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World Journal of Clinical Oncology 2022年第2期13卷 116-124页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Hakan Gamsiz Bora Uysal fatih Ozcan Onurhan Colak Esra Gumustepe Yelda Elcim Esin Gundem Bahar Dirican Murat Beyzadeoglu Gulhane Medical Faculty Department of Radiation Oncology University of Health SciencesAnkara 0090Turkey

Lung cancer is a global health concern as the leading cause of cancer related mortality *** cell lung cancer(SCLC)poses a formidable challenge to the treating physicians with the worst prognosis among all lung ***,limited stage SCLC(LS-SCLC)has a relatively better outcome with multimodality *** have been focused on optimal integration of treatment modalities to achieve an improved therapeutic ratio for patients with *** chemotherapy and thoracic radiation therapy(TRT)are primary components of initial management for LS-SCLC,there is no consensus on optimal timing of *** this context,we herein provide a concise overview of current evidence and future prospects regarding the optimal timing of thoracic irradiation for LS-SCLC in light of the literature.

关键词： Small cell lung cancer Thoracic irradiation Limited stage small cell lung cancer Timing of thoracic radiation therapy Thoracic radiation therapy

Al靶喷涂对（Ti，Al）N／AlN多层涂层的组织和生长形貌的影响

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现代冶金（内蒙古） 2007年第1期 68-71,75页

作者： fatih Ustel[德国] 冯岩青(译) 李智丽(校)

通过直流脉冲磁电管将来自于两个靶的多层TiAIN和AIN涂层沉积在高速钢（HSS）和硬质金属（HM）基体上。TiAl靶的能量是保持衡定的。而灿靶的能量是变化的。用扫描电镜和X-射线衍射技术对组织的形态学进行研究。灿靶的能量对涂层组织和... 详细信息

通过直流脉冲磁电管将来自于两个靶的多层TiAIN和AIN涂层沉积在高速钢（HSS）和硬质金属（HM）基体上。TiAl靶的能量是保持衡定的。而灿靶的能量是变化的。用扫描电镜和X-射线衍射技术对组织的形态学进行研究。灿靶的能量对涂层组织和形态会产生一定的影响。在较低的Al靶能量下生成的涂层具有B1型立方结构。随着能量的增加，六方晶体结构就会逐渐清晰。

关键词：涂层组织多层涂层 Al靶生长形貌 AlN X-射线衍射技术喷涂涂层沉积

Treatment of Crohn's disease and familial Mediterranean fever by leukopheresis:Single shot for two targets

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World Journal of Gastroenterology 2015年第13期21卷 4078-4081页

作者： Mahmut Yuksel fatih Saygili Orhan Coskun Nuretdin Suna Mustafa Kaplan Ufuk Baris Kuzu Zeki Mesut Yalin Kilic Yasemin Ozderin Ozin Ertugrul Kayacetin Department of Gastroenterology Turkiye Yuksek Ihtisas Training and Education HospitalAnkara 06230Turkey

Coexistence of Crohn's disease(CD) and familial Mediterranean fever(FMF) is a rare condition and knowledge about this clinical situation is limited with a few case reports in the literature. The treatment of both diseases depends on their individual therapies. However, it is very hard to deal with this coexistence when CD is refractory to standard therapies. Ongoing activity of CD triggers the clinical attacks of FMF and the symptoms like abdominal pain interfere with both disease presentations which can cause problems about diagnostic and therapeutic approach. The main therapeutic agent for FMF is colchicine and diarrhea is the most common side effect of this drug. This side effect also causes problems about management of these diseases when both of them are clinically active. Here we report probably the first case in the literature with coexisting CD and FMF who was successfully treated by leukopheresis since he was refractory to conventional therapies for CD.

