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Pharmacological evaluation of Musa seminifera Lour. fruit

Journal of Integrative Medicine 2013年第4期11卷 253-261页

作者： Sanjib Saha faroque hossain Md. Anisuzzman Md. Khirul Islam Phytochemistry and Pharmacology Research Laboratory Pharmacy Discipline Life Science School Khulna University

OBJECTIVE： To study potential antioxidant, analgesic, antidiarrheal, and antibacterial activities of the ethanol extract of Musa seminifera Lour. fruit in different established in vivo and in vitro experimental models. METHODS： In vitro antioxidant activity was studied in 2,2-diphenyl-1-picrylhydrazyl （DPPH） radical-scavenging assay. Phenolic content was determined using Folin-Ciocalteu＇s reagent. Reducing ability was evaluated by ferric reducing power assay. Peripherally and centrally acting analgesic activity was studied in three different in vivo models, namely, acetic acid-induced writhing, hot-plate test, and tail-flick test in Swiss albino mice. In vivo antidiarrheal activity was evaluated in castor oil- and magnesium sulfate-induced diarrhea in mice. Gastrointestinal motility test was also carried out in mice. All studies in mice were undertaken at the doses of 250 and 500 mg/kg body weight. Antibacterial activity was assessed by disk diffusion assay against some Gram-positive and Gram-negative bacterial strains. Acute toxicity test was conducted to assess the safe doses of the extract. RESULTS： The extract showed 50% inhibitory concentration value of 12.65 μg/mL in DPPH radical- scavenging assay. Phenolic content was found to be 589.83 mg gallic acid equivalent per 100 g of dried fruits extract. Reducing power was in a concentration-dependent manner, and strongly comparable with the standard ascorbic acid. The extract demonstrated significant inhibition of writhing in acetic acid-induced writhing test at both dose levels （P〈0.01）. The extract also raised pain threshold in both hot-plate and tail-flick test in a dose-dependent manner, and the results were statistically significant （P〈0.01）. The extract significantly （P〈0.01） increased latent period, and decreased defecation in both castor oil- and magnesium sulfate-induced diarrhea. The extract also decreased gastrointestinal motility in mice. In disk diffusion assay, the extract showed potential antibacteria

关键词： Musa plant extracts antioxidants antidiarrheals analgesics agents, antibacterial mice

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Aqua Forestry and Duck Integration in Tamil Nadu, India

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Journal of Life Sciences 2012年第7期6卷 817-825页

作者： faroque Rahamathulla Sheriff Department of Poultry Science Madras Veterinary College Chennai 600007 India

A study was taken up on integration of ducks in private and community fish ponds in Tami Nadu. A total of 50 ha of land under private holding and community water bodies each were selected to implement this model. Ducks were integrated based on the water spread area. Fodder, fruit, nuts, fuel, timber trees and vegetables were grown on pond bunds. Control units of fish ponds of farmers holding without integration of ducks also were taken up. A control unit also was established in the university farm land with and without integration of ducks. In private water bodies coconut trees and banana fetched additional revenue. During the first year the average fish production from the private land model was 1,552 kg and 1,731 kg for the first and second year respectively per Hectare. In community ponds the yields were 1,610 and 1,337 kg for the first and second year respectively. In field control units there was no increase in fish yield over the years. In private water bodies the beneficiaries got egg yield of 148 and 90 eggs and community water bodies 144 and 127 eggs per bird were obtained during first and second year resoectivelv.

关键词： Aqua forestry duck integration plant integration duck egg production.

