital Conakry Guinea Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea Gynecology-Obstetrics Department Donka National Hospital Conakry Guinea

Background: Ovarian cancer is the seventh most common cancer in women in the world and is the leading cause of death among gynecological cancers. Objective: The objective of this study was to describe the clinical, therapeutic and prognostic aspects of ovarian cancer in the both Gynecology-Obstetrics departments Donka and Ignace Deen of the Conakry University Hospital. Methods: This was a retrospective, descriptive study lasting 12 years from January 1, 2011 to December 31, 2022, covering the files of patients treated for ovarian cancer in the both Gynecology-Obstetrics departments Donka and Ignace Deen. The study focused on the epidemiological, clinical, histological and therapeutic aspects of the disease. Results: In total, 135 files of patients with ovarian cancer were collected out of the 3821 files of gynecological pathologies recorded in the two departments during the study period, either a frequency of 3.5%. Among gynecological and breast cancers, ovarian cancer represented 9.1%. The average age of the patients was 46.3± 17.8 years and the average parity was 4 ± 3. The revealing clinical signs were dominated by pelvic pain (92.6%) and increased abdominal volume (53.3%). The diagnosis of the disease was made mainly at stages III and IV (71.9%). The most common histological type was serous papillary adenocarcinoma (57.0%). Exclusive surgical treatment was performed in 8.1% of patients, surgery combined with chemotherapy in 63.0% of patients and exclusive chemotherapy in 11.1% of patients. After an average follow-up of 42 months, 29 patients out of the 96 operated on were alive (30.2%), 51 had died (53.1%) and 16 patients were lost to follow-up (16.7%). Conclusion: Ovarian cancer is the third most common cancer in both departments. Diagnosis is often late and the prognosis is poor.

关键词： Cancer Ovary Ignace Deen Donka

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Risk Factors Associated with Obstetric Perineal Tear in a Maternity Ward of the Communal Medical Center of Ratoma-Conakry-Guinea

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Open Journal of Obstetrics and Gynecology 2024年第10期14卷 1628-1639页

作者： Mamadou Hady diallo fatoumata bamba diallo Alhassane II Sow Ibrahima Tangaly diallo fatoumata Kora Balde Alpha Boubacar Barry Abdourahamane diallo Ibrahima Sory Balde Telly Sy Namory Keita Department of Gynecology-Obstetrics Donka National Hospital Conakry Guinea Department of Gynecology-Obstetrics Ignace Deen National Hospital Conakry Guinea Maternity of Ratoma Communal Medical Centre Conakry Guinea

Introduction: Obstetric perineal tears are a common complication during childbirth. The objectives of this study were to describe the sociodemographic characteristics, the different types of perineal tears and to identify the associated risk factors. Patients and Method: The maternity of the CMC of Ratoma served as a setting for carrying out this study. This was a prospective study of a descriptive and analytical type, which took place over a period of 6 months from July 1, 2021 to January 1, 2022. Results: The frequency of perineal tear was 9%. The average age of the patients concerned was 23.99 years ± 5.18 years, with extremes of 15 and 38 years. Housewives were the most numerous (30.88%). Most of our parturient had undergone excision (99.6%) and they were more frequently primiparous (40.44%) and pauciparous (47.79%). The multiplicity of risk factors was a remarkable fact (scarred perineum, edematous, short, and infected). The presentation was cephalic in 96.33%, posterior variety in 3.81% and the variety of positions could not be specified by the health worker who provided care to the parturient in 46.56%. The expulsion took place in OP (92.37%) and in OS (2.30%). In most cases, midwives carried out deliveries (93%). Perineal tears were 1st degree (54.41%), 2nd degree (39.70%), 3rd degree (5.15%) and 4th degree (0.74%). Conclusion: Prevention of perineal obstetric injuries is based on better knowledge of risk factors and delivery by qualified personnel. The main limitation of this study is the impossibility of highlighting occult perineal lesions due to the weakness of the technical platform.

