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Umbilical cord-derived mesenchymal stem cells preconditioned with isorhamnetin:potential therapy for burn wounds

World Journal of Stem Cells 2020年第12期12卷 1652-1666页

作者： Shazmeen Aslam Irfan Khan fatima jameel Midhat Batool Zaidi Asmat Salim Stem Cell Laboratory Dr.Panjwani Center for Molecular Medicine and Drug ResearchInternational Center for Chemical and Biological SciencesUniversity of KarachiKarachi 74700SindhPakistan

BACKGROUND Impaired wound healing can be associated with different pathological *** wounds are the most common and detrimental injuries and remain a major health issue *** stem cells(MSCs)possess the ability to regenerate tissues by secreting factors involved in promoting cell migration,proliferation and differentiation,while suppressing immune *** of MSCs with small molecules having cytoprotective properties can enhance the potential of these cells for their use in cell-based *** To enhance the therapeutic potential of MSCs by preconditioning them with isorhamnetin for second degree burn wounds in *** Human umbilical cord MSCs(hU-MSCs)were isolated and characterized by surface markers,CD105,vimentin and *** preconditioning,hU-MSCs were treated with isorhamnetin after selection of the optimized concentration(5μmol/L)by cytotoxicity *** migration potential of these MSCs was analyzed by the in vitro scratch *** healing potential of normal,and preconditioned hU-MSCs was compared by transplanting these MSCs in a rat model of a second degree burn ***,and preconditioned MSCs(IH+MSCs)were transplanted after 72 h of burn injury and observed for 2 *** and gene expression analyses were performed on day 7 and 14 after cell transplantation to determine complete wound *** The scratch assay analysis showed a significant reduction in the scratch area in the case of IH+MSCs compared to the normal untreated MSCs at 24 h,while complete closure of the scratch area was observed at 48 *** analysis showed reduced inflammation,completely remodeled epidermis and dermis without scar formation and regeneration of hair follicles in the group that received IH+*** expression analysis was time dependent and more pronounced in the case of IH+***(IL)-1β,IL-6 and Bcl-2 associated X genes showed significant downregulation,while transforming growth f

关键词： Burn wound Isorhamnetin Mesenchymal stem cells Preconditioning Wound healing Small molecule

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TSS （Tourism Support System） as a New Competitive Tourism Marketing Instrument

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Computer Technology and Application 2013年第6期4卷 291-295页

作者： Boumedyen Shannaq Kaneez fatima Sadriwala Fouad jameel Ibrahim AIAzzawi Department of Information Technology and Computer Since Mazoon University College Muscat 133 The Sultanate of Oman Department of Management (Accounting) University of Nizwa Muscat 113 The Sultanate of Oman Department of Software Engineering A I-Rafidain University College Baghdad 5042 716 Iraq

The recent trend in tourism marketing is focus on customer relationship management. Tourism industry today is one of the highest revenue generating industry and strategic approach for sustainable development of this industry hosts benefits not only for the tourism related stakeholders but also the community and economy on the whole. Oman is one of the most preferred destinations for the tourists especially after the declaration of Muscat, Arab tourism Capital for 2012. Thus to materialize this honor and position, the scientific study and analysis of tourist behavior will help to predict the future trend of tourism and will give direction for effort investment. This work presents a novel strategy to identify, analyze and highlights the main tourist behavioral factors that could increase tourists＇ loyalty to a specific destination or agency. The analytical TSS （tourism support system） will also classify customers into two categories--first category will be classified as ＂LT （loyal tourists）＂ and second category as ＂NLT （non-loyal tourists）＂. Dataset is collected from a tourism business organization. Twenty-four attributes and 545 instances were collected and were analyzed by algorithms like logistics, forest of random trees, naive Bayes, J48 and Id3. The explanatory variables were defined, and some transformations were done to identify the response variable. Entropy was used and adapted in order to find the response variable from the explanatory variables. The results obtained from this work confirm that the generated rules can be used for future prediction and tourism business can be improved and efforts can be directed in right place for the right consumer resulting in high return on investment.

关键词： Tourism marketing Oman entropy sustainable development.

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