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Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

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Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： fatima aldali Chunchu Deng Mingbo Nie Hong Chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

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Regenerative rehabilitation:a novel multidisciplinary field to maximize patient outcomes

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Medical Review 2024年第5期4卷 413-434页

作者： Chunchu Deng fatima aldali Hongmei Luo Hong Chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China

Regenerative rehabilitation is a novel and rapidly developing multidisciplinaryﬁeld that converges regenerative medicine and rehabilitation science,aiming to maximize the functions of disabled patients and their *** regenerative medicine provides state-of-the-art technologies that shed light on diﬃcult-to-treated diseases,regenerative rehabilitation offers rehabilitation interventions to improve the positive effects of regenerative ***,regenerative scientists and rehabilitation professionals focus on their aspects without enough exposure to advances in each other’sﬁ*** disconnect has impeded the development of thisﬁ***,this reviewﬁrst introduces cutting-edge tech-nologies such as stem cell technology,tissue engineering,biomaterial science,gene editing,and computer sciences that promote the progress pace of regenerative medicine,followed by a summary of preclinical studies and examples of clinical investigations that integrate rehabilitative methodologies into regenerative ***,challenges in thisﬁeld are discussed,and possible solutions are provided for future *** aim to provide a platform for regenerative and rehabilitative professionals and clinicians in other areas to better understand the progress of regenerative rehabilitation,thus contributing to the clinical translation and management of innovative and reliable therapies.

关键词： regenerative rehabilitation stem cell therapy rehabilitation strategies enhanced motor functions

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