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Association between baseline levels of.muscular strength and risk of.stroke in later lif.:The Cooper Center Longitudinal Study

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Journal of.Sport and Health Science 2024年第5期13卷 642-649页

作者： Stephen W.farrell David Leonard Qing Li Carolyn E.Barlow Kerem Shuval Jarett D.Berry Andjelka Pavlovic Laura f.Def.na Research Division The Cooper InstituteDallasTX 75230USA Department of.Internal Medicine University of Texas at Tyler School of MedicineTylerTX 75799USA

Background:Muscular strength is an important component of.physical *** evaluated the relationship between baseline muscular strength and risk of.stroke among adults who were aged≥65 years during ***:We included 7627 healthy adults(mean age=43.9 years,86.0%male)underwent a baseline physical examination between 1980 and *** strength was determined by 1-repetition maximum measures f.r bench press and leg press and categorized into age-and sex-specif.c tertiles f.r each *** f.tness(CRf.was assessed via a maximal treadmill exercise *** enrolled in f.e-f.r-service Medicare f.om 1999 to 2019 were included in the *** between baseline strength and stroke outcomes were estimated using a modif.ed Cox proportional hazards *** a secondary analysis,we examined stroke risk by categories of.CRf.where Quintile 1=low,Quintiles 2-3=moderate,and Quintiles 4-5=high CRf.based on age and ***:Af.er 70,072 person-years of.Medicare f.llow-up,there were 1211 earliest indications of.incident *** multivariable analyses,the hazard ratio(95%conf.dence interval(95%CI))f.r stroke across bench press categories were 1.0(ref.rent),0.96(0.83-1.11),and 0.89(0.77-1.04),respectively(p trend=0.14).The trend across categories of.leg press was also non-signif.cant(p trend=0.79).Adjusted hazard ratio(95%CI)f.r stroke across ordered CRf.categories were 1.0(ref.rent),0.90(0.71-1.13),and 0.72(0.57-0.92)(p trendf.r muscular strengthening activities is likely to improve muscular strength as well as many health outcomes in older adults,perf.rming such activities may not be helpf.l in preventing ***,meeting guidelines f.r aerobic activity is likely to improve CRf.and lower stroke risk.

关键词： Cardiorespiratory f.tness Medicare Muscular strength Stroke

Python Server Page Perf.rmance Analysis and Modeling

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Communications and Network 2024年第1期16卷 1-30页

作者： Razaf.ndraibe Marolahy Alix Randrianomenjanahary Lala f.rdinand Raf.mantanantsoa f.ntaine Mahatody thomas f. Angelo Raherinirina University of.f.anarantsoa Fianarantsoa Madagascar

Today, in the f.eld of.computer networks, new services have been developed on the Internet or intranets, including the mail server, database management, sounds, videos and the web server itself.Apache. The number of.solutions f.r this server is theref.re growing continuously, these services are becoming more and more complex and expensive, without being able to f.lf.ll the needs of.the users. The absence of.benchmarks f.r websites with dynamic content is the major obstacle to research in this area. These users place high demands on the speed of.access to inf.rmation on the Internet. This is why the perf.rmance of.the web server is critically important. Several f.ctors inf.uence perf.rmance, such as server execution speed, network saturation on the internet or intranet, increased response time, and throughputs. By measuring these f.ctors, we propose a perf.rmance evaluation strategy f.r servers that allows us to determine the actual perf.rmance of.dif.erent servers in terms of.user satisf.ction. f.rthermore, we identif.ed perf.rmance characteristics such as throughput, resource utilization, and response time of.a system through measurement and modeling by simulation. f.nally, we present a simple queue model of.an Apache web server, which reasonably represents the behavior of.a saturated web server using the Simulink model in Matlab (Matrix Laboratory) and also incorporates sporadic incoming traf.ic. We obtain server perf.rmance metrics such as average response time and throughput through simulations. Compared to other models, our model is conceptually straightf.rward. The model has been validated through measurements and simulations during the tests that we conducted.

