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The Safety and Efficacy of Combination Therapy of Dapagliflozin and Metformin in Patient with Type 2 Diabetes Mellitus: A Review Study

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Journal of Diabetes Mellitus 2022年第4期12卷 271-283页

作者： Saif K. Alkhanferi Khadeejah H. Alhuraiz Hussein S. Alyami Sultan L. Alenazi Mohammed F. Aldhaban Naif Alrowedann Yazeed Y. Albedaiwi Nawal Alnazawi Abrar Bokhamseen fatimah A. Talaqof King Abdulaziz Medical City National Guard Health Affairs Riyadh Saudi Arabia King Abdullah International Medical Research Center Riyadh Saudi Arabia Imam Abdurrahman Bin Faisal Hospital National Guard Health Affairs Dammam Saudi Arabia Qassim Primary Health Care Center National Guard Health Affairs Qassim Saudi Arabia

Background: Sodium glucose co-transporter 2 (SGLT2) inhibitors are a new class that approved by FDA for patient with type 2 DM. Dapagliflozin alone or in combination therapy with metformin provided effective glycemic control and HbA1c reduction, with minimal hypoglycemia and hypotension adverse effects. Objective: To evaluate the safety and efficacy of the combination therapy of dapagliflozin and metformin in type 2 diabetes mellitus patients. Methods: Research was conducted through MEDLINE and Embase databases in search of randomized controlled studies including dapagliflozin, sodium glucose co-transporter 2, metformin, and efficacy. Results: Forty seven articles were spotted, 3 randomized controlled studies were involved in this review. Dapagliflozin and metformin combination was found beneficial in HbA1c reduction equal to 20.7% - 31.5% from the baseline compared to patients on metformin alone. 40.6% of patients on combination therapy achieved the ADA recommended reduction in HbA1c to less than 7%. Moreover fasting plasma glucose level was reduced by 23.4 mg/dl from the baseline in the combination therapy compared to 5.9 mg/dl in metformin group. Body weight reduction was statistically significant (P Conclusion: The combination therapy of dapagliflozin and metformin found to be safe and effective in type 2 diabetes mellitus management with minimal adverse effects.

关键词： Dapagliflozin Sodium Glucose Co-Transporter 2 SGLT2 Metformin Efficacy

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Colour Features Extraction Techniques and Approaches for Content-Based Image Retrieval（CBIR） System

Colour Features Extraction Techniques and Approaches for Con...

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作者： Muhammad Naim Abdullah Mohd Afizi Mohd Shukran Mohd Rizal Mohd Isa Nor Suraya Mariam Ahmad Mohammad Adib Khairuddin Mohd Sidek Fadhil Mohd Yunus fatimah Ahmad Universiti Pertahanan Nasional Malaysia (UPNM) Universiti Pendidikan Sultan Idris (UPSI)

An image retrieval system was developed purposely to provide an efficient tool for a set of images from a collection of images in the large database that matches the user’s requirements in similarity evaluations such as image content similarity, edge, and colour similarity. Retrieving images based on the contents which are colour, texture, and shape is called content-based image retrieval（CBIR）. This paper discusses and describes about the colour features technique for image retrieval systems. Several colour features technique and algorithms produced by the previous researcher are used to calculate the similarity between extracted features. This paper also describes about the specific technique about the colour basis features and combined features（hybrid techniques） between colour and shape features.

关键词： Content-Based Image Retrieval Colour Features CBIR

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Work Stress and Outcome of Stress Among Malaysian Managers

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Psychology Research 2011年第4期1卷 270-277页

作者： Wong Shiet-Ching Omar fatimah Mahmud Malissa-Maria Sunway University Selangor Malaysia Universiti Kebangsaan Malaysia Bangi Malaysia

Work stress is always associated with managers’ satisfaction, mental and physical well-being. Nevertheless, there are limited studies on causal relationship of stressors, satisfaction, organization and mental and physical well-being by using SEM (structural equation modeling) analysis among managers in Malaysia. The purpose of the present study is to ascertain the causal relationship of stress and the outcome of stress on managers’ well-being. This was a cross sectional research, which consisted of 338 managers from various private sectors in Klang Valley and Kuala Lumpur, Malaysia. Pressure management indicator questionnaire was used as the measurement instrument in this study. The SEM results indicate that work stress has direct effect on satisfaction, mental and physical well-being. Meanwhile, satisfaction has direct effect on organization and mental well-being, organization has direct effect on mental well-being and mediators also have been identified in the study. The impact of work stress shows that mental well-being has greater effect on physical well-being compared to work stress.