关键词： Crohn’s disease Familial Mediterranean fever Leuko

Bio-refinery of plant drinks press cake permeate using ultrafiltration and lactobacillus fermentation into antimicrobials and its effect on the growth of wheatgrass in vivo

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Food Bioscience 2022年第2期46卷 951-958页

作者： Karolina Trakselyte-Rupsiene Grazina Juodeikiene Gabriele Alzbergaite Daiva Zadeike Elena Bartkiene fatih Ozogul Lukas Rueller Josef Robert Jo˜ao Miguel F.Rocha Department of Food Science and Technology Kaunas University of TechnologyRadvilenu Rd.19LT-50254KaunasLithuania Department of Food Safety and Quality Lithuanian University of Health SciencesTilzes Str.18LT-47181KaunasLithuania Department of Seafood Processing Technology Faculty of FisheriesCukurova University01330BalcaliAdanaTurkey Fraunhofer Institut UMSICHT Osterfelder Str.3DE-46047OberhausenGermany LEPABE-Laboratory for Process Engineering EnvironmentBiotechnology and EnergyDepartment of Chemical Engineering(DEQ)Faculty of EngineeringUniversity of Porto(FEUP)Rua Dr.Roberto FriasS/nP-4200-465PortoPortugal

For sustainable plant drinks production,the biorefinery concept of obtained press cakes(PC)using ultrasonication,mechanical separation,and ultra-filtration was designed in Fraunhofer UMSICHT(Germany).In this study obtained permeates,as wastes after ultrafiltration of PC(soyabeans,almonds,coconut,oats,and rice)were analyzed and their bio-stimulatory effect on the growth of wheatgrass in vivo was *** with higher soluble protein content(soy,almonds,and coconut)resulted in a significant increase in germination parameters(germination percentage(GP),length of stem and root as well as biomass of stem and root increased on averge by 8.3%,15.8%,9.2%,2.22 times and 1.8 times,respectively)compared to the control ***,the fermentation using antimicrobial lactic acid bacteria(LAB)strains(Lactobacillus brevis LUHS173,Pediococcus acidilactici LUHS236 and Lactobacillus farraginis LUHS206)was applied for bio-treatment of *** efficiency of fermentation process was evaluated on the changes of pH,TTA,LAB growth kinetics and lactic acid and its isomers ***,the antifungal activity of selected fermented products against fungi(Fusarium graminearum F,***,and ***)was *** was found that the highest antifungal activity(18.0 mm and 16.5 mm,respectively)was obtained by 48 h fermentation of permeates from grain press cake(oats and rice),containing the most reducing saccharides,and they significantly improved the germination of contaminated *** in the sustainable production of plant-origin drinks enable to implementation of new,environmentally friendly technologies in food sector.

关键词： Biorefynery Plant drinks waste Press cakes Wheatgrass Lactobacillus fermentation Antifungal activity

Author Correction:Machine-learned impurity level prediction for semiconductors:the example of Cd-based chalcogenides

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npj Computational Materials 2020年第1期6卷 558-560页

作者： Arun Mannodi-Kanakkithodi Michael Y.Toriyama fatih G.Sen Michael J.Davis Robert F.Klie Maria K.Y.Chan Center for Nanoscale Materials Argonne National Laboratory Argonne USA Chemical Sciences and Engineering Division Argonne National Laboratory Argonne USA Department of Physics University of Illinois at Chicago Chicago USA

The authors became aware of a mistake in the original version of this ***,some of the band gap values plotted and reported in Fig.1c and Table SI-1 were *** error originated because two different types of k-point meshes were used in DFT computations performed on CdTe,CdSe and CdS:one which is gamma-centered and one which is not gamma-centered.

关键词： prediction originated centered

New treatment strategies for hepatitis c infection

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World Journal of Hepatology 2015年第17期7卷 2100-2109页

作者： fatih Ermis Elif Senocak Department of Gastroenterology Duzce University Faculty of Medicine Department of Internal Medicine Duzce University Faculty of Medicine