关键词： Perineal Tear Risk Factors Conakry

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Morbidity and Mortality Related to Obstetrical Evacuations in a Country with Limited Resources: The Case of the Maternity Ward of the Prefectural Hospital of Coyah, Guinea

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Open Journal of Obstetrics and Gynecology 2021年第9期11卷 1140-1150页

作者： Mamadou Hady diallo Ibrahima Sory Baldé fatoumata bamba diallo Alpha Boubacar Barry Massa Keita Emile Tinguiano Telly Sy Namory Keita University Department of Gynecology-Obstetrics Donka National Hospital Conakry Guinea University Department of Gynecology-Obstetrics Ignace Deen National Hospital Conakry Guinea Maternity Ward of the Prefectural Hospital of Coyah Coyah Guinea

Obstetric complications requiring evacuation are found all over the world with a high frequency in developing countries where they are responsible for high fetal-maternal morbidity and mortality. The objectives of this study were to calculate the frequency of obstetric evacuations in the maternity ward of the Coyah prefectural hospital, describe the socio-demographic characteristics of the evacuated patients, identify the main reasons for evacuation, determine the means of transport used and specify the maternal and fetal prognosis. Patients and Method: This was a prospective descriptive and analytical study conducted over a 6-month period (April 1-September 30, 2020) at the maternity ward of the Coyah prefectural hospital. All patients evacuated for complications of gravidopuerperium were included in the study. Results: We recorded 84 cases of obstetric evacuations out of a total of 2206 consultations, i.e. a frequency of 3.8%. The average age of the patients was 25.22 years with extremes of 15 and 45. Housewives (58.82%), nulliparous women (36.93%) and women with no education (64.29%) were the most numerous ones. No patient received medical transportation. More than half of the patients were evacuated by a nurse (51.21%). Hemorrhage in the last quarter was the main reason for evacuation. The average distance traveled by patients was 18.3 km with extremes of 12 and 68 km. The average transfer time was 63 min (1 h 3 minutes) with extremes of 20 min and 300 min (5 h). Maternal mortality was 5.95%. The perinatal mortality rate was 46.42%. No counter-referral was made. Conclusion:

关键词： Morbidity Mortality Obstetrical Evacuations Maternity Guinea

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Prevention of Mother-to-Child Transmission of HIV/AIDS: Acceptability, Knowledge, Attitude and Implementation at Ratoma CMC-Conakry-Guinea

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Open Journal of Obstetrics and Gynecology 2021年第10期11卷 1323-1332页

作者： Mamadou Hady diallo Mamoudou Magassouba Ibrahima Sory Baldé fatoumata bamba diallo Ousmane Baldé Alpha Boubacar Barry Sipo Onivogui Namory Keita University Department of Gynecology-Obstetrics Donka National Hospital Conakry Guinea University Department of Gynecology-Obstetrics Ignace Deen National Hospital Conakry Guinea Maternity Ward of Ratoma Communal Medical Center (CMC) Conakry Guinea

The objectives of the study were to determine the level of knowledge, acceptability and implementation of Prevention of mother-to-child transmission (PMTCT) of HIV HIV/AIDS at Ratoma communal medical center (CMC). Patients and Method: It was a descriptive cross-sectional study with prospective data collection from November 1, 2019 to April 30, 2020 at the maternal and child health department of Ratoma communal medical center. Results: The acceptance rate was 85.45%. The average age of our patients was 27 with extremes of 15 and 39. Women doing a liberal activity were the most affected (70.36%), followed by housewives (20%), secondary school (5%) and university students (4.64%). The Caesarean section was cited as a means of PMTCT in 20.84% of cases, taking antiretroviral drugs at the end of pregnancy in 9.94%. Most of our patients accepted the HIV screening, i.e. a participation rate of 85.45%. The average age of our patients was 27 with extremes of 15 and 39. Women doing a liberal activity were the most affected (70.36%), followed b

关键词： HIV PMTCT Acceptability Knowledge CMC Ratoma

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Gynecological and Obstetrical Emergencies at the University Clinic of Gynecology-Obstetrics of the National Hospital Donka Guinea

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Open Journal of Obstetrics and Gynecology 2021年第12期11卷 1862-1874页

作者： Mamadou Hady diallo fatoumata bamba diallo Massa Keita Djénabou Binta Baldé Alpha Boubacar Barry Ibrahima Sory Baldé Telly Sy Namory Keita University Department of Gynecology-Obstetrics National Hospital Donka Conakry Guinea University Department of Gynecology and Obstetrics National Hospital Ignace Deen Conakry Guinea

