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Relevance of Protein Content within the Renal Scaffold for Kidney Bioengineering and Regeneration

Journal of Biomedical Science and Engineering 2017年第11期10卷 509-526页

作者： fatima guerrero Andres Carmona Rosa Ortega Sagrario Canadillas Rodolfo Crespo Concha Herrera Pedro Aljama Maimonides Institute of Biomedical Research of Cordoba CordobaSpain Anatomical Pathology Service Reina Sofia University HospitalCordobaSpain Cellular Therapy Unit Reina Sofia University HospitalCordobaSpain Department of Nephrology Nephrology ServiceReina Sofia University HospitalCordobaSpain University of Cordoba CordobaSpain Hematology Departament Reina Sofia University HospitalCordobaSpain RETICs Red Renal Instituto de Salud Carlos IIIMadridSpain

Chronic kidney disease is currently a major public health problem around the world. Although hemodialysis increases survival of patients with end-stage renal disease, kidney transplantation remains the only potentially curative treatment. However, transplantation as a therapeutic option is limited by availability of suitable donor organs. This situation highlights the urgent need to find new and potentially inexhaustible sources of transplantable organs. Perfusion decellularizarion of whole organs is a novel approach to organ engineering and regeneration. In the present research, we used a continuous perfusion decellularization protocol to eliminate cellular componet of kidney and evaluated residual scaffold components after decellularizarion process by proteomics analysis. Our proteomic data show that this protocol results in incomplete removal of cellular proteins. However, unlike other authors, we assume that proteins retained within decellularized kidney scaffold could be the basis for specific homing and celular differentation in the recellularization process.

关键词： Bioengineering Kidney Decellularization Scaffold Proteomic

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Extending the Economic Life of the Ogallala Aquifer with Water Conservation Policies in the Texas Panhandle

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Journal of Water Resource and Protection 2017年第3期9卷 255-270页

作者： Lal K. Almas Bridget L. guerrero David G. Lust Hina fatima Rachna Tewari Robert Taylor Department of Agricultural Sciences West Texas A & M University Canyon TX USA fatima Jinnah Women University Rawalpindi Pakistan Department of Agriculture Geosciences and Natural Resources The University of Tennessee at Martin Martin TN USA Institutional Research & Effectiveness Clarendon College Clarendon TX USA

The continued decline in the availability of water from the Ogallala Aquifer in the Texas Panhandle has led to an increased interest in conservation policies designed to extend the life of the aquifer and sustain rural economies. Four counties were chosen for evaluation. This study evaluates the effectiveness of five policies in terms of changes in the saturated thickness, crop mix, water use per acre, and the net present value of farm profits over a 60-year planning horizon. The dynamic optimization models were developed using GAMS for the baseline as well as one for all five of the policy alternatives for each county. Results indicate that the policy scenarios of biotechnology adoption and a water use restriction will conserve the most water among the policies analyzed. In terms of economic returns, the biotechnology adoption policy by far provides the greatest benefit to producers due to yield increases that are estimated with current annual growth rates in new seed varieties. The water use restriction policy, on the other hand, has the lowest net present value of returns, indicating that conservation is accompanied with significant costs to producers. The irrigation adoption technology scenario is the next best policy in terms of net present value of returns (following biotechnology);however, it ranks last in terms of reducing aquifer depletion. It is important to note that while the models do not perfectly predict the factors being evaluated, it is the basis for comparison between the policy scenarios which are important. These comparisons will aid policy makers in determining the most effective strategy to conserve water while simultaneously considering the economic costs to producers. In addition, the results of this study can be applied to other areas facing similar conditions, either currently or in the future, throughout the Texas Panhandle.

关键词： Groundwater Conservation Irrigated Agriculture Ogallala Aquifer Texas Panhandle Water Management Policy

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