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Optimized Identification with Severity Factors of Gastric Cancer for Internet of Medical Things

Computers, Materials & Continua 2023年第4期75卷 785-798页

作者： Kamalrulnizam Bin Abu Bakar fatima tul zuhra Babangida Isyaku Fuad A.Ghaleb Faculty of Computing Universiti Teknologi MalaysiaJohor Bahru81310Malaysia Faculty of Science and Technology Shaheed Benazir Bhutto University Sanghar CampusPakistan Faculty of Computing and Information Technology Sule Lamido UniversityKafin HausaP.M.B.048Nigeria

The Internet of Medical Things (IoMT) emerges with the visionof the Wireless Body Sensor Network (WBSN) to improve the health monitoringsystems and has an enormous impact on the healthcare system forrecognizing the levels of risk/severity factors (premature diagnosis, treatment,and supervision of chronic disease i.e., cancer) via wearable/electronic healthsensor i.e., wireless endoscopic capsule. However, AI-assisted endoscopy playsa very significant role in the detection of gastric cancer. Convolutional NeuralNetwork (CNN) has been widely used to diagnose gastric cancer based onvarious feature extraction models, consequently, limiting the identificationand categorization performance in terms of cancerous stages and gradesassociated with each type of gastric cancer. This paper proposed an optimizedAI-based approach to diagnose and assess the risk factor of gastric cancerbased on its type, stage, and grade in the endoscopic images for smarthealthcare applications. The proposed method is categorized into five phasessuch as image pre-processing, Four-Dimensional (4D) image conversion,image segmentation, K-Nearest Neighbour (K-NN) classification, and multigradingand staging of image intensities. Moreover, the performance of theproposed method has experimented on two different datasets consisting ofcolor and black and white endoscopic images. The simulation results verifiedthat the proposed approach is capable of perceiving gastric cancer with 88.09%sensitivity, 95.77% specificity, and 96.55% overall accuracy respectively.

关键词： Artificial intelligence internet of things internet of medical things wireless body sensor network wireless endoscopic capsule gastric cancer

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Assessment of phytochemicals, antioxidant, anti-hemolytic, anti-inflammatory and anti-cancer potential of flowers, leaves and stem extracts of Rosa arvensis

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Journal of Traditional Chinese Medicine 2024年第4期44卷 804-812页

作者： Zubaria tul Ain Iram fatima Sana Naseer Sobia Kanwal Tariq Mahmood Department of Plant Sciences Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Biology Allama Iqbal Open UniversityIslamabad 04403Pakistan Department of Plant Sciences Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabad 45320Pakistan Pakistan Academy of Sciences Islamabad 04403Pakistan

OBJECTIVE:To evaluate phytochemicals and in vitro biological potential of flowers,leaves and stem extracts of Rosa ***:Presence of twenty secondary metabolites was confirmed and then phenolic and flavonoid contents were quantified *** Transform Infrared spectroscopy was conducted to ascertain functional groups and antioxidant potential was examined using 2,2-diphenyl-1-picrylhydrazyl scavenging activity,total antioxidant capacity and total reducing power *** erythrocytes were used to assess anti-hemolytic activity and five bacterial strains were examined to determine antibacterial potential of plant *** seeds were used to perform phytotoxic activity and cytotoxic potential was evaluated via brine shrimps and PC3 cell ***:Highest phenolic contents were detected in the methanolic extract of Rosa arvensis flower(RAFM)[(151.635±0.005)gallic acid equivalent mg/g]and highest flavonoid contents in the chloroform leaf extract(RALC)[(108.228±0.004)quercetin equivalent mg/g].Fourier-transform infrared spectroscopy analysis showed the presence of wide range of functional *** antioxidant assays indicated highest DPPH scavenging activity[IC50(23.5±0.6)μg/mL]in the methanolic stem extract(RASM),highest total antioxidant capacity[(265.1±0.9)μg/mL]in RAFM and highest reducing potential[(209.9±0.6)μg/mL]in leaf extract(RALM).Highest antihemolytic activity[(90.0±0.5)μg/mL]was recorded in RAFM and brine shrimp cytotoxicity potential[(52.3±0.3)μg/mL]in *** antimicrobial activity was detected highest[(21.1±0.5)mm inhibition zones]in RALM against Streptococcus *** the end,antiinflammatory and anti-cancer activity results depicted less than 50%inhibition in the methanolic ***:Our findings will be helpful in designing pharmaceutical regimens and therefore,more studies can be recommended to isolate and characterize compounds associated with the biological activities of Rosa arvensis.