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Synthesis,Crystal Structure and Spectroscopic Properties of 1,2-Benzothiazine Derivatives:An Experimental and DFT Study

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Chinese Journal of Structural Chemistry 2015年第1期34卷 15-25页

作者： MUHAMMAD Nadeem Arshad TARIQ Mahmood ATHER faroque Khan MUHAMMAD Zia-Ur-Rehman ABDULLAH M.Asiri ISLAM Ullah Khan RIFFAT-Un-Nisa KHURSHID Ayub AZAM Mukhtar MUHAMMAD Tariq Saeed Chemistry Department Faculty of ScienceKing Abdulaziz University Centre of Excellence for Advanced Materials Research (CEAMR) King Abdulaziz University Department of Chemistry COMSATS Institute of Information TechnologyAbbottabad IRCBM COMSATS Institute of Information Technology Applied Chemistry Research Center PCSIR Laboratories ComplexFerozpur RoadLahore 54600Pakistan Materials Chemistry Laboratory Department of ChemistryGC University Department of Chemistry College of ScienceKing Faisal University Department of Chemistry University of EducationOkara CampusOkara-Pakistan

1,2-Benzothiazine derivatives methyl 3-methoxy-4-oxo-3,4-dihydro-2H-benzo[e] [1,2]thiazine-3-carboxylate 1,1-dioxide（1） and methyl 2-ethyl-3-hydroxy-4-oxo-3,4-dihydro-2Hbenzo[e][1,2]thiazine-3-carboxylate 1,1-dioxide（2） were synthesized, and characterized by spectroscopic techniques; 1H-NMR and infrared（IR） spectroscopy. Crystals of 1 and 2 were grown by slow evaporation of methanol and ethyl acetate, respectively and their crystal structures were investigated by single-crystal X-ray diffraction analysis. Geometric properties were calculated by the B3 LYP method of density functional theory（DFT） at the 6-31G＋（d） basis set to compare with the experimental data. Simulated properties were found in strong agreement with the experimental ones. Intermolecular forces have also been modeled in order to investigate the strength of packing and strong hydrogen bonding was observed in both compounds 1 and 2. Electronic properties such as Ionization Potential（IP）, Electron Affinities（EA） and coefficients of the highest occupied molecular orbital（HOMO） and the lowest unoccupied molecular orbital（LUMO） of com- pounds 1 and 2 were simulated for the first time.

关键词： 1,2-benzothiazine B3LYP/6-31+G (d) density functional theory (DFT) HUMO-LUMO crystal structures

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Triglyceride and Glucose Index (TyG) is a Reliable Biomarker to Predict Non-Alcoholic Fatty Liver Disease

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Journal of Biosciences and Medicines 2020年第11期8卷 124-136页

作者： Sania hossain Suraya Sultana Khan Md. Shahariar Zaman Sabrina Shafiq A. K. M. Shahidur Rahman Shah Md. Zakir hossain Saiful Islam Mahammod Selim Uddin Md. Omar faroque Sheuly Ferdoushi Debatosh Paul Md. Quddusur Rahman Department of Cytopathology National Institute of Cancer Research and Hospital (NICRH) Dhaka Bangladesh Laboratory Services Division Sheikh Hasina National Institute of Burn and Plastic Surgery Dhaka Bangladesh Department of Laboratory Medicine Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Hepatology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Medicine Mymensingh Medical College Hospital (MMCH) Mymensingh Bangladesh

Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide. There is no specific biomarker for the diagnosis of NAFLD. Trigly-ceride and glucose index (TyG) may predict the subsequent occurrence of NAFLD in later life. This cross sectional study was aimed to evaluate the effectiveness of triglyceride and glucose index (TyG) as a possible biomarker of NAFLD. The study was conducted at the Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from March 2019 to February 2020. A total of 124 subjects were taken as study population following selection criteria. Among them 62 were diagnosed patients of NAFLD and 62 were healthy subjects as control group. Fasting plasma glucose was measured by glucose oxidase method and serum triglyceride was measured by enzymatic-colorimetric method, while TyG index was calculated accordingly. The mean age was 39.5 ± 11.27 years in NAFLD patients and 37.10 ± 12.28 years in control subjects with male female ratio 1:1.7 and 1:1.8 respectively. Major portion of NAFLD patients (62.9%) were overweight (BMI ≥ 25). The mean fasting plasma glucose level was 5.73 ± 1.47 mmol/L in NAFLD patients and 5.27 ± 0.69 mmol/L in control group (p < 0.027). The mean serum triglyceride level was 237.19 ± 96.47 mg/dl in NAFLD patients and 117.32 ± 53.07 mg/dl in control group (p < 0.001). The triglyceride and glucose index (TyG) was 9.36 ± 0.47 in NAFLD group and 8.53 ± 0.42 in control group. TyG index was significantly higher in NAFLD patients in comparison to control group (p < 0.001). In ROC analysis, cut off value of TyG index was 8.85 with sensitivity 93.5% and specificity 79%. As a fast and effective method, TyG index can be used as a diagnostic tool to predict NAFLD.