关键词： Perf.rmance Analysis Queue Perf.rmance Model Web Server Internet World Wide Web Web Server Perf.rmance

EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

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Signal Transduction and Targeted Therapy 2024年第2期9卷 679-692页

作者： Keith Al-Hasani Saf.ya Naina Marikar Harikrishnan Kaipananickal Scott Maxwell Jun Okabe Ishant Khurana thomas Karagiannis Julia J.Liang Lina Mariana thomas Loudovaris thomas Kay Assam El-Osta Epigenetics in Human Health and Disease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia Department of.Diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and Disease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of.Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia Department of.Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of.Diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of.Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomedical Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of.endocrine cell f.und in pancreatic islets that synthesize,store and release *** type 1 diabetes(T1D),T-cells of.the immune system selectively destroy the insulin-producingβ-*** of.these cells leads to a lif.long dependence on exogenous insulin administration f.r ***,there is an urgent need to identif. novel therapies that stimulateβ-cell growth and induceβ-cell *** and others have shown that pancreatic ductal progenitor cells are a promising source f.r regeneratingβ-cells f.r T1D owing to their inherent dif.erentiation *** transcriptional suppression is ref.actory to exocrine reaction and tightly controls the regenerative potential by the EZH2 *** the present study,we show that transient stimulation of.exocrine cells,derived f.om juvenile and adult T1D donors to the f.Aapproved EZH2 inhibitors GSK126 and Tazemetostat(Taz)inf.uence a phenotypic shif. towards aβ-like cell *** transition f.om repressed to permissive chromatin states are dependent on bivalent H3K27me3 and H3K4me3 chromatin *** EZH2 is f.ndamental toβ-cell regenerative *** pancreatic ductal cells exhibit insulin production and secretion in response to a physiological glucose challenge ex *** pre-clinical studies underscore the potential of.small molecule inhibitors as novel modulators of.ductal progenitor dif.erentiation and a promising new approach f.r the restoration of.-like cell f.nction.

关键词： EZH2 struction inhibitors

B-cell and antibody responses to SARS-CoV-2:inf.ction,vaccination,and hybrid immunity

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Cellular & Molecular Immunology 2024年第2期21卷 144-158页

作者： Dennis Lapuente thomas H.Winkler Matthias Tenbusch Institut f.r klinische und molekulare Virologie Universitätsklinikum Erlangen und Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossgarten 491054 ErlangenGermany Department of.Biology Division of GeneticsNikolaus-Fiebiger-Center for Molecular MedicineFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)ErlangenGermany Medical Immunology Campus Erlangen Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossplatz 191054 ErlangenGermany

The emergence of.severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 prompted scientif.c,medical,and biotech communities to investigate inf.ction-and vaccine-induced immune responses in the context of.this pathogen.B-cell and antibody responses are at the center of.these investigations,as neutralizing antibodies(nAbs)are an important correlate of.protection(COP)f.om inf.ction and the primary target of.SARS-CoV-2 vaccine *** addition to absolute levels,nAb longevity,neutralization breadth,immunoglobulin isotype and subtype composition,and presence at mucosal sites have become important topics f.r scientists and health policy *** recent pandemic was and still is a unique setting in which to study de novo and memory B-cell(MBC)and antibody responses in the dynamic interplay of.inf.ction-and vaccine-induced *** also provided an opportunity to explore new vaccine platf.rms,such as mRNA or adenoviral vector vaccines,in unprecedented cohort *** with the technological advances of.recent years,this situation has provided detailed mechanistic insights into the development of.B-cell and antibody responses but also revealed some unexpected *** this review,we summarize the key f.ndings of.the last 2.5 years regarding inf.ction-and vaccine-induced B-cell immunity,which we believe are of.signif.cant value not only in the context of.SARS-CoV-2 but also f.r f.ture vaccination approaches in endemic and pandemic settings.

关键词： SARS-CoV-2 neutralizing antibodies memory responses vaccines IgG4

The impact of.demographic dynamics on f.od consumption and its environmental outcomes:Evidence f.om China

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Journal of.Integrative Agriculture 2024年第2期23卷 414-429页

作者： Shaoting Li Xuan Chen Yanjun Ren thomas Glauben College of.Economics and Management Northwest A&F UniversityYangling 712100China Leibniz Institute of.Agricultural Development in Transition Economies(IAMO) Halle(Saale)06120Germany Sino-German Center f.r Agricultural and f.od Economics Northwest A&F UniversityYangling 712100China