关键词： anti-inflammatory agents spectroscopy,fourier transform infrared hemolysis oxidative stress PC-3 cells

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Immobilization techniques for beverage production using yeast cell systems: challenges, types, and future perspectives - a mini review

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Food and Health 2024年第4期6卷 27-38页

作者： Syed Sib tul Hassan Shah Iqra Naeem Aimen Naeem Nabeel Khalid Bhutta fatima Noor Zhejiang Province Key Laboratory of Plant Secondary Metabolism and Regulation College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou310018China School of Biological Sciences University of the PunjabLahorePakistan Laboratory of Anti-allergic Functional Molecules College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhouZhejiang310018China Department of Zoology Government College UniversityFaisalabadPunjabPakistan

Yeast immobilization is a process of physical entrapment of yeast cells using different techniques while maintaining their biological *** fermentation systems have significant advantages over conventional *** highlights that immobilized yeast cell systems have several benefits as compared to free yeast *** immobilized yeast cell systems improve fermentation rates,especially when paired with continuous fermentation and appropriate immobilization *** various immobilization techniques,continuous fermentation processes,yeast metabolic activity related to beverage flavor production,and bioreactor designs is vital for optimizing the use of immobilized yeast cells systems on industrial *** review provides an overview of recent basic research on immobilized yeast cell systems,with a focus on continuous beverage *** this study,different reactor configurations and immobilization techniques are *** study focus on the impacts of immobilization on the yeast cells,and discuss the recent advancements in these *** review concludes with a discussion on the practical applications of immobilized yeast cells and continuous fermentation in beverage production.

关键词： Yeast Cell System Beverages Continuous Fermentation Microbial System

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Dynamical study of varicella-zoster virus model in sense of Mittag-Leffler kernel

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International Journal of Biomathematics 2024年第3期17卷 153-183页

作者： Qura tul Ain Aziz Khan Thabet Abdeljawad J.F.Gomez-Aguilar Saleem Riaz Department of Mathematics Guizhou University GuiyangGuizhou 550025P.R.China Department of Mathematics and Sciences Prince Sultan University P.O.Bor 66833 11586 RiyadhSaudi Arabia Department of Medical Research China Medical University Taichung 40402Taiwan CONACyT-Tecnologico Nacional de Mécico/CENIDET Interior Internado Palmira S/N Col.Palmira C.P.62490CuernavacaMorelosMécico IConsejo Academico Universidad Virtual CNCIMonterreyMécico School of Automation Northwestern Polytechnical University 170072 Xian P.R.China

The primary varicella-zoster virus(VzV)infection that causes chickenpox(also known as varicella),spreads quickly among people and,in severe circumstances,can cause to fever and *** this paper,the Mittag-Leffler fractional operator is used to examine the mathematical representation of the *** fractional-order differential equations are created in terms of the disease's dynamical analysis such as S:Susceptible,V:Vaccinated,E:Exposed,I:Infectious and R:*** derive the existence criterion,positive solution,Hyers-Ulam stability,and boundedness of results in order to examine the suggested fractional-order model's ***,some numerical examples for the VzV model of various fractional orders are shown with the aid of the generalized Adams-Bashforth-Moulton approach to show the viability of the obtained results.

关键词： Varicella-zoster virus model Hyers-Ulam stability ABC fractional operator Schauder fix point theory numerical analysis

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Developments in the study of Chinese herbal medicine's assessment index and action mechanism for diabetes mellitus

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Animal Models and Experimental Medicine 2024年第4期7卷 433-443页

作者： Xin-Yue Liu Han-Wen Zheng Feng-Zhong Wang tul-Wahab Atia Bei Fan Qiong Wang Institute of Food Science and Technology Chinese Academy of Agricultural SciencesBeijingChina Sino-Portugal TCM International Cooperation Center the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhouChina Dr.Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of KarachiKarachiPakistan

In traditional Chinese medicine(TCM),based on various pathogenic symptoms and the‘golden chamber’medical text,Huangdi Neijing,diabetes mellitus falls under the category‘collateral disease’.TCM,with its wealth of experience,has been treating diabetes for over two *** antidiabetic Chinese herbal medicines re-duce blood sugar,with their effective ingredients exerting unique *** well as a glucose lowering effect,TCM also regulates bodily functions to prevent diabetes associated complications,with reduced side effects compared to western synthetic *** herbal medicine is usually composed of polysaccharides,saponins,al-kaloids,flavonoids,and *** active ingredients reduce blood sugar via various mechanism of actions that include boosting endogenous insulin secretion,enhancing insulin sensitivity and adjusting key enzyme activity and scavenging free *** actions regulate glycolipid metabolism in the body,eventually achiev-ing the goal of normalizing blood *** different animal models,a number of molecular markers are available for the detection of diabetes induction and the molecular pathology of the disease is becoming ***,there is a dearth of scientific data about the pharmacology,dose-effect relationship,and structure-activity relationship of TCM and its *** research into the efficacy,toxicity and mode of action of TCM,using different metabolic and molecular markers,is key to developing novel TCM antidiabetic formulations.