Gynecological and obstetrical emergencies are found all over the world, especially in developing countries where women pay a heavy price for giving birth. They can occur at any time during pregnancy and outside of pregnancy often in a socio-economic context. The objectives of this study were to describe the sociodemographic characteristics and the maternal and fetal prognosis of gynecological and obstetric emergencies. Patients and Methods: This was a descriptive cross-sectional study with prospective data collection, conducted at the University Clinic of Gynecology and Obstetrics of the Donka National Hospital between June 1 and September 30, 2015. It involved all patients admitted to our department in emergency for a gynecological or obstetrical complaint. Results: We collected 361 cases of gynecological and obstetrical emergencies out of a total of 1779 consultations, i.e. a frequency of 20.29%. Obstetrical emergencies were predominant with 91.41% and gynecological emergencies represented 8.59%. The average age of patients was 29.5 with extremes of 14 and 47. Nulliparous women were the most numerous (34.35%). More than half of the patients did not attend school (52.08%) and 56.70% were evacuees. Abdominopelvic pain and hemorrhage were the main reasons for consultation (54.29% and 49.58%). Admission diagnoses were dominated by acute fetal distress and hemorrhage in the last quarter of pregnancy (52.3% and 36.01%). The caesarean section rate was high (82.12%). Maternal and perinatal lethality rates were high (5.2% and 30.3%). Conclusion:

关键词： Gynecological Emergencies Obstetrical Donka Guinea

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Obstetric Hemorrhage during the Third Trimester of Pregnancy: Experience in a University Hospital in Guinea

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Open Journal of Obstetrics and Gynecology 2022年第4期12卷 349-360页

作者： fatoumata bamba diallo Elhadj Mamoudou Bah Massa Keita Abdoul Aziz Baldé Ibrahima Sory Baldé Telly Sy Namory Keita University Department of Gynecology-Obstetrics Donka National Hospital Conakry Guinea University Department of Gynecology-Obstetrics Ignace Deen National Hospital Conakry Guinea

Aims: Obstetric hemorrhage, especially during the 3rd trimester of pregnancy, causes maternal, fetal and neonatal mortality and morbidity. We attempted to characterize its clinical features in Guinea. The objectives of this study were to describe the socio-demographic characteristics of the patients, identify the causes and contributing factors, describe the management and evaluate the maternal-fetal prognosis in such patients. Methods: We retrieved and analyzed patients with 3rd trimester hemorrhage whom we managed at Ignace Deen National Hospital, Guinea during 1-year period (1st of December 2019-30th of November 2020). Results: We experienced recorded 401 patients with 3rd trimester obstetric hemorrhage out of 5468 deliveries during the corresponding period;the rate being 7.33%. The main causes were as follows: placental hematoma (65.33%), placenta previa (27.68%) and uterine rupture (6.99%). The socio-demographic profiles were as follows: the age group of 25 - 29 years (28.42%), married (94.51%), uneducated (50.12%), and with a liberal profession. (43.64%) and pauciparous (30.42%). The conditions were considered to be preventable by managing risk factors during the prenatal consultation (PNC): 7.73% underwent no PNC. Cesarean accounted for 84.78% of patients. Prognosis was as follows: 14 maternal deaths (3.45% of a fatality), 34.66% of anemia, and 16.95% of hemorrhagic shock. Fetal/neonatal prognoses were poor. Conclusion: Obstetric hemorrhage during 3rd trimester remains the main cause of poor outcomes in Guinea. This study identified that this type of hemorrhage still represents an important cause of maternal and fetal morbidity and mortality in developing countries.

关键词： Obstetric Hemorrhage in the Third Trimester Etiologies Management and Prognosis Ignace Deen Guinea

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Hemorrhages in the First Trimester of Pregnancy: Etiological Aspect and Management at the Maternity Ward of the Ignace Deen National Hospital of the University Hospital of Conakry

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Open Journal of Obstetrics and Gynecology 2022年第8期12卷 719-730页

作者： fatoumata bamba diallo Elhadj Mamoudou Bah Massa Keita Mamadou Sanoussy Barry Abdoul Aziz Balde Mamadou Dian Balde Ibrahima Sory Balde Telly Sy University Department of Gynecology-Obstetrics Donka National Hospital Conakry Guinea University Department of Gynecology-Obstetrics Ignace Deen National Hospital Conakry Guinea