With increasing population and changing demographics,f.od consumption has experienced a signif.cant transition in quantity and ***,a dearth of.knowledge remains regarding its environmental impacts and how it responds to demographic dynamics,particularly in emerging economies like *** the two-stage Quadratic Almost Demand System(QUAIDS)model,this study empirically examines the impact of.demographic dynamics on f.od consumption and its environmental outcomes based on the provincial data f.om 2000 to 2020 in *** various scenarios,according to changes in demographics,we extend our analysis to project the long-term trend of.f.od consumption and its environmental impacts,including greenhouse gas(GHG)emissions,water f.otprint(Wf.,and land appropriation(LA).The results reveal that an increase in the proportion of.senior people signif.cantly decreases the consumption of.grain and livestock meat and increases the consumption of.poultry,egg,and aquatic products,particularly f.r urban ***,an increase in the proportion of.males in the population leads to higher consumption of.poultry and aquatic ***,in the current scenario of.an increased aging population and sex ratio,it is anticipated that GHG emissions,Wf.and LA are likely to decrease by 1.37,2.52,and 3.56%,*** importantly,in the scenario adhering to the standards of.nutritional intake according to the Dietary Guidelines f.r Chinese Residents in 2022,GHG emissions,Wf.and LA in urban areas would increase by 12.78,20.94,and 18.32%,*** f.ndings suggest that changing demographics should be considered when designing policies to mitigate the diet-environment-health trilemma and achieve sustainable f.od consumption.

关键词： demographic dynamics f.od consumption environmental impacts nutrition intakes

Modelling of.the elastoplastic behaviour of.the bio-cemented soils using an extended Modif.ed Cam Clay model

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Journal of.Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2184-2197页

作者： Xuerui Wang Christian B.Silbermann thomas Nagel Udo Nackenhorst Institute of.Mechanics and Computational Mechanics Leibniz UniversitätHannoverAppelstr.9aHannover30167Germany Gesellschaf. f.r Anlagen-und Reaktorsicherheit(GRS)gGmbH Theodor-Heuss-Straße 4Braunschweig38122Germany Geotechnical Institute Technische Universität BergakademieFreibergGustav-Zeuner-Str.1Freiberg09599Germany

An elastoplastic constitutive model based on the Modif.ed Cam Clay(MCC)model is developed to describe the mechanical behaviour of.soils cemented via microbially induced calcite precipitation(MICP).It considers the increase of.the elastic stif.ness,the change of.the yield surf.ce due to MICP cementation and the degradation of.calcium carbonate bonds during ***,to capture the typical contraction-dilation transition in MICP soils,the original volumetric hardening rule in the MCC model is modif.ed to a combined deviatoric and volumetric hardening *** model could reproduce a series of.drained triaxial tests on MICP-treated soils with dif.erent calcium carbonate ***,we carry out a parametric study and observe numerical instability in some *** combination with an analytical analysis,our numerical modelling has identif.ed the benef.ts and limitations of.using MCCbased models in the simulation of.MICP-cemented soils,leading to suggestions f.r f.rther model development.

关键词： Microbially induced calcite precipitation(MICP) Elastoplasticity Modif.ed cam clay(MCC) OpenGeoSys Mf.ont Contraction-dilation transition

Numerical study of.novel OME_(1-6) combustion mechanism and spray combustion at changed ambient environments

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f.ontiers in Energy 2024年第4期18卷 483-505页

作者： f.ederik WIESMANN Zeyan QIU Dong HAN Lukas STRAUβ Sebastian RIEβ Michael WENSING thomas LAUER Institute of.Powertrains and Automotive Technology TU Wien1060 ViennaAustria Key Laboratory f.r Power Machinery and Engineering of.Ministry of.Education Shanghai Jiao Tong UniversityShanghai 200240China Prof.ssorship f.r f.uid Systems Technology Friedrich-AlexanderUniversität Erlangen-Nürnberg91058 ErlangenGermany

f.r a climate-neutral f.ture mobility,the socalled e-f.els can play an essential ***,oxygenated e-f.els containing oxygen in their chemical f.rmula have the additional potential to burn with signif.cantly lower soot *** particular,polyoxymethylene dimethyl ethers or oxymethylene ethers(PODEs or OMEs)do not contain carbon-carbon bonds,prohibiting the production of.soot precursors like acetylene(C_(2)H_(2)).These properties make OMEs a highly interesting candidate f.r f.ture climate-neutral compression-ignition ***,to f.lly leverage their potential,the auto-ignition process,f.ame propagation,and mixing regimes of.the combustion need to be *** achieve this,ef.icient oxidation mechanisms suitable f.r computational f.uid dynamics(Cf.)calculations must be developed and *** present work aims to highlight the improvements made by developing an adapted oxidation mechanism f.r OME1-6 and introducing it into a validated spray combustion Cf. model f.r *** simulations were conducted f.r single-and multi-injection patterns,changing ambient temperatures,and oxygen *** results were validated against high-pressure and high-temperature constantpressure chamber ****-chemiluminescence measurements accomplished the characterization of.the auto-ignition *** experiments and simulations were conducted f.r two dif.erent *** improvements concerning the prediction of.the ignition delay time were accomplished while also retaining an excellent agreement f.r the f.ame lif.-of. *** spatial zones of.high-temperature reaction activity were also af.ected by the adaption of.the reaction *** showed a greater tendency to f.rm OH^(*) radicals within the center of.the spray in accordance with the experiments.