关键词： Non-Alcoholic Fatty Liver Disease (NAFLD) Plasma Glucose Serum Triglyceride Triglyceride and Glucose Index (TyG)

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Effect of hand hygiene intervention on the absenteeism of pre-school children in Klang Valley,Malaysia:a quasi-experimental study

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World Journal of Pediatrics 2020年第4期16卷 416-421页

作者： Nurul Azmawati Mohamed Mohd Dzulkhairi Mohd Rani Tengku Zetty Maztura Tengku Jamaluddin Zarini Ismail Shalinawati Ramli Habibah faroque Farisha Nur Abd Samad Abdul Rashid Ariffien Aisyah Ar Redha Che Amir FaridIlina Isahak Faculty of Medicine and Health Sciences Universiti Sains Islam MalaysiaPandan Indah55100Kuala LumpurMalaysia Faculty of Medicine and Health Sciences Universiti Putra Malaysia43400SerdangSelangorMalaysia

Background Absenteeism amongst pre-school children is often due to illnesses such as hand,foot,and mouth disease,acute gastroenteritis,cold and flu,which are easily spread amongst *** is because of weak immunity and lack of knowledge on proper hand *** quasi-experimental study assessed the efficacy of an intervention consisting of a hand hygiene education programme,along with digital tools in bringing about a change in behaviour and health conditions amongst pre-school children in Klang Valley,*** A total of 377 school children,male and female,aged 5–6 years old,participated and were assigned to either the intervention or a control *** the 2 months intervention period,children in the test group were trained on proper hand hygiene practices and techniques with the aid of the interactive android-based *** numbers of absent days of all the children were recorded for 2 months before the intervention and during the *** In the test group,there was a 25%increase in the total number of absent days from the pre-intervention period to the intervention period,a much lesser increment observed as compared to that of control group in which the increase was much higher at 89%.Results showed a significant difference(P<0·05)between the absenteeism rates for the test and control group during the intervention *** These results suggest that proper education and intervention increase hand hygiene compliance,which may help decrease school absenteeism due to illness;however,a longer study duration may be necessary to evaluate the benefit further.

关键词： Absenteeism Hand hygiene Povidone-iodine Pre-school children

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Non-Diabetic Renal Disease in Patients with Type 2 Diabetes Mellitus with Proteinuria

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Journal of Biosciences and Medicines 2019年第12期7卷 68-78页

作者： Manik Chandra Mondal Rana Mokarrom hossain K. B. M. Hadiuzzaman Md. Omar faroque Shah Md. Zakir hossain A. K. M. Shahidur Rahman Fahad Al Shatil Ashrafee Popy Sarker Abu Zafor Md. Salahuddin Mohammad Kamrul Ahsan Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Orthodontics and Dento-Facial Orthopaedics Dhaka Dental College and Hospital (DDCH) Dhaka Bangladesh Department of Nephrology Mymensingh Medical College Hospital (MMCH) Mymensingh Bangladesh Holy Family Red Crescent Medical College Hospital (HFRCMCH) Dhaka Bangladesh