Aims: Hemorrhages in the first trimester of pregnancy constitute a public health problem in developing countries with maternal mortality which is still very high. This is the most common reason for consultation in early pregnancy. The objectives of this study were to describe the sociodemographic characteristics of the patients, identify the etiologies, describe the management and evaluate the maternal prognosis in patients presenting with hemorrhage in the first trimester of pregnancy. Methods: This was a descriptive-type prospective study lasting 12 months from January 1 to December 31, 2020, carried out at the maternity ward of Ignace Deen National Hospital. Results: During the study period, we recorded 163 cases of hemorrhage in the first trimester of pregnancy out of 5478 deliveries, i.e. a frequency of 2.97%. The main incriminated etiologies were spontaneous abortion (46.62%), ectopic pregnancy (28.22%), hydatidiform mole (16.56%), threatened abortion (5.52%) and pregnancy stopped (3.06%). The socio-demographic profile of the patients was that of a woman in the age group of 26 - 30 years (33.12%), married (79.14%), with secondary level (35.58%), exercising a liberal profession (36.19%) and nulliparous (60.12%). More than half of the patients came directly from home (57.66%) with metrorrhagia (44.78%) and abdominal pain (33.12%) as reasons for consultation. The gestational age between 7-11SA was more represented (82.82%). Manual intrauterine aspiration (58.89%) and salpingectomy (28.22%) were the most practiced therapeutic procedures. We transfused 10.42% of patients and 20.85% received medical treatment. The maternal prognosis was good in 47.87%. The main complications recorded were anemia (38.65%) and the state of shock (10.42%). Conclusion: Hemorrhages in the first trimester of pregnancy represent an important cause of maternal morbidity in developing countries. The improvement of the maternal prognosis would pass by the early consultation in front of any ca

关键词： Pregnancy First Trimester Hemorrhage Etiologies Management Ignace Deen Guinea

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Burden of Invasive Candidiasis in West Africa: A Systematic Review and Meta-Analysis

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Journal of Biosciences and Medicines 2024年第12期12卷 285-304页

作者： Seydou Nakanabo diallo Isidore W. Yerbanga Serge Henri Zango Isabel Montesinos Olivier Denis Annie Robert Sanata bamba Hector Rodriguez-Villalobos Centre Muraz/Institut National de Sant Publique Bobo-Dioulasso Burkina Faso Ecole Doctorale des Sciences de la Sant Universit Nazi Boni Bobo-Dioulasso Burkina Faso Ple de Microbiologie Mdicale Institut de Recherche Exprimentale et Clinique (IREC) Universit Catholique de Louvain (UCLouvain) Bruxelles Belgique Centre Hospitalier Universitaire Rgional de Ouahigouya Ouahigouya Burkina Faso Institut de Recherche en Sciences de la Sant Direction Rgionale du Centre Ouest (IRSS/DRCO) Burkina Faso Ouagadougou Burkina Faso Ple dEpidmiologie et Biostatistique Institut de Recherche Exprimentale et Clinique (IREC) Universit Catholique de Louvain (UCLouvain) Bruxelles Belgique Department of Microbiology CHU Namur Site-Godinne Universit Catholique de Louvain Yvoir Belgium Ecole de Sant Publique Universit Libre de Bruxelles Bruxelles Belgique Centre Hospitalier Universitaire Sour Sanou Bobo-Dioulasso Burkina Faso Department of Microbiology Cliniques Universitaires Saint-Luc Universit Catholique de Louvain Bruxelles Belgique

Invasive candidiasis (IC) is an emerging opportunistic fungal infection associated with high mortality among hospitalized patients. Although the epidemiology of IC is progressively changing worldwide, the trend in Africa still needs to be established. This review aimed to evaluate the epidemiology of IC in Western region of Africa. A comprehensive literature search was performed on major electronic databases to identify relevant articles. DerSimonian and Laird random-effects model was used to pool overall prevalence and estimated incidence data. We identified 1975 articles, among which 23 met our inclusion criteria for the systematic review. Available data showed that only 50% (8/16) of West African countries were reported data on IC and only 25% reported at least one laboratory confirmed IC case. The global prevalence of candidemia and non-candidemic deep-seated candidiasis were 0.35% [95% CI 0.23;0.47] and 0.32% [95% CI 0.00;2.03], respectively. Among clinical IC cases, only 5.21% were reported before 2010, while 50.08% were reported in the past 5 years. The pooled estimated incidence was 5.55/100,000 [95% CI 5.46;5.64] and 1.15/100,000 [95% CI 1.11;1.19, 95% CI]/inhabitants for candidemia, and Candida peritonitis, respectively. The case fatality rate was 57.58%. Low gestational age, exposure to broad-spectrum antibiotics and invasive procedures were associated with a higher risk of IC in newborn patients. Candida albicans (32.98%) was the most common causative species of IC followed by C. tropicalis (11.34%) and C. parapsilosis (6.19%). This study showed the scarcity of IC data in western region of Africa and the existence of undiagnosed IC cases.