Hepatitis C infection can lead to cirrhosis and hepatocellular carcinoma and it is an important cause of mortality and morbidity. Achieving a sustained virological response has been the major aim for decades. Interferon treatment was the primarily developed therapy against the infection. Addition of the guanosine analog ribavirin to stop viral RNA synthesis increased the response rates as well as the adverse effects of the treatment. The increasing demands for alternative regimens led to the development of direct-acting antivirals(DAAs). The approval of sofosbuvir and simeprevir signaled a new era of antiviral treatment for hepatitis C infection. Although the majority of studies have been performed with DAAs in combination with interferon and resulted in a decrease in treatment duration and increase in response rates, the response rates achieved with interferon-free regimens provided hope for patients ineligible for therapy with interferon. Most DAA studies are in phase Ⅱ leading to phase Ⅲ. In the near future more DAAs are expected to be approved. The main disadvantage of the therapy remains the cost of the drugs. Here, we focus on new treatment strategies for hepatitis C infection as well as agents targeting hepatitis C virus replication that are in clinical development.

关键词： Direct-acting antivirals Eradication Genotype Hepatitis C virus infection Interferon-free Treatment

Effects of Melatonin on Ischemia-Reperfusion Injury in Rat Ovary:Histopathologic and Immunohistochemical Study

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Open Journal of Obstetrics and Gynecology 2015年第11期5卷 639-645页

作者： Deniz Balsak Cihan Togrul Cenap Ekinci Kerem Doga Seckin Mehmet fatih Karsli Aysun Ekinci Ali Emre Tahaoglu Hanefi Bademkiran Zuat Acar Senem Yaman Tunc Engin Deveci Günsen Kirman Department of Obstetrics and Gynecology School of Medicine Hospital University of Halic Istanbul Turkey Department of Obstetrics and Gynecology School of Medicine University of Hitit Corum Turkey Department of Histology and Embryology School of Medicine Hospital University of Dicle Diyarbakir Turkey Department of Obstetrics and Gynecology Kanuni Sultan Süleyman Education and Research Hospital Istanbul Turkey Department of Obstetrics and Gynecology Dr. Sami Ulus Education and Research Hospital Ankara Turkey Department of Biochemistry Faculty of Medicine University of Dicle Diyarbakir Turkey Department of Obstetrics and Gynecology Diyarbakir Gazi Yasargil Education and Research Hospital Diyarbakir Turkey Department of Obstetrics and Gynecology Diyarbakir Obstetrics and Gynecology Hospital Diyarbakir Turkey Department of Obstetrics and Gynecology Memory Hospital Diyarbakir Turkey Department of Obstetrics and Gynecology School of Medicine Hospital University of Dicle Diyarbakir Turkey

Aim: To investigate the effect of melatonin on ischemia–reperfusion (I/R) injury in rat ovary. Material and Method: A total of 24 Wistar rats were divided into four groups. The rats were first numbered randomly and then randomly divided into four equal groups: sham, torsion, detorsion and melatonin groups. In group I (n = 6) sham, as well as in group II ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. In group IV, melatonin was dissolved in 1% ethanol just before use. Melatonin was injected 1 hour before torsion to the torsion plus melatonin group. Right ovaries were surgically removed in all groups. Result: Malondialdehyde (MDA) levels were measured. We suggested that administration of melatonin would be in treating ovaries from torsion/detorsion induced damage in humans. The histopathological changes such as vascular congestion, edema, hemorrhage, and follicular degeneration were found to be decreased in the melatonin + ischemia-reperfusion group. Ischemia-reperfusion group: PECAM-I expression is positive in vessel of the stromal area. The follicles and interfolicular area infiltrated with CD68 positive cells were increased in a time of ischemia-reperfusion exposure dependent manner. Conclusions: Melatonin after ischemia-reperfusion CD31 and CD68 expressions is weak, due to the reduction of the inflammatory effects and hemorrhage is thought that melatonin is effective.