Background: Diabetes mellitus (DM) is the leading cause of end stage renal disease (ESRD) worldwide. Although DM with proteinuria is the ultimate result of diabetic nephropathy (DN), a wide spectrum of non-diabetic renal diseases (NDRD) can occur in such patients. Objective: To observe the frequency and histological pattern of NDRD in diabetic patients with proteinuria and to explore their association with clinical and laboratory parameters. Methods: This cross-sectional study was conducted in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from April 2016 to September 2017. In this study a total of 38 cases of DM with proteinuria (>1 gm/24-hour) were selected purposively. Renal biopsy was done in all patients. Based on histological findings they were categorized into two groups;Group 1 with NDRD and Group II with DN. Their clinical and laboratory parameters were analyzed and compared. Results: Among the total study subjects, 21 (55.3%) were male and 17 (44.7%) were female, mean (±SD) age 43.45 ± 9.99 years in the NDRD group and 41.57 ± 9.50 years in the DN group. Thirty one cases (81.6%) out of thirty eight had NDRD and seven (18.4%) cases had isolated DN;therefore more than two third cases had NDRD. Duration of DM was found to be significantly shorter (p = 0.004) in the NDRD group. Diabetic retinopathy was present in 12.9% cases in NDRD group vs. 57.1% cases in DN group (p = 0.025). Frequency of microscopic hematuria was significantly higher (90.3%) in NDRD patients (p = 0.002). Conclusion: The frequency of NDRD in type 2 diabetic patients other than diabetic nephropathy is relatively high. Membrano proliferative glomeru-lonephritis and membranous nephropathy are more common in NDRD. Absence of diabetic retinopathy, presence of hematuria and shorter duration of DM are markers associated with NDRD in type 2 DM, which are important indicators for renal biopsy in diabetic patients with proteinuria.

关键词： Diabetes Mellitus (DM) Diabetic Nephropathy (DN) Non-Diabetic Renal Disease (NDRD) Renal Biopsy

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Ocular Fundus Abnormalities in Pre-Dialytic Chronic Kidney Disease Patients

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Journal of Biosciences and Medicines 2019年第11期7卷 20-35页

作者： Mohammad Kamrul Ahsan Muhammad Rafiqul Alam Asia Khanam A. H. Hamid Ahmed Md. Omar faroque K. B. M. Hadiuzzaman A. K. M. Shahidur Rahman Rafi Nazrul Islam Manik Chandra Mondal Md. Azizur Rahman Holy Family Red Crescent Medical College Hospital (HFRCMCH) Dhaka Bangladesh Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Nephrology & Dialysis BIRDEM General Hospital Dhaka Bangladesh Bangladesh Eye Hospital & Institute Dhaka Bangladesh

Background: Chronic kidney disease (CKD) affects 10% - 16% of the adult population. Although ocular findings related to renal insufficiency include cataract, conjunctival calcification, lid edema, conjunctival pallor and xanthalesma, by far the most important is retinopathy. Objective: To evaluate the ocular fundus abnormalities in pre-dialytic chronic kidney disease patients of the adult population. Methodology: This cross-sectional observational study was conducted in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from April 2012 to March 2014. A total of 100 hospital admitted CKD patients were purposively selected for this study. Age, gender, blood pressure, Body Mass Index (BMI), 24 hours Urinary Total Protein (UTP), haemoglobin level, serum creatinine, serum cholesterol, serum triglyceride and color fundus photography findings of both eyes were recorded for each patient. Inter-group comparisons were made between patients with retinopathy and those without retinopathy. Results: Out of 100 adult non-dialytic CKD patients, 43 (43%) had ocular fundus abnormalities, among them 27 (62.8%) were male and 16 (37.2%) were female. The risk of development of retinopathy was significantly higher among older patients (p = 0.006), those with low haemoglobin level (p = 0.0001) and high blood pressure. Retinopathy was significantly (p = 0.0001) increased with reduction of e-GFR. There was no relationship between BMI and high serum triglyceride level with retinal abnormality. Among 43 (43%) patients with retinal abnormality, 30 (69.76%) patients showed only hypertensive retinopathy and 5 (11.6%) patients showed only diabetic retinopathy. Mixed hypertensive and diabetic retinopathy was found in 8 (18.6%) patients. Maculopathy was seen in 11 (25.58%) patients, of whom 3 (6.98%) had hypertensive retinopathy and 8 (18.87%) had diabetic retinopathy. Optic atrophy was seen in 2 (4.6%) patients and drusen like retinal deposits were

关键词： Chronic Kidney Disease (CKD) Ocular Fundus Retinopathy

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