关键词： animal model Chinese herbal medicine diabetes mellitus evaluation index mechanism of action

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Unveiling the dynamic role of innate and adaptive immune cells in COPD pathogenesis induced by cigarette smoke

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Life Research 2024年第4期7卷 29-41页

作者： Dur E Maknoon Razia Syed Sib tul Hassan Shah Tabish Faheem Department of Pathogen Biology College of Basic Medical SciencesJilin UniversityChangchun 130015China Zhejiang Province Key Laboratory of Plant Secondary Metabolism and Regulation College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou 310018China Department of Surgery Nishtar Medical universityMultan 66000Pakistan.

Chronic obstructive pulmonary disease(COPD)is a multifaceted syndrome characterized by a dysregulated inflammatory cascade within the respiratory system,primarily triggered by exposure to harmful particles and gases,notably from cigarette *** inflammatory response is orchestrated by innate immune cells like macrophages and epithelial cells,which recognize danger signals released from damaged *** inflammation prompts an adaptive immune reaction mediated by dendritic cells,culminating in the formation of lymphoid follicles and involving a complex interplay of T and B cells,as well as cytotoxic ***,both viral and bacterial infections exacerbate COPD by further igniting inflammatory pathways,perpetuating the chronic inflammatory *** comprehensive review encapsulates the intricate interplay between innate and adaptive immunity in COPD,with a particular focus on the role of cigarette smoke in its pathogenesis and potential therapeutic targets.

关键词： chronic obstructive pulmonary disease innate immunity adaptive immunity cigarette smoke inflammation oxidative stress protease-antiprotease imbalance

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Modelling Intelligent Driving Behaviour Using Machine Learning

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Computers, Materials & Continua 2021年第9期68卷 3061-3077页

作者： Qura-tul-Ain Khan Sagheer Abbas Muhammad Adnan Khan Areej fatima Saad Alanazi Nouh Sabri Elmitwally School of Computer Science NCBA&ELahore54000Pakistan Riphah School of Computing&Innovation Faculty of ComputingRiphah International UniversityLahore CampusLahore54000Pakistan Department of Computer Science Lahore Garrison UniversityLahore54000Pakistan Department of Computer Science College of Computer and Information SciencesJouf UniversitySkakaAljouf72341Saudi Arabia Department of Computer Science Faculty of Computers and Artificial IntelligenceCairo University12613Egypt

In vehicular systems,driving is considered to be the most complex task,involving many aspects of external sensory skills as well as cognitive *** skills include the estimation of distance and speed,time perception,visual and auditory perception,attention,the capability to drive safely and action-reaction *** intelligence works as an internal mechanism that manages and holds the overall driver’s intelligent *** cognitive capacities constitute the frontiers for generating adaptive behaviour for dynamic *** parameters for understanding intelligent behaviour are knowledge,reasoning,decision making,habit and cognitive *** intelligent behaviour reveals that many of these parameters operate simultaneously to enable drivers to react to current *** changes prompt the parameter values to change,a process which continues unless and until all processes are *** paper model intelligent behaviour by using a‘driver behaviour model’to obtain accurate intelligent driving behaviour *** model works on layering patterns in which hierarchy and coherence are maintained to transfer the data with accuracy from one module to *** patterns constitute the outcome of different modules that collaborate to generate appropriate *** this case,accurate patterns were acquired using ANN static and dynamic non-linear autoregressive approach was used and for further accuracy validation,time-series dynamic backpropagation artificial neural network,multilayer perceptron and random sub-space on real-world data were also applied.

关键词： Machine learning artificial neural network ann time series intelligent behaviour agent

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Effects of thermal fluctuations on the Kerr–Newman–NUT–AdS black hole

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Communications in Theoretical Physics 2021年第8期73卷 114-123页

作者： M Sharif Qanitah Ama-tul-Mughani Department of Mathematics University of the PunjabQuaid-e-Azam CampusLahore-54590Pakistan

This paper is devoted to studying the impact of thermal fluctuations on thermodynamics of rotating as well as charged anti-de Sitter black holes with the Newman–Unti–Tamburino(NUT)*** this end,we derive the analytic expression of thermodynamic variables,namely the Hawking temperature,volume,angular velocity,and entropy within the limits of extended phase *** variables meet the first law of thermodynamics as well as the Smarr relation in the presence of new NUT *** analyze the effects of quantum fluctuations,we derive the exact expression of corrected entropy,which yields modification in other thermodynamical equations of *** local stability and phase transition of the considered black hole are also examined through specific *** is found that the NUT parameter increases the stability of small black holes,while the logarithmic corrections induce instability in the system.