关键词： Ischemia-Reperfusion Ovary Rat CD31 CD68

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中东精英如何认知土耳其外交？

西亚非洲 2015年第6期 108-123页

作者：萨瓦斯·根奇法提赫·阿吉土耳其法提赫大学北京100871 大学国际关系学院北京100871

2014年,土耳其法提赫大学在中东9个国家做了题为"中东精英的土耳其观"的问卷调查。对于"如何认知土耳其外交"这一议题,大多数被调查者认为:"阿拉伯觉醒"发生后,土耳其外交政策已然发生明显变化,其对外政策超出了自身能力;土耳其虽仍属... 详细信息

2014年,土耳其法提赫大学在中东9个国家做了题为"中东精英的土耳其观"的问卷调查。对于"如何认知土耳其外交"这一议题,大多数被调查者认为:"阿拉伯觉醒"发生后,土耳其外交政策已然发生明显变化,其对外政策超出了自身能力;土耳其虽仍属中东地区大国,但威望有所下降;在对待伊斯兰极端组织问题上,土耳其并没有采取支持的态度;土耳其在解决叙利亚危机方面,应扮演调停的角色;面对变局后的埃及,土耳其宜密切与之发展合作关系。基于近几年土耳其所遇到的地区外交挫折,土耳其政府应采用新外交理念,调整对外政策,方能拓展其外交空间。

关键词：舆情 “阿拉伯觉醒” 土耳其对外政策中东精英

Current Helicobacter pylori treatment in 2014

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World Journal of Methodology 2015年第2期5卷 101-107页

作者： fatih Ermis Elif Senocak Tasci Department of Gastroenterology Duzce University Faculty of Medicine Department of Internal Medicine Duzce University Faculty of Medicine

Helicobacter pylori is one of the most commonly seen bacterium ***'s in the etiology of multiple gastrointestinal diseases,ranging from gastritis to gastric *** antimicrobial therapies,which are frequently prescribed empirically,are losing their effectivity as a result of the increasing antimicrobial *** the standard triple therapy is now leftespecially in areas with high-clarithromycin resistance due to decreased eradication rates,quadruple therapies are recommended in most regions of the ***,concomitant,sequential and hybrid therapies are *** is still a debate going on about the use of levofloxacin-based therapy in order to prevent the increase in quinolone *** no regimen can achieve the desired eradication rate,culture-guided individualized therapies are highly ***,statins and n-acetylcysteine are helpful as adjuvant therapies in order to increase the effectiveness of the eradication ***,we focused on different eradication regimens in order to highlight the current Helicobacter pylori treatment.

关键词： Helicobacter pylori Eradication Treatment Bismuth-quadruple therapy Sequential therapy Concomitant therapy Hybrid therapy

Gastroesophageal reflux in asymptomatic obese subjects:An esophageal impedance-pH study

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World Journal of Gastroenterology 2015年第10期21卷 3030-3034页

作者： Filiz Akyüz Ahmet Uyanikoglu fatih Ermis Serpil Arici ümit Akyüz Divison of Gastroenterology Department of Internal Medicine Faculty of Medicine Yeditepe University Bülent Baran Binnur Pinarbasi Nurdan Gul Division of Gastroenterohepatology Department of Internal Medicine Istanbul Faculty of Medicine Istanbul University Divison of Gastroenterology Department of Internal Medicine Faculty of Medicine Harran University Divison of Gastroenterology Department of Internal MedicineFaculty of MedicineDuzce University Division of Endocrinology Department of Internal Medicine Istanbul Faculty of Medicine Istanbul University

AIM:To investigate the relationship between reflux and body mass index(BMI) in the asymptomatic obese population using the impedance-p H ***:Gastroesophageal reflux is frequent in the obese ***,the relationship between acid reflux and BMI in asymptomatic obese people is ***-six obese(BMI > 25 kg/m2) people were enrolled in this prospective *** evaluated the demographic findings and 24-h impedance p H values of the whole ***,acid(p H 30 kg/m2).Demographic and endoscopic findings,and impedance results were similar in these two ***,there was a positive correlation between BMI and total and supine p H<4 episodes(P=0.002,r=0.414;P=0.000,r=0.542),p H<4 reflux time(P=0.015,r=0.319;P=0.003,r=0.403),and De Meester score(P=0.012,r=0.333).CONCLUSION:Acid reflux is correlated with BMI in asymptomatic obese individuals.

关键词： Reflux Impedance Obesity 24-h p H-metry Body mass