关键词： oxygenated f.els reaction kinetics oxidation mechanisms computational f.uid dynamics(Cf.) oxymethylene ethers(OME) e-f.els multiinjection spray-combustion

A simulation study on spatial and time resolution f.r a cost-ef.ective positron emission particle tracking system

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Particuology 2024年第5期88卷 312-322页

作者： Josephine Oppotsch Matthias Steinke Miriam f.itsch f.itz-Herbert Heinsius thomas Held Nikoline Hilse Viktor Scherer Ulrich Wiedner Ruhr-Universität Bochum Institut für Experimentalphysik I44801 BochumGermany Ruhr-Universität Bochum Lehrstuhl für Energieanlagen und Energieprozesstechnik44801 BochumGermany

This work is the second part of.a simulation study investigating the processing of.densely packed and moving granular assemblies by positron emission particle tracking (PEPT).Since medical positron emission tomography (PET) scanners commonly used f.r PEPT are very expensive,a PET-like detector system based on cost-ef.ective organic plastic scintillator bars is being developed and tested f.r its *** this context,the spatial resolution of.a resting positron source,a source moving on a f.eely designed model path,and a particle motion given by a discrete element method (DEM) simulation is studied using Monte Carlo simulations and the sof.ware toolkit *** not only extended the simulation and reconstruction to a moving source but also signif.cantly improved the spatial resolution compared to previous work by adding oversampling and iteration to the reconstruction ***,in the case of.a source f.llowing a trajectory developed f.om DEM simulations,a very good resolution of.about 1 mm in all three directions and an average 3D deviation between simulated and reconstructed events of.2.3 mm could be ***,the resolution f.r realistic particle motion within the generic grate system (which is the test rig f.r f.rther experimental studies) is well below the smallest particle *** simulation of.the dependence of.the reconstruction accuracy on tracer particle location revealed a nearly constant ef.iciency within the entire detector system,which demonstrates that boundary ef.ects can be neglected.

关键词： Positron emission particle tracking Monte Carlo method Time-of.f.ight Plastic scintillators Silicon photomultipliers(SiPMs)

A simulation study f.r a cost-ef.ective PET-like detector system intended to track particles in granular assemblies

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Particuology 2024年第1期84卷 117-125页

作者： Josephine Oppotsch Antonios Athanassiadis Miriam f.itsch f.itz-Herbert Heinsius thomas Held Nikoline Hilse Viktor Scherer Matthias Steinke Ulrich Wiedner Ruhr-Universität Bochum Institut für Experimentalphysik I44801 BochumGermany Ruhr-Universität Bochum Lehrstuhl für Energieanlagen und Energieprozesstechnik44801 BochumGermany

Since many industrial applications rely on the processing of.densely packed and moving granular ma-terial,obtaining bulk internal inf.rmation on the particle movement inside the reactors is of.great *** inf.rmation can be delivered by Positron Emission Particle Tracking(PEPT).By marking pellets with a positron-emitting radioisotope,the position of.these tracer particles can be determined via the time-of.f.ight dif.erences of.the emitted gamma-ray *** current paper proposes a PET-like detector system based on cost-ef.ective organic plastic scintillators instead of.the more common but expensive inorganic *** system is currently under construction and was tested f.r its resolution and ef.iciency in this simulation *** Monte Carlo simulations and the sof.ware toolkit Geant4,three dif.erent geometries(an empty glass box,a generic grate system,and a cubic box of.1 m3 completely f.lled with pellets)were investigated,leading to a spatial resolution in the millimeter range and an ef.iciency,def.ned as the ratio of.reconstructed decay locations to simulated decays,of.2.7%,1.4%,and 0.3%.

关键词： Positron emission particle tracking Geant4 Monte Carlo method Time-of.f.ight Plastic scintillators Silicon photomultipliers(SiPMs)