关键词： black hole thermal fluctuations thermodynamics NUT parameter

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Mixed Matrix Membranes of Polysulfone/Polyimide Reinforced with Modified Zeolite Based Filler: Preparation, Properties and Application

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Chinese Journal of Polymer Science 2018年第1期36卷 65-77页

作者： Sedra tul Muntha Muhammad Siddiq Ayesha Kausar Anum Khan Department of Chemistry Quaid i Azam University Department of Microbiology Quaid i Azam University

In this work, polysulfone/polyimide（PSf/PI） mixed matrix membranes were fabricated by reinforcement of modified zeolite（MZ） particles through solution casting method for investigation of antibacterial activity against two gram negative bacteria（Salmonella typhi, Klebsella pneumonia） and two gram positive bacteria（Staphylococcus aureus, Bacillus subtilis）. The modified zeolite particles were incorporated to PSf and PI matrix and the influence of these particles on thermal, mechanical and structural properties was evaluated. The morphological evolution was investigated through scanning electron microscopy（SEM） and transmission electron microscopy（TEM） analysis, which revealed good compatibility between organic polymer matrix and inorganic filler. Mechanical stability was investigated by tensile testing while thermal analysis was evaluated by thermogravimetric analysis（TGA） and differential scanning calorimetry（DSC）. This revealed improvement in thermal properties with increasing filler concentration from 1 wt% to 10 wt%. Structural analysis was successfully done using X-ray diffraction analysis（XRD） and Fourier transform infrared（FTIR） spectroscopy. Solvent content of fabricated mixed matrix membranes was observed to decrease while moving from more hydrophilic to less hydrophilic solvent. However, addition of filler content enhanced the porosity of fabricated membranes. The synthesized mixed matrix membranes exhibited good antibacterial activity and the highest activity was shown by PSf/PI/MZ mixed matrix membrane. Therefore, the combination effect of PSf, PI and MZ sufficiently enhanced the antibacterial activity of mixed matrix membranes.

关键词： Modified zeolite Polysulfone/polyimide blend membrane Mixed matrix membrane Thermal analysis Antibacterial activity

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A Review Featuring Fabrication, Properties and Applications of Carbon Nanotubes(CNTs) Reinforced Polymer and Epoxy Nanocomposites

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Chinese Journal of Polymer Science 2018年第4期36卷 445-461页

作者： Sobia Imtiaz Muhammad Siddiq Ayesha Kausar Sedra tul Muntha Jaweria Ambreen Iram Bibi Department of Chemistry Quaid-i-Azam University Department of Physics Comsats Institute of Information Technology Department of Chemistry Hazara University

Carbon nanotubes（CNTs） have long been recognized as the stiffest and strongest man-made material known to date. In addition, their high electrical conductivity has roused interest in the areas of electrical appliances and communication related applications. However, due to their miniature size, the excellent properties of these nanostructures can only be exploited if they are homogeneously embedded into light-weight matrices as those offered by a whole series of engineering polymers. In order to enhance their chemical affinity to engineering polymer matrices, chemical modification of the graphitic sidewalls and tips is necessary. The mechanical and electrical properties to date of a whole range of nanocomposites of various carbon nanotube contents are also reviewed in this attempt to facilitate progress in this emerging area. Recently, carbonaceous nano-fillers such as graphene and carbon nanotubes（CNTs） play a promising role due to their better structural and functional properties and broad range of applications in every field. Since CNTs usually form stabilized bundles due to van der Waals interactions, they are extremely difficult to disperse and align in a polymer matrix. The biggest issues in the preparation of CNTs reinforced composites reside in efficient dispersion of CNTs into a polymer matrix, the assessment of the dispersion, and the alignment and control of the CNTs in the matrix. An overview of various CNT functionalization methods is given. In particular, CNT functionalization using click chemistry and the preparation of CNT composites employing hyperbranched polymers are stressed as potential techniques to achieve good CNT dispersion. In addition, discussions on mechanical, thermal, electrical, electrochemical and applications of polymer/CNT composites are also included.

关键词： Polymer nanocomposites CNTs Epoxy Conducting polymers RAMs

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