关键词：工作压力马来西亚经理人应力身体健康精神健康结构方程模型因果关系

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PMO势在何方

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项目管理评论 2020年第1期 18-19页

作者：法蒂玛·阿博奇尉艳娟(编译) 敏捷管理办公室不详

学术研究和实地走访结果表明,传统的PMO管理方法已经过时,不能为组织创造价值,PMO亟须转型。在快速变化的环境中,如果PMO能够在交付、战略和运营之间取得正确的平衡,并成为组织成功的协调者,那么PMO将有机会蓬勃发展。未来几年内,PMO将... 详细信息

学术研究和实地走访结果表明,传统的PMO管理方法已经过时,不能为组织创造价值,PMO亟须转型。在快速变化的环境中,如果PMO能够在交付、战略和运营之间取得正确的平衡,并成为组织成功的协调者,那么PMO将有机会蓬勃发展。未来几年内,PMO将面临数字化转型,以下五大趋势值得关注。

关键词：数字化转型学术研究协调者 PMO 实地走访

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Emotionally Intelligent among Nurses and Nursing Managers:An Integrative Review

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Open Journal of Nursing（护理学期刊） 2022年第10期

作者： fatimah hassan suwaidi

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Controlling the Bandgaps of One-Dimensional TiO2/SiO2, TiO2/SnO2, and SiO2/SnO2 Photonic Crystals Using the Transfer Matrix Method

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Optics and Photonics Journal（光学与光子学期刊） 2022年第7期

作者： fatimah alamrani edreese alsharaeh

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Psychological and Mental Health among Isolated Hospitalized Suspected and Confirmed COVID-19 Patients, Qatif Central Hospital, Eastern Province,Saudi Arabia: A Single-Center Descriptive Study

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Open Journal of Internal Medicine（内科学期刊） 2020年第3期

作者： Alya Hassan Alhajjaj Taaweel Hussain Al Abduljaber Zainab Ali Alsadeq fatimah Lateef Alkhabbaz Hoor Hussain Alobaidan fatimah Ali Al Saeed Jumana Mansour Al-Jishi Ghada Ali Aljanobi

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AtzABC Catabolic Gene Probe from Novel Atrazine-Degrading Rhodococcus Strain Isolated from a Nigerian Agricultural Soil

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Advances in Microbiology（微生物学） 2012年第4期

作者： Ahmed Faruk Umar fatimah Tahir Michael J. Larkin Olubukola Mojisola Oyawoye Balarabe Lawal Musa Mohammed Bello Yerima Ediga Bede Agbo

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Determination of the Stability Studies of the Sudanese Camel Insulin

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Pharmacology & Pharmacy（药理与制药） 2013年第7期 549-555页

作者： Abdella Imam Abdella Baragob Waleed Hassan AlMalki Imran Shahid Hanouf Saeed Bafhaid fatimah Abdullah Bakhdhar Salwa Muhamed Khojali Samia Abdella

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The Viewpoint of Community Pharmacists about Their Professional Role in Dispensing Beauty Products: A Study from Western Region of Saudi Arabia

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Pharmacology & Pharmacy（药理与制药） 2021年第3期

作者： Ali Mofleh Alshahrani Taghreed Mubarak Alotaibi Nawal Safar Alrabie Bashayer Mohammed Althobaiti fatimah Nasser Alshelawi Maram Abdullah Althobaiti Mona Yaser Alsheikh Ahmed Ibrahim Fathelrahman

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