关键词： Invasive Candidiasis Epidemiology West Africa Meta-Analysis

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Portal Thrombosis: Clinical, Etiological and Therapeutic Aspects in the Hepato-Gastroenterology Department of the Aristide Le Dantec Hospital in Dakar (Senegal)

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Open Journal of Gastroenterology 2021年第11期11卷 220-229页

作者： Salamata diallo Coumba Ndaw Diagne Marie Louise Bassène Mamadou Ngoné Gueye Mariéme Polele Fall Mame Aissé Thioubou Cheikh Ahmadou bamba Cissé Daouda Dia Hôpital Aristide Le Dantec Dakar Sénégal Dakar Senegal Hôpital Idrissa Pouye Dakar Sénégal Dakar Senegal Hôpital de la paix Ziguinchor Sénégal Dakar Senegal

Background: Portal thrombosis (PT) is a rare pathology. Its prevalence is estimated at 1%. Its consequences depend on the acute or chronic nature, the extent of the clot and the etiology. In Sub-Saharan Africa, very few studies have been devoted to it. Patients and Method: The objective of our work was to determine the prevalence of PT and to describe its clinical and etiological presentation as well as its therapeutic management in the Hepato-gastroenterology department of the Aristide Le Dantec hospital in Dakar. This was a retrospective, longitudinal and descriptive study during the period from January 1, 2012, to December 31, 2018. It included all patients followed in ambulatory or inpatient, who presented a PT objectively determined by a medical imaging examination (ultrasound and/or CT scan). Age, gender, clinical and radiological aspects, proposed treatments and etiology of PT were collected. Results: We collected 71 observations. The prevalence of PT was 1.9%. The mean age of the patients was 41 years 15 and 75 years. A predominance of men was found with a sex ratio of 2.73. The clinical manifestations were dominated by abdominal pain (74.6%), ascites (35.7%) and gastrointestinal bleeding (25.4%). Imaging allowed the diagnosis to be made in 50 patients on ultrasound and 21 patients on abdominal CT scan. PT was acute in 5 patients and chronic in 66 patients. Thrombosis was complete in 71.4% of cases and extended to the spleno-mesaraic venous trunk and the superior mesenteric vein in 2.8% and 8.4% respectively. Etiological research found cirrhosis complicated by hepatocellular carcinoma in 67.6% of cases, cirrhosis with cruoric thrombosis in 21.1% of cases, a combined protein C and S deficiency in 1.4% of cases. No aetiology was objectified in 9.9% of cases. Treatment with beta-blockers was initiated in 32 patients. Anticoagulant treatment was performed in one patient. Evo

关键词： Portal Thrombosis Cirrhosis Portal Hypertension

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Indications and Results of Lower Gastrointestinal Endoscopy in a Regional Hospital Center in Senegal

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Open Journal of Gastroenterology 2023年第1期13卷 43-48页

作者： Marième Polèle Fall Marie Louise Basséne Salamata diallo Mamadou Ngoné Gueye Cheikh Ahamadou bamba Cissé Madoky Magatte Diop Daouda Dia Mouhamadou Mbengue Department of Gastroenterology and Hepatology Aristide Le Dantec Hospital Dakar Senegal Department of Gastroenterology and Hepatology General Hospital Idrrisa Pouye Dakar Senegal Department of Internal Medecine Regional Hospital Center of Thiès Thiès Senegal

Introduction: Gastrointestinal endoscopy plays a crucial role in the management of gastrointestinal diseases. The aim of this study was to report the indications and results of lower digestive endoscopy in a hospital center in Senegal. Patients and Methods: We conducted a descriptive retrospective study from September 1st, 2017, to September 30, 2018 at the gastrointestinal endoscopy unit of the regional hospital center of Thiès. All patients received for lower gastrointestinal endoscopy and whose reports were usable, were included. In the reports, we collected and analyzed sociodemographic data, indication and results of the endoscopic examination. Results: We included 250 patients. There were 140 men (sex ratio 1.27). The average age was 42 years [range 1 - 92 years]. There were 37 colonoscopies (14.8%), 51 rectosigmoidoscopies (20.4%) and 162 anorectoscopies (64.8%). The patients were from the region of Thiès in 82% of cases. In most cases, they were most often referred by general practitioners (22.8%) and surgeons (20.8%). The main indications were rectal bleeding (36.8%), hemorrhoidal disease (23.2%) and proctalgia (11.6%). Hemorrhoidal disease (63.6%), anal fistula (14%) and tumors (8.8%) were the most common pathologies. Conclusion: Admitted patients at the gastrointestinal endoscopy unit of the regional hospital center of Thiès have many indications as well as pathologies. Anal pathology is dominated by hemorrhoidal disease.

关键词： Lower Gastrointestinal Endoscopy Rectal Bleeding Hemorrhoidal Disease

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